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A computational study on hydroxychloroquine binding to target proteins related to SARS-COV-2 infection

Navya et al., Informatics in Medicine Unlocked, doi:10.1016/j.imu.2021.100714
Aug 2021  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now known with p < 0.00000000001 from 422 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments. c19hcq.org
In Silico analysis showing that HCQ binds to multiple targets related to SARS-CoV-2 infection, including the ACE2 receptor, α7 nicotinic acetylcholine receptor, α1D-adrenergic receptor, and topoisomerase III β, suggesting that HCQ may interfere with viral entry, replication, and inflammation through interactions with these targets. Results support action of HCQ both at the entry and post-entry stages of SARS-CoV2 infection.
Navya et al., 23 Aug 2021, peer-reviewed, 2 authors. Contact: hosurmv@nias.res.in.
In Silico studies are an important part of preclinical research, however results may be very different in vivo.
This PaperHCQAll
A computational study on hydroxychloroquine binding to target proteins related to SARS-COV-2 infection
V B Navya, M V Hosur
Informatics in Medicine Unlocked, doi:10.1016/j.imu.2021.100714
Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre -including this research content -immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
Declaration of competing interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Appendix A. Supplementary data Supplementary data to this article can be found online at https://doi. org/10.1016/j.imu.2021.100714.
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