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The In Vitro, In Vivo, and PBPK Evaluation of a Novel Lung-Targeted Cardiac-Safe Hydroxychloroquine Inhalation Aerogel

Alsmadi et al., AAPS PharmSciTech, doi:10.1208/s12249-023-02627-3
Aug 2023  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020, now with p < 0.00000000001 from 419 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 112 treatments. c19hcq.org
Analysis of a novel inhaled formulation of HCQ showing sustained drug release, higher lung bioavailability, longer residence time, faster absorption, and lower cardiac enzyme levels compared to oral HCQ. Inhaled formulations may help prevent progression to other tissues and improve efficacy and safety within the lung.
5 studies investigate novel formulations of HCQ for improved efficacy1-5
Alsmadi et al., 11 Aug 2023, peer-reviewed, 6 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
This PaperHCQAll
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