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The In Vitro, In Vivo, and PBPK Evaluation of a Novel Lung-Targeted Cardiac-Safe Hydroxychloroquine Inhalation Aerogel

Alsmadi et al., AAPS PharmSciTech, doi:10.1208/s12249-023-02627-3
Aug 2023  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now known with p < 0.00000000001 from 422 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19hcq.org
Analysis of a novel inhaled formulation of HCQ showing sustained drug release, higher lung bioavailability, longer residence time, faster absorption, and lower cardiac enzyme levels compared to oral HCQ. Inhaled formulations may help prevent progression to other tissues and improve efficacy and safety within the lung.
5 studies investigate novel formulations of HCQ for improved efficacy Alsmadi, Faísca, Kavanagh, Klimke, Zelenko
Alsmadi et al., 11 Aug 2023, peer-reviewed, 6 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
This PaperHCQAll
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