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In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect
Andreani et al., Microbial Pathogenesis, doi:/10.1016/j.micpath.2020.104228 (In Vitro)
Andreani et al., In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect, Microbial Pathogenesis, doi:/10.1016/j.micpath.2020.104228 (In Vitro)
Apr 2020   Source   PDF  
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In Vitro study showing that HCQ and AZ have a synergistic effect on SARS-CoV-2 at concentrations compatible with that obtained in human lung.
14 In Vitro studies support the efficacy of HCQ [Andreani, Clementi, Dang, Delandre, Faísca, Hoffmann, Liu, Ou, Purwati, Sheaff, Wang, Wang (B), Yao, Yuan].
Andreani et al., 25 Apr 2020, peer-reviewed, 11 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
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Abstract: Microbial Pathogenesis 145 (2020) 104228 Contents lists available at ScienceDirect Microbial Pathogenesis journal homepage: www.elsevier.com/locate/micpath In vitro testing of combined hydroxychloroquine and azithromycin on SARSCoV-2 shows synergistic effect T Julien Andreania,b, Marion Le Bideaua,b, Isabelle Duflota,b, Priscilla Jardota,b, Clara Rollanda,b, Manon Boxbergera,b, Nathalie Wurtza,b, Jean-Marc Rolaina,b, Philippe Colsona,b, Bernard La Scolaa,b,∗∗, Didier Raoulta,b,∗ a b IHU-Méditerranée Infection, Marseille, France Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France A R T I C LE I N FO A B S T R A C T Keywords: 2019-nCoV SARS-CoV-2 COVID-19 Hydroxychloroquine Azithromycin Vero E6 Human coronaviruses SARS-CoV-2 appeared at the end of 2019 and led to a pandemic with high morbidity and mortality. As there are currently no effective drugs targeting this virus, drug repurposing represents a short-term strategy to treat millions of infected patients at low costs. Hydroxychloroquine showed an antiviral effect in vitro. In vivo it showed efficacy, especially when combined with azithromycin in a preliminary clinical trial. Here we demonstrate that the combination of hydroxychloroquine and azithromycin has a synergistic effect in vitro on SARS-CoV-2 at concentrations compatible with that obtained in human lung.
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