In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect
Andreani et al.
, In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect
, Microbial Pathogenesis, doi:/10.1016/j.micpath.2020.104228 (In Vitro)
study showing that HCQ and AZ have a synergistic effect on SARS-CoV-2 at concentrations compatible with that obtained in human lung.14 In Vitro studies
support the efficacy of HCQ [Andreani, Clementi, Dang, Delandre, Faísca, Hoffmann, Liu, Ou, Purwati, Sheaff, Wang, Wang (B), Yao, Yuan]
Andreani et al., 25 Apr 2020, peer-reviewed, 11 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
Abstract: Microbial Pathogenesis 145 (2020) 104228
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journal homepage: www.elsevier.com/locate/micpath
In vitro testing of combined hydroxychloroquine and azithromycin on SARSCoV-2 shows synergistic eﬀect
Julien Andreania,b, Marion Le Bideaua,b, Isabelle Duﬂota,b, Priscilla Jardota,b, Clara Rollanda,b,
Manon Boxbergera,b, Nathalie Wurtza,b, Jean-Marc Rolaina,b, Philippe Colsona,b,
Bernard La Scolaa,b,∗∗, Didier Raoulta,b,∗
IHU-Méditerranée Infection, Marseille, France
Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France
A R T I C LE I N FO
A B S T R A C T
Human coronaviruses SARS-CoV-2 appeared at the end of 2019 and led to a pandemic with high morbidity and
mortality. As there are currently no eﬀective drugs targeting this virus, drug repurposing represents a short-term
strategy to treat millions of infected patients at low costs. Hydroxychloroquine showed an antiviral eﬀect in vitro.
In vivo it showed eﬃcacy, especially when combined with azithromycin in a preliminary clinical trial. Here we
demonstrate that the combination of hydroxychloroquine and azithromycin has a synergistic eﬀect in vitro on
SARS-CoV-2 at concentrations compatible with that obtained in human lung.
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