In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect
Andreani et al.,
In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect,
Microbial Pathogenesis, doi:/10.1016/j.micpath.2020.104228 (In Vitro)
In Vitro study showing that HCQ and AZ have a synergistic effect on SARS-CoV-2 at concentrations compatible with that obtained in human lung.
14 In Vitro studies support the efficacy of HCQ
[Andreani, Clementi, Dang, Delandre, Faísca, Hoffmann, Liu, Ou, Purwati, Sheaff, Wang, Wang (B), Yao, Yuan].
Andreani et al., 25 Apr 2020, peer-reviewed, 11 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
Abstract: Microbial Pathogenesis 145 (2020) 104228
Contents lists available at ScienceDirect
Microbial Pathogenesis
journal homepage: www.elsevier.com/locate/micpath
In vitro testing of combined hydroxychloroquine and azithromycin on SARSCoV-2 shows synergistic effect
T
Julien Andreania,b, Marion Le Bideaua,b, Isabelle Duflota,b, Priscilla Jardota,b, Clara Rollanda,b,
Manon Boxbergera,b, Nathalie Wurtza,b, Jean-Marc Rolaina,b, Philippe Colsona,b,
Bernard La Scolaa,b,∗∗, Didier Raoulta,b,∗
a
b
IHU-Méditerranée Infection, Marseille, France
Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France
A R T I C LE I N FO
A B S T R A C T
Keywords:
2019-nCoV
SARS-CoV-2
COVID-19
Hydroxychloroquine
Azithromycin
Vero E6
Human coronaviruses SARS-CoV-2 appeared at the end of 2019 and led to a pandemic with high morbidity and
mortality. As there are currently no effective drugs targeting this virus, drug repurposing represents a short-term
strategy to treat millions of infected patients at low costs. Hydroxychloroquine showed an antiviral effect in vitro.
In vivo it showed efficacy, especially when combined with azithromycin in a preliminary clinical trial. Here we
demonstrate that the combination of hydroxychloroquine and azithromycin has a synergistic effect in vitro on
SARS-CoV-2 at concentrations compatible with that obtained in human lung.
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