Cholinergic α7 nAChR signaling suppresses SARS-CoV-2 infection and inflammation in lung epithelial cells
Jing Wen, Jing Sun, Yanhong Tang, Jincun Zhao, Xiao Su
doi:10.1093/jmcb/mjad048/7231085
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced coronavirus disease 2019 (COVID-19) has caused more than 6 million deaths and poses a huge threat to the global economy and public health. SARS-CoV-2 enters lung epithelial cells depending on S protein binding with angiotensin converting enzyme 2 (ACE2). In-silico studies have shown that both SARS-CoV and SARS-CoV-2 S glycoproteins can interact with the extracellular domain of α7 nicotinic acetylcholine receptor (nAChR). Hydroxychloroquine, a known SARS-CoV-2 inhibitor, acts at the entry stage of SARS-CoV-2 by blocking the virus-binding sites on the two receptors, ACE2 and α7 nAChR (Navya and Hosur, 2021). Given that α7 nAChR possesses anti-inflammatory effects and could interact with the SARS-CoV-2 S protein,
References
Azabou, Bao, Bounab, Vagus Nerve Stimulation: A Potential Adjunct Therapy for COVID-19, Frontiers in medicine
Bonaz, Sinniger, Pellissier, Targeting the cholinergic anti-inflammatory pathway with vagus nerve stimulation in patients with Covid-19?, Bioelectronic medicine
Hsieh, Wang, Wu, Reactive Oxygen Species-Dependent c-Fos/Activator Protein 1 Induction Upregulates Heme Oxygenase-1 Expression by Bradykinin in Brain Astrocytes, Antioxidants & redox signaling
Kipshidze, Chekanov, Kipshidze, Transpulmonary electrotherapy for reduction of lung viral load of SARS-CoV-2 in patients with COVID-19, Medical hypotheses
Kox, Pompe, Peters, alpha7 nicotinic acetylcholine receptor agonist GTS-21 attenuates ventilator-induced tumour necrosis factor-alpha production and lung injury, Br J Anaesth
Li, Li, Wang, SARS-CoV-2 spike promotes inflammation and apoptosis through autophagy by ROS-suppressed PI3K/AKT/mTOR signaling, Biochimica et biophysica acta. Molecular basis of disease
{ 'indexed': {'date-parts': [[2023, 7, 27]], 'date-time': '2023-07-27T04:29:17Z', 'timestamp': 1690432157617},
'reference-count': 0,
'publisher': 'Oxford University Press (OUP)',
'license': [ { 'start': { 'date-parts': [[2023, 7, 26]],
'date-time': '2023-07-26T00:00:00Z',
'timestamp': 1690329600000},
'content-version': 'am',
'delay-in-days': 1,
'URL': 'https://creativecommons.org/licenses/by/4.0/'}],
'content-domain': {'domain': [], 'crossmark-restriction': False},
'DOI': '10.1093/jmcb/mjad048',
'type': 'journal-article',
'created': {'date-parts': [[2023, 7, 26]], 'date-time': '2023-07-26T03:39:02Z', 'timestamp': 1690342742000},
'source': 'Crossref',
'is-referenced-by-count': 0,
'title': 'Cholinergic α7 nAChR signaling suppresses SARS-CoV-2 infection and inflammation in lung '
'epithelial cells',
'prefix': '10.1093',
'author': [ { 'given': 'Jing',
'family': 'Wen',
'sequence': 'first',
'affiliation': [ { 'name': 'Unit of Respiratory Infection and Immunity, Institut Pasteur of '
'Shanghai, Chinese Academy of Sciences , Shanghai 200031 , China'},
{ 'name': 'CAS Key Laboratory of Molecular Virology and Immunology, '
'Institut Pasteur of Shanghai, Chinese Academy of Sciences , '
'Shanghai 200031 , China'},
{ 'name': 'University of Chinese Academy of Sciences , Beijing 100049 , '
'China'}]},
{ 'given': 'Jing',
'family': 'Sun',
'sequence': 'additional',
'affiliation': [ { 'name': 'State Key Laboratory of Respiratory Disease, National Clinical '
'Research Centre for Respiratory Disease, Guangzhou Institute of '
'Respiratory Health, the First Affiliated Hospital of Guangzhou '
'Medical University , Guangzhou 510120 , China'}]},
{ 'given': 'Yanhong',
'family': 'Tang',
'sequence': 'additional',
'affiliation': [ { 'name': 'State Key Laboratory of Respiratory Disease, National Clinical '
'Research Centre for Respiratory Disease, Guangzhou Institute of '
'Respiratory Health, the First Affiliated Hospital of Guangzhou '
'Medical University , Guangzhou 510120 , China'}]},
{ 'given': 'Jincun',
'family': 'Zhao',
'sequence': 'additional',
'affiliation': [ { 'name': 'State Key Laboratory of Respiratory Disease, National Clinical '
'Research Centre for Respiratory Disease, Guangzhou Institute of '
'Respiratory Health, the First Affiliated Hospital of Guangzhou '
'Medical University , Guangzhou 510120 , China'}]},
{ 'ORCID': 'http://orcid.org/0000-0002-8692-8365',
'authenticated-orcid': False,
'given': 'Xiao',
'family': 'Su',
'sequence': 'additional',
'affiliation': [ { 'name': 'Unit of Respiratory Infection and Immunity, Institut Pasteur of '
'Shanghai, Chinese Academy of Sciences , Shanghai 200031 , China'},
{ 'name': 'CAS Key Laboratory of Molecular Virology and Immunology, '
'Institut Pasteur of Shanghai, Chinese Academy of Sciences , '
'Shanghai 200031 , China'},
{ 'name': 'University of Chinese Academy of Sciences , Beijing 100049 , '
'China'}]}],
'member': '286',
'published-online': {'date-parts': [[2023, 7, 25]]},
'container-title': 'Journal of Molecular Cell Biology',
'original-title': [],
'language': 'en',
'link': [ { 'URL': 'https://academic.oup.com/jmcb/advance-article-pdf/doi/10.1093/jmcb/mjad048/50961624/mjad048.pdf',
'content-type': 'application/pdf',
'content-version': 'am',
'intended-application': 'syndication'},
{ 'URL': 'https://academic.oup.com/jmcb/advance-article-pdf/doi/10.1093/jmcb/mjad048/50961624/mjad048.pdf',
'content-type': 'unspecified',
'content-version': 'vor',
'intended-application': 'similarity-checking'}],
'deposited': { 'date-parts': [[2023, 7, 26]],
'date-time': '2023-07-26T03:39:03Z',
'timestamp': 1690342743000},
'score': 1,
'resource': { 'primary': { 'URL': 'https://academic.oup.com/jmcb/advance-article/doi/10.1093/jmcb/mjad048/7231085'}},
'subtitle': [],
'short-title': [],
'issued': {'date-parts': [[2023, 7, 25]]},
'references-count': 0,
'URL': 'http://dx.doi.org/10.1093/jmcb/mjad048',
'relation': {},
'ISSN': ['1674-2788', '1759-4685'],
'subject': ['Cell Biology', 'Genetics', 'Molecular Biology', 'General Medicine'],
'published': {'date-parts': [[2023, 7, 25]]}}
