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All Studies   Meta Analysis    Recent:   

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

Wang et al., Cell Res. 30, 269–271, doi:10.1038/s41422-020-0282-0
Feb 2020  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now with p < 0.00000000001 from 411 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments. c19hcq.org
In Vitro study showing that Remdesivir and CQ potently blocked SARS-CoV-2 infection.
34 preclinical studies support the efficacy of HCQ for COVID-19:
Wang et al., 4 Feb 2020, peer-reviewed, 10 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
This PaperHCQAll
Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
Manli Wang, Ruiyuan Cao, Leike Zhang, Xinglou Yang, Jia Liu, Mingyue Xu, Zhengli Shi, Zhihong Hu, Wu Zhong, Gengfu Xiao
Cell Research, doi:10.1038/s41422-020-0282-0
a novel pneumonia caused by a previously unknown pathogen emerged in Wuhan, a city of 11 million people in central China. The initial cases were linked to exposures in a seafood market in Wuhan. 1 As of January 27, 2020, the Chinese authorities reported 2835 confirmed cases in mainland China, including 81 deaths. Additionally, 19 confirmed cases were identified in Hong Kong, Macao and Taiwan, and 39 imported cases were identified in Thailand,
AUTHOR CONTRIBUTIONS G.X., W.Z., Z.H., M.W., R.C., and L.Z. conceived and designed the experiments. X.Y., J.L., M.X., M.W., R.C., and L.Z. participated in multiple experiments; G.X., W.Z., Z.H., Z.S., M.W., R.C., and L.Z. analyzed the data. M.W., L.Z., R.C., and Z.H. wrote the manuscript. G.X., W.Z., and Z.H. provided the final approval of the manuscript. ADDITIONAL INFORMATION Supplementary information accompanies this paper at https://doi.org/10.1038/ s41422-020-0282-0. Competing interests: The authors declare no competing interests. Manli Wang
References
Huang, None, The Lancet, doi:10.1016/S0140-6736(20)30183-5
Mackenzie, None, Am. J. Med
Mulangu, None, N. Engl. J. Med
Oestereich, None, Antivir. Res
Savarino, Di Trani, Donatelli, Cauda, Cassone, None, Lancet Infect. Dis
Sheahan, None, Sci. Transl. Med
Vincent, None, Virol. J
Warren, None, Nature
Yan, None, Cell Res
Zhou, None, Nature
Zumla, Chan, Azhar, Hui, Yuen, None, Nat. Rev. Drug Discov
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