New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?
Devaux et al.
, New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?
, International Journal of Antimicrobial Agents, doi:10.1016/j.ijantimicag.2020.105938 (Theory)
Discusses mechanisms of CQ interference with the SARS-CoV-2 replication cycle.
Devaux et al., 12 Mar 2020, peer-reviewed, 4 authors.
Abstract: International Journal of Antimicrobial Agents 55 (2020) 105938
Contents lists available at ScienceDirect
International Journal of Antimicrobial Agents
journal homepage: www.elsevier.com/locate/ijantimicag
New insights on the antiviral effects of chloroquine against
coronavirus: what to expect for COVID-19?
Christian A. Devaux a,b,c,∗, Jean-Marc Rolain a,c, Philippe Colson a,c, Didier Raoult a,c
Aix-Marseille Université, IRD, APHM, MEPHI, IHU–Méditerranée Infection, Marseille, France
CNRS, Marseille, France
IHU–Méditerranée Infection, 19–21 boulevard Jean Moulin, 13005 Marseille, France
a r t i c l e
i n f o
Editor: Jose Fernando Oliveira
a b s t r a c t
Recently, a novel coronavirus (2019-nCoV), oﬃcially known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in China. Despite drastic containment measures, the spread of this virus
is ongoing. SARS-CoV-2 is the aetiological agent of coronavirus disease 2019 (COVID-19) characterised by
pulmonary infection in humans. The efforts of international health authorities have since focused on rapid
diagnosis and isolation of patients as well as the search for therapies able to counter the most severe effects of the disease. In the absence of a known eﬃcient therapy and because of the situation of a publichealth emergency, it made sense to investigate the possible effect of chloroquine/hydroxychloroquine
against SARS-CoV-2 since this molecule was previously described as a potent inhibitor of most coronaviruses, including SARS-CoV-1. Preliminary trials of chloroquine repurposing in the treatment of COVID19 in China have been encouraging, leading to several new trials. Here we discuss the possible mechanisms of chloroquine interference with the SARS-CoV-2 replication cycle.
© 2020 Published by Elsevier B.V.
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