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New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?

Devaux et al., International Journal of Antimicrobial Agents, doi:10.1016/j.ijantimicag.2020.105938
Mar 2020  
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Discusses mechanisms of CQ interference with the SARS-CoV-2 replication cycle.
Devaux et al., 12 Mar 2020, peer-reviewed, 4 authors.
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New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?
Christian A Devaux, Jean-Marc Rolain, Philippe Colson, Didier Raoult
International Journal of Antimicrobial Agents, doi:10.1016/j.ijantimicag.2020.105938
Recently, a novel coronavirus (2019-nCoV), officially known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in China. Despite drastic containment measures, the spread of this virus is ongoing. SARS-CoV-2 is the aetiological agent of coronavirus disease 2019 (COVID-19) characterised by pulmonary infection in humans. The effort s of international health authorities have since focused on rapid diagnosis and isolation of patients as well as the search for therapies able to counter the most severe effects of the disease. In the absence of a known efficient therapy and because of the situation of a publichealth emergency, it made sense to investigate the possible effect of chloroquine/hydroxychloroquine against SARS-CoV-2 since this molecule was previously described as a potent inhibitor of most coronaviruses, including SARS-CoV-1. Preliminary trials of chloroquine repurposing in the treatment of COVID-19 in China have been encouraging, leading to several new trials. Here we discuss the possible mechanisms of chloroquine interference with the SARS-CoV-2 replication cycle.
Competing interests: None declared. Ethical approval: Not required.
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