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Combined Prophylactic and Therapeutic Use Maximizes Hydroxychloroquine Anti-SARS-CoV-2 Effects in vitro
Clementi et al., Front. Microbiol., 10 July 2020, doi:10.3389/fmicb.2020.01704 (date from earlier preprint) (In Vitro)
Clementi et al., Combined Prophylactic and Therapeutic Use Maximizes Hydroxychloroquine Anti-SARS-CoV-2 Effects in vitro, Front. Microbiol., 10 July 2020, doi:10.3389/fmicb.2020.01704 (date from earlier preprint) (In Vitro)
Mar 2020   Source   PDF  
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In Vitro study showing greater inhibition for combined pre and post-exposure treatment for Vero E6 and Caco-2 cells.
14 In Vitro studies support the efficacy of HCQ [Andreani, Clementi, Dang, Delandre, Faísca, Hoffmann, Liu, Ou, Purwati, Sheaff, Wang, Wang (B), Yao, Yuan].
Clementi et al., 31 Mar 2020, peer-reviewed, 10 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
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Abstract: ORIGINAL RESEARCH published: 10 July 2020 doi: 10.3389/fmicb.2020.01704 Combined Prophylactic and Therapeutic Use Maximizes Hydroxychloroquine Anti-SARS-CoV-2 Effects in vitro Nicola Clementi 1,2 , Elena Criscuolo 1 , Roberta Antonia Diotti 1 , Roberto Ferrarese 1 , Matteo Castelli 1 , Lorenzo Dagna 3 , Roberto Burioni 1 , Massimo Clementi 1,2 and Nicasio Mancini 1,2* 1 Laboratory of Microbiology and Virology, Vita-Salute San Raffaele University, Milan, Italy, 2 Laboratory of Microbiology and Virology, IRCCS San Raffaele Scientific Institute, Milan, Italy, 3 Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy Edited by: Lars Kaderali, Universitätsmedizin Greifswald, Germany Reviewed by: Sibylle Haid, Twincore Center for Experimental and Clinical Infection Research GmbH, Germany Alexander Freiberg, The University of Texas Medical Branch at Galveston, United States *Correspondence: Nicasio Mancini mancini.nicasio@hsr.it Specialty section: This article was submitted to Virology, a section of the journal Frontiers in Microbiology Received: 09 April 2020 Accepted: 29 June 2020 Published: 10 July 2020 Citation: Clementi N, Criscuolo E, Diotti RA, Ferrarese R, Castelli M, Dagna L, Burioni R, Clementi M and Mancini N (2020) Combined Prophylactic and Therapeutic Use Maximizes Hydroxychloroquine Anti-SARS-CoV-2 Effects in vitro. Front. Microbiol. 11:1704. doi: 10.3389/fmicb.2020.01704 While the SARS-CoV-2 pandemic is heavily hitting the world, it is of extreme importance that significant in vitro observations guide the quick set up of clinical trials. In this study, we evidence that the anti-SARS-CoV2 activity of a clinically achievable hydroxychloroquine concentration is maximized only when administered before and after the infection of Vero E6 and Caco-2 cells. This suggests that only a combined prophylactic and therapeutic use of hydroxychloroquine may be effective in limiting viral replication in patients. Keywords: hydroxychloroquine, SARS-CoV-2, COVID-19, prophylaxis, therapy
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