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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Mortality 51% Improvement Relative Risk c19hcq.org Arshad et al. HCQ for COVID-19 LATE TREATMENT Favors HCQ Favors control
Treatment with Hydroxychloroquine, Azithromycin, and Combination in Patients Hospitalized with COVID-19
Arshad et al., Int. J. Infect. Dis., July 1 2020, doi:10.1016/j.ijid.2020.06.099
1 Jul 2020    Source   PDF   Share   Tweet
HCQ decreases mortality from 26.4% to 13.5% (HCQ) or 20.1% (HCQ+AZ). Propensity matched HCQ HR 0.487, p=0.009. Michigan 2,541 patients retrospective. Before propensity matching the HCQ group average age is 5 years younger and the percentage of male patients is 4% higher which is likely to favor the treatment and the control respectively in the before-propensity matching results.
Some reported limtiations of this study are inaccurate [ijidonline.com]. Corticosteroids were controlled for in the multivariate and propensity analyses as were age and comorbidities including cardiac disease and severity of illness. Age was an independent risk factor associated with mortality. HCQ was independently associated with decreased mortality, distinct from the steroid effect. 91% of all patients began treatment within two days of admission. HCQ was used throughout the study period, limiting time bias. Patients assigned to HCQ group had moderate and severe illness at presentation, which would favor worse outcome with HCQ.
risk of death, 51.3% lower, HR 0.49, p = 0.009, treatment 162 of 1,202 (13.5%), control 108 of 409 (26.4%), NNT 7.7.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Arshad et al., 1 Jul 2020, retrospective, USA, peer-reviewed, 12 authors.
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This PaperHCQAll
Late treatment
is less effective
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