Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
PPIs
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Abstract
All HCQ studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19hcq.org COVID-19 treatment researchHCQHCQ (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis       

Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies

Gao et al., BioScience Trends, 2020, doi:10.5582/bst.2020.01047
Feb 2020  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020, now with p < 0.00000000001 from 419 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 109 treatments. c19hcq.org
Results from 15 clinical trials in China showing CQ is effective.
Gao et al., 19 Feb 2020, peer-reviewed, 3 authors.
This PaperHCQAll
Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies
Jianjun Gao, Zhenxue Tian, Xu Yang
BioScience Trends, doi:10.5582/bst.2020.01047
The coronavirus disease 2019 (COVID-19) virus, emerged in December 2019, has spread rapidly, with cases now confirmed in multiple countries. As of February 16, 2020, the virus has caused 70,548 infections and 1,770 deaths in mainland China and 413 infections in Japan (1). A great deal of effort has been made to find effective drugs against the virus in China (2). On February 17, 2020, the State Council of China held a news briefing indicating that chloroquine phosphate, an old drug for treatment of malaria, had demonstrated marked efficacy and acceptable safety in treating COVID-19 associated pneumonia in multicenter clinical trials conducted in China (3). In the early in vitro studies, chloroquine was found to block COVID-19 infection at low-micromolar concentration, with a half-maximal effective concentration (EC 50 ) of 1.13 μM and a half-cytotoxic concentration (CC 50 ) greater than 100 μM (4). A number of subsequent clinical trials (ChiCTR2000029939,
References
Lu, Drug treatment options for the 2019-new coronavirus (2019-nCoV), Biosci Trends
Savarino, Boelaert, Cassone, Majori, Cauda, Effects of chloroquine on viral infections: an old drug against today's diseases?, Lancet Infect Dis
Wang, Cao, Zhang, Yang, Liu et al., Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro, Cell Res
Yan, Zou, Sun, Li, Xu et al., Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model, Cell Res
{ 'indexed': {'date-parts': [[2024, 5, 14]], 'date-time': '2024-05-14T18:41:18Z', 'timestamp': 1715712078226}, 'reference-count': 7, 'publisher': 'International Research and Cooperation Association for Bio & Socio-Sciences Advancement ' '(IRCA-BSSA)', 'issue': '1', 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'published-print': {'date-parts': [[2020, 2, 29]]}, 'DOI': '10.5582/bst.2020.01047', 'type': 'journal-article', 'created': {'date-parts': [[2020, 2, 18]], 'date-time': '2020-02-18T22:14:54Z', 'timestamp': 1582064094000}, 'page': '72-73', 'source': 'Crossref', 'is-referenced-by-count': 1740, 'title': 'Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 ' 'associated pneumonia in clinical studies', 'prefix': '10.5582', 'volume': '14', 'author': [ { 'given': 'Jianjun', 'family': 'Gao', 'sequence': 'first', 'affiliation': [ { 'name': 'Department of Pharmacology, School of Pharmacy, Qingdao ' 'University, Qingdao, China.'}]}, { 'given': 'Zhenxue', 'family': 'Tian', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Pharmacy, Qingdao Municipal Hospital, Qingdao, ' 'China.'}]}, { 'given': 'Xu', 'family': 'Yang', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Pharmacy, Qingdao Municipal Hospital, Qingdao, ' 'China.'}]}], 'member': '3542', 'reference': [ { 'key': '1', 'unstructured': '1. Notification of 2019-nCoV infection. National Health Commission of ' 'the People&apos;s Republic of China. ' '<i>http://www.nhc.gov.cn/xcs/yqfkdt/202002/18546da875d74445bb537ab014e7a1c6.shtml</i> ' '(accessed February 17, 2020). (in Chinese)'}, { 'key': '2', 'doi-asserted-by': 'crossref', 'unstructured': '2. Lu H. Drug treatment options for the 2019-new coronavirus ' '(2019-nCoV). Biosci Trends. 2020.', 'DOI': '10.5582/bst.2020.01020'}, { 'key': '3', 'unstructured': '3. Audio transcript of the news briefing held by the State Council of ' 'China on February 17, 2020. The National Health Commission of the ' 'People&apos;s Republic of China. ' '<i>http://www.nhc.gov.cn/xcs/yqfkdt/202002/f12a62d10c2a48c6895cedf2faea6e1f.shtml</i> ' '(accessed February 18, 2020). (in Chinese)'}, { 'key': '4', 'doi-asserted-by': 'crossref', 'unstructured': '4. Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M, Shi Z, Hu Z, Zhong W, ' 'Xiao G. Remdesivir and chloroquine effectively inhibit the recently ' 'emerged novel coronavirus (2019-nCoV) <i>in vitro</i>. Cell Res. 2020.', 'DOI': '10.1038/s41422-020-0282-0'}, { 'key': '5', 'unstructured': '5. Chinese Clinical Trial Registry. ' '<i>http://www.chictr.org.cn/searchproj.aspx?title=%E6%B0%AF%E5%96%B9&amp;officialname=&amp;subjectid=&amp;secondaryid=&amp;applier=&amp;studyleader=&amp;ethicalcommitteesanction=&amp;sponsor=&amp;studyailment=&amp;studyailmentcode=&amp;studytype=0&amp;studystage=0&amp;studydesign=0&amp;minstudyexecutetime=&amp;maxstudyexecutetime=&amp;recruitmentstatus=0&amp;gender=0&amp;agreetosign=&amp;secsponsor=&amp;regno=&amp;regstatus=0&amp;country=&amp;province=&amp;city=&amp;institution=&amp;institutionlevel=&amp;measure=&amp;intercode=&amp;sourceofspends=&amp;createyear=0&amp;isuploadrf=&amp;whetherpublic=&amp;btngo=btn&amp;verifycode=&amp;page=1</i> ' '(accessed February 18, 2019).'}, { 'key': '6', 'unstructured': '6. Savarino A, Boelaert JR, Cassone A, Majori G, Cauda R.Effects of ' 'chloroquine on viral infections: an old drug against today&apos;s ' 'diseases? Lancet Infect Dis. 2003; 3:722-727.'}, { 'key': '7', 'doi-asserted-by': 'crossref', 'unstructured': '7. Yan Y, Zou Z, Sun Y, Li X, Xu KF, Wei Y, Jin N, Jiang C. Anti-malaria ' 'drug chloroquine is highly effective in treating avian influenza A H5N1 ' 'virus infection in an animal model. Cell Res. 2013; 23:300-302.', 'DOI': '10.1038/cr.2012.165'}], 'container-title': 'BioScience Trends', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://www.jstage.jst.go.jp/article/bst/14/1/14_2020.01047/_pdf', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2020, 3, 21]], 'date-time': '2020-03-21T03:38:02Z', 'timestamp': 1584761882000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.jstage.jst.go.jp/article/bst/14/1/14_2020.01047/_article'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2020, 2, 29]]}, 'references-count': 7, 'journal-issue': {'issue': '1', 'published-print': {'date-parts': [[2020]]}}, 'URL': 'http://dx.doi.org/10.5582/bst.2020.01047', 'relation': {}, 'ISSN': ['1881-7815', '1881-7823'], 'subject': [], 'container-title-short': 'BST', 'published': {'date-parts': [[2020, 2, 29]]}}
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit