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Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine: Involvement of p38 MAPK and ERK

Kono et al., Antiviral Research, 77:2, February 2008, 150-152, 10.1016/j.antiviral.2007.10.011 (In Vitro)
Kono et al., Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine:.., Antiviral Research, 77:2, February 2008, 150-152, 10.1016/j.antiviral.2007.10.011 (In Vitro)
Dec 2007   Source   PDF  
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CQ significantly decreased viral replication of HCoV-229E at concentrations lower than in clinical usage. CQ affects the activation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK). p38 MAPK inhibitor, SB203580, inhibits CPE induced by HCoV-229E infection and viral replication.
14 In Vitro studies support the efficacy of HCQ [Andreani, Clementi, Dang, Delandre, Faísca, Hoffmann, Liu, Ou, Purwati, Sheaff, Wang, Wang (B), Yao, Yuan].
Kono et al., 4 Dec 2007, peer-reviewed, 6 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
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Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine: Involvement of p38 MAPK and ERK
Masakazu Kono, Koichiro Tatsumi, Alberto M Imai, Kengo Saito, Takayuki Kuriyama, Hiroshi Shirasawa
Antiviral Research, doi:10.1016/j.antiviral.2007.10.011
The antiviral effects of chloroquine (CQ) on human coronavirus 229E (HCoV-229E) infection of human fetal lung cell line, L132 are reported. CQ significantly decreased the viral replication at concentrations lower than in clinical usage. We demonstrated that CQ affects the activation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK). Furthermore, p38 MAPK inhibitor, SB203580, inhibits CPE induced by HCoV-229E infection and viral replication. Our findings suggest that CQ affects the activation of MAPKs, involved in the replication of HCoV-229E.
References
Banerjee, Murine coronavirus replication-induced p38 mitogenactivated protein kinase activation promotes interleukin-6 production and virus replication in cultured cells, J. Virol
Barnard, Evaluation of immunomodulators, interferons and known in vitro SARS-CoV inhibitors for inhibition of SARS-CoV replication in BALB/c mice, Antivir. Chem. Chemother
Kopecky-Bromberg, 7a Protein of severe acute respiratory syndrome coronavirus inhibits cellular protein synthesis and activates p38 mitogenactivated protein kinase, J. Virol
Nauwynck, Entry of porcine reproductive and respiratory syndrome virus into porcine alveolar macrophages via receptor-mediated endocytosis, J. Gen. Virol
Ng, Proliferative growth of SARS coronavirus in Vero E6 cells, J. Gen. Virol
Pleschka, Influenza virus propagation is impaired by inhibition of the Raf/MEK/ERK signalling cascade, Nat. Cell Biol
Savarino, Effects of chloroquine on viral infections: an old drug against today's diseases?, Lancet Infect. Dis
Sperber, Inhibition of human immunodeficiency virus type 1 replication by hydroxychloroquine in T cells and monocytes, AIDS Res. Hum. Retrov
Su, Japanese encephalitis virus infection initiates endoplasmic reticulum stress and an unfolded protein response, J. Virol
Van Elden, Frequent detection of human coronaviruses in clinical specimens from patients with respiratory tract infection by use of a novel real-time reverse-transcriptase polymerase chain reaction, J. Infect. Dis
Vincent, Chloroquine is a potent inhibitor of SARS coronavirus infection and spread, Virol. J
Weber, Inhibition of mitogen-activated protein kinase signaling by chloroquine, J. Immunol
Xia, Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis, Science
Yi, Krieg, Rapid induction of mitogen-activated protein kinases by immune stimulatory CpG DNA, J. Immunol
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