Zinc(II)—The Overlooked Éminence Grise of Chloroquine’s Fight against COVID-19?
Aleksandra Hecel, Małgorzata Ostrowska, Kamila Stokowa-Sołtys, Joanna Wątły, Dorota Dudek, Adriana Miller, Sławomir Potocki, Agnieszka Matera-Witkiewicz, Alicia Dominguez-Martin, Henryk Kozłowski, Magdalena Rowińska-Żyrek
Pharmaceuticals, doi:10.3390/ph13090228
Zn(II) is an inhibitor of SARS-CoV-2 s RNA-dependent RNA polymerase, and chloroquine and hydroxychloroquine are Zn(II) ionophores-this statement gives a curious mind a lot to think about. We show results of the first clinical trials on chloroquine (CQ) and hydroxychloroquine (HCQ) in the treatment of COVID-19, as well as earlier reports on the anticoronaviral properties of these two compounds and of Zn(II) itself. Other FDA-approved Zn(II) ionophores are given a decent amount of attention and are thought of as possible COVID-19 therapeutics.
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doi:10.1002/chem.201602376{ 'indexed': {'date-parts': [[2024, 1, 29]], 'date-time': '2024-01-29T21:41:30Z', 'timestamp': 1706564490514},
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'abstract': '<jats:p>Zn(II) is an inhibitor of SARS-CoV-2′s RNA-dependent RNA polymerase, and chloroquine '
'and hydroxychloroquine are Zn(II) ionophores–this statement gives a curious mind a lot to '
'think about. We show results of the first clinical trials on chloroquine (CQ) and '
'hydroxychloroquine (HCQ) in the treatment of COVID-19, as well as earlier reports on the '
'anticoronaviral properties of these two compounds and of Zn(II) itself. Other FDA-approved '
'Zn(II) ionophores are given a decent amount of attention and are thought of as possible '
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'title': 'Zinc(II)—The Overlooked Éminence Grise of Chloroquine’s Fight against COVID-19?',
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