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Zinc(II)—The Overlooked Éminence Grise of Chloroquine’s Fight against COVID-19?

Hecel et al., Pharmaceuticals, 13:9, 228, doi:10.3390/ph13090228
Sep 2020  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
*, now with p < 0.00000000001 from 411 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments.
Review of zinc as an inhibitor of SARS-CoV-2′s RNA-dependent RNA polymerase, and zinc ionophores including CQ/HCQ, showing the latest evidence for zinc and CQ/HCQ having antiviral, and in particular anticoronaviral action.
Reviews covering hydroxychloroquine for COVID-19 include1-17.
Hecel et al., 1 Sep 2020, peer-reviewed, 11 authors.
This PaperHCQAll
Zinc(II)—The Overlooked Éminence Grise of Chloroquine’s Fight against COVID-19?
Aleksandra Hecel, Małgorzata Ostrowska, Kamila Stokowa-Sołtys, Joanna Wątły, Dorota Dudek, Adriana Miller, Sławomir Potocki, Agnieszka Matera-Witkiewicz, Alicia Dominguez-Martin, Henryk Kozłowski, Magdalena Rowińska-Żyrek
Pharmaceuticals, doi:10.3390/ph13090228
Zn(II) is an inhibitor of SARS-CoV-2 s RNA-dependent RNA polymerase, and chloroquine and hydroxychloroquine are Zn(II) ionophores-this statement gives a curious mind a lot to think about. We show results of the first clinical trials on chloroquine (CQ) and hydroxychloroquine (HCQ) in the treatment of COVID-19, as well as earlier reports on the anticoronaviral properties of these two compounds and of Zn(II) itself. Other FDA-approved Zn(II) ionophores are given a decent amount of attention and are thought of as possible COVID-19 therapeutics.
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