Abstract: Bioorg. Med. Chem. 32 (2021) 115973 Contents lists available at ScienceDirect Bioorganic & Medicinal Chemistry journal homepage: www.elsevier.com/locate/bmc A comprehensive review on the biological interest of quinoline and its derivatives Basavarajaiah Suliphuldevara Matada a, *, Raviraj Pattanashettar b, Nagesh Gunavanthrao Yernale c, * a b c PG Department of Chemistry, Vijaya College, Bengaluru 560 004, Karnataka, India Salicylates and Chemicals Pvt. Ltd., Hyderabad 500 076, Telangana, India Department of Chemistry, Guru Nanak First Grade Science, Commerce and Post Graduate College, Bidar 585 403, Karnataka, India A R T I C L E I N F O A B S T R A C T Keywords: Heterocyclic compounds Quinolines Natural sources Marketed drugs Approved drugs Biological Interest Amongst heterocyclic compounds, quinoline is an advantaged scaffold that appears as a significant assembly motif for the development of new drug entities. Quinoline and its derivatives tested with diverse biological activity constitute an important class of compounds for new drug development. Therefore, many scientific communities have developed these compounds as intent structure and evaluated their biological activities. The present, review provides brief natural sources of quinoline and including a new extent of quinoline-based marketed drugs. This review also confers information about the biological activities of quinoline derivatives such as antibacterial, antifungal, antimycobacterial, antiviral, anti-protozoal, antimalarial, anticancer, cardio­ vascular, CNS effects, antioxidant, anticonvulsant, analgesic, anti-inflammatory, anthelmintic and miscellaneous activities.