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There is no such thing as a Ministry of Truth and why it is important to challenge conventional “wisdom” - A personal view

Brouqui et al., New Microbes and New Infections, doi:10.1016/j.nmni.2023.101155

Jun 2023

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HCQ for COVID-19

1st treatment shown to reduce risk in March 2020

^*, now known with p < 0.00000000001 from 422 studies, recognized in 42 countries.

Lower risk for mortality, hospitalization, recovery, cases, and viral clearance.

No treatment is 100% effective. Protocols combine complementary and synergistic treatments. ^* >10% efficacy in meta analysis with ≥3 clinical studies.

4,100+ studies for 60+ treatments. c19hcq.org

Discussion of censorship in scientific journals and the media; fraudulent, false, and misleading information used to justify censorship and the termination of trials; harassment of highly cited and respected researchers reporting life-saving research with results that are inconvenient for conflicted parties; and conflicts of interest including the correlation between the amount of money received from Gilead and public opposition to HCQ.

Reviews covering hydroxychloroquine for COVID-19 include Al-Bari, Brouqui, Colson, Derwand, Gao, Goldstein, Hecel, IHU, Kaur, Li, Loo, Matada, Roussel, Sahraei, Todaro, Vigbedor.

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1. Al-Bari, M., Targeting endosomal acidification by chloroquine analogs as a promising strategy for the treatment of emerging viral diseases, Pharmacology Research & Perspectives, doi:10.1002/prp2.293.wiley.com, doi.org.

2. Brouqui et al., There is no such thing as a Ministry of Truth and why it is important to challenge conventional “wisdom” - A personal view, New Microbes and New Infections, doi:10.1016/j.nmni.2023.101155.sciencedirect.com, doi.org.

3. Colson et al., Chloroquine and Hydroxychloroquine as Available Weapons to Fight COVID-19, Int J. Antimicrob Agents, doi: 10.1016/j.ijantimicag.2020.105932. Epub 2020 Mar 4., www.ncbi.nlm.nih.gov/pmc/articles/PMC7135139/.nih.gov.

4. Derwand et al., Does zinc supplementation enhance the clinical efficacy of chloroquine/hydroxychloroquine to win today's battle against COVID-19?, Medical Hypotheses, doi:10.1016/j.mehy.2020.109815.sciencedirect.com, doi.org.

5. Gao et al., Update on Use of Chloroquine/Hydroxychloroquine to Treat Coronavirus Disease 2019 (COVID-19), Biosci Trends, May 21, 2020, 14:2, 156-158, doi:10.5582/bst.2020.03072.go.jp, doi.org.

6. Goldstein, L., Hydroxychloroquine-based COVID-19 Treatment, A Systematic Review of Clinical Evidence and Expert Opinion from Physicians’ Surveys, Preprint, July 7, 2020, wattsupwiththat.com/2020/07/07/hydroxychloroquine-based-covid-19-treatment-a-systematic-review-of-clinical-evidence-and-expert-opinion-from-physicians-surveys/.wattsupwiththat.com.

7. Hecel et al., Zinc(II)—The Overlooked Éminence Grise of Chloroquine’s Fight against COVID-19?, Pharmaceuticals, 13:9, 228, doi:10.3390/ph13090228.mdpi.com, doi.org.

8. IHU, Natural history and therapeutic options for COVID-19, Expert Review of Clinical Immunology, www.mediterranee-infection.com/wp-content/uploads/2020/09/ERM-2020-0073.R1_Proof_hi.pdf.mediterranee-infection.com.

9. Kaur et al., Folic acid as placebo in controlled clinical trials of hydroxychloroquine prophylaxis in COVID-19: Is it scientifically justifiable?, Medical Hypotheses, doi:10.1016/j.mehy.2021.110539.sciencedirect.com, doi.org.

10. Li et al., Is hydroxychloroquine beneficial for COVID-19 patients?, Cell Death & Disease volume 11, doi:10.1038/s41419-020-2721-8.nature.com, doi.org.

11. Loo et al., Recent Advances in Inhaled Nanoformulations of Vaccines and Therapeutics Targeting Respiratory Viral Infections, Pharmaceutical Research, doi:10.1007/s11095-023-03520-1.springer.com, doi.org.

12. Matada et al., A comprehensive review on the biological interest of quinoline and its derivatives, Bioorganic & Medicinal Chemistry, doi:10.1016/j.bmc.2020.115973.sciencedirect.com, doi.org.

13. Roussel et al., Influence of conflicts of interest on public positions in the COVID-19 era, the case of Gilead Sciences, New Microbes and New Infections, Volume 38 , doi:10.1016/j.nmni.2020.100710.sciencedirect.com, doi.org.

14. Sahraei et al., Aminoquinolines against coronavirus disease 2019 (COVID-19): chloroquine or hydroxychloroquine, Int. J. Antimicrobial Agents, April 2020, 55:4, doi:10.1016/j.ijantimicag.2020.105945.europepmc.org, doi.org.

15. Todaro et al., An Effective Treatment for Coronavirus (COVID-19), github.com/covidtrial/info/raw/master/An%20Effective%20Treatment%20for%20Coronavirus%20(COVID-19).pdf.github.com.

16. Vigbedor et al., Review of four major biomolecular target sites for COVID-19 and possible inhibitors as treatment interventions, Journal of Applied Pharmaceutical Science, doi:10.7324/JAPS.2021.110825.japsonline.com, doi.org.

Brouqui et al., 22 Jun 2023, peer-reviewed, 3 authors.

This Paper HCQ All

There is no such thing as a Ministry of Truth and why it is important to challenge conventional “wisdom” - A personal view

Philippe Brouqui, Michel Drancourt, Didier Raoult

New Microbes and New Infections, doi:10.1016/j.nmni.2023.101155

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Conflict of interest. None Text Words: 1199 Online supplemental data There is no such thing as a Ministry of Truth and why it is important to challenge conventional "wisdom" -a personal view. Authors

References

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Axfors, Schmitt, Janiaud, Van't Hooft, Abd-Elsalam et al., Mortality outcomes with HCQ and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials, Nat Commun

Bik, la déceleuse de fraudes scientifiques" qui critique constamment Didier Raoult, estelle au-dessus de tout soupçon ? | FranceSoir

Brouqui, Boudjema, Soto Aladro, Chabrière, Florea et al., New Approaches to Prevent Healthcare-Associated Infection, Clin Infect Dis

Brouqui, Drancourt, Raoult, on behalf of the IHU Task Force. COVID-19 Management at IHU Méditerranée Infection: A One-Year Experience, Journal of Clinical Medicine

Colson, Fournier, Chaudet, Delerce, Gatineau et al., Analysis of SARS-CoV-2 Variants From 24,181 Patients Exemplifies the Role of Globalization and Zoonosis in Pandemics, Frontiers in Microbiology, doi:10.3389/fmicb.2021.786233

Didier, Au dela de l'affaire de la choroquine [Internet]. Michel Lafon. Michel Lafon; 2021 [cited

Dubée, Roy, Vielle, Parot-Schinkel, Blanchet et al., HCQ in mild-tomoderate coronavirus disease 2019: a placebo-controlled double blind trial, Clinical Microbiology and Infection

Elisha, Guetzkow, Shir-Raz, Ronel, Suppressing Scientific Discourse on Vaccines? Selfperceptions of researchers and practitioners

Gautret, Lagier, Parola, Hoang, Meddeb et al., HCQ and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial, International Journal of Antimicrobial Agents

Gautret, Lagier, Parola, Hoang, Meddeb et al., Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial, Int J Antimicrob Agents

Ivermectin, Covid-19, Treatment Guidelines

Lagier, Million, Cortaredona, Delorme, Colson et al., Outcomes of 2111 COVID-19 Hospitalized Patients Treated with HCQ/Azithromycin and Other Regimens in Marseille, France, 2020: A Monocentric Retrospective Analysis, Ther Clin Risk Manag

Lagier, Million, Gautret, Colson, Cortaredona et al., Outcomes of 3,737 COVID-19 patients treated with HCQ/azithromycin and other regimens in Marseille, France: A retrospective analysis, Travel Med Infect Dis

Lane, Weaver, Kostka, Duarte-Salles, Abrahao et al., Risk of HCQ alone and in combination with azithromycin in the treatment of rheumatoid arthritis: a multinational, retrospective study, Lancet Rheumatol

Liester, The Suppression of Dissent During the COVID-19 Pandemic. Social Epistemology Review and Reply Collective [Internet]

Mehra, Desai, Kuy, Henry, Patel, Retraction: Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19, N Engl J Med, doi:10.1056/NEJMoa2007621

Mehra, Desai, Ruschitzka, Patel, RETRACTED: HCQ or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis, Lancet

Million, Lagier, Tissot-Dupont, Ravaux, Dhiver et al., Early combination therapy with HCQ and azithromycin reduces mortality in 10,429 COVID-19 outpatients, Rev Cardiovasc Med

Niemiec, COVID-19 and misinformation: Is censorship of social media a remedy to the spread of medical misinformation? EMBO Rep

Orwell, Secker & Warburg

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Recovery Collaborative Group, Horby, Mafham, Linsell, Bell et al., Effect of HCQ in Hospitalized Patients with Covid-19, N Engl J Med

Recovery Collaborative Group, Horby, Mafham, Linsell, Bell et al., Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19, N Engl J Med

Roussel, Raoult, Influence of conflicts of interest on public positions in the COVID-19 era, the case of Gilead Sciences. New Microbes and New Infections

Sanchezruiz, Nuzum, Kouzi, Oral ivermectin for the treatment of head lice infestation, Am J Health Syst Pharm

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Shir-Raz, Martin, Ronel, Guetzkow, Censorship and Suppression of Covid-19 Heterodoxy: Tactics and Counter-Tactics, Minerva

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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.

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