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Recent Advances in Inhaled Nanoformulations of Vaccines and Therapeutics Targeting Respiratory Viral Infections

Loo et al., Pharmaceutical Research, doi:10.1007/s11095-023-03520-1
Apr 2023  
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Review of nanoformulations for inhaled therapeutics for respiratory viral infections including COVID-19.
Inhaled formulations can deliver treatment directly to the respiratory tract, enabling higher concentrations while minimising systemic side effects, and providing a solution for instability and low solubility issues.
This study includes ivermectin and HCQ.
Loo et al., 25 Apr 2023, peer-reviewed, 3 authors.
Contact: cyloo@unikl.edu.my, tonyzhou@purdue.edu.
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Recent Advances in Inhaled Nanoformulations of Vaccines and Therapeutics Targeting Respiratory Viral Infections
Ching-Yee Loo, Wing-Hin Lee, Qi Tony Zhou
Pharmaceutical Research, doi:10.1007/s11095-023-03520-1
With the rapid outbreak of respiratory viral infections, various biological (e.g. vaccines, peptides, recombinant proteins, antibodies and genes) and antiviral agents (e.g. ribavirin, palivizumab and valaciclovir) have been successfully developed for the treatment of respiratory virus infections such as influenza, respiratory syncytial virus and SARS-CoV-2 infections. These therapeutics are conventionally delivered via oral, intramuscular or injection route and are associated with several adverse events due to systemic toxicity. The inherent in vivo instability of biological therapeutics may hinder them from being administered without proper formulations. Therefore, we have witnessed a boom in nanotechnology coupled with a needle-free administration approach such as the inhalation route for the delivery of complex therapeutics to treat respiratory infections. This review discussed the recent advances in the inhalation strategies of nanoformulations that target virus respiratory infections.
Author Contributions Ching-Yee Loo: Substantial contributions to the conception or design of the work; drafting the work or revising it critically for important intellectual content; final approval of the version to be published. Wing-Hin Lee: Substantial contributions to the conception or design of the work; drafting the work or revising it critically for important intellectual content; final approval of the version to be published. Qi Tony Zhou: Substantial contributions to the conception of the work; revising it critically for important intellectual content; final approval of the version to be published. Declarations Conflict of Interest The authors declare no conflict of interest to this review.
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