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Is hydroxychloroquine beneficial for COVID-19 patients?

Li et al., Cell Death & Disease volume 11, doi:10.1038/s41419-020-2721-8
Jul 2020  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
*, now known with p < 0.00000000001 from 421 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments.
Review of the anti-inflammatory, antiviral, and protective vascular effects of CQ and HCQ, noting that HCQ may be preferable for COVID-19 due to fewer side effects.
Reviews covering hydroxychloroquine for COVID-19 include Al-Bari, Brouqui, Colson, Derwand, Gao, Goldstein, Hecel, IHU, Kaur, Li, Loo, Matada, Roussel, Sahraei, Todaro, Vigbedor.
Li et al., 8 Jul 2020, peer-reviewed, 8 authors.
This PaperHCQAll
Is hydroxychloroquine beneficial for COVID-19 patients?
Xing Li, Ying Wang, Patrizia Agostinis, Arnold Rabson, Gerry Melino, Ernesto Carafoli, Yufang Shi, Erwei Sun
Cell Death & Disease, doi:10.1038/s41419-020-2721-8
The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in December 2019. As similar cases rapidly emerged around the world 1-3 , the World Health Organization (WHO) declared a public health emergency of international concern on January 30, 2020 and pronounced the rapidly spreading coronavirus outbreak as a pandemic on March 11, 2020 4 . The virus has reached almost all countries of the globe. As of June 3, 2020, the accumulated confirmed cases reached 6,479,405 with more than 383,013 deaths worldwide. The urgent and emergency care of COVID-19 patients calls for effective drugs, in addition to the beneficial effects of remdesivir 5 , to control the disease and halt the pandemic. US FDA approved hydroxychloroquine (HCQ) and chloroquine (CQ) for COVID-19 as an Emergency Use Authorization (EUA) with cautions issued soon after
Conflict of interest The authors declare that they have no conflict of interest. Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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