Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
PPIs
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
 
next
study
previous
study
c19hcq.org COVID-19 treatment researchHCQHCQ (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis       

Is hydroxychloroquine beneficial for COVID-19 patients?

Li et al., Cell Death & Disease volume 11, doi:10.1038/s41419-020-2721-8
Jul 2020  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020, now with p < 0.00000000001 from 419 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments.
5,200+ studies for 112 treatments. c19hcq.org
Review of the anti-inflammatory, antiviral, and protective vascular effects of CQ and HCQ, noting that HCQ may be preferable for COVID-19 due to fewer side effects.
Reviews covering hydroxychloroquine for COVID-19 include1-27.
Li et al., 8 Jul 2020, peer-reviewed, 8 authors.
This PaperHCQAll
Is hydroxychloroquine beneficial for COVID-19 patients?
Xing Li, Ying Wang, Patrizia Agostinis, Arnold Rabson, Gerry Melino, Ernesto Carafoli, Yufang Shi, Erwei Sun
Cell Death & Disease, doi:10.1038/s41419-020-2721-8
The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in December 2019. As similar cases rapidly emerged around the world 1-3 , the World Health Organization (WHO) declared a public health emergency of international concern on January 30, 2020 and pronounced the rapidly spreading coronavirus outbreak as a pandemic on March 11, 2020 4 . The virus has reached almost all countries of the globe. As of June 3, 2020, the accumulated confirmed cases reached 6,479,405 with more than 383,013 deaths worldwide. The urgent and emergency care of COVID-19 patients calls for effective drugs, in addition to the beneficial effects of remdesivir 5 , to control the disease and halt the pandemic. US FDA approved hydroxychloroquine (HCQ) and chloroquine (CQ) for COVID-19 as an Emergency Use Authorization (EUA) with cautions issued soon after
Conflict of interest The authors declare that they have no conflict of interest. Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
References
Al-Bari, Chloroquine analogues in drug discovery: new directions of uses, mechanisms of actions and toxic manifestations from malaria to multifarious diseases, J. Antimicrob. Chemother
An, Woodward, Sasaki, Minie, Elkon, Cutting edge: antimalarial drugs inhibit IFN-β production through blockade of cyclic GMP-AMP synthase-DNA interaction, J. Immunol
Ballabio, Bonifacino, Lysosomes as dynamic regulators of cell and organismal homeostasis, Nat. Rev. Mol. Cell Biol
Beigel, Remdesivir for the treatment of Covid-19-preliminary report, N. Engl. J. Med, doi:10.1056/NEJMoa2007764
Ben-Zvi, Kivity, Langevitz, Yehuda, Hydroxychloroquine: from malaria to autoimmunity, Clin. Rev. Allergy Immunol
Chatre, Cardiac complications attributed to chloroquine and hydroxychloroquine: a systematic review of the literature, Drug Saf
Chen, COVID-19 infection: the China and Italy perspectives, Cell Death Dis
Chung, Dysregulated autophagy contributes to caspase-dependent neuronal apoptosis, Cell Death Dis
Costedoat-Chalumeau, A critical review of the effects of hydroxychloroquine and chloroquine on the eye, Clin. Rev. Allergy Immunol
Costedoat-Chalumeau, Dunogué, Morel, Guern, Guettrot-Imbert, Hydroxychloroquine: a multifaceted treatment in lupus, Presse Med
Costedoat-Chalumeau, Heart conduction disorders related to antimalarials toxicity: an analysis of electrocardiograms in 85 patients treated with hydroxychloroquine for connective tissue diseases, Rheumatology
Dai, Chloroquine ameliorates carbon tetrachloride-induced acute liver injury in mice via the concomitant inhibition of inflammation and induction of apoptosis, Cell Death Dis
Devaux, New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?, Int. J. Antimicrob. Agents
Ferner, Aronson, Chloroquine and hydroxychloroquine in covid-19, BMJ
Fiehn, Safety management of the treatment with antimalarial drugs in rheumatology. Interdisciplinary recommendations based on a systematic literature search, Z. Rheumatol
Gao, Tian, Yang, Breakthrough: chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies, Biosci. Trends
Gautret, Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial, Int. J. Antimicrob. Agents, doi:10.1016/j.ijantimicag
Geleris, Observational study of hydroxychloroquine in hospitalized patients with Covid-19, N. Engl. J. Med, doi:10.1056/NEJMoa2012410
Gunst, Van Den Berghe, Intensive care nutrition and post-intensive care recovery, Crit. Care Clin
Han, Novel function of hydroxychloroquine: down regulation of T follicular helper cells in collagen-induced arthritis, Biomed. Pharmacother
Jorge, Hydroxychloroquine retinopathy-implications of research advances for rheumatology care, Nat. Rev. Rheumatol
Lancet, Expression of concern, The Lancet, doi:10.1016/S0140-6736(20)31290-3
Lau, RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement, J. Exp. Med
Lenzer, Covid-19: US gives emergency approval to hydroxychloroquine despite lack of evidence, BMJ
Li, Hypoxia-induced autophagy of stellate cells inhibits expression and secretion of lumican into microenvironment of pancreatic ductal adenocarcinoma, Cell Death Differ
Liu, Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro, Cell Discov
Maes, Tumor vessel normalization by chloroquine independent of autophagy, Cancer Cell
Mauthe, Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion, Autophagy
Mehra, Cardiovascular disease, drug therapy, and mortality in Covid-19, N. Engl. J. Med, doi:10.1056/NEJMoa2007621
Mehra, Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis, The Lancet, doi:10.1016/S0140-6736(20)31180-6
Monteil, Inhibition of SARS-CoV-2 infections in engineered human tissues using clinical-grade soluble human ACE2, Cell
Morawski, Bolland, Expanding the B cell-centric view of systemic lupus erythematosus, Trends Immunol
Netea, Trained immunity: a tool for reducing susceptibility to and the severity of SARS-CoV-2 infection, Cell, doi:10.1016/j.cell.2020.04.042
Nguyen, Cardiovascular toxicities associated with hydroxychloroquine and azithromycin: an analysis of the world health organization pharmacovigilance database, Circulation, doi:10.1161/CIRCULATIONAHA.120.048238
Phua, Intensive care management of coronavirus disease 2019 (COVID-19): challenges and recommendations, Lancet Respir. Med
Rosenberg, Association of treatment with hydroxychloroquine or azithromycin with in-hospital mortality in patients with COVID-19 in New York State, JAMA, doi:10.1001/jama.2020.8630
Rubin, Expression of concern: drug therapy, and mortality in Covid-19, N. Engl. J. Med, doi:10.1056/NEJMe2020822
Ruiz-Irastorza, Ramos-Casals, Brito-Zeron, Khamashta, Clinical efficacy and side effects of antimalarials in systemic lupus erythematosus: a systematic review, Ann. Rheum. Dis
Sacre, Criswell, Mccune, Hydroxychloroquine is associated with impaired interferon-alpha and tumor necrosis factor-alpha production by plasmacytoid dendritic cells in systemic lupus erythematosus, Arthritis Res. Ther
Salem, Chloroquine or hydroxychloroquine for COVID-19: why might they be hazardous?, The Lancet, doi:10.1016/S0140-6736(20)31174-0
Sawa, Doctors Face Sanctions for Prescribing Unproven Covid-19 Drugs to Friends and Family
Schrezenmeier, Dorner, Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology, Nat. Rev. Rheumatol
Sharma, BCG Vaccination Policy and preventive chloroquine usage: do they have an impact on COVID-19 pandemic?, Cell Death Dis
Shi, COVID-19 infection: the perspectives on immune responses, Cell Death Differ
Shimabukuro-Vornhagen, Cytokine release syndrome, J. Immunother. Cancer
Shu, Li, Li, The mechanism of double stranded DNA sensing through the cGAS-STING pathway, Cytokine Growth Factor Rev
Singh, Kumar, Aluri, Lenert, Interfering with B cells at the lupus tollway: promises, successes, and failed expectations, J. Allergy Clin. Immunol
Srinivasa, Tosounidou, Gordon, Increased incidence of gastrointestinal side effects in patients taking hydroxychloroquine: a brand-related issue?, J. Rheumatol
Tang, Hydroxychloroquine attenuates renal ischemia/reperfusion injury by inhibiting cathepsin mediated NLRP3 inflammasome activation, Cell Death Dis
Van Den Borne, Dijkmans, De Rooij, Cessie, Verwei, Chloroquine and hydroxychloroquine equally affect tumor necrosis factor-alpha, interleukin 6, and interferon-gamma production by peripheral blood mononuclear cells, J. Rheumatol
Varga, Endothelial cell infection and endotheliitis in COVID-19, The Lancet, doi:10.1016/S0140-6736(20)30937-5
Vellingiri, COVID-19: a promising cure for the global panic, Sci. Total Environ
Vollmer, Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8, J. Exp. Med
Volpe, The RNA binding protein Sam68 controls T helper 1 differentiation and anti-mycobacterial response through modulation of miR-29, Cell Death Differ
Wallace, Linker-Israeli, Hyun, Klinenberg, Stecher, The effect of hydroxychloroquine therapy on serum levels of immunoregulatory molecules in patients with systemic lupus erythematosus, J. Rheumatol
Wang, Intestinal autophagy links psychosocial stress with gut microbiota to promote inflammatory bowel disease, Cell Death Dis
Wang, Lim, What is the role of hydroxychloroquine in reducing thrombotic risk in patients with antiphospholipid antibodies, Hematol. Am. Soc. Hematol. Educ. Program
Wang, Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro, Cell Res
Who, WHO Announces COVID-19 Outbreak a Pandemic (The World Health Organization
Wärri, Autophagy and unfolded protein response (UPR) regulate mammary gland involution by restraining apoptosis-driven irreversible changes, Cell Death Discov
Yam, Kwok, Ocular toxicity of hydroxychloroquine, Hong Kong Med. J
Yao, In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Clin. Infect. Dis, doi:10.1093/cid/ciaa237
Zamora, Paclitaxel induces lymphatic endothelial cells autophagy to promote metastasis, Cell Death Dis
Zhai, The epidemiology, diagnosis and treatment of COVID-19, Int. J. Antimicrob. Agents
Zhang, The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop, Cell Rep
Zhitomirsky, Lysosomotropic drugs activate TFEB via lysosomal membrane fluidization and consequent inhibition of mTORC1 activity, Cell Death Dis
{ 'indexed': {'date-parts': [[2024, 4, 18]], 'date-time': '2024-04-18T04:35:22Z', 'timestamp': 1713414922199}, 'reference-count': 68, 'publisher': 'Springer Science and Business Media LLC', 'issue': '7', 'license': [ { 'start': { 'date-parts': [[2020, 7, 8]], 'date-time': '2020-07-08T00:00:00Z', 'timestamp': 1594166400000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}, { 'start': { 'date-parts': [[2020, 7, 8]], 'date-time': '2020-07-08T00:00:00Z', 'timestamp': 1594166400000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}], 'content-domain': {'domain': ['link.springer.com'], 'crossmark-restriction': False}, 'abstract': '<jats:title>Abstract</jats:title><jats:p>The outbreak of coronavirus disease 2019 (COVID-19) ' 'caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in ' 'December 2019. As similar cases rapidly emerged around the world<jats:sup>1–3</jats:sup>, the ' 'World Health Organization (WHO) declared a public health emergency of international concern ' 'on January 30, 2020 and pronounced the rapidly spreading coronavirus outbreak as a pandemic ' 'on March 11, 2020<jats:sup>4</jats:sup>. The virus has reached almost all countries of the ' 'globe. As of June 3, 2020, the accumulated confirmed cases reached 6,479,405 with more than ' '383,013 deaths worldwide. The urgent and emergency care of COVID-19 patients calls for ' 'effective drugs, in addition to the beneficial effects of remdesivir<jats:sup>5</jats:sup>, ' 'to control the disease and halt the pandemic.</jats:p>', 'DOI': '10.1038/s41419-020-2721-8', 'type': 'journal-article', 'created': {'date-parts': [[2020, 7, 8]], 'date-time': '2020-07-08T13:03:55Z', 'timestamp': 1594213435000}, 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 72, 'title': 'Is hydroxychloroquine beneficial for COVID-19 patients?', 'prefix': '10.1038', 'volume': '11', 'author': [ {'given': 'Xing', 'family': 'Li', 'sequence': 'first', 'affiliation': []}, {'given': 'Ying', 'family': 'Wang', 'sequence': 'additional', 'affiliation': []}, {'given': 'Patrizia', 'family': 'Agostinis', 'sequence': 'additional', 'affiliation': []}, {'given': 'Arnold', 'family': 'Rabson', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0001-9428-5972', 'authenticated-orcid': False, 'given': 'Gerry', 'family': 'Melino', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ernesto', 'family': 'Carafoli', 'sequence': 'additional', 'affiliation': []}, {'given': 'Yufang', 'family': 'Shi', 'sequence': 'additional', 'affiliation': []}, {'given': 'Erwei', 'family': 'Sun', 'sequence': 'additional', 'affiliation': []}], 'member': '297', 'published-online': {'date-parts': [[2020, 7, 8]]}, 'reference': [ { 'key': '2721_CR1', 'doi-asserted-by': 'publisher', 'first-page': '138277', 'DOI': '10.1016/j.scitotenv.2020.138277', 'volume': '725', 'author': 'B Vellingiri', 'year': '2020', 'unstructured': 'Vellingiri, B. et al. COVID-19: a promising cure for the global panic. ' 'Sci. Total Environ.725, 138277 (2020).', 'journal-title': 'Sci. Total Environ.'}, { 'key': '2721_CR2', 'doi-asserted-by': 'publisher', 'first-page': '506', 'DOI': '10.1016/S2213-2600(20)30161-2', 'volume': '8', 'author': 'J Phua', 'year': '2020', 'unstructured': 'Phua, J. et al. Intensive care management of coronavirus disease 2019 ' '(COVID-19): challenges and recommendations. Lancet Respir. Med.8, ' '506–517 (2020).', 'journal-title': 'Lancet Respir. Med.'}, { 'key': '2721_CR3', 'doi-asserted-by': 'crossref', 'unstructured': 'Chen, J. et al. COVID-19 infection: the China and Italy perspectives. ' 'Cell Death Dis. 11, 438 (2020)', 'DOI': '10.1038/s41419-020-2603-0'}, { 'key': '2721_CR4', 'unstructured': 'WHO. WHO Announces COVID-19 Outbreak a Pandemic (The World Health ' 'Organization, Geneva, Switzerland, 2020).'}, { 'key': '2721_CR5', 'doi-asserted-by': 'publisher', 'unstructured': 'Beigel, J. H. et al. Remdesivir for the treatment of ' 'Covid-19—preliminary report. N. Engl. J. Med. ' 'https://doi.org/10.1056/NEJMoa2007764 (2020).', 'DOI': '10.1056/NEJMoa2007764'}, { 'key': '2721_CR6', 'doi-asserted-by': 'publisher', 'first-page': 'm1432', 'DOI': '10.1136/bmj.m1432', 'volume': '369', 'author': 'RE Ferner', 'year': '2020', 'unstructured': 'Ferner, R. E. & Aronson, J. K. Chloroquine and hydroxychloroquine in ' 'covid-19. BMJ369, m1432 (2020).', 'journal-title': 'BMJ'}, { 'key': '2721_CR7', 'doi-asserted-by': 'crossref', 'unstructured': 'Zhai, P. et al. The epidemiology, diagnosis and treatment of COVID-19. ' 'Int. J. Antimicrob. Agents55, 105955 (2020).', 'DOI': '10.1016/j.ijantimicag.2020.105955'}, { 'key': '2721_CR8', 'doi-asserted-by': 'crossref', 'unstructured': 'Devaux, C. A. et al. New insights on the antiviral effects of ' 'chloroquine against coronavirus: what to expect for COVID-19? Int. J. ' 'Antimicrob. Agents55, 105938 (2020).', 'DOI': '10.1016/j.ijantimicag.2020.105938'}, { 'key': '2721_CR9', 'doi-asserted-by': 'publisher', 'first-page': '16', 'DOI': '10.1038/s41421-020-0156-0', 'volume': '6', 'author': 'J Liu', 'year': '2020', 'unstructured': 'Liu, J. et al. Hydroxychloroquine, a less toxic derivative of ' 'chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro. ' 'Cell Discov.6, 16 (2020).', 'journal-title': 'Cell Discov.'}, { 'key': '2721_CR10', 'doi-asserted-by': 'publisher', 'unstructured': 'Yao, X. et al. In vitro antiviral activity and projection of optimized ' 'dosing design of hydroxychloroquine for the treatment of severe acute ' 'respiratory syndrome coronavirus 2 (SARS-CoV-2). Clin. Infect. Dis. ' 'ciaa237. https://doi.org/10.1093/cid/ciaa237 (2020).', 'DOI': '10.1093/cid/ciaa237'}, { 'key': '2721_CR11', 'doi-asserted-by': 'publisher', 'unstructured': 'Geleris, J. et al. Observational study of hydroxychloroquine in ' 'hospitalized patients with Covid-19. N. Engl. J. Med. ' 'https://doi.org/10.1056/NEJMoa2012410 (2020).', 'DOI': '10.1056/NEJMoa2012410'}, { 'key': '2721_CR12', 'doi-asserted-by': 'publisher', 'unstructured': 'Rosenberg, E. S. et al. Association of treatment with hydroxychloroquine ' 'or azithromycin with in-hospital mortality in patients with COVID-19 in ' 'New York State. JAMA.\n' 'https://doi.org/10.1001/jama.2020.8630 (2020).', 'DOI': '10.1001/jama.2020.8630'}, { 'key': '2721_CR13', 'doi-asserted-by': 'publisher', 'first-page': '72', 'DOI': '10.5582/bst.2020.01047', 'volume': '14', 'author': 'J Gao', 'year': '2020', 'unstructured': 'Gao, J., Tian, Z. & Yang, X. Breakthrough: chloroquine phosphate has ' 'shown apparent efficacy in treatment of COVID-19 associated pneumonia in ' 'clinical studies. Biosci. Trends14, 72–73 (2020).', 'journal-title': 'Biosci. Trends'}, { 'key': '2721_CR14', 'doi-asserted-by': 'publisher', 'unstructured': 'Gautret, P. et al. Hydroxychloroquine and azithromycin as a treatment of ' 'COVID-19: results of an open-label non-randomized clinical trial. Int. ' 'J. Antimicrob. Agents 105949. https://doi.org/10.1016/j.ijantimicag ' '(2020).', 'DOI': '10.1016/j.ijantimicag'}, { 'key': '2721_CR15', 'doi-asserted-by': 'publisher', 'first-page': '1335', 'DOI': '10.1136/bmj.m1335', 'volume': '369', 'author': 'J Lenzer', 'year': '2020', 'unstructured': 'Lenzer, J. Covid-19: US gives emergency approval to hydroxychloroquine ' 'despite lack of evidence. BMJ369, 1335 (2020).', 'journal-title': 'BMJ'}, { 'key': '2721_CR16', 'unstructured': 'Indian Council for Medical Research. Recommendation for Empiric Use of ' 'Hydroxychloroquine for Prophylaxis of SARS-CoV-2 Infection. ' 'https://icmr.nic.in/sites/default/files/upload_documents/HCQ_Recommendation_22March_final_MM_V2.pdf. ' 'Accessed 3 April 2020.'}, { 'key': '2721_CR17', 'unstructured': 'U.S. Department of Health and Human Services. HHS Accepts Donations of ' 'Medicine to Strategic National Stockpile as Possible Treatments for ' 'Covid-19 Patients: FDA Issues Emergency Use Authorization for Donated ' 'Hydroxychloroquine Sulfate, Chloroquine Phosphate. ' 'https://www.hhs.gov/about/news/2020/03/29/hhs-accepts-donations-of-medicine-tostrategic-national-stockpile-as-possible-treatments-for-covid-19-patients.html. ' 'Accessed 30 Mar 2020.'}, { 'key': '2721_CR18', 'unstructured': 'Sawa T. Doctors Face Sanctions for Prescribing Unproven Covid-19 Drugs ' 'to Friends and Family, Regulators Warn. CBC.ca. ' 'https://www.cbc.ca/news/health/sanctions-canadian-doctors-experimental-drugs-1.5511244. ' 'Accessed 27 Mar 2020.'}, { 'key': '2721_CR19', 'doi-asserted-by': 'publisher', 'unstructured': 'Funck-Brentano & Salem, J. E. Chloroquine or hydroxychloroquine for ' 'COVID-19: why might they be hazardous? The Lancet.\n' 'https://doi.org/10.1016/S0140-6736(20)31174-0 (2020).', 'DOI': '10.1016/S0140-6736(20)31174-0'}, { 'key': '2721_CR20', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41419-018-1136-2', 'volume': '9', 'author': 'C Dai', 'year': '2018', 'unstructured': 'Dai, C. et al. Chloroquine ameliorates carbon tetrachloride-induced ' 'acute liver injury in mice via the concomitant inhibition of ' 'inflammation and induction of apoptosis. Cell Death Dis.9, 1164 (2018).', 'journal-title': 'Cell Death Dis.'}, { 'key': '2721_CR21', 'doi-asserted-by': 'publisher', 'first-page': '190', 'DOI': '10.1016/j.ccr.2014.06.025', 'volume': '26', 'author': 'H Maes', 'year': '2014', 'unstructured': 'Maes, H. et al. Tumor vessel normalization by chloroquine independent of ' 'autophagy. Cancer Cell26, 190–206 (2014).', 'journal-title': 'Cancer Cell'}, { 'key': '2721_CR22', 'doi-asserted-by': 'publisher', 'unstructured': 'Netea, M. G. et al. Trained immunity: a tool for reducing susceptibility ' 'to and the severity of SARS-CoV-2 infection. Cell S0092-8674(20)30507-9. ' 'https://doi.org/10.1016/j.cell.2020.04.042 (2020).', 'DOI': '10.1016/j.cell.2020.04.042'}, { 'key': '2721_CR23', 'doi-asserted-by': 'publisher', 'first-page': '40', 'DOI': '10.1038/s41420-018-0105-y', 'volume': '4', 'author': 'A Wärri', 'year': '2018', 'unstructured': 'Wärri, A. et al. Autophagy and unfolded protein response (UPR) regulate ' 'mammary gland involution by restraining apoptosis-driven irreversible ' 'changes. Cell Death Discov.4, 40 (2018).', 'journal-title': 'Cell Death Discov.'}, { 'key': '2721_CR24', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41419-018-0378-3', 'volume': '9', 'author': 'TT Tang', 'year': '2018', 'unstructured': 'Tang, T. T. et al. Hydroxychloroquine attenuates renal ' 'ischemia/reperfusion injury by inhibiting cathepsin mediated NLRP3 ' 'inflammasome activation. Cell Death Dis.9, 351 (2018).', 'journal-title': 'Cell Death Dis.'}, { 'key': '2721_CR25', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41419-018-1229-y', 'volume': '9', 'author': 'Y Chung', 'year': '2018', 'unstructured': 'Chung, Y. et al. Dysregulated autophagy contributes to caspase-dependent ' 'neuronal apoptosis. Cell Death Dis.9, 1189 (2018).', 'journal-title': 'Cell Death Dis.'}, { 'key': '2721_CR26', 'doi-asserted-by': 'publisher', 'first-page': '1169', 'DOI': '10.1038/s41418-018-0201-9', 'volume': '26', 'author': 'Volpe', 'year': '2019', 'unstructured': 'Volpe et al. The RNA binding protein Sam68 controls T helper 1 ' 'differentiation and anti-mycobacterial response through modulation of ' 'miR-29. Cell Death Differ.26, 1169–1180 (2019).', 'journal-title': 'Cell Death Differ.'}, { 'key': '2721_CR27', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41419-019-1634-x', 'volume': '10', 'author': 'SL Wang', 'year': '2019', 'unstructured': 'Wang, S. L. et al. Intestinal autophagy links psychosocial stress with ' 'gut microbiota to promote inflammatory bowel disease. Cell Death Dis.10, ' '391 (2019).', 'journal-title': 'Cell Death Dis.'}, { 'key': '2721_CR28', 'doi-asserted-by': 'publisher', 'first-page': '382', 'DOI': '10.1038/s41418-018-0207-3', 'volume': '26', 'author': 'X Li', 'year': '2019', 'unstructured': 'Li, X. et al. Hypoxia-induced autophagy of stellate cells inhibits ' 'expression and secretion of lumican into microenvironment of pancreatic ' 'ductal adenocarcinoma. Cell Death Differ.26, 382–393 (2019).', 'journal-title': 'Cell Death Differ.'}, { 'key': '2721_CR29', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41419-019-2181-1', 'volume': '10', 'author': 'A Zamora', 'year': '2019', 'unstructured': 'Zamora, A. et al. Paclitaxel induces lymphatic endothelial cells ' 'autophagy to promote metastasis. Cell Death Dis.10, 956 (2019).', 'journal-title': 'Cell Death Dis.'}, { 'key': '2721_CR30', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41419-018-1227-0', 'volume': '9', 'author': 'B Zhitomirsky', 'year': '2018', 'unstructured': 'Zhitomirsky, B. et al. Lysosomotropic drugs activate TFEB via lysosomal ' 'membrane fluidization and consequent inhibition of mTORC1 activity. Cell ' 'Death Dis.9, 1191 (2018).', 'journal-title': 'Cell Death Dis.'}, { 'key': '2721_CR31', 'doi-asserted-by': 'publisher', 'first-page': '269', 'DOI': '10.1038/s41422-020-0282-0', 'volume': '30', 'author': 'M Wang', 'year': '2020', 'unstructured': 'Wang, M. et al. Remdesivir and chloroquine effectively inhibit the ' 'recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res.30, ' '269–271 (2020).', 'journal-title': 'Cell Res.'}, { 'key': '2721_CR32', 'doi-asserted-by': 'publisher', 'first-page': '20', 'DOI': '10.1136/ard.2008.101766', 'volume': '69', 'author': 'G Ruiz-Irastorza', 'year': '2010', 'unstructured': 'Ruiz-Irastorza, G., Ramos-Casals, M., Brito-Zeron, P. & Khamashta, M. A. ' 'Clinical efficacy and side effects of antimalarials in systemic lupus ' 'erythematosus: a systematic review. Ann. Rheum. Dis.69, 20–28 (2010).', 'journal-title': 'Ann. Rheum. Dis.'}, { 'key': '2721_CR33', 'doi-asserted-by': 'publisher', 'first-page': '101', 'DOI': '10.1038/s41580-019-0185-4', 'volume': '21', 'author': 'A Ballabio', 'year': '2020', 'unstructured': 'Ballabio, A. & Bonifacino, J. S. Lysosomes as dynamic regulators of cell ' 'and organismal homeostasis. Nat. Rev. Mol. Cell Biol.21, 101–118 (2020).', 'journal-title': 'Nat. Rev. Mol. Cell Biol.'}, { 'key': '2721_CR34', 'doi-asserted-by': 'publisher', 'first-page': '1435', 'DOI': '10.1080/15548627.2018.1474314', 'volume': '14', 'author': 'M Mauthe', 'year': '2018', 'unstructured': 'Mauthe, M. et al. Chloroquine inhibits autophagic flux by decreasing ' 'autophagosome–lysosome fusion. Autophagy14, 1435–1455 (2018).', 'journal-title': 'Autophagy'}, { 'key': '2721_CR35', 'doi-asserted-by': 'publisher', 'first-page': '167', 'DOI': '10.1016/j.lpm.2014.03.007', 'volume': '43', 'author': 'N Costedoat-Chalumeau', 'year': '2014', 'unstructured': 'Costedoat-Chalumeau, N., Dunogué, B., Morel, N., Guern, V. L. & ' 'Guettrot-Imbert, G. et al. Hydroxychloroquine: a multifaceted treatment ' 'in lupus. Presse Med.43, 167–180 (2014).', 'journal-title': 'Presse Med.'}, { 'key': '2721_CR36', 'doi-asserted-by': 'publisher', 'first-page': 'R155', 'DOI': '10.1186/ar3895', 'volume': '27', 'author': 'K Sacre', 'year': '2012', 'unstructured': 'Sacre, K., Criswell, L. A. & McCune, J. M. Hydroxychloroquine is ' 'associated with impaired interferon-alpha and tumor necrosis ' 'factor-alpha production by plasmacytoid dendritic cells in systemic ' 'lupus erythematosus. Arthritis Res. Ther.27, R155 (2012).', 'journal-title': 'Arthritis Res. Ther.'}, { 'key': '2721_CR37', 'doi-asserted-by': 'publisher', 'first-page': '1325', 'DOI': '10.1016/j.jaci.2015.12.1326', 'volume': '137', 'author': 'N Singh', 'year': '2016', 'unstructured': 'Singh, N., Kumar, B., Aluri, V. & Lenert, P. Interfering with baffled B ' 'cells at the lupus tollway: promises, successes, and failed ' 'expectations. J. Allergy Clin. Immunol.137, 1325–1333 (2016).', 'journal-title': 'J. Allergy Clin. Immunol.'}, { 'key': '2721_CR38', 'doi-asserted-by': 'publisher', 'first-page': '838', 'DOI': '10.1016/j.biopha.2017.10.132', 'volume': '97', 'author': 'J Han', 'year': '2018', 'unstructured': 'Han, J. et al. Novel function of hydroxychloroquine: down regulation of ' 'T follicular helper cells in collagen-induced arthritis. Biomed. ' 'Pharmacother.97, 838–843 (2018).', 'journal-title': 'Biomed. Pharmacother.'}, { 'key': '2721_CR39', 'first-page': '55', 'volume': '24', 'author': 'BE van den Borne', 'year': '1997', 'unstructured': 'van den Borne, B. E., Dijkmans, B. A., de Rooij, H. H., Cessie, S. & ' 'Verwei, S. L. et al. Chloroquine and hydroxychloroquine equally affect ' 'tumor necrosis factor-alpha, interleukin 6, and interferon-gamma ' 'production by peripheral blood mononuclear cells. J. Rheumatol.24, 55–60 ' '(1997).', 'journal-title': 'J. Rheumatol.'}, { 'key': '2721_CR40', 'doi-asserted-by': 'publisher', 'first-page': '373', 'DOI': '10.1016/j.it.2017.02.001', 'volume': '5', 'author': 'P Morawski', 'year': '2017', 'unstructured': 'Morawski, P. & Bolland, S. Expanding the B cell-centric view of systemic ' 'lupus erythematosus. Trends Immunol.5, 373–382 (2017).', 'journal-title': 'Trends Immunol.'}, { 'key': '2721_CR41', 'doi-asserted-by': 'publisher', 'first-page': '1171', 'DOI': '10.1084/jem.20050630', 'volume': '202', 'author': 'CM Lau', 'year': '2005', 'unstructured': 'Lau, C. M. et al. RNA-associated autoantigens activate B cells by ' 'combined B cell antigen receptor/Toll-like receptor 7 engagement. J. ' 'Exp. Med.202, 1171–1177 (2005).', 'journal-title': 'J. Exp. Med.'}, { 'key': '2721_CR42', 'doi-asserted-by': 'publisher', 'first-page': '1575', 'DOI': '10.1084/jem.20051696', 'volume': '202', 'author': 'J Vollmer', 'year': '2005', 'unstructured': 'Vollmer, J. et al. Immune stimulation mediated by autoantigen binding ' 'sites within small nuclear RNAs involves Toll- like receptors 7 and 8. ' 'J. Exp. Med.202, 1575–1585 (2005).', 'journal-title': 'J. Exp. Med.'}, { 'key': '2721_CR43', 'doi-asserted-by': 'publisher', 'first-page': '4089', 'DOI': '10.4049/jimmunol.1402793', 'volume': '194', 'author': 'J An', 'year': '2015', 'unstructured': 'An, J., Woodward, J. J., Sasaki, T., Minie, M. & Elkon, K. B. Cutting ' 'edge: antimalarial drugs inhibit IFN-β production through blockade of ' 'cyclic GMP–AMP synthase–DNA interaction. J. Immunol.194, 4089–4093 ' '(2015).', 'journal-title': 'J. Immunol.'}, { 'key': '2721_CR44', 'doi-asserted-by': 'publisher', 'first-page': '421', 'DOI': '10.1016/j.celrep.2014.01.003', 'volume': '6', 'author': 'X Zhang', 'year': '2014', 'unstructured': 'Zhang, X. et al. The cytosolic DNA sensor cGAS forms an oligomeric ' 'complex with DNA and undergoes switch-like conformational changes in the ' 'activation loop. Cell Rep.6, 421–430 (2014).', 'journal-title': 'Cell Rep.'}, { 'key': '2721_CR45', 'doi-asserted-by': 'publisher', 'first-page': '641', 'DOI': '10.1016/j.cytogfr.2014.06.006', 'volume': '25', 'author': 'C Shu', 'year': '2014', 'unstructured': 'Shu, C., Li, X. & Li, P. The mechanism of double stranded DNA sensing ' 'through the cGAS-STING pathway. Cytokine Growth Factor Rev.25, 641–648 ' '(2014).', 'journal-title': 'Cytokine Growth Factor Rev.'}, { 'key': '2721_CR46', 'first-page': '375', 'volume': '21', 'author': 'DJ Wallace', 'year': '1994', 'unstructured': 'Wallace, D. J., Linker-Israeli, M., Hyun, S., Klinenberg, J. R. & ' 'Stecher, V. et al. The effect of hydroxychloroquine therapy on serum ' 'levels of immunoregulatory molecules in patients with systemic lupus ' 'erythematosus. J. Rheumatol.21, 375–376 (1994).', 'journal-title': 'J. Rheumatol.'}, { 'key': '2721_CR47', 'doi-asserted-by': 'publisher', 'first-page': '1451', 'DOI': '10.1038/s41418-020-0530-3', 'volume': '27', 'author': 'Y Shi', 'year': '2020', 'unstructured': 'Shi, Y. et al. COVID-19 infection: the perspectives on immune responses. ' 'Cell Death Differ.27, 1451–1454 (2020).', 'journal-title': 'Cell Death Differ.'}, { 'key': '2721_CR48', 'doi-asserted-by': 'crossref', 'unstructured': 'Sharma, A. et al. BCG Vaccination Policy and preventive chloroquine ' 'usage: do they have an impact on COVID-19 pandemic? Cell Death Dis. ' '(2020). (in press).', 'DOI': '10.1038/s41419-020-2720-9'}, { 'key': '2721_CR49', 'doi-asserted-by': 'publisher', 'first-page': '56', 'DOI': '10.1186/s40425-018-0343-9', 'volume': '6', 'author': 'A Shimabukuro-Vornhagen', 'year': '2018', 'unstructured': 'Shimabukuro-Vornhagen, A. et al. Cytokine release syndrome. J. ' 'Immunother. Cancer6, 56 (2018).', 'journal-title': 'J. Immunother. Cancer'}, { 'key': '2721_CR50', 'doi-asserted-by': 'publisher', 'first-page': '905', 'DOI': '10.1016/j.cell.2020.04.004', 'volume': '181', 'author': 'V Monteil', 'year': '2020', 'unstructured': 'Monteil, V. et al. Inhibition of SARS-CoV-2 infections in engineered ' 'human tissues using clinical-grade soluble human ACE2. Cell181, 905–913 ' '(2020).', 'journal-title': 'Cell'}, { 'key': '2721_CR51', 'doi-asserted-by': 'publisher', 'unstructured': 'Varga, Z. et al. Endothelial cell infection and endotheliitis in ' 'COVID-19. The Lancet. https://doi.org/10.1016/S0140-6736(20)30937-5 ' '(2020).', 'DOI': '10.1016/S0140-6736(20)30937-5'}, { 'key': '2721_CR52', 'doi-asserted-by': 'publisher', 'first-page': '714', 'DOI': '10.1182/asheducation-2016.1.714', 'volume': '1', 'author': 'TF Wang', 'year': '2016', 'unstructured': 'Wang, T. F. & Lim, W. What is the role of hydroxychloroquine in reducing ' 'thrombotic risk in patients with antiphospholipid antibodies. Hematol. ' 'Am. Soc. Hematol. Educ. Program.1, 714–716 (2016).', 'journal-title': 'Hematol. Am. Soc. Hematol. Educ. Program.'}, { 'key': '2721_CR53', 'doi-asserted-by': 'publisher', 'first-page': '1608', 'DOI': '10.1093/jac/dkv018', 'volume': '70', 'author': 'MA Al-Bari', 'year': '2015', 'unstructured': 'Al-Bari, M. A. Chloroquine analogues in drug discovery: new directions ' 'of uses, mechanisms of actions and toxic manifestations from malaria to ' 'multifarious diseases. J. Antimicrob. Chemother.70, 1608–1621 (2015).', 'journal-title': 'J. Antimicrob. Chemother.'}, { 'key': '2721_CR54', 'doi-asserted-by': 'publisher', 'first-page': '145', 'DOI': '10.1007/s12016-010-8243-x', 'volume': '42', 'author': 'I Ben-Zvi', 'year': '2012', 'unstructured': 'Ben-Zvi, I., Kivity, S., Langevitz, P. & Yehuda, S. et al. ' 'Hydroxychloroquine: from malaria to autoimmunity. Clin. Rev. Allergy ' 'Immunol.42, 145–153 (2012).', 'journal-title': 'Clin. Rev. Allergy Immunol.'}, { 'key': '2721_CR55', 'doi-asserted-by': 'publisher', 'first-page': '155', 'DOI': '10.1038/s41584-020-0372-x', 'volume': '16', 'author': 'E Schrezenmeier', 'year': '2020', 'unstructured': 'Schrezenmeier, E. & Dorner, T. Mechanisms of action of ' 'hydroxychloroquine and chloroquine: implications for rheumatology. Nat. ' 'Rev. Rheumatol.16, 155–166 (2020).', 'journal-title': 'Nat. Rev. Rheumatol.'}, { 'key': '2721_CR56', 'doi-asserted-by': 'publisher', 'first-page': '398', 'DOI': '10.3899/jrheum.161063', 'volume': '44', 'author': 'A Srinivasa', 'year': '2017', 'unstructured': 'Srinivasa, A., Tosounidou, S. & Gordon, C. Increased incidence of ' 'gastrointestinal side effects in patients taking hydroxychloroquine: a ' 'brand-related issue? J. Rheumatol.44, 398 (2017).', 'journal-title': 'J. Rheumatol.'}, { 'key': '2721_CR57', 'doi-asserted-by': 'publisher', 'first-page': '693', 'DOI': '10.1038/s41584-018-0111-8', 'volume': '14', 'author': 'A Jorge', 'year': '2018', 'unstructured': 'Jorge, A. et al. Hydroxychloroquine retinopathy—implications of research ' 'advances for rheumatology care. Nat. Rev. Rheumatol.14, 693–703 (2018).', 'journal-title': 'Nat. Rev. Rheumatol.'}, { 'key': '2721_CR58', 'doi-asserted-by': 'publisher', 'first-page': '317', 'DOI': '10.1007/s12016-015-8469-8', 'volume': '49', 'author': 'N Costedoat-Chalumeau', 'year': '2015', 'unstructured': 'Costedoat-Chalumeau, N. et al. A critical review of the effects of ' 'hydroxychloroquine and chloroquine on the eye. Clin. Rev. Allergy ' 'Immunol.49, 317–326 (2015).', 'journal-title': 'Clin. Rev. Allergy Immunol.'}, { 'key': '2721_CR59', 'first-page': '808', 'volume': '46', 'author': 'N Costedoat-Chalumeau', 'year': '2017', 'unstructured': 'Costedoat-Chalumeau, N. et al. Heart conduction disorders related to ' 'antimalarials toxicity: an analysis of electrocardiograms in 85 patients ' 'treated with hydroxychloroquine for connective tissue diseases. ' 'Rheumatology 200746, 808–810 (2017).', 'journal-title': 'Rheumatology 2007'}, { 'key': '2721_CR60', 'doi-asserted-by': 'publisher', 'first-page': '919', 'DOI': '10.1007/s40264-018-0689-4', 'volume': '41', 'author': 'C Chatre', 'year': '2018', 'unstructured': 'Chatre, C. et al. Cardiac complications attributed to chloroquine and ' 'hydroxychloroquine: a systematic review of the literature. Drug Saf.41, ' '919–931 (2018).', 'journal-title': 'Drug Saf.'}, { 'key': '2721_CR61', 'first-page': '294', 'volume': '12', 'author': 'JC Yam', 'year': '2006', 'unstructured': 'Yam, J. C. & Kwok, A. K. Ocular toxicity of hydroxychloroquine. Hong ' 'Kong Med. J.12, 294–304 (2006).', 'journal-title': 'Hong Kong Med. J.'}, { 'key': '2721_CR62', 'doi-asserted-by': 'publisher', 'first-page': '186', 'DOI': '10.1007/s00393-020-00751-0', 'volume': '79', 'author': 'C Fiehn', 'year': '2020', 'unstructured': 'Fiehn, C. et al. Safety management of the treatment with antimalarial ' 'drugs in rheumatology. Interdisciplinary recommendations based on a ' 'systematic literature search. Z. Rheumatol.79, 186–194 (2020).', 'journal-title': 'Z. Rheumatol.'}, { 'key': '2721_CR63', 'doi-asserted-by': 'publisher', 'unstructured': 'Mehra, M. R. et al. Hydroxychloroquine or chloroquine with or without a ' 'macrolide for treatment of COVID-19: a multinational registry analysis. ' 'The Lancet.\n' 'https://doi.org/10.1016/S0140-6736(20)31180-6 (2020).', 'DOI': '10.1016/S0140-6736(20)31180-6'}, { 'key': '2721_CR64', 'doi-asserted-by': 'publisher', 'unstructured': 'The Lancet Editors. Expression of concern. The Lancet. ' 'https://doi.org/10.1016/S0140-6736(20)31290-3 (2020).', 'DOI': '10.1016/S0140-6736(20)31290-3'}, { 'key': '2721_CR65', 'doi-asserted-by': 'publisher', 'first-page': '573', 'DOI': '10.1016/j.ccc.2018.06.004', 'volume': '34', 'author': 'J Gunst', 'year': '2018', 'unstructured': 'Gunst, J. & Van den Berghe, G. Intensive care nutrition and ' 'post-intensive care recovery. Crit. Care Clin.34, 573–583 (2018).', 'journal-title': 'Crit. Care Clin.'}, { 'key': '2721_CR66', 'doi-asserted-by': 'publisher', 'unstructured': 'Nguyen, L. S. et al. Cardiovascular toxicities associated with ' 'hydroxychloroquine and azithromycin: an analysis of the world health ' 'organization pharmacovigilance database. Circulation. ' 'https://doi.org/10.1161/CIRCULATIONAHA.120.048238 (2020).', 'DOI': '10.1161/CIRCULATIONAHA.120.048238'}, { 'key': '2721_CR67', 'doi-asserted-by': 'publisher', 'unstructured': 'Mehra, M. R. et al. Cardiovascular disease, drug therapy, and mortality ' 'in Covid-19. N. Engl. J. Med. https://doi.org/10.1056/NEJMoa2007621 ' '(2020).', 'DOI': '10.1056/NEJMoa2007621'}, { 'key': '2721_CR68', 'doi-asserted-by': 'publisher', 'unstructured': 'Rubin, E. J. Expression of concern: drug therapy, and mortality in ' 'Covid-19. N. Engl. J. Med. https://doi.org/10.1056/NEJMe2020822 (2020).', 'DOI': '10.1056/NEJMe2020822'}], 'container-title': 'Cell Death &amp; Disease', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://www.nature.com/articles/s41419-020-2721-8.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://www.nature.com/articles/s41419-020-2721-8', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://www.nature.com/articles/s41419-020-2721-8.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 12, 5]], 'date-time': '2022-12-05T14:46:20Z', 'timestamp': 1670251580000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.nature.com/articles/s41419-020-2721-8'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2020, 7, 8]]}, 'references-count': 68, 'journal-issue': {'issue': '7', 'published-online': {'date-parts': [[2020, 7]]}}, 'alternative-id': ['2721'], 'URL': 'http://dx.doi.org/10.1038/s41419-020-2721-8', 'relation': {}, 'ISSN': ['2041-4889'], 'subject': [], 'container-title-short': 'Cell Death Dis', 'published': {'date-parts': [[2020, 7, 8]]}, 'assertion': [ { 'value': '1 May 2020', 'order': 1, 'name': 'received', 'label': 'Received', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '4 June 2020', 'order': 2, 'name': 'revised', 'label': 'Revised', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '23 June 2020', 'order': 3, 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '8 July 2020', 'order': 4, 'name': 'first_online', 'label': 'First Online', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': 'The authors declare that they have no conflict of interest.', 'order': 1, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Conflict of interest'}}], 'article-number': '512'}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit