Is hydroxychloroquine beneficial for COVID-19 patients?

DOI record: { "DOI": "10.1038/s41419-020-2721-8", "ISSN": [ "2041-4889" ], "URL": "http://dx.doi.org/10.1038/s41419-020-2721-8", "abstract": "<jats:title>Abstract</jats:title><jats:p>The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in December 2019. As similar cases rapidly emerged around the world<jats:sup>1–3</jats:sup>, the World Health Organization (WHO) declared a public health emergency of international concern on January 30, 2020 and pronounced the rapidly spreading coronavirus outbreak as a pandemic on March 11, 2020<jats:sup>4</jats:sup>. The virus has reached almost all countries of the globe. As of June 3, 2020, the accumulated confirmed cases reached 6,479,405 with more than 383,013 deaths worldwide. The urgent and emergency care of COVID-19 patients calls for effective drugs, in addition to the beneficial effects of remdesivir<jats:sup>5</jats:sup>, to control the disease and halt the pandemic.</jats:p>", "alternative-id": [ "2721" ], "article-number": "512", "assertion": [ { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Received", "name": "received", "order": 1, "value": "1 May 2020" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Revised", "name": "revised", "order": 2, "value": "4 June 2020" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Accepted", "name": "accepted", "order": 3, "value": "23 June 2020" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "First Online", "name": "first_online", "order": 4, "value": "8 July 2020" }, { "group": { "label": "Conflict of interest", "name": "EthicsHeading" }, "name": "Ethics", "order": 1, "value": "The authors declare that they have no conflict of interest." } ], "author": [ { "affiliation": [], "family": "Li", "given": "Xing", "sequence": "first" }, { "affiliation": [], "family": "Wang", "given": "Ying", "sequence": "additional" }, { "affiliation": [], "family": "Agostinis", "given": "Patrizia", "sequence": "additional" }, { "affiliation": [], "family": "Rabson", "given": "Arnold", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0001-9428-5972", "affiliation": [], "authenticated-orcid": false, "family": "Melino", "given": "Gerry", "sequence": "additional" }, { "affiliation": [], "family": "Carafoli", "given": "Ernesto", "sequence": "additional" }, { "affiliation": [], "family": "Shi", "given": "Yufang", "sequence": "additional" }, { "affiliation": [], "family": "Sun", "given": "Erwei", "sequence": "additional" } ], "container-title": "Cell Death &amp; Disease", "container-title-short": "Cell Death Dis", "content-domain": { "crossmark-restriction": false, "domain": [ "link.springer.com" ] }, "created": { "date-parts": [ [ 2020, 7, 8 ] ], "date-time": "2020-07-08T13:03:55Z", "timestamp": 1594213435000 }, "deposited": { "date-parts": [ [ 2022, 12, 5 ] ], "date-time": "2022-12-05T14:46:20Z", "timestamp": 1670251580000 }, "indexed": { "date-parts": [ [ 2024, 4, 18 ] ], "date-time": "2024-04-18T04:35:22Z", "timestamp": 1713414922199 }, "is-referenced-by-count": 72, "issue": "7", "issued": { "date-parts": [ [ 2020, 7, 8 ] ] }, "journal-issue": { "issue": "7", "published-online": { "date-parts": [ [ 2020, 7 ] ] } }, "language": "en", "license": [ { "URL": "https://creativecommons.org/licenses/by/4.0", "content-version": "tdm", "delay-in-days": 0, "start": { "date-parts": [ [ 2020, 7, 8 ] ], "date-time": "2020-07-08T00:00:00Z", "timestamp": 1594166400000 } }, { "URL": "https://creativecommons.org/licenses/by/4.0", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2020, 7, 8 ] ], "date-time": "2020-07-08T00:00:00Z", "timestamp": 1594166400000 } } ], "link": [ { "URL": "https://www.nature.com/articles/s41419-020-2721-8.pdf", "content-type": "application/pdf", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://www.nature.com/articles/s41419-020-2721-8", "content-type": "text/html", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://www.nature.com/articles/s41419-020-2721-8.pdf", "content-type": "application/pdf", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "297", "original-title": [], "prefix": "10.1038", "published": { "date-parts": [ [ 2020, 7, 8 ] ] }, "published-online": { "date-parts": [ [ 2020, 7, 8 ] ] }, "publisher": "Springer Science and Business Media LLC", "reference": [ { "DOI": "10.1016/j.scitotenv.2020.138277", "author": "B Vellingiri", "doi-asserted-by": "publisher", "first-page": "138277", "journal-title": "Sci. 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