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Targeting endosomal acidification by chloroquine analogs as a promising strategy for the treatment of emerging viral diseases

Al-Bari, M., Pharmacology Research & Perspectives, doi:10.1002/prp2.293
Jan 2017  
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Review of the use of chloroquine analogs for endosomal low pH dependent viruses including Ebola, Marburg, dengue, Chikungunya, SARS, and HIV.
Reviews covering hydroxychloroquine for COVID-19 include Al-Bari, Brouqui, Colson, Derwand, Gao, Goldstein, Hecel, IHU, Kaur, Li, Loo, Matada, Roussel, Sahraei, Todaro, Vigbedor.
Al-Bari et al., 23 Jan 2017, peer-reviewed, 1 author.
This PaperHCQAll
Targeting endosomal acidification by chloroquine analogs as a promising strategy for the treatment of emerging viral diseases
Md Abdul, Alim Al-Bari
Pharmacology Research & Perspectives, doi:10.1002/prp2.293
Emerging viruses such as HIV, dengue, influenza A, SARS coronavirus, Ebola, and other viruses pose a significant threat to human health. Majority of these viruses are responsible for the outbreaks of pathogenic lethal infections. To date, there are no effective therapeutic strategies available for the prophylaxis and treatment of these infections. Chloroquine analogs have been used for decades as the primary and most successful drugs against malaria. Concomitant with the emergence of chloroquine-resistant Plasmodium strains and a subsequent decrease in the use as antimalarial drugs, other applications of the analogs have been investigated. Since the analogs have interesting biochemical properties, these drugs are found to be effective against a wide variety of viral infections. As antiviral action, the analogs have been shown to inhibit acidification of endosome during the events of replication and infection. Moreover, immunomodulatory effects of analogs have been beneficial to patients with severe inflammatory complications of several viral diseases. Interestingly, one of the successful targeting strategies is the inhibition of HIV replication by the analogs in vitro which are being tested in several clinical trials. This review focuses on the potentialities of chloroquine analogs for the treatment of endosomal low pH dependent emerging viral diseases.
Disclosure The author wish to confirm that there are no known conflicts of interest associated with this publication and there has been no financial support for this work that could have influenced its outcome. The author also declared not to receive any assistance of a professional medical writer or similar service. Thus, it can be stated 'None to declare'.
Accapezzato, Visco, Francavilla, Molette, Donato et al., Chloroquine enhances human CD8 + T cell responses against soluble antigens in vivo, J Exp Med
Adachi, Ichinose, Takizawa, Watanabe, Kitazato et al., Chloroquine analogues in drug discovery: new directions of uses, mechanisms of actions and toxic manifestations from malaria to multifarious diseases, J Antimicrob Chemother
Ashfaq, Javed, Rehman, Nawaz, Riazuddin, Lysosomotropic agents as HCV entry inhibitors, Virol J
Augustijns, Geusens, Verbeke, Chloroquine levels in blood during chronic treatment of patients with rheumatoid arthritis, Eur J Clin Pharmacol
Avina-Zubieta, Galindo-Rodriguez, Newman, Suarez-Almazor, Russell, Long-term effectiveness of antimalarial drugs in rheumatic diseases, Ann Rheum Dis
Baize, Leroy, Georges, Mc, Capron et al., Inflammatory responses in Ebola virus-infected patients, Clin Exp Immunol
Baize, Leroy, Mc, Capron, Lansoud-Soukate et al., Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients, Nat Med
Barrow, Nicola, Liu, Multiscale perspectives of virus entry via endocytosis, Virol J
Bekerman, Einav, Infectious disease. Combating emerging viral threats, Science
Bhattacharyya, Warfield, Ruthel, Bavari, Aman et al., Ebola virus uses clathrin-mediated endocytosis as an entry pathway, Virology
Bishop, Potential and emerging treatment options for Ebola virus disease, Ann Pharmacother
Blanchard, Belouzard, Goueslain, Wakita, Dubuisson et al., Hepatitis C virus entry depends on clathrin-mediated endocytosis, J Virol
Boelaert, Sperber, Piette, The additive in vitro anti-HIV-1 effect of chloroquine, when combined with zidovudine and hydroxyurea, Biochem Pharmacol
Boelaert, Yaro, Augustijns, Meda, Schneider et al., Chloroquine accumulates in breastmilk cells: potential impact in the prophylaxis of postnatal mother-to-child transmission of HIV-1, AIDS
Boonyasuppayakorn, Reichert, Manzano, Nagarajan, Padmanabhan, Amodiaquine, an antimalarial drug, inhibits dengue virus type 2 replication and infectivity, Antiviral Res
Borba, Saad, Pasoto, Calich, Aikawa et al., Influenza A/H1N1 vaccination of patients with SLE: can antimalarial drugs restore diminished response under immunosuppressive therapy?, Rheumatology (Oxford)
Borges, Castro, Fonseca, Chloroquine use improves dengue-related symptoms, Mem Inst Oswaldo Cruz
Brighton, Chloroquine phosphate treatment of chronic Chikungunya arthritis. An open pilot study, S Afr Med J
Brouwers, Vermeire, Schols, Augustijns, Development and in vitro evaluation of chloroquine gels as microbicides against HIV-1 infection, Virology
Chandran, Sullivan, Felbor, Whelan, Cunningham, Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection, Science
Chauhan, Mehla, Vijayakumar, Handy, Endocytosis-mediated HIV-1 entry and its significance in the elusive behavior of the virus in astrocytes, Virology
Chauhan, Tikoo, The enigma of the clandestine association between chloroquine and HIV-1 infection, HIV Med
Chiang, Sassaroli, Louie, Chen, Stecher et al., Inhibition of HIV-1 replication by hydroxychloroquine: mechanism of action and comparison with zidovudine, Clin Ther
Clemente, De, Torre, Cell entry of Borna disease virus follows a clathrin-mediated endocytosis pathway that requires Rab5 and microtubules, J Virol
Daecke, Fackler, Dittmar, Krausslich, Involvement of clathrin-mediated endocytosis in human immunodeficiency virus type 1 entry, J Virol
De Lamballerie, Boisson, Reynier, Enault, Charrel et al., On chikungunya acute infection and chloroquine treatment
Dedania, Wu, Di Trani, Savarino, Campitelli et al., Different pH requirements are associated with divergent inhibitory effects of chloroquine on human and avian influenza A viruses, J Clin Transl Hepatol
Dowall, Bosworth, Watson, Bewley, Taylor et al., Chloroquine inhibited Ebola virus replication in vitro but failed to protect against infection and
Ekins, Freundlich, Coffee, A common feature pharmacophore for FDA-approved drugs inhibiting the Ebola virus, F1000Res
Engchanil, Kosalaraksa, Lumbiganon, Lulitanond, Pongjunyakul et al., Therapeutic potential of chloroquine added to zidovudine plus didanosine for HIV-1 infected children, J Med Assoc Thai
Ewald, Lee, Lau, Wickliffe, Shi et al., The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor, Nature
Falzarano, Safronetz, Prescott, Marzi, Feldmann et al., Lack of protection against ebola virus from chloroquine in mice and hamsters, Emerg Infect Dis
Farias, Machado, Almeida, Aquino, Fonseca, Chloroquine interferes with dengue-2 virus replication in U937 cells, Microbiol Immunol
Farias, Machado, Fonseca, Chloroquine inhibits dengue virus type 2 replication in Vero cells but not in C6/36 cells, Scientific World J
Farias, Machado, Muniz, Imbeloni, Fonseca, Antiviral activity of chloroquine against dengue virus type 2 replication in Aotus monkeys, Viral Immunol
Fatima, Sharma, Saxena, Tripathi, Shukla et al., One pot efficient diversity oriented synthesis of polyfunctional styryl thiazolopyrimidines and their bioevaluation as antimalarial and anti-HIV agents, Eur J Med Chem
Fedson, Confronting an influenza pandemic with inexpensive generic agents: can it be done?, Lancet Infect Dis
Freund, Roitburd-Berman, Sui, Marasco, Gershoni et al., Dengue virus activates membrane TRAIL relocalization and IFN-alpha production by human plasmacytoid dendritic cells in vitro and in vivo, Protein Eng Des Sel
Garulli, Mario, Sciaraffia, Accapezzato, Barnaba et al., Enhancement of T cell-mediated immune responses to whole inactivated influenza virus by chloroquine treatment in vivo, Vaccine
Gay, Bernard, Solignat, Chazal, Devaux et al., pH-dependent entry of chikungunya virus into Aedes albopictus cells, Infect Genet Evol
Geisbert, Hensley, Larsen, Young, Reed et al., Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection, Am J Pathol
Geisbert, Strong, Feldmann, Considerations in the use of nonhuman primate models of ebola virus and marburg virus infection, J Infect Dis
Gonzalez-Dunia, Cubitt, De, Torre, Mechanism of Borna disease virus entry into cells, J Virol
Iss, 1 | e00293 disease in the in vivo guinea pig model, J Gen Virol
Iss, None
Jiang, Li, Zhu, Xu, Wang et al., Pharmacological modulation of autophagy enhances Newcastle disease virus-mediated oncolysis in drug-resistant lung cancer cells, BMC Cancer
Kaur, Chu, Chikungunya virus: an update on antiviral development and challenges, Drug Discov Today
Keyaerts, Vijgen, Maes, Neyts, Van Ranst, In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine, Biochem Biophys Res Commun
Kissing, Hermsen, Repnik, Nesset, Bargen et al., Vacuolar ATPase in phagosomelysosome fusion, J Biol Chem
Kraft, Armstrong, Heitmeier, Odom, Hruz, The glucose transporter PfHT1 is an antimalarial target of the HIV protease inhibitor lopinavir, Antimicrob Agents Chemother
Laaksonen, Koskiahde, Juva, Dosage of antimalarial drugs for children with juvenile rheumatoid arthritis and systemic lupus erythematosus. A clinical study with determination of serum concentrations of chloroquine and hydroxychloroquine, Scand J Rheumatol
Leroux-Roels, Bourguignon, Willekens, Janssens, Clement et al., Immunogenicity and safety of a booster dose of an investigational adjuvanted polyprotein HIV-1 vaccine in healthy adults and effect of administration of chloroquine, Clin Vaccine Immunol
Leroy, Baize, Volchkov, Fisher-Hoch, Mc et al., Human asymptomatic Ebola infection and strong inflammatory response, Lancet
Li, Moore, Vasilieva, Sui, Wong et al., Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus, Nature
Long, Wright, Molesti, Temperton, Barclay, Antiviral therapies against Ebola and other emerging viral diseases using existing medicines that block virus entry, F1000Res
Mackenzie, Antimalarial drugs for rheumatoid arthritis, Am J Med
Madrid, Chopra, Manger, Gilfillan, Keepers et al., A systematic screen of FDAapproved drugs for inhibitors of biological threat agents, PLoS ONE
Martinson, Montoya, Usuga, Ronquillo, Landay et al., Chloroquine modulates HIV-1-induced plasmacytoid dendritic cell alpha interferon: implication for Tcell activation, Antimicrob Agents Chemother
Marzi, Reinheckel, Feldmann, Cathepsin B & L are not required for ebola virus replication, PLoS Negl Trop Dis
Matsuda, Suzuki, Kataoka, Watashi, Aizaki et al., Alternative endocytosis pathway for productive entry of hepatitis C virus, J Gen Virol
Meng, Zhang, Wu, Pei, Xu et al., RNAi induces innate immunity through multiple cellular signaling pathways, PLoS ONE
Meng, Zhou, Jiang, Yu, Jia et al., Newcastle disease virus triggers autophagy in U251 glioma cells to enhance virus replication, Arch Virol
Mizuguchi, Ohashi, Nomura, Komoriya, Hashimoto et al., Anti-HIV screening for cellpenetrating peptides using chloroquine and identification of anti-HIV peptides derived from matrix proteins, Bioorg Med Chem
Mizui, Yamashina, Tanida, Takei, Ueno et al., Inhibition of hepatitis C virus replication by chloroquine targeting virus-associated autophagy, J Gastroenterol
Munster, Gibbs, Shen, Baethge, Botstein et al., Hydroxychloroquine concentrationresponse relationships in patients with rheumatoid arthritis, Arthritis Rheum
Murr, Widner, Wirleitner, Fuchs, Neopterin as a marker for immune system activation, Curr Drug Metab
Murray, Down, Boulware, Stauffer, Cavert et al., Reduction of immune activation with chloroquine therapy during chronic HIV infection, J Virol
Naarding, Baan, Pollakis, Paxton, Effect of chloroquine on reducing HIV-1 replication in vitro and the DC-SIGN mediated transfer of virus to CD4 + Tlymphocytes, Retrovirology
Neely, Kalyesubula, Bagenda, Myers, Olness, Effect of chloroquine on human immunodeficiency virus (HIV) vertical transmission, Afr Health Sci
Ooi, Chew, Loh, Chua, Ozden et al., Inhibition of Chikungunya virus infection in cultured human muscle cells by furin inhibitors: impairment of the maturation of the E2 surface glycoprotein, J Biol Chem
Parris, The timing is right: Evolution of AIDScausing HIV strains is consistent with history of chloroquine use, Med Hypotheses
Paton, Goodall, Dunn, Franzen, Collaco-Moraes et al., Effects of hydroxychloroquine on immune activation and disease progression among HIVinfected patients not receiving antiretroviral therapy: a randomized controlled trial, JAMA
Paton, Lee, Xu, Ooi, Cheung et al., Chloroquine for influenza prevention: a randomised, double-blind, placebo controlled trial, Lancet Infect Dis
Pellicelli, Morrone, Barbieri, Andreoli, Porphyria cutanea tarda in an HCV-positive liver transplant patient: a case report, Ann Hepatol
Peng, Wang, Chen, Zhang, Gao et al., Entry of dengue virus serotype 2 into ECV304 cells depends on clathrin-dependent endocytosis, but not on caveolae-dependent endocytosis, Can J Microbiol
Piconi, Parisotto, Rizzardini, Passerini, Terzi et al., Hydroxychloroquine drastically reduces immune activation in HIV-infected, antiretroviral therapy-treated immunologic nonresponders, Curr Pharm Des
Routy, Angel, Patel, Kanagaratham, Radzioch et al., Assessment of chloroquine as a modulator of immune activation to improve CD4 recovery in immune nonresponding HIV-infected patients receiving antiretroviral therapy, HIV Med
Sanchez-Felipe, Villar, Munoz-Barroso, Entry of newcastle disease virus into the host cell: role of acidic pH and endocytosis, Biochim Biophys Acta
Savarino, Boelaert, Cassone, Majori, Cauda, Effects of chloroquine on viral infections: an old drug against today's diseases?, Lancet Infect Dis
Savarino, Gennero, Chen, Serrano, Malavasi et al., Anti-HIV effects of chloroquine: mechanisms of inhibition and spectrum of activity, AIDS
Savarino, Gennero, Sperber, Boelaert, The anti-HIV-1 activity of chloroquine, J Clin Virol
Savarino, Lucia, Rastrelli, Rutella, Golotta et al., Anti-HIV effects of chloroquine: inhibition of viral particle glycosylation and synergism with protease inhibitors, J Acquir Immune Defic Syndr
Savarino, Shytaj, Chloroquine and beyond: exploring anti-rheumatic drugs to reduce immune hyperactivation in HIV/AIDS, Retrovirology
Savarino, Trani, Donatelli, Cauda, Cassone, New insights into the antiviral effects of chloroquine, Lancet Infect Dis
Savarino, Use of chloroquine in viral diseases, Lancet Infect Dis
Schroder, Hertzog, Ravasi, Hume, None
Shivanna, Kim, Ko, Endosomal acidification cathepsin L activity is required for calicivirus replication, Virology
Sourisseau, Schilte, Casartelli, Trouillet, Guivel-Benhassine et al., Characterization of reemerging chikungunya virus, PLoS Pathog
Sperber, Louie, Kraus, Proner, Sapira et al., Hydroxychloroquine treatment of patients with human immunodeficiency virus type 1, Clin Ther
Stock, Chikungunya fever-expanded distribution of a re-emerging tropical infectious disease, Med Monatsschr Pharm
Stuart, Brown, Entry of feline calicivirus is dependent on clathrin-mediated endocytosis and acidification in endosomes, J Virol
Sun, Tien, From endocytosis to membrane fusion: emerging roles of dynamin in virus entry, Crit Rev Microbiol
Sun, Yu, Ding, Meng, Meng et al., Autophagy benefits the replication of Newcastle disease virus in chicken cells and tissues, J Virol
Takada, Robison, Goto, Sanchez, Murti et al., A system for functional analysis of Ebola virus glycoprotein, Proc Natl Acad Sci
Taubitz, Cramer, Kapaun, Pfeffer, Drosten et al., Chikungunya fever in travelers: clinical presentation and course, Clin Infect Dis
Tobin, Krohel, Rynes, Hydroxychloroquine. Seven-year experience, Arch Ophthalmol
Tracey, Cerami, Tumor necrosis factor: a pleiotropic cytokine and therapeutic target, Annu Rev Med
Tricou, Minh, Van, Lee, Farrar et al., A randomized controlled trial of chloroquine for the treatment of dengue in Vietnamese adults, PLoS Negl Trop Dis
Uneke, Ogbonna, Malaria and HIV co-infection in pregnancy in sub-Saharan Africa: impact of treatment using antimalarial and antiretroviral agents, Trans R Soc Trop Med Hyg
Vausselin, Calland, Belouzard, Descamps, Douam et al., The antimalarial ferroquine is an inhibitor of hepatitis C virus, Hepatology
Vigerust, Mccullers, Chloroquine is effective against influenza A virus in vitro but not in vivo, Influenza Other Respir Viruses
Villinger, Rollin, Brar, Chikkala, Winter et al., Markedly elevated levels of interferon (IFN)-gamma, IFN-alpha, interleukin (IL)-2, IL-10, and tumor necrosis factor-alpha associated with fatal Ebola virus infection, J Infect Dis
Vincent, Bergeron, Benjannet, Erickson, Rollin et al., Chloroquine is a potent inhibitor of SARS coronavirus infection and spread, Virol J
Wang, Jiang, Influenza A virus H5N1 entry into host cells is through clathrin-dependent endocytosis, Sci China C Life Sci
Wilde, Jochmans, Posthuma, Zevenhoven-Dobbe, Van Nieuwkoop et al., Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture, Antimicrob Agents Chemother
Wu, Dai, Zhao, Chen, Wang et al., Chloroquine enhances replication of influenza A virus A/WSN/ 33 (H1N1) in dose-, time-, and MOI-dependent manners in human lung epithelial cells A549, J Med Virol
Yan, Zou, Sun, Li, Xu et al., Antimalaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model, Cell Res
Yang, Delgado, Xu, Todd, Nabel et al., Distinct cellular interactions of secreted and transmembrane Ebola virus glycoproteins, Science
Yang, Duckers, Sullivan, Sanchez, Nabel et al., Identification of the Ebola virus glycoprotein as the main viral determinant of vascular cell cytotoxicity and injury, Nat Med
Zhou, Liu, Franksson, Lederer, Ljunggren et al., Characterization of TAP-independent and brefeldin A-resistant presentation of Sendai virus antigen to CD8 + cytotoxic T lymphocytes, Scand J Immunol
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