Emerging viruses such as HIV, dengue, influenza A, SARS coronavirus, Ebola, and other viruses pose a significant threat to human health. Majority of these viruses are responsible for the outbreaks of pathogenic lethal infections. To date, there are no effective therapeutic strategies available for the prophylaxis and treatment of these infections. Chloroquine analogs have been used for decades as the primary and most successful drugs against malaria. Concomitant with the emergence of chloroquine-resistant Plasmodium strains and a subsequent decrease in the use as antimalarial drugs, other applications of the analogs have been investigated. Since the analogs have interesting biochemical properties, these drugs are found to be effective against a wide variety of viral infections. As antiviral action, the analogs have been shown to inhibit acidification of endosome during the events of replication and infection. Moreover, immunomodulatory effects of analogs have been beneficial to patients with severe inflammatory complications of several viral diseases. Interestingly, one of the successful targeting strategies is the inhibition of HIV replication by the analogs in vitro which are being tested in several clinical trials. This review focuses on the potentialities of chloroquine analogs for the treatment of endosomal low pH dependent emerging viral diseases.

Disclosure The author wish to confirm that there are no known conflicts of interest associated with this publication and there has been no financial support for this work that could have influenced its outcome. The author also declared not to receive any assistance of a professional medical writer or similar service. Thus, it can be stated 'None to declare'.

References

Accapezzato, Visco, Francavilla, Molette, Donato et al., Chloroquine enhances human CD8 + T cell responses against soluble antigens in vivo, J Exp Med

Adachi, Ichinose, Takizawa, Watanabe, Kitazato et al., Chloroquine analogues in drug discovery: new directions of uses, mechanisms of actions and toxic manifestations from malaria to multifarious diseases, J Antimicrob Chemother

Ashfaq, Javed, Rehman, Nawaz, Riazuddin, Lysosomotropic agents as HCV entry inhibitors, Virol J

Augustijns, Geusens, Verbeke, Chloroquine levels in blood during chronic treatment of patients with rheumatoid arthritis, Eur J Clin Pharmacol

Avina-Zubieta, Galindo-Rodriguez, Newman, Suarez-Almazor, Russell, Long-term effectiveness of antimalarial drugs in rheumatic diseases, Ann Rheum Dis

Baize, Leroy, Georges, Mc, Capron et al., Inflammatory responses in Ebola virus-infected patients, Clin Exp Immunol

Baize, Leroy, Mc, Capron, Lansoud-Soukate et al., Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients, Nat Med

Barrow, Nicola, Liu, Multiscale perspectives of virus entry via endocytosis, Virol J

Bekerman, Einav, Infectious disease. Combating emerging viral threats, Science

Bhattacharyya, Warfield, Ruthel, Bavari, Aman et al., Ebola virus uses clathrin-mediated endocytosis as an entry pathway, Virology

Bishop, Potential and emerging treatment options for Ebola virus disease, Ann Pharmacother

Blanchard, Belouzard, Goueslain, Wakita, Dubuisson et al., Hepatitis C virus entry depends on clathrin-mediated endocytosis, J Virol

Boelaert, Sperber, Piette, The additive in vitro anti-HIV-1 effect of chloroquine, when combined with zidovudine and hydroxyurea, Biochem Pharmacol

Boelaert, Yaro, Augustijns, Meda, Schneider et al., Chloroquine accumulates in breastmilk cells: potential impact in the prophylaxis of postnatal mother-to-child transmission of HIV-1, AIDS

Boonyasuppayakorn, Reichert, Manzano, Nagarajan, Padmanabhan, Amodiaquine, an antimalarial drug, inhibits dengue virus type 2 replication and infectivity, Antiviral Res

Borba, Saad, Pasoto, Calich, Aikawa et al., Influenza A/H1N1 vaccination of patients with SLE: can antimalarial drugs restore diminished response under immunosuppressive therapy?, Rheumatology (Oxford)

Borges, Castro, Fonseca, Chloroquine use improves dengue-related symptoms, Mem Inst Oswaldo Cruz

Brighton, Chloroquine phosphate treatment of chronic Chikungunya arthritis. An open pilot study, S Afr Med J

Brouwers, Vermeire, Schols, Augustijns, Development and in vitro evaluation of chloroquine gels as microbicides against HIV-1 infection, Virology

Chandran, Sullivan, Felbor, Whelan, Cunningham, Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection, Science

Chauhan, Mehla, Vijayakumar, Handy, Endocytosis-mediated HIV-1 entry and its significance in the elusive behavior of the virus in astrocytes, Virology

Chauhan, Tikoo, The enigma of the clandestine association between chloroquine and HIV-1 infection, HIV Med

Chiang, Sassaroli, Louie, Chen, Stecher et al., Inhibition of HIV-1 replication by hydroxychloroquine: mechanism of action and comparison with zidovudine, Clin Ther

Clemente, De, Torre, Cell entry of Borna disease virus follows a clathrin-mediated endocytosis pathway that requires Rab5 and microtubules, J Virol

Daecke, Fackler, Dittmar, Krausslich, Involvement of clathrin-mediated endocytosis in human immunodeficiency virus type 1 entry, J Virol

De Lamballerie, Boisson, Reynier, Enault, Charrel et al., On chikungunya acute infection and chloroquine treatment

Dedania, Wu, Di Trani, Savarino, Campitelli et al., Different pH requirements are associated with divergent inhibitory effects of chloroquine on human and avian influenza A viruses, J Clin Transl Hepatol

Dowall, Bosworth, Watson, Bewley, Taylor et al., Chloroquine inhibited Ebola virus replication in vitro but failed to protect against infection and

Ekins, Freundlich, Coffee, A common feature pharmacophore for FDA-approved drugs inhibiting the Ebola virus, F1000Res

Engchanil, Kosalaraksa, Lumbiganon, Lulitanond, Pongjunyakul et al., Therapeutic potential of chloroquine added to zidovudine plus didanosine for HIV-1 infected children, J Med Assoc Thai

Ewald, Lee, Lau, Wickliffe, Shi et al., The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor, Nature

Falzarano, Safronetz, Prescott, Marzi, Feldmann et al., Lack of protection against ebola virus from chloroquine in mice and hamsters, Emerg Infect Dis

Farias, Machado, Almeida, Aquino, Fonseca, Chloroquine interferes with dengue-2 virus replication in U937 cells, Microbiol Immunol

Farias, Machado, Fonseca, Chloroquine inhibits dengue virus type 2 replication in Vero cells but not in C6/36 cells, Scientific World J

Farias, Machado, Muniz, Imbeloni, Fonseca, Antiviral activity of chloroquine against dengue virus type 2 replication in Aotus monkeys, Viral Immunol

Fatima, Sharma, Saxena, Tripathi, Shukla et al., One pot efficient diversity oriented synthesis of polyfunctional styryl thiazolopyrimidines and their bioevaluation as antimalarial and anti-HIV agents, Eur J Med Chem

Fedson, Confronting an influenza pandemic with inexpensive generic agents: can it be done?, Lancet Infect Dis

Freund, Roitburd-Berman, Sui, Marasco, Gershoni et al., Dengue virus activates membrane TRAIL relocalization and IFN-alpha production by human plasmacytoid dendritic cells in vitro and in vivo, Protein Eng Des Sel

Garulli, Mario, Sciaraffia, Accapezzato, Barnaba et al., Enhancement of T cell-mediated immune responses to whole inactivated influenza virus by chloroquine treatment in vivo, Vaccine

Gay, Bernard, Solignat, Chazal, Devaux et al., pH-dependent entry of chikungunya virus into Aedes albopictus cells, Infect Genet Evol

Geisbert, Hensley, Larsen, Young, Reed et al., Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection, Am J Pathol

Geisbert, Strong, Feldmann, Considerations in the use of nonhuman primate models of ebola virus and marburg virus infection, J Infect Dis

Gonzalez-Dunia, Cubitt, De, Torre, Mechanism of Borna disease virus entry into cells, J Virol

Iss, 1 | e00293 disease in the in vivo guinea pig model, J Gen Virol

Iss, None

Jiang, Li, Zhu, Xu, Wang et al., Pharmacological modulation of autophagy enhances Newcastle disease virus-mediated oncolysis in drug-resistant lung cancer cells, BMC Cancer

Kaur, Chu, Chikungunya virus: an update on antiviral development and challenges, Drug Discov Today

Keyaerts, Vijgen, Maes, Neyts, Van Ranst, In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine, Biochem Biophys Res Commun

Kissing, Hermsen, Repnik, Nesset, Bargen et al., Vacuolar ATPase in phagosomelysosome fusion, J Biol Chem

Kraft, Armstrong, Heitmeier, Odom, Hruz, The glucose transporter PfHT1 is an antimalarial target of the HIV protease inhibitor lopinavir, Antimicrob Agents Chemother

Laaksonen, Koskiahde, Juva, Dosage of antimalarial drugs for children with juvenile rheumatoid arthritis and systemic lupus erythematosus. A clinical study with determination of serum concentrations of chloroquine and hydroxychloroquine, Scand J Rheumatol

Leroux-Roels, Bourguignon, Willekens, Janssens, Clement et al., Immunogenicity and safety of a booster dose of an investigational adjuvanted polyprotein HIV-1 vaccine in healthy adults and effect of administration of chloroquine, Clin Vaccine Immunol

Leroy, Baize, Volchkov, Fisher-Hoch, Mc et al., Human asymptomatic Ebola infection and strong inflammatory response, Lancet

Li, Moore, Vasilieva, Sui, Wong et al., Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus, Nature

Long, Wright, Molesti, Temperton, Barclay, Antiviral therapies against Ebola and other emerging viral diseases using existing medicines that block virus entry, F1000Res

Mackenzie, Antimalarial drugs for rheumatoid arthritis, Am J Med

Madrid, Chopra, Manger, Gilfillan, Keepers et al., A systematic screen of FDAapproved drugs for inhibitors of biological threat agents, PLoS ONE

Martinson, Montoya, Usuga, Ronquillo, Landay et al., Chloroquine modulates HIV-1-induced plasmacytoid dendritic cell alpha interferon: implication for Tcell activation, Antimicrob Agents Chemother

Marzi, Reinheckel, Feldmann, Cathepsin B & L are not required for ebola virus replication, PLoS Negl Trop Dis

Matsuda, Suzuki, Kataoka, Watashi, Aizaki et al., Alternative endocytosis pathway for productive entry of hepatitis C virus, J Gen Virol

Meng, Zhang, Wu, Pei, Xu et al., RNAi induces innate immunity through multiple cellular signaling pathways, PLoS ONE

Meng, Zhou, Jiang, Yu, Jia et al., Newcastle disease virus triggers autophagy in U251 glioma cells to enhance virus replication, Arch Virol

Mizuguchi, Ohashi, Nomura, Komoriya, Hashimoto et al., Anti-HIV screening for cellpenetrating peptides using chloroquine and identification of anti-HIV peptides derived from matrix proteins, Bioorg Med Chem

Mizui, Yamashina, Tanida, Takei, Ueno et al., Inhibition of hepatitis C virus replication by chloroquine targeting virus-associated autophagy, J Gastroenterol

Munster, Gibbs, Shen, Baethge, Botstein et al., Hydroxychloroquine concentrationresponse relationships in patients with rheumatoid arthritis, Arthritis Rheum

Murr, Widner, Wirleitner, Fuchs, Neopterin as a marker for immune system activation, Curr Drug Metab

Murray, Down, Boulware, Stauffer, Cavert et al., Reduction of immune activation with chloroquine therapy during chronic HIV infection, J Virol

Naarding, Baan, Pollakis, Paxton, Effect of chloroquine on reducing HIV-1 replication in vitro and the DC-SIGN mediated transfer of virus to CD4 + Tlymphocytes, Retrovirology

Neely, Kalyesubula, Bagenda, Myers, Olness, Effect of chloroquine on human immunodeficiency virus (HIV) vertical transmission, Afr Health Sci

Ooi, Chew, Loh, Chua, Ozden et al., Inhibition of Chikungunya virus infection in cultured human muscle cells by furin inhibitors: impairment of the maturation of the E2 surface glycoprotein, J Biol Chem

Parris, The timing is right: Evolution of AIDScausing HIV strains is consistent with history of chloroquine use, Med Hypotheses

Paton, Goodall, Dunn, Franzen, Collaco-Moraes et al., Effects of hydroxychloroquine on immune activation and disease progression among HIVinfected patients not receiving antiretroviral therapy: a randomized controlled trial, JAMA

Paton, Lee, Xu, Ooi, Cheung et al., Chloroquine for influenza prevention: a randomised, double-blind, placebo controlled trial, Lancet Infect Dis

Pellicelli, Morrone, Barbieri, Andreoli, Porphyria cutanea tarda in an HCV-positive liver transplant patient: a case report, Ann Hepatol

Peng, Wang, Chen, Zhang, Gao et al., Entry of dengue virus serotype 2 into ECV304 cells depends on clathrin-dependent endocytosis, but not on caveolae-dependent endocytosis, Can J Microbiol

Piconi, Parisotto, Rizzardini, Passerini, Terzi et al., Hydroxychloroquine drastically reduces immune activation in HIV-infected, antiretroviral therapy-treated immunologic nonresponders, Curr Pharm Des

Routy, Angel, Patel, Kanagaratham, Radzioch et al., Assessment of chloroquine as a modulator of immune activation to improve CD4 recovery in immune nonresponding HIV-infected patients receiving antiretroviral therapy, HIV Med

Sanchez-Felipe, Villar, Munoz-Barroso, Entry of newcastle disease virus into the host cell: role of acidic pH and endocytosis, Biochim Biophys Acta

Savarino, Boelaert, Cassone, Majori, Cauda, Effects of chloroquine on viral infections: an old drug against today's diseases?, Lancet Infect Dis

Savarino, Gennero, Chen, Serrano, Malavasi et al., Anti-HIV effects of chloroquine: mechanisms of inhibition and spectrum of activity, AIDS

Savarino, Gennero, Sperber, Boelaert, The anti-HIV-1 activity of chloroquine, J Clin Virol

Savarino, Lucia, Rastrelli, Rutella, Golotta et al., Anti-HIV effects of chloroquine: inhibition of viral particle glycosylation and synergism with protease inhibitors, J Acquir Immune Defic Syndr

Savarino, Shytaj, Chloroquine and beyond: exploring anti-rheumatic drugs to reduce immune hyperactivation in HIV/AIDS, Retrovirology

Savarino, Trani, Donatelli, Cauda, Cassone, New insights into the antiviral effects of chloroquine, Lancet Infect Dis

Savarino, Use of chloroquine in viral diseases, Lancet Infect Dis

Schroder, Hertzog, Ravasi, Hume, None

Shivanna, Kim, Ko, Endosomal acidification cathepsin L activity is required for calicivirus replication, Virology

Sourisseau, Schilte, Casartelli, Trouillet, Guivel-Benhassine et al., Characterization of reemerging chikungunya virus, PLoS Pathog

Sperber, Louie, Kraus, Proner, Sapira et al., Hydroxychloroquine treatment of patients with human immunodeficiency virus type 1, Clin Ther

Stock, Chikungunya fever-expanded distribution of a re-emerging tropical infectious disease, Med Monatsschr Pharm

Stuart, Brown, Entry of feline calicivirus is dependent on clathrin-mediated endocytosis and acidification in endosomes, J Virol

Sun, Tien, From endocytosis to membrane fusion: emerging roles of dynamin in virus entry, Crit Rev Microbiol

Sun, Yu, Ding, Meng, Meng et al., Autophagy benefits the replication of Newcastle disease virus in chicken cells and tissues, J Virol

Takada, Robison, Goto, Sanchez, Murti et al., A system for functional analysis of Ebola virus glycoprotein, Proc Natl Acad Sci

Taubitz, Cramer, Kapaun, Pfeffer, Drosten et al., Chikungunya fever in travelers: clinical presentation and course, Clin Infect Dis

Tobin, Krohel, Rynes, Hydroxychloroquine. Seven-year experience, Arch Ophthalmol

Tracey, Cerami, Tumor necrosis factor: a pleiotropic cytokine and therapeutic target, Annu Rev Med

Tricou, Minh, Van, Lee, Farrar et al., A randomized controlled trial of chloroquine for the treatment of dengue in Vietnamese adults, PLoS Negl Trop Dis

Uneke, Ogbonna, Malaria and HIV co-infection in pregnancy in sub-Saharan Africa: impact of treatment using antimalarial and antiretroviral agents, Trans R Soc Trop Med Hyg

Vausselin, Calland, Belouzard, Descamps, Douam et al., The antimalarial ferroquine is an inhibitor of hepatitis C virus, Hepatology

Vigerust, Mccullers, Chloroquine is effective against influenza A virus in vitro but not in vivo, Influenza Other Respir Viruses

Villinger, Rollin, Brar, Chikkala, Winter et al., Markedly elevated levels of interferon (IFN)-gamma, IFN-alpha, interleukin (IL)-2, IL-10, and tumor necrosis factor-alpha associated with fatal Ebola virus infection, J Infect Dis

Vincent, Bergeron, Benjannet, Erickson, Rollin et al., Chloroquine is a potent inhibitor of SARS coronavirus infection and spread, Virol J

Wang, Jiang, Influenza A virus H5N1 entry into host cells is through clathrin-dependent endocytosis, Sci China C Life Sci

Wilde, Jochmans, Posthuma, Zevenhoven-Dobbe, Van Nieuwkoop et al., Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture, Antimicrob Agents Chemother

Wu, Dai, Zhao, Chen, Wang et al., Chloroquine enhances replication of influenza A virus A/WSN/ 33 (H1N1) in dose-, time-, and MOI-dependent manners in human lung epithelial cells A549, J Med Virol

Yan, Zou, Sun, Li, Xu et al., Antimalaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model, Cell Res

Yang, Delgado, Xu, Todd, Nabel et al., Distinct cellular interactions of secreted and transmembrane Ebola virus glycoproteins, Science

Yang, Duckers, Sullivan, Sanchez, Nabel et al., Identification of the Ebola virus glycoprotein as the main viral determinant of vascular cell cytotoxicity and injury, Nat Med

Zhou, Liu, Franksson, Lederer, Ljunggren et al., Characterization of TAP-independent and brefeldin A-resistant presentation of Sendai virus antigen to CD8 + cytotoxic T lymphocytes, Scand J Immunol

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Combating emerging viral threats', 'volume': '348', 'author': 'Bekerman', 'year': '2015', 'journal-title': 'Science'}, { 'key': '10.1002/prp2.293-BIB0011|prp2293-cit-0011', 'doi-asserted-by': 'crossref', 'first-page': '18', 'DOI': '10.1016/j.virol.2010.02.015', 'article-title': 'Ebola virus uses clathrin-mediated endocytosis as an entry pathway', 'volume': '401', 'author': 'Bhattacharyya', 'year': '2010', 'journal-title': 'Virology'}, { 'key': '10.1002/prp2.293-BIB0501|prp2293-cit-0501', 'doi-asserted-by': 'crossref', 'first-page': '196', 'DOI': '10.1177/1060028014561227', 'article-title': 'Potential and emerging treatment options for Ebola virus disease', 'volume': '49', 'author': 'Bishop', 'year': '2014', 'journal-title': 'Ann Pharmacother'}, { 'key': '10.1002/prp2.293-BIB0012|prp2293-cit-0012', 'doi-asserted-by': 'crossref', 'first-page': '6964', 'DOI': '10.1128/JVI.00024-06', 'article-title': 'Hepatitis C virus entry depends on clathrin-mediated endocytosis', 'volume': '80', 'author': 'Blanchard', 'year': '2006', 'journal-title': 'J Virol'}, { 'key': '10.1002/prp2.293-BIB0013|prp2293-cit-0013', 'doi-asserted-by': 'crossref', 'first-page': '1531', 'DOI': '10.1016/S0006-2952(01)00576-7', 'article-title': 'The additive in\xa0vitro anti-HIV-1 effect of chloroquine, when ' 'combined with zidovudine and hydroxyurea', 'volume': '61', 'author': 'Boelaert', 'year': '2001a', 'journal-title': 'Biochem Pharmacol'}, { 'key': '10.1002/prp2.293-BIB0014|prp2293-cit-0014', 'doi-asserted-by': 'crossref', 'first-page': '2205', 'DOI': '10.1097/00002030-200111090-00024', 'article-title': 'Chloroquine accumulates in breast-milk cells: potential impact in the ' 'prophylaxis of postnatal mother-to-child transmission of HIV-1', 'volume': '15', 'author': 'Boelaert', 'year': '2001b', 'journal-title': 'AIDS'}, { 'key': '10.1002/prp2.293-BIB0015|prp2293-cit-0015', 'doi-asserted-by': 'crossref', 'first-page': '125', 'DOI': '10.1016/j.antiviral.2014.03.014', 'article-title': 'Amodiaquine, an antimalarial drug, inhibits dengue virus type 2 ' 'replication and infectivity', 'volume': '106', 'author': 'Boonyasuppayakorn', 'year': '2014', 'journal-title': 'Antiviral Res'}, { 'key': '10.1002/prp2.293-BIB0016|prp2293-cit-0016', 'doi-asserted-by': 'crossref', 'first-page': '1061', 'DOI': '10.1093/rheumatology/ker427', 'article-title': 'Influenza A/H1N1 vaccination of patients with SLE: can antimalarial ' 'drugs restore diminished response under immunosuppressive therapy?', 'volume': '51', 'author': 'Borba', 'year': '2012', 'journal-title': 'Rheumatology (Oxford)'}, { 'key': '10.1002/prp2.293-BIB0502|prp2293-cit-0502', 'doi-asserted-by': 'crossref', 'first-page': '596', 'DOI': '10.1590/S0074-02762013000500010', 'article-title': 'Chloroquine use improves dengue-related symptoms', 'volume': '108', 'author': 'Borges', 'year': '2013', 'journal-title': 'Mem Inst Oswaldo Cruz'}, { 'key': '10.1002/prp2.293-BIB0017|prp2293-cit-0017', 'first-page': '217', 'article-title': 'Chloroquine phosphate treatment of chronic Chikungunya arthritis. An ' 'open pilot study', 'volume': '66', 'author': 'Brighton', 'year': '1984', 'journal-title': 'S Afr Med J'}, { 'key': '10.1002/prp2.293-BIB0018|prp2293-cit-0018', 'doi-asserted-by': 'crossref', 'first-page': '306', 'DOI': '10.1016/j.virol.2008.06.005', 'article-title': 'Development and in\xa0vitro evaluation of chloroquine gels as ' 'microbicides against HIV-1 infection', 'volume': '378', 'author': 'Brouwers', 'year': '2008', 'journal-title': 'Virology'}, { 'key': '10.1002/prp2.293-BIB0019|prp2293-cit-0019', 'doi-asserted-by': 'crossref', 'first-page': '1643', 'DOI': '10.1126/science.1110656', 'article-title': 'Endosomal proteolysis of the Ebola virus glycoprotein is necessary for ' 'infection', 'volume': '308', 'author': 'Chandran', 'year': '2005', 'journal-title': 'Science'}, { 'key': '10.1002/prp2.293-BIB0020|prp2293-cit-0020', 'doi-asserted-by': 'crossref', 'first-page': '585', 'DOI': '10.1111/hiv.12295', 'article-title': 'The enigma of the clandestine association between chloroquine and HIV-1 ' 'infection', 'volume': '16', 'author': 'Chauhan', 'year': '2015', 'journal-title': 'HIV Med'}, { 'key': '10.1002/prp2.293-BIB0021|prp2293-cit-0021', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1016/j.virol.2014.03.002', 'article-title': 'Endocytosis-mediated HIV-1 entry and its significance in the elusive ' 'behavior of the virus in astrocytes', 'volume': '456-457', 'author': 'Chauhan', 'year': '2014', 'journal-title': 'Virology'}, { 'key': '10.1002/prp2.293-BIB0022|prp2293-cit-0022', 'doi-asserted-by': 'crossref', 'first-page': '1080', 'DOI': '10.1016/S0149-2918(96)80063-4', 'article-title': 'Inhibition of HIV-1 replication by hydroxychloroquine: mechanism of ' 'action and comparison with zidovudine', 'volume': '18', 'author': 'Chiang', 'year': '1996', 'journal-title': 'Clin Ther'}, { 'key': '10.1002/prp2.293-BIB0023|prp2293-cit-0023', 'doi-asserted-by': 'crossref', 'first-page': '10406', 'DOI': '10.1128/JVI.00990-09', 'article-title': 'Cell entry of Borna disease virus follows a clathrin-mediated ' 'endocytosis pathway that requires Rab5 and microtubules', 'volume': '83', 'author': 'Clemente', 'year': '2009', 'journal-title': 'J Virol'}, { 'key': '10.1002/prp2.293-BIB0024|prp2293-cit-0024', 'doi-asserted-by': 'crossref', 'first-page': '1581', 'DOI': '10.1128/JVI.79.3.1581-1594.2005', 'article-title': 'Involvement of clathrin-mediated endocytosis in human immunodeficiency ' 'virus type 1 entry', 'volume': '79', 'author': 'Daecke', 'year': '2005', 'journal-title': 'J Virol'}, { 'key': '10.1002/prp2.293-BIB0025|prp2293-cit-0025', 'doi-asserted-by': 'crossref', 'first-page': '837', 'DOI': '10.1089/vbz.2008.0049', 'article-title': 'On chikungunya acute infection and chloroquine treatment', 'volume': '8', 'author': 'Lamballerie', 'year': '2008', 'journal-title': 'Vector Borne Zoonotic Dis'}, { 'key': '10.1002/prp2.293-BIB0026|prp2293-cit-0026', 'doi-asserted-by': 'crossref', 'first-page': '101', 'DOI': '10.2174/187152609787847712', 'article-title': 'Antiviral treatment of chikungunya virus infection', 'volume': '9', 'author': 'Lamballerie', 'year': '2009', 'journal-title': 'Infect Disord Drug Targets'}, { 'key': '10.1002/prp2.293-BIB0027|prp2293-cit-0027', 'doi-asserted-by': 'crossref', 'first-page': '4875', 'DOI': '10.1128/AAC.03011-14', 'article-title': 'Screening of an FDA-approved compound library identifies four ' 'small-molecule inhibitors of Middle East respiratory syndrome ' 'coronavirus replication in cell culture', 'volume': '58', 'author': 'Wilde', 'year': '2014', 'journal-title': 'Antimicrob Agents Chemother'}, { 'key': '10.1002/prp2.293-BIB0028|prp2293-cit-0028', 'first-page': '127', 'article-title': 'Dermatologic Extrahepatic Manifestations of Hepatitis C', 'volume': '3', 'author': 'Dedania', 'year': '2015', 'journal-title': 'J Clin Transl Hepatol'}, { 'key': '10.1002/prp2.293-BIB0029|prp2293-cit-0029', 'doi-asserted-by': 'crossref', 'first-page': '39', 'DOI': '10.1186/1743-422X-4-39', 'article-title': 'Different pH requirements are associated with divergent inhibitory ' 'effects of chloroquine on human and avian influenza A viruses', 'volume': '4', 'author': 'Di Trani', 'year': '2007', 'journal-title': 'Virol J'}, { 'key': '10.1002/prp2.293-BIB0030|prp2293-cit-0030', 'doi-asserted-by': 'crossref', 'first-page': '3484', 'DOI': '10.1099/jgv.0.000309', 'article-title': 'Chloroquine inhibited Ebola virus replication in\xa0vitro but failed to ' 'protect against infection and disease in the in\xa0vivo guinea pig ' 'model', 'volume': '96', 'author': 'Dowall', 'year': '2015', 'journal-title': 'J Gen Virol'}, { 'key': '10.1002/prp2.293-BIB0031|prp2293-cit-0031', 'doi-asserted-by': 'crossref', 'first-page': '277', 'DOI': '10.12688/f1000research.5741.1', 'article-title': 'A common feature pharmacophore for FDA-approved drugs inhibiting the ' 'Ebola virus', 'volume': '3', 'author': 'Ekins', 'year': '2015', 'journal-title': 'F1000Res'}, { 'key': '10.1002/prp2.293-BIB0032|prp2293-cit-0032', 'first-page': '1229', 'article-title': 'Therapeutic potential of chloroquine added to zidovudine plus ' 'didanosine for HIV-1 infected children', 'volume': '89', 'author': 'Engchanil', 'year': '2006', 'journal-title': 'J Med Assoc Thai'}, { 'key': '10.1002/prp2.293-BIB0033|prp2293-cit-0033', 'doi-asserted-by': 'crossref', 'first-page': '658', 'DOI': '10.1038/nature07405', 'article-title': 'The ectodomain of Toll-like receptor 9 is cleaved to generate a ' 'functional receptor', 'volume': '456', 'author': 'Ewald', 'year': '2008', 'journal-title': 'Nature'}, { 'key': '10.1002/prp2.293-BIB0503|prp2293-cit-0503', 'doi-asserted-by': 'crossref', 'first-page': '1065', 'DOI': '10.3201/eid2106.150176', 'article-title': 'Lack of protection against ebola virus from chloroquine in mice and ' 'hamsters', 'volume': '21', 'author': 'Falzarano', 'year': '2015', 'journal-title': 'Emerg Infect Dis'}, { 'key': '10.1002/prp2.293-BIB0034|prp2293-cit-0034', 'doi-asserted-by': 'crossref', 'first-page': '282734', 'DOI': '10.1155/2013/282734', 'article-title': 'Chloroquine inhibits dengue virus type 2 replication in Vero cells but ' 'not in C6/36 cells', 'volume': '2013', 'author': 'Farias', 'year': '2013', 'journal-title': 'Scientific World J'}, { 'key': '10.1002/prp2.293-BIB0035|prp2293-cit-0035', 'doi-asserted-by': 'crossref', 'first-page': '318', 'DOI': '10.1111/1348-0421.12154', 'article-title': 'Chloroquine interferes with dengue-2 virus replication in U937 cells', 'volume': '58', 'author': 'Farias', 'year': '2014', 'journal-title': 'Microbiol Immunol'}, { 'key': '10.1002/prp2.293-BIB0036|prp2293-cit-0036', 'doi-asserted-by': 'crossref', 'first-page': '161', 'DOI': '10.1089/vim.2014.0090', 'article-title': 'Antiviral activity of chloroquine against dengue virus type 2 ' 'replication in Aotus monkeys', 'volume': '28', 'author': 'Farias', 'year': '2015', 'journal-title': 'Viral Immunol'}, { 'key': '10.1002/prp2.293-BIB0037|prp2293-cit-0037', 'doi-asserted-by': 'crossref', 'first-page': '195', 'DOI': '10.1016/j.ejmech.2012.07.018', 'article-title': 'One pot efficient diversity oriented synthesis of polyfunctional styryl ' 'thiazolopyrimidines and their bio-evaluation as antimalarial and ' 'anti-HIV agents', 'volume': '55', 'author': 'Fatima', 'year': '2012', 'journal-title': 'Eur J Med Chem'}, { 'key': '10.1002/prp2.293-BIB0038|prp2293-cit-0038', 'doi-asserted-by': 'crossref', 'first-page': '571', 'DOI': '10.1016/S1473-3099(08)70070-7', 'article-title': 'Confronting an influenza pandemic with inexpensive generic agents: can ' 'it be done?', 'volume': '8', 'author': 'Fedson', 'year': '2008', 'journal-title': 'Lancet Infect Dis'}, { 'key': '10.1002/prp2.293-BIB0039|prp2293-cit-0039', 'first-page': '567', 'article-title': 'Reconstitution of the receptor-binding motif of the SARS coronavirus', 'volume': '28', 'author': 'Freund', 'year': '2015', 'journal-title': 'Protein Eng Des Sel'}, { 'key': '10.1002/prp2.293-BIB0040|prp2293-cit-0040', 'doi-asserted-by': 'crossref', 'first-page': 'e2257', 'DOI': '10.1371/journal.pntd.0002257', 'article-title': 'Dengue virus activates membrane TRAIL relocalization and IFN-alpha ' 'production by human plasmacytoid dendritic cells in\xa0vitro and in\xa0' 'vivo', 'volume': '7', 'author': 'Gandini', 'year': '2013', 'journal-title': 'PLoS Negl Trop Dis'}, { 'key': '10.1002/prp2.293-BIB0041|prp2293-cit-0041', 'doi-asserted-by': 'crossref', 'first-page': '1717', 'DOI': '10.1016/j.vaccine.2013.01.037', 'article-title': 'Enhancement of T cell-mediated immune responses to whole inactivated ' 'influenza virus by chloroquine treatment in\xa0vivo', 'volume': '31', 'author': 'Garulli', 'year': '2013', 'journal-title': 'Vaccine'}, { 'key': '10.1002/prp2.293-BIB0042|prp2293-cit-0042', 'doi-asserted-by': 'crossref', 'first-page': '1275', 'DOI': '10.1016/j.meegid.2012.02.003', 'article-title': 'pH-dependent entry of chikungunya virus into Aedes albopictus cells', 'volume': '12', 'author': 'Gay', 'year': '2012', 'journal-title': 'Infect Genet Evol'}, { 'key': '10.1002/prp2.293-BIB0043|prp2293-cit-0043', 'doi-asserted-by': 'crossref', 'first-page': '2347', 'DOI': '10.1016/S0002-9440(10)63591-2', 'article-title': 'Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: ' 'evidence that dendritic cells are early and sustained targets of ' 'infection', 'volume': '163', 'author': 'Geisbert', 'year': '2003', 'journal-title': 'Am J Pathol'}, { 'issue': 'Suppl 2', 'key': '10.1002/prp2.293-BIB0044|prp2293-cit-0044', 'doi-asserted-by': 'crossref', 'first-page': 'S91', 'DOI': '10.1093/infdis/jiv284', 'article-title': 'Considerations in the use of nonhuman primate models of ebola virus and ' 'marburg virus infection', 'volume': '212', 'author': 'Geisbert', 'year': '2015', 'journal-title': 'J Infect Dis'}, { 'key': '10.1002/prp2.293-BIB0045|prp2293-cit-0045', 'doi-asserted-by': 'crossref', 'first-page': '783', 'DOI': '10.1128/JVI.72.1.783-788.1998', 'article-title': 'Mechanism of Borna disease virus entry into cells', 'volume': '72', 'author': 'Gonzalez-Dunia', 'year': '1998', 'journal-title': 'J Virol'}, { 'key': '10.1002/prp2.293-BIB0046|prp2293-cit-0046', 'doi-asserted-by': 'crossref', 'first-page': '551', 'DOI': '10.1186/1471-2407-14-551', 'article-title': 'Pharmacological modulation of autophagy enhances Newcastle disease ' 'virus-mediated oncolysis in drug-resistant lung cancer cells', 'volume': '14', 'author': 'Jiang', 'year': '2014', 'journal-title': 'BMC Cancer'}, { 'key': '10.1002/prp2.293-BIB0047|prp2293-cit-0047', 'doi-asserted-by': 'crossref', 'first-page': '969', 'DOI': '10.1016/j.drudis.2013.05.002', 'article-title': 'Chikungunya virus: an update on antiviral development and challenges', 'volume': '18', 'author': 'Kaur', 'year': '2013', 'journal-title': 'Drug Discov Today'}, { 'key': '10.1002/prp2.293-BIB0048|prp2293-cit-0048', 'doi-asserted-by': 'crossref', 'first-page': '264', 'DOI': '10.1016/j.bbrc.2004.08.085', 'article-title': 'In vitro inhibition of severe acute respiratory syndrome coronavirus by ' 'chloroquine', 'volume': '323', 'author': 'Keyaerts', 'year': '2004', 'journal-title': 'Biochem Biophys Res Commun'}, { 'key': '10.1002/prp2.293-BIB0049|prp2293-cit-0049', 'doi-asserted-by': 'crossref', 'first-page': '14166', 'DOI': '10.1074/jbc.M114.628891', 'article-title': 'Vacuolar ATPase in phagosome-lysosome fusion', 'volume': '290', 'author': 'Kissing', 'year': '2014', 'journal-title': 'J Biol Chem'}, { 'key': '10.1002/prp2.293-BIB0050|prp2293-cit-0050', 'doi-asserted-by': 'crossref', 'first-page': '6203', 'DOI': '10.1128/AAC.00899-15', 'article-title': 'The glucose transporter PfHT1 is an antimalarial target of the HIV ' 'protease inhibitor lopinavir', 'volume': '59', 'author': 'Kraft', 'year': '2015', 'journal-title': 'Antimicrob Agents Chemother'}, { 'key': '10.1002/prp2.293-BIB0051|prp2293-cit-0051', 'doi-asserted-by': 'crossref', 'first-page': '103', 'DOI': '10.3109/03009747409115809', 'article-title': 'Dosage of antimalarial drugs for children with juvenile rheumatoid ' 'arthritis and systemic lupus erythematosus. A clinical study with ' 'determination of serum concentrations of chloroquine and ' 'hydroxychloroquine', 'volume': '3', 'author': 'Laaksonen', 'year': '1974', 'journal-title': 'Scand J Rheumatol'}, { 'key': '10.1002/prp2.293-BIB0052|prp2293-cit-0052', 'doi-asserted-by': 'crossref', 'first-page': '302', 'DOI': '10.1128/CVI.00617-13', 'article-title': 'Immunogenicity and safety of a booster dose of an investigational ' 'adjuvanted polyprotein HIV-1 vaccine in healthy adults and effect of ' 'administration of chloroquine', 'volume': '21', 'author': 'Leroux-Roels', 'year': '2014', 'journal-title': 'Clin Vaccine Immunol'}, { 'key': '10.1002/prp2.293-BIB0053|prp2293-cit-0053', 'doi-asserted-by': 'crossref', 'first-page': '2210', 'DOI': '10.1016/S0140-6736(00)02405-3', 'article-title': 'Human asymptomatic Ebola infection and strong inflammatory response', 'volume': '355', 'author': 'Leroy', 'year': '2000', 'journal-title': 'Lancet'}, { 'key': '10.1002/prp2.293-BIB0054|prp2293-cit-0054', 'doi-asserted-by': 'crossref', 'first-page': '450', 'DOI': '10.1038/nature02145', 'article-title': 'Angiotensin-converting enzyme 2 is a functional receptor for the SARS ' 'coronavirus', 'volume': '426', 'author': 'Li', 'year': '2003', 'journal-title': 'Nature'}, { 'key': '10.1002/prp2.293-BIB0055|prp2293-cit-0055', 'doi-asserted-by': 'crossref', 'first-page': '30', 'DOI': '10.12688/f1000research.6085.1', 'article-title': 'Antiviral therapies against Ebola and other emerging viral diseases ' 'using existing medicines that block virus entry', 'volume': '4', 'author': 'Long', 'year': '2015', 'journal-title': 'F1000Res'}, { 'key': '10.1002/prp2.293-BIB0056|prp2293-cit-0056', 'doi-asserted-by': 'crossref', 'first-page': '48', 'DOI': '10.1016/0002-9343(83)90474-6', 'article-title': 'Antimalarial drugs for rheumatoid arthritis', 'volume': '75', 'author': 'Mackenzie', 'year': '1983', 'journal-title': 'Am J Med'}, { 'key': '10.1002/prp2.293-BIB0057|prp2293-cit-0057', 'doi-asserted-by': 'crossref', 'first-page': 'e60579', 'DOI': '10.1371/journal.pone.0060579', 'article-title': 'A systematic screen of FDA-approved drugs for inhibitors of biological ' 'threat agents', 'volume': '8', 'author': 'Madrid', 'year': '2013', 'journal-title': 'PLoS ONE'}, { 'key': '10.1002/prp2.293-BIB0058|prp2293-cit-0058', 'doi-asserted-by': 'crossref', 'first-page': '871', 'DOI': '10.1128/AAC.01246-09', 'article-title': 'Chloroquine modulates HIV-1-induced plasmacytoid dendritic cell alpha ' 'interferon: implication for T-cell activation', 'volume': '54', 'author': 'Martinson', 'year': '2014', 'journal-title': 'Antimicrob Agents Chemother'}, { 'key': '10.1002/prp2.293-BIB0059|prp2293-cit-0059', 'doi-asserted-by': 'crossref', 'first-page': 'e1923', 'DOI': '10.1371/journal.pntd.0001923', 'article-title': 'Cathepsin B & L are not required for ebola virus replication', 'volume': '6', 'author': 'Marzi', 'year': '2012', 'journal-title': 'PLoS Negl Trop Dis'}, { 'key': '10.1002/prp2.293-BIB0060|prp2293-cit-0060', 'doi-asserted-by': 'crossref', 'first-page': '2658', 'DOI': '10.1099/vir.0.068528-0', 'article-title': 'Alternative endocytosis pathway for productive entry of hepatitis C ' 'virus', 'volume': '95', 'author': 'Matsuda', 'year': '2014', 'journal-title': 'J Gen Virol'}, { 'key': '10.1002/prp2.293-BIB0061|prp2293-cit-0061', 'doi-asserted-by': 'crossref', 'first-page': '1011', 'DOI': '10.1007/s00705-012-1270-6', 'article-title': 'Newcastle disease virus triggers autophagy in U251 glioma cells to ' 'enhance virus replication', 'volume': '157', 'author': 'Meng', 'year': '2012', 'journal-title': 'Arch Virol'}, { 'key': '10.1002/prp2.293-BIB0062|prp2293-cit-0062', 'doi-asserted-by': 'crossref', 'first-page': 'e64708', 'DOI': '10.1371/journal.pone.0064708', 'article-title': 'RNAi induces innate immunity through multiple cellular signaling ' 'pathways', 'volume': '8', 'author': 'Meng', 'year': '2013', 'journal-title': 'PLoS ONE'}, { 'key': '10.1002/prp2.293-BIB0063|prp2293-cit-0063', 'doi-asserted-by': 'crossref', 'first-page': '4423', 'DOI': '10.1016/j.bmc.2015.06.020', 'article-title': 'Anti-HIV screening for cell-penetrating peptides using chloroquine and ' 'identification of anti-HIV peptides derived from matrix proteins', 'volume': '23', 'author': 'Mizuguchi', 'year': '2015', 'journal-title': 'Bioorg Med Chem'}, { 'key': '10.1002/prp2.293-BIB0064|prp2293-cit-0064', 'doi-asserted-by': 'crossref', 'first-page': '195', 'DOI': '10.1007/s00535-009-0132-9', 'article-title': 'Inhibition of hepatitis C virus replication by chloroquine targeting ' 'virus-associated autophagy', 'volume': '45', 'author': 'Mizui', 'year': '2009', 'journal-title': 'J Gastroenterol'}, { 'key': '10.1002/prp2.293-BIB0065|prp2293-cit-0065', 'doi-asserted-by': 'crossref', 'first-page': '1460', 'DOI': '10.1002/art.10307', 'article-title': 'Hydroxychloroquine concentration-response relationships in patients ' 'with rheumatoid arthritis', 'volume': '46', 'author': 'Munster', 'year': '2002', 'journal-title': 'Arthritis Rheum'}, { 'key': '10.1002/prp2.293-BIB0066|prp2293-cit-0066', 'doi-asserted-by': 'crossref', 'first-page': '175', 'DOI': '10.2174/1389200024605082', 'article-title': 'Neopterin as a marker for immune system activation', 'volume': '3', 'author': 'Murr', 'year': '2002', 'journal-title': 'Curr Drug Metab'}, { 'key': '10.1002/prp2.293-BIB0067|prp2293-cit-0067', 'doi-asserted-by': 'crossref', 'first-page': '12082', 'DOI': '10.1128/JVI.01466-10', 'article-title': 'Reduction of immune activation with chloroquine therapy during chronic ' 'HIV infection', 'volume': '84', 'author': 'Murray', 'year': '2010', 'journal-title': 'J Virol'}, { 'key': '10.1002/prp2.293-BIB0068|prp2293-cit-0068', 'doi-asserted-by': 'crossref', 'first-page': '6', 'DOI': '10.1186/1742-4690-4-6', 'article-title': 'Effect of chloroquine on reducing HIV-1 replication in\xa0vitro and the ' 'DC-SIGN mediated transfer of virus to CD4\xa0+\xa0 T-lymphocytes', 'volume': '4', 'author': 'Naarding', 'year': '2007', 'journal-title': 'Retrovirology'}, { 'key': '10.1002/prp2.293-BIB0069|prp2293-cit-0069', 'first-page': '61', 'article-title': 'Effect of chloroquine on human immunodeficiency virus (HIV) vertical ' 'transmission', 'volume': '3', 'author': 'Neely', 'year': '2003', 'journal-title': 'Afr Health Sci'}, { 'key': '10.1002/prp2.293-BIB0070|prp2293-cit-0070', 'doi-asserted-by': 'crossref', 'first-page': '39', 'DOI': '10.1186/1743-422X-3-39', 'article-title': 'In vitro inhibition of human influenza A virus replication by ' 'chloroquine', 'volume': '3', 'author': 'Ooi', 'year': '2006', 'journal-title': 'Virol J'}, { 'key': '10.1002/prp2.293-BIB0071|prp2293-cit-0071', 'doi-asserted-by': 'crossref', 'first-page': '21899', 'DOI': '10.1074/jbc.M802444200', 'article-title': 'Inhibition of Chikungunya virus infection in cultured human muscle ' 'cells by furin inhibitors: impairment of the maturation of the E2 ' 'surface glycoprotein', 'volume': '283', 'author': 'Ozden', 'year': '2008', 'journal-title': 'J Biol Chem'}, { 'key': '10.1002/prp2.293-BIB0072|prp2293-cit-0072', 'doi-asserted-by': 'crossref', 'first-page': '1258', 'DOI': '10.1016/j.mehy.2006.05.013', 'article-title': 'The timing is right: Evolution of AIDS-causing HIV strains is ' 'consistent with history of chloroquine use', 'volume': '67', 'author': 'Parris', 'year': '2006', 'journal-title': 'Med Hypotheses'}, { 'key': '10.1002/prp2.293-BIB0073|prp2293-cit-0073', 'doi-asserted-by': 'crossref', 'first-page': '677', 'DOI': '10.1016/S1473-3099(11)70065-2', 'article-title': 'Chloroquine for influenza prevention: a randomised, double-blind, ' 'placebo controlled trial', 'volume': '11', 'author': 'Paton', 'year': '2011', 'journal-title': 'Lancet Infect Dis'}, { 'key': '10.1002/prp2.293-BIB0504|prp2293-cit-0504', 'doi-asserted-by': 'crossref', 'first-page': '353', 'DOI': '10.1001/jama.2012.6936', 'article-title': 'Effects of hydroxychloroquine on immune activation and disease ' 'progression among HIV-infected patients not receiving antiretroviral ' 'therapy: a randomized controlled trial', 'volume': '308', 'author': 'Paton', 'year': '2012', 'journal-title': 'JAMA'}, { 'key': '10.1002/prp2.293-BIB0074|prp2293-cit-0074', 'doi-asserted-by': 'crossref', 'first-page': '951', 'DOI': '10.1016/S1665-2681(19)31424-3', 'article-title': 'Porphyria cutanea tarda in an HCV-positive liver transplant patient: a ' 'case report', 'volume': '11', 'author': 'Pellicelli', 'year': '2012', 'journal-title': 'Ann Hepatol'}, { 'key': '10.1002/prp2.293-BIB0075|prp2293-cit-0075', 'doi-asserted-by': 'crossref', 'first-page': '139', 'DOI': '10.1139/W08-107', 'article-title': 'Entry of dengue virus serotype 2 into ECV304 cells depends on ' 'clathrin-dependent endocytosis, but not on caveolae-dependent ' 'endocytosis', 'volume': '55', 'author': 'Peng', 'year': '2009', 'journal-title': 'Can J Microbiol'}, { 'key': '10.1002/prp2.293-BIB0076|prp2293-cit-0076', 'doi-asserted-by': 'crossref', 'first-page': 'e0140824', 'DOI': '10.1371/journal.pone.0140824', 'article-title': 'Dengue-3 virus entry into vero cells: role of clathrin-mediated ' 'endocytosis in the outcome of infection', 'volume': '10', 'author': 'Piccini', 'year': '2015', 'journal-title': 'PLoS ONE'}, { 'key': '10.1002/prp2.293-BIB0505|prp2293-cit-0505', 'doi-asserted-by': 'crossref', 'first-page': '3263', 'DOI': '10.1182/blood-2011-01-329060', 'article-title': 'Hydroxychloroquine drastically reduces immune activation in ' 'HIV-infected, antiretroviral therapy-treated immunologic nonresponders', 'volume': '118', 'author': 'Piconi', 'year': '2011', 'journal-title': 'Blood'}, { 'key': '10.1002/prp2.293-BIB0077|prp2293-cit-0077', 'doi-asserted-by': 'crossref', 'first-page': '251', 'DOI': '10.1038/nature12005', 'article-title': 'Dipeptidyl peptidase 4 is a functional receptor for the emerging human ' 'coronavirus-EMC', 'volume': '495', 'author': 'Raj', 'year': '2013', 'journal-title': 'Nature'}, { 'key': '10.1002/prp2.293-BIB0078|prp2293-cit-0078', 'doi-asserted-by': 'crossref', 'first-page': '2643', 'DOI': '10.2174/1381612043383791', 'article-title': 'Chloroquine and hydroxychloroquine as inhibitors of human ' 'immunodeficiency virus (HIV-1) activity', 'volume': '10', 'author': 'Romanelli', 'year': '2004', 'journal-title': 'Curr Pharm Des'}, { 'key': '10.1002/prp2.293-BIB0079|prp2293-cit-0079', 'doi-asserted-by': 'crossref', 'first-page': '48', 'DOI': '10.1111/hiv.12171', 'article-title': 'Assessment of chloroquine as a modulator of immune activation to ' 'improve CD4 recovery in immune nonresponding HIV-infected patients ' 'receiving antiretroviral therapy', 'volume': '16', 'author': 'Routy', 'year': '2014', 'journal-title': 'HIV Med'}, { 'key': '10.1002/prp2.293-BIB0080|prp2293-cit-0080', 'doi-asserted-by': 'crossref', 'first-page': '300', 'DOI': '10.1016/j.bbamem.2013.08.008', 'article-title': 'Entry of newcastle disease virus into the host cell: role of acidic pH ' 'and endocytosis', 'volume': '1838', 'author': 'Sanchez-Felipe', 'year': '2013', 'journal-title': 'Biochim Biophys Acta'}, { 'key': '10.1002/prp2.293-BIB0081|prp2293-cit-0081', 'doi-asserted-by': 'crossref', 'first-page': '653', 'DOI': '10.1016/S1473-3099(11)70092-5', 'article-title': 'Use of chloroquine in viral diseases', 'volume': '11', 'author': 'Savarino', 'year': '2011', 'journal-title': 'Lancet Infect Dis'}, { 'key': '10.1002/prp2.293-BIB0082|prp2293-cit-0082', 'doi-asserted-by': 'crossref', 'first-page': '51', 'DOI': '10.1186/s12977-015-0178-0', 'article-title': 'Chloroquine and beyond: exploring anti-rheumatic drugs to reduce immune ' 'hyperactivation in HIV/AIDS', 'volume': '12', 'author': 'Savarino', 'year': '2015', 'journal-title': 'Retrovirology'}, { 'key': '10.1002/prp2.293-BIB0083|prp2293-cit-0083', 'doi-asserted-by': 'crossref', 'first-page': '2221', 'DOI': '10.1097/00002030-200111230-00002', 'article-title': 'Anti-HIV effects of chloroquine: mechanisms of inhibition and spectrum ' 'of activity', 'volume': '15', 'author': 'Savarino', 'year': '2001a', 'journal-title': 'AIDS'}, { 'key': '10.1002/prp2.293-BIB0084|prp2293-cit-0084', 'doi-asserted-by': 'crossref', 'first-page': '131', 'DOI': '10.1016/S1386-6532(00)00139-6', 'article-title': 'The anti-HIV-1 activity of chloroquine', 'volume': '20', 'author': 'Savarino', 'year': '2001b', 'journal-title': 'J Clin Virol'}, { 'key': '10.1002/prp2.293-BIB0085|prp2293-cit-0085', 'doi-asserted-by': 'crossref', 'first-page': '722', 'DOI': '10.1016/S1473-3099(03)00806-5', 'article-title': "Effects of chloroquine on viral infections: an old drug against today's " 'diseases?', 'volume': '3', 'author': 'Savarino', 'year': '2003', 'journal-title': 'Lancet Infect Dis'}, { 'key': '10.1002/prp2.293-BIB0086|prp2293-cit-0086', 'doi-asserted-by': 'crossref', 'first-page': '223', 'DOI': '10.1097/00126334-200403010-00002', 'article-title': 'Anti-HIV effects of chloroquine: inhibition of viral particle ' 'glycosylation and synergism with protease inhibitors', 'volume': '35', 'author': 'Savarino', 'year': '2004', 'journal-title': 'J Acquir Immune Defic Syndr'}, { 'key': '10.1002/prp2.293-BIB0087|prp2293-cit-0087', 'doi-asserted-by': 'crossref', 'first-page': '67', 'DOI': '10.1016/S1473-3099(06)70361-9', 'article-title': 'New insights into the antiviral effects of chloroquine', 'volume': '6', 'author': 'Savarino', 'year': '2006', 'journal-title': 'Lancet Infect Dis'}, { 'key': '10.1002/prp2.293-BIB0088|prp2293-cit-0088', 'doi-asserted-by': 'crossref', 'first-page': '163', 'DOI': '10.1189/jlb.0603252', 'article-title': 'Interferon-gamma: an overview of signals, mechanisms and functions', 'volume': '75', 'author': 'Schroder', 'year': '2004', 'journal-title': 'J Leukoc Biol'}, { 'key': '10.1002/prp2.293-BIB0089|prp2293-cit-0089', 'doi-asserted-by': 'crossref', 'first-page': '287', 'DOI': '10.1016/j.virol.2014.07.025', 'article-title': 'Endosomal acidification and cathepsin L activity is required for ' 'calicivirus replication', 'volume': '464-465', 'author': 'Shivanna', 'year': '2014', 'journal-title': 'Virology'}, { 'key': '10.1002/prp2.293-BIB0090|prp2293-cit-0090', 'doi-asserted-by': 'crossref', 'first-page': 'e89', 'DOI': '10.1371/journal.ppat.0030089', 'article-title': 'Characterization of reemerging chikungunya virus', 'volume': '3', 'author': 'Sourisseau', 'year': '2007', 'journal-title': 'PLoS Pathog'}, { 'key': '10.1002/prp2.293-BIB0506|prp2293-cit-0506', 'doi-asserted-by': 'crossref', 'first-page': '622', 'DOI': '10.1016/0149-2918(95)80039-5', 'article-title': 'Hydroxychloroquine treatment of patients with human immunodeficiency ' 'virus type 1', 'volume': '17', 'author': 'Sperber', 'year': '1995', 'journal-title': 'Clin Ther'}, { 'key': '10.1002/prp2.293-BIB0091|prp2293-cit-0091', 'first-page': '17', 'article-title': 'Chikungunya fever-expanded distribution of a re-emerging tropical ' 'infectious disease', 'volume': '32', 'author': 'Stock', 'year': '2009', 'journal-title': 'Med Monatsschr Pharm'}, { 'key': '10.1002/prp2.293-BIB0092|prp2293-cit-0092', 'doi-asserted-by': 'crossref', 'first-page': '7500', 'DOI': '10.1128/JVI.02452-05', 'article-title': 'Entry of feline calicivirus is dependent on clathrin-mediated ' 'endocytosis and acidification in endosomes', 'volume': '80', 'author': 'Stuart', 'year': '2006', 'journal-title': 'J Virol'}, { 'key': '10.1002/prp2.293-BIB0093|prp2293-cit-0093', 'doi-asserted-by': 'crossref', 'first-page': '166', 'DOI': '10.3109/1040841X.2012.694412', 'article-title': 'From endocytosis to membrane fusion: emerging roles of dynamin in virus ' 'entry', 'volume': '39', 'author': 'Sun', 'year': '2012', 'journal-title': 'Crit Rev Microbiol'}, { 'key': '10.1002/prp2.293-BIB0094|prp2293-cit-0094', 'doi-asserted-by': 'crossref', 'first-page': '525', 'DOI': '10.1128/JVI.01849-13', 'article-title': 'Autophagy benefits the replication of Newcastle disease virus in ' 'chicken cells and tissues', 'volume': '88', 'author': 'Sun', 'year': '2013', 'journal-title': 'J Virol'}, { 'key': '10.1002/prp2.293-BIB0095|prp2293-cit-0095', 'doi-asserted-by': 'crossref', 'first-page': '14764', 'DOI': '10.1073/pnas.94.26.14764', 'article-title': 'A system for functional analysis of Ebola virus glycoprotein', 'volume': '94', 'author': 'Takada', 'year': '1997', 'journal-title': 'Proc Natl Acad Sci U S A'}, { 'key': '10.1002/prp2.293-BIB0096|prp2293-cit-0096', 'doi-asserted-by': 'crossref', 'first-page': 'e1', 'DOI': '10.1086/518701', 'article-title': 'Chikungunya fever in travelers: clinical presentation and course', 'volume': '45', 'author': 'Taubitz', 'year': '2007', 'journal-title': 'Clin Infect Dis'}, { 'key': '10.1002/prp2.293-BIB0097|prp2293-cit-0097', 'doi-asserted-by': 'crossref', 'first-page': '81', 'DOI': '10.1001/archopht.1982.01030030083006', 'article-title': 'Hydroxychloroquine. Seven-year experience', 'volume': '100', 'author': 'Tobin', 'year': '1982', 'journal-title': 'Arch Ophthalmol'}, { 'key': '10.1002/prp2.293-BIB0098|prp2293-cit-0098', 'doi-asserted-by': 'crossref', 'first-page': '491', 'DOI': '10.1146/annurev.med.45.1.491', 'article-title': 'Tumor necrosis factor: a pleiotropic cytokine and therapeutic target', 'volume': '45', 'author': 'Tracey', 'year': '1994', 'journal-title': 'Annu Rev Med'}, { 'key': '10.1002/prp2.293-BIB0507|prp2293-cit-0507', 'doi-asserted-by': 'crossref', 'first-page': 'e785', 'DOI': '10.1371/journal.pntd.0000785', 'article-title': 'A randomized controlled trial of chloroquine for the treatment of ' 'dengue in Vietnamese adults', 'volume': '4', 'author': 'Tricou', 'year': '2010', 'journal-title': 'PLoS Negl Trop Dis'}, { 'key': '10.1002/prp2.293-BIB0099|prp2293-cit-0099', 'doi-asserted-by': 'crossref', 'first-page': '761', 'DOI': '10.1016/j.trstmh.2008.06.017', 'article-title': 'Malaria and HIV co-infection in pregnancy in sub-Saharan Africa: impact ' 'of treatment using antimalarial and antiretroviral agents', 'volume': '103', 'author': 'Uneke', 'year': '2009', 'journal-title': 'Trans R Soc Trop Med Hyg'}, { 'key': '10.1002/prp2.293-BIB0100|prp2293-cit-0100', 'doi-asserted-by': 'crossref', 'first-page': '86', 'DOI': '10.1002/hep.26273', 'article-title': 'The antimalarial ferroquine is an inhibitor of hepatitis C virus', 'volume': '58', 'author': 'Vausselin', 'year': '2013', 'journal-title': 'Hepatology'}, { 'key': '10.1002/prp2.293-BIB0101|prp2293-cit-0101', 'doi-asserted-by': 'crossref', 'first-page': '189', 'DOI': '10.1111/j.1750-2659.2007.00027.x', 'article-title': 'Chloroquine is effective against influenza A virus in\xa0vitro but not ' 'in\xa0vivo', 'volume': '1', 'author': 'Vigerust', 'year': '2007', 'journal-title': 'Influenza Other Respir Viruses'}, { 'issue': 'Suppl 1', 'key': '10.1002/prp2.293-BIB0102|prp2293-cit-0102', 'doi-asserted-by': 'crossref', 'first-page': 'S188', 'DOI': '10.1086/514283', 'article-title': 'Markedly elevated levels of interferon (IFN)-gamma, IFN-alpha, ' 'interleukin (IL)-2, IL-10, and tumor necrosis factor-alpha associated ' 'with fatal Ebola virus infection', 'volume': '179', 'author': 'Villinger', 'year': '1999', 'journal-title': 'J Infect Dis'}, { 'key': '10.1002/prp2.293-BIB0103|prp2293-cit-0103', 'doi-asserted-by': 'crossref', 'first-page': '69', 'DOI': '10.1186/1743-422X-2-69', 'article-title': 'Chloroquine is a potent inhibitor of SARS coronavirus infection and ' 'spread', 'volume': '2', 'author': 'Vincent', 'year': '2005', 'journal-title': 'Virol J'}, { 'key': '10.1002/prp2.293-BIB0104|prp2293-cit-0104', 'doi-asserted-by': 'crossref', 'first-page': '464', 'DOI': '10.1007/s11427-009-0061-0', 'article-title': 'Influenza A virus H5N1 entry into host cells is through ' 'clathrin-dependent endocytosis', 'volume': '52', 'author': 'Wang', 'year': '2009', 'journal-title': 'Sci China C Life Sci'}, { 'key': '10.1002/prp2.293-BIB0105|prp2293-cit-0105', 'doi-asserted-by': 'crossref', 'first-page': '1096', 'DOI': '10.1002/jmv.24135', 'article-title': 'Chloroquine enhances replication of influenza A virus A/WSN/33 (H1N1) ' 'in dose-, time-, and MOI-dependent manners in human lung epithelial ' 'cells A549', 'volume': '87', 'author': 'Wu', 'year': '2015', 'journal-title': 'J Med Virol'}, { 'key': '10.1002/prp2.293-BIB0106|prp2293-cit-0106', 'doi-asserted-by': 'crossref', 'first-page': '300', 'DOI': '10.1038/cr.2012.165', 'article-title': 'Anti-malaria drug chloroquine is highly effective in treating avian ' 'influenza A H5N1 virus infection in an animal model', 'volume': '23', 'author': 'Yan', 'year': '2012', 'journal-title': 'Cell Res'}, { 'key': '10.1002/prp2.293-BIB0107|prp2293-cit-0107', 'doi-asserted-by': 'crossref', 'first-page': '1034', 'DOI': '10.1126/science.279.5353.1034', 'article-title': 'Distinct cellular interactions of secreted and transmembrane Ebola ' 'virus glycoproteins', 'volume': '279', 'author': 'Yang', 'year': '1998', 'journal-title': 'Science'}, { 'key': '10.1002/prp2.293-BIB0108|prp2293-cit-0108', 'doi-asserted-by': 'crossref', 'first-page': '886', 'DOI': '10.1038/78645', 'article-title': 'Identification of the Ebola virus glycoprotein as the main viral ' 'determinant of vascular cell cytotoxicity and injury', 'volume': '6', 'author': 'Yang', 'year': '2000', 'journal-title': 'Nat Med'}, { 'key': '10.1002/prp2.293-BIB0109|prp2293-cit-0109', 'doi-asserted-by': 'crossref', 'first-page': '66', 'DOI': '10.1111/j.1365-3083.1995.tb03627.x', 'article-title': 'Characterization of TAP-independent and brefeldin A-resistant ' 'presentation of Sendai virus antigen to CD8\xa0+\xa0 cytotoxic T ' 'lymphocytes', 'volume': '42', 'author': 'Zhou', 'year': '1995', 'journal-title': 'Scand J Immunol'}], 'container-title': 'Pharmacology Research & Perspectives', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 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