Clinical Efficacy of Chloroquine derivatives in COVID-19 Infection: Comparative metaanalysis between the Big data and the real world

Million et al., New Microbes and New Infections, doi:10.1016/j.nmni.2020.100709 (meta analysis)

Million et al., Clinical Efficacy of Chloroquine derivatives in COVID-19 Infection: Comparative metaanalysis between the Big.., New Microbes and New Infections, doi:10.1016/j.nmni.2020.100709 (meta analysis)

Jun 2020 Source PDF

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[H]CQ effective and reduces mortality by a factor 3. Meta analysis of 20 studies.

Currently there are 36 HCQ early treatment studies and meta analysis shows:

Outcome	Improvement
Mortality	72% lower [57‑81%]
Ventilation	67% lower [-710‑99%]
ICU admission	28% lower [-17‑55%]
Hospitalization	41% lower [28‑52%]

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Million et al., 6 Jun 2020, peer-reviewed, 14 authors.

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Clinical efficacy of chloroquine derivatives in COVID-19 infection: comparative meta-analysis between the big data and the real world

M Million, P Gautret, P Colson, Y Roussel, G Dubourg, E Chabriere, S Honore, J-M Rolain, F Fenollar, P-E Fournier, J-C Lagier, P Parola, P Brouqui, D Raoult

New Microbes and New Infections, doi:10.1016/j.nmni.2020.100709

In the context of the current coronavirus disease 2019 (COVID-19) pandemic, we conducted a meta-analysis on the effects of chloroquine derivatives in patients, based on unpublished and published reports available publicly on the internet as of 27 May 2020. The keywords 'hydroxychloroquine', 'chloroquine', 'coronavirus', 'COVID-19' and 'SARS-Cov-2' were used in the PubMed, Google Scholar and Google search engines without any restrictions as to date or language. Twenty studies were identified involving 105 040 patients (19 270 treated patients) from nine countries (

Declaration of competing interest The authors declare no competing interests. Funding sources had no role in the design and conduct of the study; collection, management, analysis and interpretation of the data; and preparation, review or approval of the manuscript. Our group used widely available generic drugs distributed by many pharmaceutical companies. Appendix A. Supplementary data Supplementary data to this article can be found online at https:// doi.org/10.1016/j.nmni.2020.100709.

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