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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Death/hospitalization/c.. 24% Improvement Relative Risk c19hcq.org Ladapo et al. HCQ for COVID-19 META ANALYSIS Favors HCQ Favors control
Randomized Controlled Trials of Early Ambulatory Hydroxychloroquine in the Prevention of COVID-19 Infection, Hospitalization, and Death: Meta-Analysis
Ladapo et al., medRxiv, doi:10.1101/2020.09.30.20204693 (Preprint) (meta analysis)
30 Sep 2020    Source   PDF   Share   Tweet
Meta analysis of prophylactic and early treatment RCTs, 24% reduction in cases, hospitalization or death with HCQ, RR 0.76, p=0.025. No serious adverse cardiac events were reported. 5,577 patients.
The Boulware study provides a breakdown for treatment delay. For the case of < ~4 days (2 days enrollment, ~46 hours shipping), the result of the meta analysis becomes RR 0.68, p=0.0097.
The actual effect may be larger due to treatment delays, followup loss, protocol deviation, active placebos, no severity analysis for cases, and suboptimal regimens.
For the individual studies see [Boulware, Mitjà, Mitjà (B), Rajasingham, Skipper].
Currently there are 36 HCQ early treatment studies and meta analysis shows:
OutcomeImprovement
Mortality72% lower [57‑81%]
Ventilation67% lower [-710‑99%]
ICU admission28% lower [-17‑55%]
Hospitalization41% lower [28‑52%]
risk of death/hospitalization/cases, 24.0% lower, RR 0.76, p = 0.03.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ladapo et al., 30 Sep 2020, preprint, 4 authors.
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