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All Studies   Meta Analysis   Recent:  
0 0.5 1 1.5 2+ Radiological progression 29% Improvement Relative Risk Viral+ at day 7 -100% c19hcq.org Chen et al. HCQ for COVID-19 RCT LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? RCT 30 patients in China Lower progression with HCQ (not stat. sig., p=0.57) Chen et al., J. Zhejiang University, doi:10.3785/j.issn.1008-9292.2020.03.03 Favors HCQ Favors control
A pilot study of hydroxychloroquine in treatment of patients with common coronavirus disease-19 (COVID-19)
Chen et al., J. Zhejiang University (Med Sci), doi:10.3785/j.issn.1008-9292.2020.03.03
Chen et al., A pilot study of hydroxychloroquine in treatment of patients with common coronavirus disease-19 (COVID-19), J. Zhejiang University (Med Sci), doi:10.3785/j.issn.1008-9292.2020.03.03
Mar 2020   Source   PDF  
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30 moderate hospitalized cases, all recovered. Time to RNA negative comparable. Less frequent radiological progression with HCQ but not statistically significant. One HCQ patient developed to a severe case. Treatment group 4 years older and with higher incidence of hypertension.
risk of radiological progression, 29.0% lower, RR 0.71, p = 0.57, treatment 5 of 15 (33.3%), control 7 of 15 (46.7%), NNT 7.5.
risk of viral+ at day 7, 100% higher, RR 2.00, p = 1.00, treatment 2 of 15 (13.3%), control 1 of 15 (6.7%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Chen et al., 6 Mar 2020, Randomized Controlled Trial, China, peer-reviewed, 14 authors.
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This PaperHCQAll
Late treatment
is less effective
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