Systematic review and meta-analysis of randomized trials of hydroxychloroquine for the prevention of COVID-19
García-Albéniz et al., European Journal of Epidemiology, doi:10.1007/s10654-022-00891-4 (date from earlier preprint) (meta analysis)
García-Albéniz et al., Systematic review and meta-analysis of randomized trials of hydroxychloroquine for the prevention of COVID-19, European Journal of Epidemiology, doi:10.1007/s10654-022-00891-4 (date from earlier preprint) (meta analysis)
Systematic review and meta-analysis of HCQ prophylaxis RCTs showing a statistically significant reduction in cases for pre-exposure prophylaxis.For PEP trials there were very long treatment delays - in one trial about a third of participants were enrolled 4 days after exposure with an additional shipping delay of ~46 hours on average, and in another trial participants were enrolled up to 7 days after exposure, with an unknown additional delay before treatment, and results suggesting that exposure detection was delayed.Currently there are 36 HCQ early treatment studies and meta analysis shows:
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