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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Case, PrEP 28% Improvement Relative Risk Case, PEP 9% c19hcq.org García-Albéniz et al. HCQ for COVID-19 META ANALYSIS Favors HCQ Favors control
Systematic review and meta-analysis of randomized trials of hydroxychloroquine for the prevention of COVID-19
García-Albéniz et al., European Journal of Epidemiology, doi:10.1007/s10654-022-00891-4 (date from earlier preprint) (meta analysis)
9 Aug 2022    Source   PDF   Share   Tweet
Systematic review and meta-analysis of HCQ prophylaxis RCTs showing a statistically significant reduction in cases for pre-exposure prophylaxis.
For PEP trials there were very long treatment delays - in one trial about a third of participants were enrolled 4 days after exposure with an additional shipping delay of ~46 hours on average, and in another trial participants were enrolled up to 7 days after exposure, with an unknown additional delay before treatment, and results suggesting that exposure detection was delayed.
Currently there are 36 HCQ early treatment studies and meta analysis shows:
OutcomeImprovement
Mortality72% lower [57‑81%]
Ventilation67% lower [-710‑99%]
ICU admission28% lower [-17‑55%]
Hospitalization41% lower [28‑52%]
risk of case, 28.0% lower, RR 0.72, p = 0.003, PrEP.
risk of case, 9.0% lower, RR 0.91, p = 0.45, PEP.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
García-Albéniz et al., 9 Aug 2022, peer-reviewed, 5 authors.
Contact: xgarcia@rti.org.
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