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0 0.5 1 1.5 2+ Mortality 59% Improvement Relative Risk HCQ for COVID-19  Lagier et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 3,737 patients in France Lower mortality with HCQ (p=0.048) c19hcq.org Lagier et al., Travel Med. Infect. Dis.., Jun 2020 Favors HCQ Favors control

Outcomes of 3,737 COVID-19 patients treated with hydroxychloroquine/azithromycin and other regimens in Marseille, France: A retrospective analysis

Lagier et al., Travel Med. Infect. Dis. 101791, Jun 25, 2020, doi:10.1016/j.tmaid.2020.101791
Jun 2020  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now known with p < 0.00000000001 from 421 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments. c19hcq.org
Early treatment leads to significantly better clinical outcome and faster viral load reduction. Matched sample mortality HR 0.41 p-value 0.048. Retrospective 3,737 patients. This study includes both outpatients and hospitalized patients.
risk of death, 59.0% lower, HR 0.41, p = 0.048, treatment 35 of 3,119 (1.1%), control 58 of 618 (9.4%), adjusted per study.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Lagier et al., 25 Jun 2020, retrospective, France, peer-reviewed, 22 authors, dosage 200mg tid days 1-10.
This PaperHCQAll
Outcomes of 3,737 COVID-19 patients treated with hydroxychloroquine/azithromycin and other regimens in Marseille, France: A retrospective analysis
Jean-Christophe Lagier, Matthieu Million, Philippe Gautret, Philippe Colson, Sébastien Cortaredona, Audrey Giraud-Gatineau, Stéphane Honoré, Jean-Yves Gaubert, Pierre-Edouard Fournier, Hervé Tissot-Dupont, Eric Chabrière, Andreas Stein, Jean-Claude Deharo, Florence Fenollar, Jean-Marc Rolain, Yolande Obadia, Alexis Jacquier, Bernard La Scola, Philippe Brouqui, Michel Drancourt, Philippe Parola, Didier Raoult, Sophie Amrane, Camille Aubry, Matthieu Bardou, Cyril Berenger, Laurence Camoin-Jau, Nadim Cassir, Claire Decoster, Catherine Dhiver, Barbara Doudier, Sophie Edouard, Stéphanie Gentile, Katell Guillon-Lorvellec, Marie Hocquart, Anthony Levasseur, Morgane Mailhe, Isabelle Ravaux, Magali Richez, Yanis Roussel, Piseth Seng, Christelle Tomei, Christine Zandotti
Travel Medicine and Infectious Disease, doi:10.1016/j.tmaid.2020.101791
Conclusion: Although this is a retrospective analysis, results suggest that early diagnosis, early isolation and early treatment of COVID-19 patients, with at least 3 days of HCQ-AZ lead to a significantly better clinical outcome and a faster viral load reduction than other treatments. Table 1 Key numbers of activities at IHU M� editerran� ee Infection (2020, February 27th -2020 May 12th). Patients tested for SARS-CoV-2 31,003 individuals including 1,277 health care workers Patients hospitalized in day-care hospital 3,525 Patients hospitalized in infectious diseases units 705 Serology SARS-CoV-2 6,000 samples tested including 643 samples from health care workers Culture 4,786 samples inoculated 1,908 SARS-CoV-2 strains isolated Genome 466 genomes sequenced and analysed Low-dose CT scan 2,218 performed Electrocardiograms 7,800 performed Serum drug dosages 1,939 hydroxychloroquine dosages
Author's note Since this analysis was completed, and as of the 11 th June, 2020, 6 more patients died including 1 patient treated with HCQ-AZ for at least 3 days and 5 in the other group, resulting in an overall 1.1% case fatality rate for the 3,737 patients included in our study. Declaration of competing interests The authors declare no competing interests. Funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript. Our group used widely available generic drugs distributed by many pharmaceutical companies. CRediT authorship contribution statement Appendix A. Supplementary data Supplementary data to this article can be found online at https://doi. org/10.1016/j.tmaid.2020.101791.
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Late treatment
is less effective
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