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Early Hydroxychloroquine Is Associated with an Increase of Survival in COVID-19 Patients: An Observational Study

Membrillo de Novales et al., Preprints 2020, 2020050057, doi:10.20944/preprints202005.0057.v1
May 2020  
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Mortality 55% Improvement Relative Risk HCQ  Membrillo de Novales et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 166 patients in Spain Lower mortality with HCQ (p=0.002) Membrillo de Novales et al., Preprints.., May 2020 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
*, now with p < 0.00000000001 from 411 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments.
166 patients hospitalised with COVID-19, HCQ increased survival 1.4 - 1.8 times when patients admitted in early stages. Early is relative to hospital admission here - all patients were in relatively serious condition.
risk of death, 55.1% lower, RR 0.45, p = 0.002, treatment 27 of 123 (22.0%), control 21 of 43 (48.8%), NNT 3.7.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Membrillo de Novales et al., 5 May 2020, retrospective, Spain, preprint, 19 authors, average treatment delay 7.0 days.
This PaperHCQAll
Early Hydroxychloroquine Is Associated with an Increase of Survival in COVID-19 Patients: An Observational Study
Francisco Javier Membrillo, Germán Ramírez-Olivencia, Miriam Estébanez, Begoña De Dios, María Dolores Herrero, Tatiana Mata, Alberto M Borobia, Carlos Gutiérrez, María Simón, Ana Ochoa, Yolanda Martínez, Alejandro Aguirre, Francisco De Asís Alcántara, Pablo Fernández-González, Elena López, Paula Valle, Sergio Campos, María Navarro, Lucía Elena Ballester
Hydroxychloroquine has shown in vitro activity against SARS-CoV-2. Here we present an observational study. We analysed data from 164 patients admitted to our hospital diagnosed with COVID-19. Hydroxychloroquine treatment was associated with an increase in the mean cumulative survival.
Bersanelli, Controversies about COVID-19 and anticancer treatment with immune checkpoint inhibitors, Immunotherapy, doi:10.2217/imt-2020-0067
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Late treatment
is less effective
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