Early Hydroxychloroquine Is Associated with an Increase of Survival in COVID-19 Patients: An Observational Study
Francisco Javier Membrillo, Germán Ramírez-Olivencia, Miriam Estébanez, Begoña De Dios, María Dolores Herrero, Tatiana Mata, Alberto M Borobia, Carlos Gutiérrez, María Simón, Ana Ochoa, Yolanda Martínez, Alejandro Aguirre, Francisco De Asís Alcántara, Pablo Fernández-González, Elena López, Paula Valle, Sergio Campos, María Navarro, Lucía Elena Ballester
doi:10.20944/preprints202005.0057.v2
Hydroxychloroquine has shown in vitro activity against SARS-CoV-2. Here we present an observational study. We analysed data from 164 patients admitted to our hospital diagnosed with COVID-19. Hydroxychloroquine treatment was associated with an increase in the mean cumulative survival.
References
Bersanelli, Controversies about COVID-19 and anticancer treatment with immune checkpoint inhibitors, Immunotherapy,
doi:10.2217/imt-2020-0067Cao, Wang, Wen, Liu, Wang et al., A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19,
doi:10.1056/NEJMoa2001282Gao, Tian, Yang, Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies, Biosci Trends
Gautret, Lagier, Parola, Hoang, Meddeb et al., Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label nonrandomized clinical trial, Int J Antimicrob Agents,
doi:10.1016/j.ijantimicag.2020.105949Keyaerts, Vijgen, Maes, Neyts, Ranst et al., In vitro inhibition of severe acuterespiratory syndrome coronavirus by chloroquine, Biochem Biophys Res Commun
Loutfy, Blatt, Siminovitch, Interferon alfacon-1 plus corticosteroids in severe acute respiratory syndrome: a preliminary study, JAMA,
doi:10.1001/jama.290.2%204.3222Medina Segovia, Mata, Suero, Jané, Vicente Saenz et al., Internal Medicine Department: María Jesús Sánchez Carrillo
Morgenstern, Michaelis, Baer, Doerr, Cinatl, Ribavirin and interferon-beta synergistically inhibit SARS-associated coronavirus replication in animal and human cell lines, Biochem Biophys Res Commun,
doi:10.1016/j.bbrc.2004.11.128Ramos Meca, Portales, Ángeles, Mayor, Pérez Amarilla et al., Emergency Department: Preprints
Ruiz, Coca Benito, Cano Izquierdo, Lourdes Rojas, Bueno et al., General and Digestive Surgery Department: Oscar Marqueta García
Thevarajan, Nguyen, Koutsakos, Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19, Nat Med,
doi:10.1038/s41591-020-0819-2Turner, Felton, Kosak, Kelsey, Meschievitz, Prevention of experimental coronavirus colds with intranasal alpha-2b interferon, J Infect Dis,
doi:10.1093/infdis/154.3.443Vincent, Bergeron, Benjannet, Erickson, Rollin et al., Chloroquine is a potent inhibitor of SARS coronavirus infection and spread, Virol J
Wang, Xu, Gao, Lu, Han et al., Detection of SARS-CoV-2 in different types of clinical specimens, JAMA
Yao, Ye, Zhang, Cui, Huang et al., Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Clin Infect Dis,
doi:10.1093/cid/ciaa237Zhang, Song, Tong, Fei, Guo et al., First case of COVID-19 in a patient with multiple myeloma successfully treated with tocilizumab, Blood Adv,
doi:10.1182/bloodadvances.2020001907
