Early Hydroxychloroquine Is Associated with an Increase of Survival in COVID-19 Patients: An Observational Study
Francisco Javier Membrillo, Germán Ramírez-Olivencia, Miriam Estébanez, Begoña De Dios, María Dolores Herrero, Tatiana Mata, Alberto M Borobia, Carlos Gutiérrez, María Simón, Ana Ochoa, Yolanda Martínez, Alejandro Aguirre, Francisco De Asís Alcántara, Pablo Fernández-González, Elena López, Paula Valle, Sergio Campos, María Navarro, Lucía Elena Ballester
doi:10.20944/preprints202005.0057.v2
Hydroxychloroquine has shown in vitro activity against SARS-CoV-2. Here we present an observational study. We analysed data from 164 patients admitted to our hospital diagnosed with COVID-19. Hydroxychloroquine treatment was associated with an increase in the mean cumulative survival.
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doi:10.1182/bloodadvances.2020001907DOI record:
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"abstract": "<jats:p>Background: There is no treatment proven effective against COVID-19. Several drugs with in vitro potential against SARS-CoV-2 virus have been proposed. Hydroxychloroquine has in vitro anti-viral and immunomodulatory activity, but there is no current clinical evidence of its effectiveness changing the outcome of the disease. Methods: We enrolled all 18-85 years old inpatients from Central Defense Hospital &ldquo;G&oacute;mez Ulla&rdquo;, Madrid, Spain, who were hospitalised for COVID-19 and had a definitive outcome (dead or discharged). We used a statistical survival analysis to detect treatment differences associated with in-hospital death. Results: We analysed first 220 medical records. 166 patients met the inclusion criteria. 48,8 % of patients not treated with HCQ died, 22% of those treated with hydroxychloroquine (p=0,002). According to clinical picture at admission, hydroxychloroquine increased the mean cumulative survival in all groups from 1,4 to 1,8 times. This difference was statistically significant in the mild group. Conclusions: in a cohort of 166 patients from 18 to 85 years hospitalised with COVID-19, hydroxychloroquine treatment with 800mg added loading dose increased survival when patients were admitted in early stages of the disease. There was a non-statistically significant trend towards survival in all groups, which will have to be clarified in subsequent studies.</jats:p>",
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