Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All HCQ studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19hcq.org COVID-19 treatment researchHCQHCQ (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Hydroxychloroquine Pre-Exposure Prophylaxis for COVID-19 in Healthcare Workers from India: A Meta-Analysis

Stricker et al., Journal of Infection and Public Health, doi:10.1016/j.jiph.2021.08.001
Aug 2021  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Mortality 75% Improvement Relative Risk Mortality (b) 44% HCQ for COVID-19  Stricker et al.  META ANALYSIS c19hcq.org FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now with p < 0.00000000001 from 411 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments. c19hcq.org
Meta analysis of 11 HCQ PrEP studies in India covering 7,616 healthcare workers, showing significantly lower cases with treatment.
8 meta analyses show significant improvements with hydroxychloroquine for mortality1-4, hospitalization1, recovery5, combined death/hospitalization/cases6, and cases7,8.
Currently there are 106 HCQ for COVID-19 pre-exposure prophylaxis studies, showing 30% lower mortality [14‑43%] and 28% fewer cases [20‑35%].
risk of death, 75.0% lower, RR 0.25, p < 0.001, treatment 1,273, control 4,127, >=6 doses.
risk of death, 44.0% lower, RR 0.56, p = 0.004, treatment 3,489, control 4,127, any number of doses.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Stricker et al., 5 Aug 2021, peer-reviewed, 2 authors.
This PaperHCQAll
Hydroxychloroquine Pre-Exposure Prophylaxis for COVID-19 in Healthcare Workers from India: A Meta-Analysis
MD Raphael B Stricker, Melissa C Fesler
Journal of Infection and Public Health, doi:10.1016/j.jiph.2021.08.001
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Conflicts of Interest and Funding The authors have no conflicts of interest to declare. There was no funding for the study.
References
Badyal, Chandy, Chugh, Hydroxychloroquine for SARS CoV2 prophylaxis in healthcare workers -A multicentric cohort study assessing effectiveness and safety, J Assoc Physicians India
Behera, Patro, Singh, Chandanshive, Pradhan, Role of ivermectin in the prevention of SARS-CoV-2 infection among healthcare workers in India: A matched case-control study, PLoS ONE, doi:10.1371/journal.pone.0247163
Bhattacharya, Chowdhury, Mukherjee, Pre exposure hydroxychloroquine use is associated with reduced COVID19 risk in healthcare workers, MedRxiv, doi:10.1101/2020.06.09.2011680640
Chatterjee, Anand, Singh, Healthcare workers and SARS-CoV-2 infection in India: a case-control investigation in the time of COVID-19, Indian J Med Res, doi:10.4103/ijmr.IJMR_2234_2039
Datta, Ghosal, Sinha, No role of HCQ in COVID-19 prophylaxis: A survey amongst Indian doctors, J Vaccines Vaccin
Dev, Meena, Gupta, Gupta, Sankar, Risk factors and frequency of COVID-19 among healthcare workers at a tertiary care centre in India: a case-control study, Trans Royal Soc Trop Med Hyg, doi:10.1093/trstmh/trab047
Goenka, Afzalpurkar, Goenka, Seroprevalence of COVID-19 amongst health care workers in a tertiary care hospital of a metropolitan city from India, J Assoc Physicians India
Haynes, Corey, Fernandes, Prospects for a safe COVID-19 vaccine, Sci Transl Med, doi:https://doi.org.10.1126/scitranslmed.abe0948
J O U R N A L P R E, -p r o o f, doi:10.1371/journal.pone.0247163
Kadnur, Aggarwal, Soneja, Hydroxychloroquine pre-exposure prophylaxis for COVID-19 among healthcare workers: Initial experience from India, Lancet Preprints, doi:10.2139/ssrn.3622350
Khurana, Kaushal, Gupta, Verma, Sharma et al., Prevalence and clinical correlates of COVID-19 outbreak among health care workers in a tertiary level hospital in Delhi, Am J Infect Dis, doi:10.3844/ajidsp.2021.107.119
Lofgren, Nicol, Bangdiwala, Safety of hydroxychloroquine among outpatient clinical trial participants for COVID-19, Open Forum Infect Dis
Mathai, Behera, Hande, Hydroxychloroquine as pre-exposure prophylaxis against COVID-19 in health-care workers: A single-center experience, J Mar Med Soc, doi:10.4103/jmms.jmms_115_20
Mutambudzi, Niedwiedz, Macdonald, Occupation and risk of severe COVID-19: prospective cohort study of 120 075 UK Biobank participants, Occup Environ Med, doi:https://doi.org.10.1136/oemed-2020-106731
Sogut, Can, Guven, Safety and efficacy of hydroxychloroquine in 152 outpatients with confirmed COVID-19: A pilot observational study, Am J Emerg Med
Stricker, Fesler, Flattening the risk: Pre-exposure prophylaxis for COVID-19, Infect Drug Resist
Yadav, Pate, Shankarkumar, Sero-survey for health-care workers provides corroborative evidence for the effectiveness of Hydroxychloroquine prophylaxis against J o u r n a l P r e -p r o o f COVID-19 infection, J Epidemiol Global Health, doi:https://doi.org.10.1136/oemed-2020-106731
{ 'indexed': {'date-parts': [[2024, 1, 9]], 'date-time': '2024-01-09T13:03:40Z', 'timestamp': 1704805420004}, 'reference-count': 18, 'publisher': 'Elsevier BV', 'issue': '9', 'license': [ { 'start': { 'date-parts': [[2021, 9, 1]], 'date-time': '2021-09-01T00:00:00Z', 'timestamp': 1630454400000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://www.elsevier.com/tdm/userlicense/1.0/'}, { 'start': { 'date-parts': [[2021, 8, 2]], 'date-time': '2021-08-02T00:00:00Z', 'timestamp': 1627862400000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'http://creativecommons.org/licenses/by-nc-nd/4.0/'}], 'content-domain': { 'domain': [ 'clinicalkey.fr', 'clinicalkey.jp', 'clinicalkey.es', 'clinicalkey.com.au', 'clinicalkey.com', 'elsevier.com', 'sciencedirect.com'], 'crossmark-restriction': True}, 'published-print': {'date-parts': [[2021, 9]]}, 'DOI': '10.1016/j.jiph.2021.08.001', 'type': 'journal-article', 'created': {'date-parts': [[2021, 8, 5]], 'date-time': '2021-08-05T16:10:52Z', 'timestamp': 1628179852000}, 'page': '1161-1163', 'update-policy': 'http://dx.doi.org/10.1016/elsevier_cm_policy', 'source': 'Crossref', 'is-referenced-by-count': 7, 'title': 'Hydroxychloroquine Pre-Exposure Prophylaxis for COVID-19 in Healthcare Workers from India: A ' 'Meta-Analysis', 'prefix': '10.1016', 'volume': '14', 'author': [ { 'ORCID': 'http://orcid.org/0000-0003-2149-8517', 'authenticated-orcid': False, 'given': 'Raphael B.', 'family': 'Stricker', 'sequence': 'first', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-5531-6032', 'authenticated-orcid': False, 'given': 'Melissa C.', 'family': 'Fesler', 'sequence': 'additional', 'affiliation': []}], 'member': '78', 'reference': [ { 'issue': 'October', 'key': '10.1016/j.jiph.2021.08.001_bib0005', 'doi-asserted-by': 'crossref', 'first-page': '3689', 'DOI': '10.2147/IDR.S264831', 'article-title': 'Flattening the risk: pre-exposure prophylaxis for COVID-19', 'volume': '13', 'author': 'Stricker', 'year': '2020', 'journal-title': 'Infect Drug Resist'}, { 'issue': 'November (568)', 'key': '10.1016/j.jiph.2021.08.001_bib0010', 'article-title': 'Prospects for a safe COVID-19 vaccine', 'volume': '12', 'author': 'Haynes', 'year': '2020', 'journal-title': 'Sci Transl Med'}, { 'issue': 'November', 'key': '10.1016/j.jiph.2021.08.001_bib0015', 'article-title': 'Occupation and risk of severe COVID-19: prospective cohort study of 120 ' '075 UK biobank participants', 'author': 'Mutambudzi', 'year': '2020', 'journal-title': 'Occup Environ Med'}, { 'key': '10.1016/j.jiph.2021.08.001_bib0020', 'series-title': 'Advisory on the use of Hydroxychloroquine as prophylaxis for SARS CoV2 ' 'infection', 'author': 'Indian Council of Medical Research National Taskforce for COVID-19', 'year': '2020'}, { 'issue': '5', 'key': '10.1016/j.jiph.2021.08.001_bib0025', 'doi-asserted-by': 'crossref', 'first-page': '459', 'DOI': '10.4103/ijmr.IJMR_2234_20', 'article-title': 'Healthcare workers and SARS-CoV-2 infection in India: a case-control ' 'investigation in the time of COVID-19', 'volume': '151', 'author': 'Chatterjee', 'year': '2020', 'journal-title': 'Indian J Med Res'}, { 'key': '10.1016/j.jiph.2021.08.001_bib0030', 'doi-asserted-by': 'crossref', 'first-page': '89', 'DOI': '10.18203/2320-6012.ijrms20205444', 'article-title': 'Pre exposure hydroxychloroquine use is associated with reduced COVID19 ' 'risk in healthcare workers', 'volume': '9', 'author': 'Bhattacharya', 'year': '2020', 'journal-title': 'Internat J Res Med Sci'}, { 'key': '10.1016/j.jiph.2021.08.001_bib0035', 'doi-asserted-by': 'crossref', 'first-page': '107', 'DOI': '10.3844/ajidsp.2021.107.119', 'article-title': 'Prevalence and clinical correlates of COVID-19 outbreak among health ' 'care workers in a tertiary level hospital in Delhi', 'volume': '17', 'author': 'Khurana', 'year': '2021', 'journal-title': 'Am J Infect Dis'}, { 'key': '10.1016/j.jiph.2021.08.001_bib0040', 'first-page': '14', 'article-title': 'Seroprevalence of COVID-19 amongst health care workers in a tertiary ' 'care hospital of a metropolitan city from India', 'volume': '68', 'author': 'Goenka', 'year': '2020', 'journal-title': 'J Assoc Physicians India'}, { 'key': '10.1016/j.jiph.2021.08.001_bib0045', 'doi-asserted-by': 'crossref', 'DOI': '10.2991/jegh.k.210518.001', 'article-title': 'Sero-survey for health-care workers provides corroborative evidence for ' 'the effectiveness of hydroxychloroquine prophylaxis against COVID-19 ' 'infection', 'author': 'Yadav', 'year': '2021', 'journal-title': 'J Epidemiol Global Health'}, { 'key': '10.1016/j.jiph.2021.08.001_bib0050', 'article-title': 'Hydroxychloroquine pre-exposure prophylaxis for COVID-19 among ' 'healthcare workers: initial experience from India', 'author': 'Kadnur', 'year': '2020', 'journal-title': 'Lancet Preprints'}, { 'key': '10.1016/j.jiph.2021.08.001_bib0055', 'doi-asserted-by': 'crossref', 'DOI': '10.1093/trstmh/trab047', 'article-title': 'Risk factors and frequency of COVID-19 among healthcare workers at a ' 'tertiary care centre in India: a case–control study', 'author': 'Dev', 'year': '2021', 'journal-title': 'Trans Royal Soc Trop Med Hyg'}, { 'key': '10.1016/j.jiph.2021.08.001_bib0060', 'first-page': 'S98', 'article-title': 'Hydroxychloroquine as pre-exposure prophylaxis against COVID-19 in ' 'health-care workers: a single-center experience', 'volume': '22', 'author': 'Mathai', 'year': '2020', 'journal-title': 'J Mar Med Soc'}, { 'key': '10.1016/j.jiph.2021.08.001_bib0065', 'first-page': '002', 'article-title': 'No role of HCQ in COVID-19 prophylaxis: a survey amongst Indian doctors', 'volume': 'S6', 'author': 'Datta', 'year': '2020', 'journal-title': 'J Vaccines Vaccin'}, { 'issue': '2', 'key': '10.1016/j.jiph.2021.08.001_bib0070', 'doi-asserted-by': 'crossref', 'DOI': '10.1371/journal.pone.0247163', 'article-title': 'Role of ivermectin in the prevention of SARS-CoV-2 infection among ' 'healthcare workers in India: a matched case-control study', 'volume': '16', 'author': 'Behera', 'year': '2021', 'journal-title': 'PLoS One'}, { 'issue': '6', 'key': '10.1016/j.jiph.2021.08.001_bib0075', 'first-page': '17', 'article-title': 'Hydroxychloroquine for SARS CoV2 prophylaxis in healthcare workers – a ' 'multicentric cohort study assessing effectiveness and safety', 'volume': '69', 'author': 'Badyal', 'year': '2021', 'journal-title': 'J Assoc Physicians India'}, { 'key': '10.1016/j.jiph.2021.08.001_bib0080', 'doi-asserted-by': 'crossref', 'DOI': '10.1093/ofid/ofaa500', 'article-title': 'Safety of hydroxychloroquine among outpatient clinical trial ' 'participants for COVID-19', 'volume': '7', 'author': 'Lofgren', 'year': '2020', 'journal-title': 'Open Forum Infect Dis'}, { 'issue': 'December', 'key': '10.1016/j.jiph.2021.08.001_bib0085', 'first-page': '41', 'article-title': 'Safety and efficacy of hydroxychloroquine in 152 outpatients with ' 'confirmed COVID-19: a pilot observational study', 'volume': '40', 'author': 'Sogut', 'year': '2020', 'journal-title': 'Am J Emerg Med'}, { 'key': '10.1016/j.jiph.2021.08.001_bib0090', 'article-title': 'Response to: A living WHO guideline on drugs to prevent COVID-19', 'volume': '372', 'author': 'Stricker', 'year': '2021', 'journal-title': 'BMJ'}], 'container-title': 'Journal of Infection and Public Health', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://api.elsevier.com/content/article/PII:S1876034121002197?httpAccept=text/xml', 'content-type': 'text/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://api.elsevier.com/content/article/PII:S1876034121002197?httpAccept=text/plain', 'content-type': 'text/plain', 'content-version': 'vor', 'intended-application': 'text-mining'}], 'deposited': { 'date-parts': [[2022, 5, 15]], 'date-time': '2022-05-15T17:08:42Z', 'timestamp': 1652634522000}, 'score': 1, 'resource': {'primary': {'URL': 'https://linkinghub.elsevier.com/retrieve/pii/S1876034121002197'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2021, 9]]}, 'references-count': 18, 'journal-issue': {'issue': '9', 'published-print': {'date-parts': [[2021, 9]]}}, 'alternative-id': ['S1876034121002197'], 'URL': 'http://dx.doi.org/10.1016/j.jiph.2021.08.001', 'relation': {}, 'ISSN': ['1876-0341'], 'subject': [ 'Infectious Diseases', 'Public Health, Environmental and Occupational Health', 'General Medicine'], 'container-title-short': 'Journal of Infection and Public Health', 'published': {'date-parts': [[2021, 9]]}, 'assertion': [ {'value': 'Elsevier', 'name': 'publisher', 'label': 'This article is maintained by'}, { 'value': 'Hydroxychloroquine Pre-Exposure Prophylaxis for COVID-19 in Healthcare Workers ' 'from India: A Meta-Analysis', 'name': 'articletitle', 'label': 'Article Title'}, { 'value': 'Journal of Infection and Public Health', 'name': 'journaltitle', 'label': 'Journal Title'}, { 'value': 'https://doi.org/10.1016/j.jiph.2021.08.001', 'name': 'articlelink', 'label': 'CrossRef DOI link to publisher maintained version'}, {'value': 'article', 'name': 'content_type', 'label': 'Content Type'}, { 'value': '© 2021 The Author(s). Published by Elsevier Ltd on behalf of King Saud Bin ' 'Abdulaziz University for Health Sciences.', 'name': 'copyright', 'label': 'Copyright'}]}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit