Role of ivermectin in the prevention of SARS-CoV-2 infection among healthcare workers in India: A matched case-control study
Behera et al.,
Role of ivermectin in the prevention of SARS-CoV-2 infection among healthcare workers in India: A matched..,
PLoS ONE, doi:10.1371/journal.pone.0247163 (date from earlier preprint)
Retrospective matched case-control prophylaxis study for HCQ, ivermectin, and vitamin C with 372 healthcare workers, showing lower COVID-19 incidence for all treatments, with statistical significance reached for ivermectin.
HCQ OR 0.56,
p = 0.29
Ivermectin OR 0.27,
p < 0.001
Vitamin C OR 0.82,
p = 0.58
Although the 28% fewer cases is not statistically significant, it is consistent with the significant 30% fewer cases
[22‑38%] from meta analysis of the
73 cases results to date.
risk of case, 27.9% lower, RR 0.72, p = 0.29, treatment 7 of 19 (36.8%), control 179 of 353 (50.7%), NNT 7.2, adjusted per study, odds ratio converted to relative risk, model 2 conditional logistic regression.
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risk of case, 26.3% lower, RR 0.74, p = 0.25, treatment 7 of 19 (36.8%), control 179 of 353 (50.7%), NNT 7.2, odds ratio converted to relative risk, matched pair analysis.
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Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
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Behera et al., 3 Nov 2020, retrospective, India, peer-reviewed, 13 authors.
Abstract: PLOS ONE
RESEARCH ARTICLE
Role of ivermectin in the prevention of SARSCoV-2 infection among healthcare workers in
India: A matched case-control study
Priyamadhaba Behera1, Binod Kumar Patro1, Arvind Kumar Singh1, Pradnya
Dilip Chandanshive1, Ravikumar S. R. ID1, Somen Kumar Pradhan1, Siva Santosh
Kumar Pentapati1, Gitanjali Batmanabane ID2*, Prasanta Raghab Mohapatra3, Biswa
Mohan Padhy4, Shakti Kumar Bal3, Sudipta Ranjan Singh5, Rashmi Ranjan Mohanty6
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1 Department of Community Medicine and Family Medicine, All India Institute of Medical Sciences
Bhubaneswar, Bhubaneswar, India, 2 All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar,
India, 3 Department of Pulmonary Medicine and Critical Care, All India Institute of Medical Sciences
Bhubaneswar, Bhubaneswar, India, 4 Department of Pharmacology, All India Institute of Medical Sciences
Bhubaneswar, Bhubaneswar, India, 5 Department of Forensic Medicine and Toxicology, All India Institute of
Medical Sciences Bhubaneswar, Bhubaneswar, India, 6 Department of General Medicine, All India Institute
of Medical Sciences Bhubaneswar, Bhubaneswar, India
* director@aiimsbhubaneswar.edu.in
OPEN ACCESS
Citation: Behera P, Patro BK, Singh AK,
Chandanshive PD, S. R. R, Pradhan SK, et al.
(2021) Role of ivermectin in the prevention of
SARS-CoV-2 infection among healthcare workers
in India: A matched case-control study. PLoS ONE
16(2): e0247163. https://doi.org/10.1371/journal.
pone.0247163
Editor: Muhammad Adrish, BronxCare Health
System, UNITED STATES
Abstract
Background
Ivermectin is one among several potential drugs explored for its therapeutic and preventive
role in SARS-CoV-2 infection. The study was aimed to explore the association between ivermectin prophylaxis and the development of SARS-CoV-2 infection among healthcare
workers.
Received: December 14, 2020
Accepted: February 2, 2021
Published: February 16, 2021
Peer Review History: PLOS recognizes the
benefits of transparency in the peer review
process; therefore, we enable the publication of
all of the content of peer review and author
responses alongside final, published articles. The
editorial history of this article is available here:
https://doi.org/10.1371/journal.pone.0247163
Copyright: © 2021 Behera et al. This is an open
access article distributed under the terms of the
Creative Commons Attribution License, which
permits unrestricted use, distribution, and
reproduction in any medium, provided the original
author and source are credited.
Data Availability Statement: The anonymized data
set has been uploaded to the public repository
(figshare). The dataset can be accessed at the
Methods
A hospital-based matched case-control study was conducted among healthcare workers of
AIIMS Bhubaneswar, India, from September to October 2020. Profession, gender, age and
date of diagnosis were matched for 186 case-control pairs. Cases and controls were healthcare workers who tested positive and negative, respectively, for COVID-19 by RT-PCR.
Exposure was defined as the intake of ivermectin and/or hydroxychloroquine and/or vitamin-C and/or other prophylaxis for COVID-19. Data collection and entry was done in Epicollect5, and analysis was performed using STATA version 13. Conditional logistic regression
models were used to describe the associated factors for SARS-CoV-2 infection.
Results
Ivermectin prophylaxis was taken by 76 controls and 41 cases. Two-dose ivermectin prophylaxis..
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