Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All HCQ studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19hcq.org COVID-19 treatment researchHCQHCQ (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Hydroxychloroquine as pre-exposure prophylaxis against COVID-19 in health-care workers: A single-center experience

Mathai et al., J. Marine Medical Society, doi:10.4103/jmms.jmms_115_20
Nov 2020  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Case 90% Improvement Relative Risk Case (b) 88% HCQ for COVID-19  Mathai et al.  Prophylaxis Is pre-exposure prophylaxis with HCQ beneficial for COVID-19? Retrospective 604 patients in India Fewer cases with HCQ (p<0.000001) c19hcq.org Mathai et al., J. Marine Medical Society, Nov 2020 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now with p < 0.00000000001 from 411 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments. c19hcq.org
90% reduction in cases with HCQ pre-exposure prophylaxis. Retrospective 604 healthcare workers.
risk of case, 89.5% lower, RR 0.10, p < 0.001, treatment 10 of 491 (2.0%), control 22 of 113 (19.5%), NNT 5.7.
risk of case, 88.5% lower, RR 0.12, p < 0.001, treatment 5 of 491 (1.0%), control 10 of 113 (8.8%), NNT 13, symptomatic.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Mathai et al., 6 Nov 2020, retrospective, India, peer-reviewed, 3 authors.
This PaperHCQAll
{ 'indexed': { 'date-parts': [[2022, 11, 27]], 'date-time': '2022-11-27T05:32:21Z', 'timestamp': 1669527141413}, 'reference-count': 31, 'publisher': 'Medknow', 'issue': '0', 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'published-print': {'date-parts': [[2020]]}, 'DOI': '10.4103/jmms.jmms_115_20', 'type': 'journal-article', 'created': {'date-parts': [[2020, 11, 6]], 'date-time': '2020-11-06T03:59:16Z', 'timestamp': 1604635156000}, 'page': '0', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Hydroxychloroquine as pre-exposure prophylaxis against COVID-19 in health-care workers: A ' 'single-center experience', 'prefix': '10.4103', 'volume': '0', 'author': [ {'given': 'Vivek', 'family': 'Hande', 'sequence': 'first', 'affiliation': []}, {'given': 'SheilaSamanta', 'family': 'Mathai', 'sequence': 'additional', 'affiliation': []}, {'given': 'Vineet', 'family': 'Behera', 'sequence': 'additional', 'affiliation': []}], 'member': '2581', 'reference': [ { 'key': 'key-10.4103/0975-3605.300159-1', 'doi-asserted-by': 'crossref', 'first-page': '147', 'DOI': '10.4103/ijmr.IJMR_519_20', 'article-title': 'The 2019 novel coronavirus disease (COVID-19) pandemic: A review of the ' 'current evidence', 'author': 'Chatterjee', 'year': '2020', 'journal-title': 'Indian J Med Res', 'ISSN': 'http://id.crossref.org/issn/0971-5916', 'issn-type': 'print'}, { 'key': 'key-10.4103/0975-3605.300159-2', 'doi-asserted-by': 'crossref', 'first-page': '1199', 'DOI': '10.1056/NEJMoa2001316', 'article-title': 'Early transmission dynamics in Wuhan, China, of novel ' 'coronavirus-infected pneumonia', 'author': 'Li', 'year': '2020', 'journal-title': 'N Engl J Med'}, { 'key': 'key-10.4103/0975-3605.300159-3', 'doi-asserted-by': 'crossref', 'unstructured': "Sikkema RS, Pas SD, Nieuwenhuijse DF, O'Toole Á, Verweij J, van der " 'Linden A, et al. COVID-19 in health-care workers in three hospitals in ' 'the south of the Netherlands: A cross-sectional study. Lancet Infect Dis ' '2020;S1473-3099(20)30527-2.', 'DOI': '10.1016/S1473-3099(20)30527-2'}, { 'key': 'key-10.4103/0975-3605.300159-4', 'unstructured': 'World Health Organization. Coronavirus Disease (COVID-19) Situation ' 'Report-167. World Health Organization; 2020.'}, { 'key': 'key-10.4103/0975-3605.300159-5', 'first-page': 'S2468', 'article-title': 'Risk of symptomatic Covid-19 among frontline healthcare workers.a ' 'prospective cohort study', 'author': 'Nguyen', 'year': '2020', 'journal-title': 'Lancet Public Health'}, { 'key': 'key-10.4103/0975-3605.300159-6', 'first-page': '922', 'article-title': 'COVID-19: Protecting health-care workers', 'author': 'The', 'year': '2020', 'journal-title': 'Lancet'}, { 'key': 'key-10.4103/0975-3605.300159-7', 'first-page': '459', 'article-title': 'Healthcare workers &amp; SARS-CoV-2 infection in India: A case-control ' 'investigation in the time of COVID-19', 'author': 'Chatterjee', 'year': '2020', 'journal-title': 'Indian J Med Res', 'ISSN': 'http://id.crossref.org/issn/0971-5916', 'issn-type': 'print'}, { 'key': 'key-10.4103/0975-3605.300159-8', 'doi-asserted-by': 'crossref', 'first-page': '010345', 'DOI': '10.7189/jogh.10.010345', 'article-title': 'Saving the frontline health workforce amidst the COVID-19 crisis: ' 'Challenges and recommendations', 'author': 'Nagesh', 'year': '2020', 'journal-title': 'J Glob Health'}, { 'key': 'key-10.4103/0975-3605.300159-9', 'first-page': '1824', 'article-title': 'Pharmacologic treatments for coronavirus disease 2019 (COVID-19): A ' 'review', 'author': 'Sanders', 'year': '2020', 'journal-title': 'JAMA'}, { 'key': 'key-10.4103/0975-3605.300159-10', 'doi-asserted-by': 'crossref', 'first-page': '16', 'DOI': '10.1038/s41421-020-0156-0', 'article-title': 'Hydroxychloroquine, a less toxic derivative of chloroquine, is ' 'effective in inhibiting SARS-CoV-2 infection in vitro', 'author': 'Liu', 'year': '2020', 'journal-title': 'Cell Discovery'}, { 'key': 'key-10.4103/0975-3605.300159-11', 'doi-asserted-by': 'crossref', 'first-page': '69', 'DOI': '10.1186/1743-422X-2-69', 'article-title': 'Chloroquine is a potent inhibitor of SARS coronavirus infection and ' 'spread', 'author': 'Vincent', 'year': '2005', 'journal-title': 'Virol J'}, { 'key': 'key-10.4103/0975-3605.300159-12', 'doi-asserted-by': 'crossref', 'first-page': '336', 'DOI': '10.1016/j.mbs.2007.02.003', 'article-title': 'Prophylaxis or treatment.Optimal use of an antiviral stockpile during ' 'an influenza pandemic?', 'author': 'McCaw', 'year': '2007', 'journal-title': 'Math Biosci'}, { 'key': 'key-10.4103/0975-3605.300159-13', 'doi-asserted-by': 'crossref', 'first-page': '105988', 'DOI': '10.1016/j.ijantimicag.2020.105988', 'article-title': 'Can post-exposure prophylaxis for COVID-19 be considered as an outbreak ' 'response strategy in long-term care hospitals?', 'author': 'Lee', 'year': '2020', 'journal-title': 'Int J Antimicrob Agents'}, { 'key': 'key-10.4103/0975-3605.300159-14', 'unstructured': 'Advisory on the use of Hydroxychloroquin as Prophylaxis for SARS CoV2 ' 'Infection. By National Task Force for COVID-19. Ministry of Health & ' 'Family Welfare, Government of India; 22 March, 2020. Available from: ' 'https://www.mohfw.gov.in.'}, { 'key': 'key-10.4103/0975-3605.300159-15', 'unstructured': 'Advisory Newer Additional Strategies for COVID-19 Testing Existing ' 'Strategies for COVID-19 Testing. Indian Council of Medical Research. ' 'Available from: ' 'https://www.icmr.gov.in/pdf/covid/strategy/Advisory_for_rapid_antigen_test_14062020.pdf. ' '[Last accessed on 2020 Aug 01].'}, { 'key': 'key-10.4103/0975-3605.300159-16', 'doi-asserted-by': 'crossref', 'first-page': '591', 'DOI': '10.1007/s40261-020-00927-1', 'article-title': 'An updated systematic review of the therapeutic role of ' 'hydroxychloroquine in coronavirus disease-19 (COVID-19)', 'author': 'Das', 'year': '2020', 'journal-title': 'Clin Drug Investig'}, { 'key': 'key-10.4103/0975-3605.300159-17', 'doi-asserted-by': 'crossref', 'first-page': '100141', 'DOI': '10.1016/j.onehlt.2020.100141', 'article-title': 'Systematic review of registered trials of Hydroxychloroquine ' 'prophylaxis for COVID-19 health-care workers at the first third of 2020', 'author': 'Bienvenu', 'year': '2020', 'journal-title': 'One Health'}, { 'key': 'key-10.4103/0975-3605.300159-18', 'unstructured': 'Bhattacharya R, Chowdhury S, Mukherjee R, Nandi A, Kulshrestha M, Ghosh ' 'R, et al. Pre-exposure Hydroxychloroquine use is associated with reduced ' 'COVID19 risk in healthcare workers. medRxiv 2020;06.09.20116806.'}, { 'key': 'key-10.4103/0975-3605.300159-19', 'doi-asserted-by': 'crossref', 'first-page': '517', 'DOI': '10.1056/NEJMoa2016638', 'article-title': 'A randomized trial of hydroxychloroquine as postexposure prophylaxis ' 'for Covid-19', 'author': 'Boulware', 'year': '2020', 'journal-title': 'N Engl J Med'}, { 'key': 'key-10.4103/0975-3605.300159-20', 'doi-asserted-by': 'crossref', 'first-page': '1667', 'DOI': '10.1093/jac/dkaa114', 'article-title': 'COVID-19: A recommendation to examine the effect of hydroxychloroquine ' 'in preventing infection and progression', 'author': 'Zhou', 'year': '2020', 'journal-title': 'J Antimicrob Chemother'}, { 'key': 'key-10.4103/0975-3605.300159-21', 'doi-asserted-by': 'crossref', 'first-page': '722', 'DOI': '10.1016/S1473-3099(03)00806-5', 'article-title': "Effects of chloroquine on viral infections: An old drug against today's " 'diseases?', 'author': 'Savarino', 'year': '2003', 'journal-title': 'Lancet Infect Dis'}, { 'key': 'key-10.4103/0975-3605.300159-22', 'doi-asserted-by': 'crossref', 'first-page': 'e00293', 'DOI': '10.1002/prp2.293', 'article-title': 'Targeting endosomal acidification by chloroquine analogs as a promising ' 'strategy for the treatment of emerging viral diseases', 'author': 'Al-Bari', 'year': '2017', 'journal-title': 'Pharmacol Res Perspect'}, { 'key': 'key-10.4103/0975-3605.300159-23', 'doi-asserted-by': 'crossref', 'first-page': '450', 'DOI': '10.1038/nature02145', 'article-title': 'Angiotensin-converting enzyme 2 is a functional receptor for the SARS ' 'coronavirus', 'author': 'Li', 'year': '2003', 'journal-title': 'Nature'}, { 'key': 'key-10.4103/0975-3605.300159-24', 'first-page': '567', 'article-title': 'Reconstitution of the receptor-binding motif of the SARS coronavirus', 'author': 'Freund', 'year': '2015', 'journal-title': 'Protein Eng Des Sel'}, { 'key': 'key-10.4103/0975-3605.300159-25', 'doi-asserted-by': 'crossref', 'unstructured': 'Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen ' 'S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is ' 'blocked by a clinically proven protease inhibitor. Cell ' '2020;181:271-80.e8.', 'DOI': '10.1016/j.cell.2020.02.052'}, { 'key': 'key-10.4103/0975-3605.300159-26', 'doi-asserted-by': 'crossref', 'unstructured': 'Magagnoli J, Narendran S, Pereira F, Cummings T, Hardin JW, Sutton SS, ' 'et al. Outcomes of hydroxychloroquine usage in United States veterans ' 'hospitalized with Covid-19. medRxiv 2020;04.16.20065920.', 'DOI': '10.1016/j.medj.2020.06.001'}, { 'key': 'key-10.4103/0975-3605.300159-27', 'doi-asserted-by': 'crossref', 'first-page': '105982', 'DOI': '10.1016/j.ijantimicag.2020.105982', 'article-title': 'Cytokine storm and immunomodulatory therapy in COVID-19: Role of ' 'chloroquine and anti-IL-6 monoclonal antibodies', 'author': 'Zhao', 'year': '2020', 'journal-title': 'Int J Antimicrob Agents'}, { 'key': 'key-10.4103/0975-3605.300159-28', 'doi-asserted-by': 'crossref', 'unstructured': 'Bhattacharyya D, Raizada N, Nagappa B, Tomar A, Maurya P, Chaudhary A, ' 'et al. Chemoprophylaxis of COVID-19 with hydroxychloroquine: A study of ' 'health care workers attitude, adherence to regimeand side effects. ' 'medRxiv 2020;06.11.20126359.', 'DOI': '10.1101/2020.06.11.20126359'}, { 'key': 'key-10.4103/0975-3605.300159-29', 'doi-asserted-by': 'crossref', 'first-page': 'e209666', 'DOI': '10.1001/jamanetworkopen.2020.9666', 'article-title': 'Coronavirus disease 2019 (COVID-2019) infection among health care ' 'workers and implications for prevention measures in a tertiary hospital ' 'in Wuhan, China', 'author': 'Lai', 'year': '2020', 'journal-title': 'JAMA Netw Open'}, { 'key': 'key-10.4103/0975-3605.300159-30', 'doi-asserted-by': 'crossref', 'unstructured': 'Zheng L, Wang X, Zhou C, Liu Q, Li S, Sun Q, et al. Analysis of the ' 'infection status of the health care workers in Wuhan during the COVID-19 ' 'outbreak: A cross-sectional study. Clin Infect Dis 2020;ciaa588.', 'DOI': '10.1093/cid/ciaa588'}, { 'key': 'key-10.4103/0975-3605.300159-31', 'doi-asserted-by': 'crossref', 'first-page': '1727', 'DOI': '10.1016/j.ajem.2020.05.113', 'article-title': 'COVID-19 in health care workers - A systematic review and meta-analysis', 'author': 'Sahu', 'year': '2020', 'journal-title': 'Am J Emerg Med'}], 'container-title': 'Journal of Marine Medical Society', 'original-title': [], 'language': 'en', 'deposited': { 'date-parts': [[2022, 11, 26]], 'date-time': '2022-11-26T23:23:30Z', 'timestamp': 1669505010000}, 'score': 1, 'resource': {'primary': {'URL': 'http://www.marinemedicalsociety.in/preprintarticle.asp?id=300159;type=0'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2020]]}, 'references-count': 31, 'journal-issue': {'issue': '0', 'published-print': {'date-parts': [[2020]]}}, 'alternative-id': ['300159'], 'URL': 'http://dx.doi.org/10.4103/jmms.jmms_115_20', 'relation': {}, 'ISSN': ['0975-3605'], 'subject': ['General Medicine'], 'container-title-short': 'J Mar Med Soc', 'published': {'date-parts': [[2020]]}}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit