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Hydroxychloroquine as pre-exposure prophylaxis against COVID-19 in health-care workers: A single-center experience

Mathai et al., J. Marine Medical Society, doi:10.4103/jmms.jmms_115_20
Nov 2020  
  Source   PDF   All Studies   Meta AnalysisMeta
Case 90% Improvement Relative Risk Case (b) 88% HCQ for COVID-19  Mathai et al.  Prophylaxis Is pre-exposure prophylaxis with HCQ beneficial for COVID-19? Retrospective 604 patients in India Fewer cases with HCQ (p<0.000001) Mathai et al., J. Marine Medical Society, Nov 2020 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
*, now with p < 0.00000000001 from 411 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments.
90% reduction in cases with HCQ pre-exposure prophylaxis. Retrospective 604 healthcare workers.
risk of case, 89.5% lower, RR 0.10, p < 0.001, treatment 10 of 491 (2.0%), control 22 of 113 (19.5%), NNT 5.7.
risk of case, 88.5% lower, RR 0.12, p < 0.001, treatment 5 of 491 (1.0%), control 10 of 113 (8.8%), NNT 13, symptomatic.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Mathai et al., 6 Nov 2020, retrospective, India, peer-reviewed, 3 authors.
This PaperHCQAll
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