Abstract: DOI: 10.1111/cts.13468
| Revised: 18 November 2022 | Accepted: 22 November 2022
ARTICLE
Hydroxychloroquine for treatment of non-hospitalized
adults with COVID-19: A meta-analysis of individual
participant data of randomized trials
Oriol Mitjà1,2,3 | Gilmar Reis4,5 | David R. Boulware6 | Adam M. Spivak7 |
Ammar Sarwar8 | Christine Johnston9 | Brandon Webb10 | Michael D. Hill11 |
Davey Smith12 | Peter Kremsner13,14 | Marla Curran15 | David Carter16 |
Jim Alexander15 | Marc Corbacho1
| Todd C. Lee6 | Katherine Huppler Hullsiek6
Emily G. McDonald17 | Rachel Hess7
| Michael Hughes8 | Jared M. Baeten9 |
Ilan Schwartz18 | Luanne Metz11 | Lawrence Richer18 | Kara W. Chew19 |
Eric Daar20 | David Wohl21 | Michael Dunne15
|
1
Fight AIDS and Infectious Diseases Foundation, Barcelona, Spain
2
Hospital Universitari Germans Trias i Pujol, Badalona, Spain
3
Lihir Medical Center–International SOS, Lihir Island, Papua New Guinea
4
Research Division, Cardresearch Cardiologia Assistencial e de Pesquisa, Pontifícia Universidade Católica de Minas Gerais, Bello Horizonte, Brazil
5
Cytel Inc., Vancouver, British Columbia, Canada
6
Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA
7
University of Utah, Salt Lake City, Utah, USA
8
Harvard Medical School, Boston, Massachusetts, USA
9
Department of Medicine and Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA
10
Intermountain Health Care, University of Utah, Salt Lake City, Utah, USA
11
University of Calgary, Calgary, Alberta, Canada
12
Division of Infectious Diseases & Global Public Health, UC San Diego School of Medicine, San Diego, California, USA
13
University Hospital of Tübingen, Tübingen, Germany
14
Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon
15
Bill & Melinda Gates Medical Research Institute, Cambridge, Massachusetts, USA
16
MMS Holdings, Canton, Michigan, USA
17
Division of General Internal Medicine, McGill University Health Center, Montreal, Quebec, Canada
18
University of Alberta, Edmonton, Canada
19
Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, California, USA
20
Lundquist Institute at Harbor-UCLA Medical Center, Torrance, California, USA
21
School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Correspondence
Oriol Mitjà, Fight AIDS and Infectious Diseases Foundation, Barcelona, Spain, Ctra. de Canyet s/n • Hosp. Univ. Germans Trias i Pujol, 08916
Badalona, Barcelona, Spain.
Email: omitja@lluita.org
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any
medium, provided the original work is properly cited and is not used for commercial purposes.
© 2023 The Authors. Clinical and Translational Science published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.
Clin Transl Sci. 2023;00:1–12.
www.cts-journal.com
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