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All Studies   Meta Analysis    Recent:   

The Effect of Hydroxychloroquine on In-Hospital Mortality in COVID-19

Aboulenain et al., HCA Healthcare Journal of Medicine, doi:10.36518/2689-0216.1169
Nov 2020  
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Mortality -15% Improvement Relative Risk HCQ for COVID-19  Aboulenain et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 175 patients in the USA (March - May 2020) No significant difference in mortality c19hcq.org Aboulenain et al., HCA Healthcare J. M.., Nov 2020 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now with p < 0.00000000001 from 411 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments. c19hcq.org
Retrospective 175 hospitalized COVID-19 patients in the USA, showing no significant difference in mortality with HCQ. Authors note that "patients treated with HCQ in our cohort were more likely to be sicker at baseline".
This study is excluded in the after exclusion results of meta analysis: substantial unadjusted confounding by indication possible.
risk of death, 15.0% higher, HR 1.15, p = 0.72, treatment 82, control 93, Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Aboulenain et al., 30 Nov 2020, retrospective, USA, peer-reviewed, 13 authors, study period March 2020 - May 2020.
This PaperHCQAll
The Effect of Hydroxychloroquine on In-Hospital Mortality in COVID-19
MD Samar Aboulenain, MD Nakeya Dewaswala, MD Fergie Ramos, MD Pedro Torres, MD Ahmed Abdallah, Mohamed Abdul Qader, MD Baher Al-Abbasi, MD Charles R Bornmann, MD Karolina N Dziadkowiec, MD Kai Chen, MD Jesus E Pino, MD, FACC, FACP Robert Chait, MD Kleper De Almeida
HCA Healthcare Journal of Medicine, doi:10.36518/2689-0216.1169
Background Hydroxychloroquine (HCQ) is an antimalarial medication that has been tested against various viral illnesses. The available evidence regarding the role of HCQ in the coronavirus disease 2019 (COVID-19) remains controversial. Methods This is a comparative retrospective cohort study that aims to evaluate the efficacy and safety of HCQ in hospitalized patients with COVID-19. The primary outcome was all-cause in-hospital mortality. Secondary outcomes included ICU admission rate, mechanical ventilation, prolonged length of stay (LOS), QTc prolongation and cardiac arrest. Results A cohort of 175 hospitalized patients with COVID-19 were included with a median (interquartile range [IQR]) age of 66 [48-79] years. Of whom, 82 (47%) patients received HCQ. The overall mortality rate was 34.1%; 95% CI [23.7-44.6] and 16.1%; 95% CI [8.5-23.7] in the HCQ group vs. the control group, respectively (p = 0.67). A Cox regression analysis was performed adjusting for age, gender, BMI, SpO2/FiO2 ratio and CXR findings, and demonstrated that the association between HCQ use and the all-cause in-hospital mortality was not statistically significant (HR = 1.15; 95% CI [0.54-2.48]; p-value = 0.72). Patients who received HCQ were more likely to be admitted to the intensive care unit, require mechanical ventilation and have a prolonged LOS compared to those who did not receive the medication. No statistically significant difference was found in the likelihood of QTc prolongation or cardiac arrest. Conclusions The use of HCQ in patients hospitalized with COVID-19 confers no benefit in patient morbidity or mortality.
Original Research The Effect of Hydroxychloroquine on In-Hospital Mortality in COVID-19 Conflicts of Interest The authors declare they have no conflicts of interest. The authors are employees of JFK Medical Center, a hospital affiliated with the journal's publisher. This research was supported (in whole or in part) by HCA Healthcare and/or an HCA Healthcare affiliated entity. The views expressed in this publication represent those of the author(s) and do not necessarily represent the official views of HCA Healthcare or any of its affiliated entities.
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Late treatment
is less effective
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