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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Viral clearance 24% Improvement Relative Risk Median time to PCR- 50% c19hcq.org Chen et al. HCQ for COVID-19 RCT LATE TREATMENT Favors HCQ Favors control
A Multicenter, randomized, open-label, controlled trial to evaluate the efficacy and tolerability of hydroxychloroquine and a retrospective study in adult patients with mild to moderate Coronavirus disease 2019 (COVID-19)
Chen et al., PLoS ONE, doi:10.1371/journal.pone.0242763
10 Jul 2020    Source   PDF   Share   Tweet
2 very small studies with hospitalized patients in Taiwan.
RCT with 21 treatment and 12 SOC patients. No mortality, or serious adverse effects. Median time to negative RNA 5 days versus 10 days SOC, p=0.4. Risk of PCR+ at day 14, RR 0.76, p = 0.71.
This paper also reports on a small retrospective study with 12 of 28 HCQ patients and 5 of 9 in the control group being PCR- at day 14, RR 1.29, p = 0.7.
Although the viral clearance result is not statistically significant, it is consistent with the significant 20% improved viral clearance [10‑29%] from meta analysis of the 41 viral clearance results to date.
risk of no viral clearance, 24.0% lower, RR 0.76, p = 0.71, treatment 4 of 21 (19.0%), control 3 of 12 (25.0%), NNT 17, day 14.
median time to PCR-, 50.0% lower, relative time 0.50, p = 0.40, treatment 21, control 12.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Chen et al., 10 Jul 2020, Randomized Controlled Trial, Taiwan, peer-reviewed, 19 authors.
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Late treatment
is less effective
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