Abstract: PLOS ONE RESEARCH ARTICLE A multicenter, randomized, open-label, controlled trial to evaluate the efficacy and tolerability of hydroxychloroquine and a retrospective study in adult patients with mild to moderate coronavirus disease 2019 (COVID-19) a1111111111 a1111111111 a1111111111 a1111111111 a1111111111 OPEN ACCESS Citation: Chen C-P, Lin Y-C, Chen T-C, Tseng T-Y, Wong H-L, Kuo C-Y, et al. (2020) A multicenter, randomized, open-label, controlled trial to evaluate the efficacy and tolerability of hydroxychloroquine and a retrospective study in adult patients with mild to moderate coronavirus disease 2019 (COVID19). PLoS ONE 15(12): e0242763. https://doi.org/ 10.1371/journal.pone.0242763 Editor: Stephen L. Atkin, Weill Cornell Medical College Qatar, QATAR Received: July 1, 2020 Accepted: November 9, 2020 Cheng-Pin Chen1,2☯, Yi-Chun Lin1,3☯, Tsung-Chia Chen4, Ting-Yu Tseng4, Hon-Lai Wong5, Cheng-Yu Kuo6, Wu-Pu Lin7, Sz-Rung Huang8, Wei-Yao Wang9, Jia-Hung Liao10, ChungShin Liao11, Yuan-Pin Hung12, Tse-Hung Lin13, Tz-Yan Chang13, Chin-Fu Hsiao14, YiWen Huang ID13,15, Wei-Sheng Chung4,16,17, Chien-Yu Cheng1,18, Shu-Hsing Cheng ID1,19*, on behalf of the Taiwan HCQ Study Group¶ 1 Department of Infectious Diseases, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan, 2 Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, 3 Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei, Taiwan, 4 Department of Internal Medicine, Taichung Hospital, Ministry of Health and Welfare, Taichung, Taiwan, 5 Department of Internal Medicine, Keelung Hospital, Ministry of Health and Welfare, Keelung City, Taiwan, 6 Department of Internal Medicine, Pingtung Hospital, Ministry of Health and Welfare, Pingtung, Taiwan, 7 Department of Internal Medicine, Taipei Hospital, Ministry of Health and Welfare, New Taipei City, Taiwan, 8 Department of Internal Medicine, Miaoli General Hospital, Ministry of Health and Welfare, Miaoli, Taiwan, 9 Department of Internal Medicine, Feng Yuan Hospital, Ministry of Health and Welfare, Taichung, Taiwan, 10 Department of Internal Medicine, Nantou Hospital, Ministry of Health and Welfare, Nantou, Taiwan, 11 Department of Internal Medicine, Chia Yi Hospital, Ministry of Health and Welfare, Chiayi, Taiwan, 12 Department of Internal Medicine, Tainan Hospital, Ministry of Health and Welfare, Tainan City, Taiwan, 13 Department of Internal Medicine, Chang Hua Hospital, Ministry of Health and Welfare, Changhua, Taiwan, 14 Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan, 15 Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, 16 Department of Health Service Administration, China Medical University, Taichung, Taiwan, 17 Department of Healthcare Administration, Central Taiwan University of Science and Technology, Taichung, Taiwan, 18 School of Public Health, National Yang-Ming University, Taipei, Taiwan, 19 School of Public Health, Taipei Medical University, Taipei, Taiwan ☯ These authors contributed equally to this work. ¶ Membership of the Taiwan HCQ Study Group is listed in the Acknowledgments. * shcheng@mail.tygh.gov.tw Published: December 2, 2020 Peer Review History: PLOS recognizes the benefits of transparency in the peer review process; therefore, we enable the publication of all of the content of peer review and author responses alongside final, published articles. The editorial history of this article is..