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Evaluation of patients treated by telemedicine in the beginning of the COVID-19 pandemic in São Paulo, Brazil: A non-randomized clinical trial preliminary study

Chechter et al., Heliyon, doi:10.1016/j.heliyon.2023.e15337 (date from preprint)
Nov 2021  
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Hospitalization 95% Improvement Relative Risk HCQ for COVID-19  Chechter et al.  EARLY TREATMENT Is early treatment with HCQ + AZ beneficial for COVID-19? Prospective study of 72 patients in Brazil Lower hospitalization with HCQ + AZ (p=0.0037) c19hcq.org Chechter et al., Heliyon, November 2021 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now with p < 0.00000000001 from 411 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments. c19hcq.org
Prospective study of 187 telemedicine patients in Brazil. 74 presenting with moderate symptoms were offered treatment with HCQ+AZ, 12 did not accept HCQ (taking AZ only), forming a control group. There was lower hospitalization and improved recovery with treatment.
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.
risk of hospitalization, 94.7% lower, RR 0.05, p = 0.004, treatment 0 of 60 (0.0%), control 3 of 12 (25.0%), NNT 4.0, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Chechter et al., 5 Nov 2021, prospective, Brazil, peer-reviewed, mean age 37.6, 14 authors, dosage 800mg day 1, 400mg days 2-5, this trial uses multiple treatments in the treatment arm (combined with AZ) - results of individual treatments may vary. Contact: mchechter@gmail.com, ruteapc@yahoo.com.
This PaperHCQAll
Evaluation of patients treated by telemedicine in the beginning of the COVID-19 pandemic in São Paulo, Brazil: A non-randomized clinical trial preliminary study
MD Michelle Chechter, Rute Gustavo Maximiliano Dutra Da Silva, Rute Alves Pereira E Costa, MD, PhD Thomas Gabriel Miklos, MD, PhD Nilzio Antonio Da Silva, MD Gabriel Lorber, Natacha Rivero Vascncellos Mota, Aline Pinheiro Dos Santos Cortada, Luciana De Nazare Lima Da Cruz, Paulo Macio Porto De Melo, Bruno Campello De Souza, PhD) 10 Francisco G Emmerich, Paolo Marinho De Andrade Zanotto, Morton Aaron Scheinberg
Heliyon, doi:10.1016/j.heliyon.2023.e15337
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
J o u r n a l P r e -p r o o f Conflicts of Interest Statement The authors declare no conflict of interest.
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