Abstract: Published online: December 30, 2020 Review Reviews in Cardiovascular Medicine Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19) Peter A. McCullough1, * , Paul E. Alexander2 , Robin Armstrong3 , Cristian Arvinte4 , Alan F. Bain5 , Richard P. Bartlett6 , Robert L. Berkowitz7 , Andrew C. Berry8 , Thomas J. Borody9 , Joseph H. Brewer10 , Adam M. Brufsky11 , Teryn Clarke12 , Roland Derwand13 , Alieta Eck14 , John Eck14 , Richard A. Eisner15 , George C. Fareed16 , Angelina Farella17 , Silvia N. S. Fonseca18 , Charles E. Geyer, Jr.19 , Russell S. Gonnering20 , Karladine E. Graves21 , Kenneth B. V. Gross22 , Sabine Hazan23 , Kristin S. Held24 , H. Thomas Hight25 , Stella Immanuel26 , Michael M. Jacobs27 , Joseph A. Ladapo28 , Lionel H. Lee29 , John Littell30 , Ivette Lozano31 , Harpal S. Mangat32 , Ben Marble33 , John E. McKinnon34 , Lee D. Merritt35 , Jane M. Orient36 , Ramin Oskoui37 , Donald C. Pompan38 , Brian C. Procter39 , Chad Prodromos40 , Juliana Cepelowicz Rajter41 , Jean-Jacques Rajter41 , C. Venkata S. Ram42 , Salete S. Rios43 , Harvey A. Risch44 , Michael J. A. Robb45 , Molly Rutherford46 , Martin Scholz47 , Marilyn M. Singleton48 , James A. Tumlin49 , Brian M. Tyson50 , Richard G. Urso51 , Kelly Victory52 , Elizabeth Lee Vliet53 , Craig M. Wax54 , Alexandre G. Wolkoff55 , Vicki Wooll56 and Vladimir Zelenko57 1 Baylor University Medical Center, Baylor Heart and Vascular Institute, Baylor Jack and Jane Hamilton Heart and Vascular Hospital, Dallas, 75226, TX, USA Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, L8S 4L8, Ontario, Canada Armstrong Medical Group, Texas City, 75510, TX, USA 4 North Suburban Medical Center and Vibra Hospital, Thornton, 80229, Colorado, USA 5 Chicago Health and Wellness Alliance, Chicago, 60603, IL, USA 6 Recipient of the Texas HHS Meritorious Service Award, 78751, Texas, USA 7 PianoPsych, LLC, Natick, 01760, MA, USA 8 Division of Gastroenterology, Department of Medicine, Larkin Community Hospital, S. Miami, 33143, FL, USA 9 Centre for Digestive Diseases, Five Dock, 2046, NSW, Australia 10 Infectious Diseases, St. Luke's Hospital, Kansas City, 64111, MO, USA 11 University of Pittsburgh, Department of Medicine, Pittsburgh, 15213, PA, USA 12 Clarke Neurology, Newport Beach, 92660, CA, USA 13 Alexion Pharma Germany GmbH, 80687, Munich, Germany 14 Affordable Health, Inc., Piscataway, 08854, NJ, USA 15 Eisner Laser Center, Macon, 31210, GA, USA 16 Pioneers Medical Center, Brawley, 92227, CA, USA 17 Privia Medical Group, Webster, 24510, TX, USA 18 Hapvida HMO, Ribeirão Preto,14015-130, SP, Brazil 19 Houston Methodist Cancer Center, Houston, 77030, TX, USA 20 The Medical College Of Wisconsin, Milwaukee, 53226, WI, USA 21 Personal Healthcare Network, Kansas City, 64116, MO, USA 22 Fusion Clinical Multimedia, Inc., Philadelphia, 19019, PA, USA 23 Ventura Clinical Trials, PROGENABIOME, Malibu Specialty Center, Ventura, 93003, CA, USA 24 Stone Oak Ophthalmology, Immediate Past President, Association of American Physicians and Surgeons, San Antonio, 78258, TX , USA 25 Cardiosound, Atlanta, 30342, GA, USA 26 Rehoboth Medical Center, Houston, 77083, TX, USA 27 Complex Primary Care Medicine, Pensacola, 32507, FL, USA 28 University of California Los Angeles, Los Angeles, 90095, CA, USA 29 Emergency Medicine, Phoenix, 85016, AZ, USA 30 Family Medicine, Kissimmee, 34741, FL, USA 31 Lozano Medical Clinic,..