Is Hydroxychloroquine a Possible Post-Exposure Prophylaxis Drug to Limit the Transmission to Health Care Workers Exposed to COVID19?

Pagliano et al., Clin. Infect. Dis., 2020 Mar 24, doi:10.1093/cid/ciaa320

Mar 2020

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CQ and HCQ inhibit replication at early stages of infection, no similar effect reported for other drugs which are only able to interfere after cell infection. Large volume of existing data on safety. (8/23: we corrected the classification of this study)

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Pagliano et al., 24 Mar 2020, peer-reviewed, 5 authors.

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2019 Novel Coronavirus Is Undergoing Active Recombination

Huiguang Yi

Clinical Infectious Diseases, doi:10.1093/cid/ciaa219

www. maths.otago.ac.nz/~dbryant/software/phimanual. pdf 9. Jiang X, Robertson DL. nCoV's relationship to bat coronaviruses and recombination signals (no snakes)-no evidence the 2019-nCoV lineage is recombinant. 2020.

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De Wilde, Jochmans, Posthuma, Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture, Antimicrob Agents Chemother

Savarino, Boelaert, Cassone, Majori, Cauda, Effects of chloroquine on viral infections: an old drug against today's diseases?, Lancet Infect Dis

Schwartz, King, Protecting health care workers during the COVID-19 coronavirus outbreak: lessons from Taiwan's SARS response

Yao, Ye, Zhang, In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Yao, Ye, Zhang, In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Clin Infect Dis

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