Clinical outcomes of patients with mild COVID-19 following treatment with hydroxychloroquine in an outpatient setting
Majid Mokhtari, Minoo Mohraz, Mohammad Mehdi Gouya, Hengameh Namdari Tabar, Jafar-Sadegh Tabrizi, Katayoun Tayeri, Saeide Aghamohamadi, Zahra Rajabpoor, Manoochehr Karami, Alireza Raeisi, Hamid Rahmani, Hossein Khalili
International Immunopharmacology, doi:10.1016/j.intimp.2021.107636
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References
Bessière, Roccia, Delinière, Charrière, Chevalier et al., Assessment of QT Intervals in a Case Series of Patients With Coronavirus Disease 2019 (COVID-19) Infection Treated With Hydroxychloroquine Alone or in Combination With Azithromycin in an Intensive Care Unit, JAMA Cardiol,
doi:10.1001/jamacardio.2020.1787Bhimraj, Morgan, Shumaker, Lavergne, Baden, Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19, Clin. Infect. Dis,
doi:10.1093/cid/ciaa478Clancy, Nguyen, A first draft of the history of treating coronavirus disease 2019 (COVID-19): Use of repurposed medications in United States hospitals, Open Forum Infect. Dis,
doi:10.1093/ofid/ofaa617Derwand, Scholz, Zelenko, COVID-19 outpatients: early risk-stratified treatment with zinc plus low-dose hydroxychloroquine and azithromycin: a retrospective case series study, Int. J. Antimicrob. Agents,
doi:10.1016/j.ijantimicag.2020.106214Duvignaud, Lhomme, Pistone, Onaisi, Sitta et al., Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial), Trials,
doi:10.1186/s13063-020-04619-1Fonseca, De Queiroz, Sousa, Wolkoff, Moreira et al., Risk of hospitalization for Covid-19 outpatients treated with various drug regimens in Brazil: Comparative analysis, Travel Med. Infect. Dis
Gautret, Lagier, Parola, Hoang, Meddeb et al., Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label nonrandomized clinical trial, Int. J. Antimicrob. Agents,
doi:10.1016/j.ijantimicag.2020.105949Geleris, Sun, Platt, Zucker, Baldwin et al., Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19, N. Engl. J. Med,
doi:10.1056/NEJMoa2012410Ghaffari Darab, Keshavarz, Sadeghi, Shahmohamadi, Kavosi, The economic burden of coronavirus disease 2019 (COVID-19): evidence from Iran, BMC Health Serv Res,
doi:10.1186/s12913-021-06126-8Göpel, Bethge, Martus, Kreth, Iftner et al., Test and treat COVID 65 plus -Hydroxychloroquine versus placebo in early ambulatory diagnosis and treatment of older patients with COVID19: A structured summary of a study protocol for a randomised controlled trial, Trials,
doi:10.1186/s13063-020-04556-zHeart, Lung, Blood, Network, Steingrub et al., Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial, JAMA,
doi:10.1001/jama.2020.22240Ip, Ahn, Zhou, Goy, Hansen et al., Hydroxychloroquine in the treatment of outpatients with mildly symptomatic COVID-19: a multi-center observational study, medRxiv preprints,
doi:10.1101/2020.08.20.20178772Jalili, Payandemehr, Saghaei, Sari, Safikhani et al., Characteristics and Mortality of Hospitalized Patients With COVID-19 in Iran: A National Retrospective Cohort Study, Ann. Intern. Med,
doi:10.7326/M20-2911Lagier, Million, Gautret, Colson, Cortaredona et al., 19 Task force. Outcomes of 3737 COVID-19 patients treated with hydroxychloroquine/azithromycin and other regimens in Marseille, France: A retrospective analysis, Travel Med Infect Dis,
doi:10.1016/j.tmaid.2020.101791Lofgren, Nicol, Bangdiwala, Pastick, Okafor et al., Safety of Hydroxychloroquine Among Outpatient Clinical Trial Participants for COVID-19. Open Forum, Infect Dis,
doi:10.1093/ofid/ofaa500Mercuro, Yen, Shim, Maher, Mccoy et al., Risk of QT Interval Prolongation Associated With Use of Hydroxychloroquine With or Without Concomitant Azithromycin Among Hospitalized Patients Testing Positive for Coronavirus Disease 2019 (COVID-19), JAMA Cardiol,
doi:10.1001/jamacardio.2020.1834Million, Lagier, Gautret, Colson, Fournier et al., Early treatment of COVID-19 patients with hydroxychloroquine and azithromycin: A retrospective analysis of 1061 cases in Marseille, France, Travel Med Infect Dis,
doi:10.1016/j.tmaid.2020.101738Mitjà, Corbacho-Monné, Ubals, Tebe, Peñafiel et al., Hydroxychloroquine for Early Treatment of Adults with Mild Covid-19: A Randomized-Controlled Trial, Clin Infect Dis,
doi:10.1093/cid/ciaa1009Mohana, Sulaiman, Mahmoud, Hassanein, Alfaifi et al., Hydroxychloroquine safety outcome with an approved therapeutic protocol for COVID-19 outpatients in Saudi Arabia, Int. J. Infect. Dis,
doi:10.1016/j.ijid.2020.10.031Pan, Peto, Henao-Restrepo, Preziosi, Sathiyamoorthy et al., Repurposed Antiviral Drugs for Covid-19 -Interim WHO Solidarity Trial Results, N Engl. J. Med,
doi:10.1056/NEJMoa2023184Prodromos, Rumschlag, Hydroxychloroquine is effective, and consistently so when provided early, for COVID-19: a systematic review, New Microbes New Infect,
doi:10.1016/j.nmni.2020.100776Raeisi, Tabrizi, Gouya, IR of Iran National Mobilization against COVID-19 Epidemic, Arch Iran Med,
doi:10.34172/aim.2020.01Recovery Collaborative Group, Horby, Mafham, Linsell, Bell et al., Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19, N Engl. J. Med,
doi:10.1056/NEJMoa2022926Rosenberg, Dufort, Udo, Wilberschied, Kumar et al., Association of Treatment with Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in New York State, JAMA,
doi:10.1001/jama.2020.8630Self, Semler, Leither, Casey, Angus et al., None
Skipper, Pastick, Engen, Bangdiwala, Abassi et al., Hydroxychloroquine in Nonhospitalized Adults With Early COVID-19: A Randomized Trial, Ann. Intern. Med,
doi:10.7326/M20-4207Yao, Ye, Zhang, Cui, Huang et al., Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Clin. Infect. Dis,
doi:10.1093/cid/ciaa237
