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All Studies   Meta Analysis    Recent:   

Safety of Hydroxychloroquine among Outpatient Clinical Trial Participants for COVID-19

Lofgren et al., Open Forum Infectious Diseases, doi:10.1093/ofid/ofaa500 (date from preprint)
Sep 2020  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now known with p < 0.00000000001 from 422 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19hcq.org
Analysis of 2,795 outpatients not showing significant safety concerns with HCQ. No deaths were related to HCQ. There was one serious event requiring hospitalization, identical to the frequency with placebo.
Lofgren et al., 21 Sep 2020, peer-reviewed, 26 authors.
This PaperHCQAll
Safety of Hydroxychloroquine Among Outpatient Clinical Trial Participants for COVID-19
MD Sarah M Lofgren, Melanie R Nicol, Ananta S Bangdiwala, Katelyn A Pastick, Elizabeth C Okafor, Caleb P Skipper, Matthew F Pullen, Nicole W Engen, Mahsa Abassi, Darlisha A Williams, Alanna A Nascene, Margaret L Axelrod, Sylvain A Lother, Lauren J Mackenzie, Glen Drobot, Nicole Marten, Matthew P Cheng, Ryan Zarychanski, Ilan S Schwartz, Michael Silverman, Zain Chagla, Lauren E Kelly, Emily G Mcdonald, Todd C Lee, Kathy H Hullsiek, David R Boulware, Radha Rajasingham
Open Forum Infectious Diseases, doi:10.1093/ofid/ofaa500
Background. Use of hydroxychloroquine in hospitalized patients with coronavirus disease 2019 , especially in combination with azithromycin, has raised safety concerns. Here, we report safety data from 3 outpatient randomized clinical trials. Methods. We conducted 3 randomized, double-blind, placebo-controlled trials investigating hydroxychloroquine as preexposure prophylaxis, postexposure prophylaxis, and early treatment for COVID-19 using an internet-based design. We excluded individuals with contraindications to hydroxychloroquine. We collected side effects and serious adverse events. We report descriptive analyses of our findings. Results. We enrolled 2795 participants. The median age of research participants (interquartile range) was 40 (34-49) years, and 59% (1633/2767) reported no chronic medical conditions. Overall 2544 (91%) participants reported side effect data, and 748 (29%) reported at least 1 medication side effect. Side effects were reported in 40% with once-daily, 36% with twice-weekly, 31% with once-weekly hydroxychloroquine, compared with 19% with placebo. The most common side effects were upset stomach or nausea (25% with oncedaily, 19% with twice-weekly, and 18% with once-weekly hydroxychloroquine, vs 11% for placebo), followed by diarrhea, vomiting, or abdominal pain (23% for once-daily, 17% twice-weekly, and 13% once-weekly hydroxychloroquine, vs 7% for placebo). Two individuals were hospitalized for atrial arrhythmias, 1 on placebo and 1 on twice-weekly hydroxychloroquine. No sudden deaths occurred. Conclusions. Data from 3 outpatient COVID-19 trials demonstrated that gastrointestinal side effects were common but mild with the use of hydroxychloroquine, while serious side effects were rare. No deaths occurred related to hydroxychloroquine. Randomized clinical trials, in cohorts of healthy outpatients, can safely investigate whether hydroxychloroquine is efficacious for COVID-19. ClinicalTrials.gov identifier. NCT04308668 for postexposure prophylaxis and early treatment trials; NCT04328467 for preexposure prophylaxis trial.
Supplementary Data Supplementary materials are available at Open Forum Infectious Diseases online. Consisting of data provided by the authors to benefit the reader, the posted materials are not copyedited and are the sole responsibility of the authors, so questions or comments should be addressed to the corresponding author.
References
Al-Kofahi, Jacobson, Boulware, Finding the dose for hydroxychloroquine prophylaxis for COVID-19: the desperate search for effectiveness, Clin Pharmacol Ther
Barnes, White, Brugada, For the Malaria Policy Advisory Committee Meeting
Borba, Val, Sampaio, Effect of high vs low doses of chloroquine diphosphate as adjunctive therapy for patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, JAMA Netw Open
Boulware, Pullen, Bangdiwala, A randomized trial of hydroxychloroquine as postexposure prophylaxis for Covid-19, N Engl J Med
Cheng, Kao, Tsao, The inhibition of immunologic response by chloroquine, Chin Med J
Cheng, Lee, Tan, Murthy, Generating randomized trial evidence to optimize treatment in the COVID-19 pandemic, CMAJ
Dhakal, Sweitzer, Indik, SARS-CoV-2 infection and cardiovascular disease: COVID-19 heart, Heart Lung Circ
Ding, Denniston, Rao, Gordon, Hydroxychloroquine-related retinal toxicity, Rheumatology
Food, Hydroxychloroquine FDA package insert
Food, of hydroxychloroquine or chloroquine for COVID-19 outside of the hospital setting or a clinical trial due to risk of heart rhythm problems
Glenza, Brazilian chloroquine study halted after high dose proved lethal for some patients
Guo, Wei, Li, Single-cell RNA analysis on ACE2 expression provides insights into SARS-CoV-2 potential entry into the bloodstream and heart injury, J Cell Physiol
Hancox, Hasnain, Vieweg, Azithromycin, cardiovascular risks, QTc interval prolongation, torsade de pointes, and regulatory issues: a narrative review based on the study of case reports, Ther Adv Infect Dis
Horby, Landray, Correspondence to all RECOVERY principal investigators
Juurlink, Safety considerations with chloroquine, hydroxychloroquine and azithromycin in the management of SARS-CoV-2 infection, CMAJ
Lippi, South, Henry, Electrolyte imbalances in patients with severe coronavirus disease 2019 (COVID-19), Ann Clin Biochem
Mehta, Mazer-Amirshahi, Alkindi, Pourmand, Pharmacotherapy in COVID-19; a narrative review for emergency providers, Am J Emerg Med
Mercuro, Yen, Shim, Risk of QT interval prolongation associated with use of hydroxychloroquine with or without concomitant azithromycin among hospitalized patients testing positive for coronavirus disease 2019 (COVID-19), JAMA Cardiol
Morgan, Patel, Dvorkina, Suspected hydroxychloroquine-associated QT-interval prolongation in a patient with systemic lupus erythematosus, J Clin Rheumatol
Munster, Gibbs, Shen, Hydroxychloroquine concentration-response relationships in patients with rheumatoid arthritis, Arthritis Rheum
Pastick, Okafor, Wang, Hydroxychloroquine and chloroquine for treatment of SARS-CoV-2 (COVID-19), Open Forum Infect Dis
Rajasingham, Bangdiwala, Nicol, Hydroxychloroquine as preexposure prophylaxis for COVID-19 in healthcare workers: a randomized trial
Roden, Harrington, Poppas, Russo, Considerations for drug interactions on QTc interval in exploratory COVID-19 treatment, Heart Rhythm
Ross, Wilson, Papillon-Ferland, COVID-SAFER: deprescribing guidance for hydroxychloroquine drug interactions in older adults, J Am Geriatr Soc
Sacher, Fauchier, Boveda, Working Group of Pacing, Electrophysiology of the French Society of Cardiology, the Board of the French Society of Cardiology. Use of drugs with potential cardiac effect in the setting of SARS-CoV-2 infection, Arch Cardiovasc Dis
Sapp, Alqarawi, Macintyre, Guidance on minimizing risk of drug-induced ventricular arrhythmia during treatment of COVID-19: a statement from the Canadian Heart Rhythm Society, Can J Cardiol
Sharma, Garcia, Arumugaswami, Svendsen, Human iPSCderived cardiomyocytes are susceptible to SARS-CoV-2 infection, bioRxiv, doi:10.1101/2020.04.21.051912
Shaw, Caution strongly recommended when using chloroquine, hydroxychloroquine in patients with cardiovascular disease, COVID-19
Skipper, Pastick, Engen, Hydroxychloroquine in nonhospitalized adults with early COVID-19: a randomized trial, Ann Intern Med
Trial, Statement from the chief investigators of the randomised evaluation of COVid-19 thERapY (RECOVERY) trial on hydroxychloroquine
Vincent, Bergeron, Benjannet, Chloroquine is a potent inhibitor of SARS coronavirus infection and spread, Virol J
Wu, Kane, Peng, SARS-CoV-2 and cardiovascular complications: from molecular mechanisms to pharmaceutical management, Biochem Pharmacol
Yao, Ye, Zhang, In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Clin Infect Dis
Yap, Camm, Drug induced QT prolongation and torsades de pointes, Heart
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'bioRxiv', 'key': '2020111009223085900_CIT0014', 'year': '2020'}, { 'DOI': '10.1016/j.bcp.2020.114114', 'article-title': 'SARS-CoV-2 and cardiovascular complications: from molecular mechanisms ' 'to pharmaceutical management', 'author': 'Wu', 'doi-asserted-by': 'crossref', 'first-page': '114114', 'journal-title': 'Biochem Pharmacol', 'key': '2020111009223085900_CIT0015', 'volume': '178', 'year': '2020'}, { 'DOI': '10.1016/j.hlc.2020.05.101', 'article-title': 'SARS-CoV-2 infection and cardiovascular disease: COVID-19 heart', 'author': 'Dhakal', 'doi-asserted-by': 'crossref', 'first-page': '973', 'journal-title': 'Heart Lung Circ', 'key': '2020111009223085900_CIT0016', 'volume': '29', 'year': '2020'}, { 'DOI': '10.1177/0004563220922255', 'article-title': 'Electrolyte imbalances in patients with severe coronavirus disease 2019 ' '(COVID-19)', 'author': 'Lippi', 'doi-asserted-by': 'crossref', 'first-page': '262', 'journal-title': 'Ann Clin Biochem', 'key': '2020111009223085900_CIT0017', 'volume': '57', 'year': '2020'}, { 'DOI': '10.1016/j.acvd.2020.04.003', 'article-title': 'Use of drugs with potential cardiac effect in the setting of SARS-CoV-2 ' 'infection', 'author': 'Sacher', 'doi-asserted-by': 'crossref', 'first-page': '293', 'journal-title': 'Arch Cardiovasc Dis', 'key': '2020111009223085900_CIT0018', 'volume': '113', 'year': '2020'}, { 'DOI': '10.7326/M20-4207', 'article-title': 'Hydroxychloroquine in nonhospitalized adults with early COVID-19: a ' 'randomized trial', 'author': 'Skipper', 'doi-asserted-by': 'crossref', 'first-page': '623', 'journal-title': 'Ann Intern Med', 'key': '2020111009223085900_CIT0019', 'volume': '173', 'year': '2020'}, { 'DOI': '10.1093/cid/ciaa1571', 'article-title': 'Hydroxychloroquine as pre-exposure prophylaxis for COVID-19 in ' 'healthcare workers: a randomized trial [published online ahead of print ' 'October 17, 2020]', 'author': 'Rajasingham', 'doi-asserted-by': 'crossref', 'journal-title': 'Clin Infect Dis', 'key': '2020111009223085900_CIT0020', 'year': '2020'}, { 'DOI': '10.1002/cpt.1874', 'article-title': 'Finding the dose for hydroxychloroquine prophylaxis for COVID-19: the ' 'desperate search for effectiveness', 'author': 'Al-Kofahi', 'doi-asserted-by': 'crossref', 'first-page': '766', 'journal-title': 'Clin Pharmacol Ther', 'key': '2020111009223085900_CIT0021', 'volume': '108', 'year': '2020'}, { 'article-title': 'The inhibition of immunologic response by chloroquine', 'author': 'Cheng', 'first-page': '531', 'journal-title': 'Chin Med J', 'key': '2020111009223085900_CIT0022', 'volume': '83', 'year': '1964'}, { 'DOI': '10.1016/j.ajem.2020.04.035', 'article-title': 'Pharmacotherapy in COVID-19; a narrative review for emergency providers', 'author': 'Mehta', 'doi-asserted-by': 'crossref', 'first-page': '1488', 'journal-title': 'Am J Emerg Med', 'key': '2020111009223085900_CIT0023', 'volume': '38', 'year': '2020'}, { 'DOI': '10.1097/RHU.0b013e31829d5e50', 'article-title': 'Suspected hydroxychloroquine-associated QT-interval prolongation in a ' 'patient with systemic lupus erythematosus', 'author': 'Morgan', 'doi-asserted-by': 'crossref', 'first-page': '286', 'journal-title': 'J Clin Rheumatol', 'key': '2020111009223085900_CIT0024', 'volume': '19', 'year': '2013'}, { 'article-title': 'Azithromycin, cardiovascular risks, QTc interval prolongation, torsade ' 'de pointes, and regulatory issues: a narrative review based on the ' 'study of case reports', 'author': 'Hancox', 'first-page': '155', 'journal-title': 'Ther Adv Infect Dis', 'key': '2020111009223085900_CIT0025', 'volume': '1', 'year': '2013'}, { 'article-title': 'For the Malaria Policy Advisory Committee Meeting, WHO Evidence Review ' 'Group Meeting, 13–14 October 2016;', 'author': 'Barnes', 'journal-title': 'Varembé Conference Centre, Geneva, Switzerland.', 'key': '2020111009223085900_CIT0026'}, {'author': 'Glenza', 'key': '2020111009223085900_CIT0027'}, {'author': 'Shaw', 'key': '2020111009223085900_CIT0028'}, { 'DOI': '10.1093/rheumatology/kev357', 'article-title': 'Hydroxychloroquine-related retinal toxicity', 'author': 'Ding', 'doi-asserted-by': 'crossref', 'first-page': '957', 'journal-title': 'Rheumatology (Oxford)', 'key': '2020111009223085900_CIT0029', 'volume': '55', 'year': '2016'}, { 'DOI': '10.1002/art.10307', 'article-title': 'Hydroxychloroquine concentration-response relationships in patients ' 'with rheumatoid arthritis', 'author': 'Munster', 'doi-asserted-by': 'crossref', 'first-page': '1460', 'journal-title': 'Arthritis Rheum', 'key': '2020111009223085900_CIT0030', 'volume': '46', 'year': '2002'}, {'author': 'Horby', 'key': '2020111009223085900_CIT0031'}, { 'article-title': 'Considerations for drug interactions on QTc interval in exploratory ' 'COVID-19 treatment', 'author': 'Roden', 'journal-title': 'Heart Rhythm', 'key': '2020111009223085900_CIT0032', 'year': ''}, { 'DOI': '10.1016/j.cjca.2020.04.003', 'article-title': 'Guidance on minimizing risk of drug-induced ventricular arrhythmia ' 'during treatment of COVID-19: a statement from the Canadian Heart ' 'Rhythm Society', 'author': 'Sapp', 'doi-asserted-by': 'crossref', 'first-page': '948', 'journal-title': 'Can J Cardiol', 'key': '2020111009223085900_CIT0033', 'volume': '36', 'year': '2020'}, { 'DOI': '10.1136/heart.89.11.1363', 'article-title': 'Drug induced QT prolongation and torsades de pointes', 'author': 'Yap', 'doi-asserted-by': 'crossref', 'first-page': '1363', 'journal-title': 'Heart', 'key': '2020111009223085900_CIT0034', 'volume': '89', 'year': '2003'}], 'reference-count': 34, 'references-count': 34, 'relation': { 'has-preprint': [ { 'asserted-by': 'object', 'id': '10.1101/2020.07.16.20155531', 'id-type': 'doi'}]}, 'resource': {'primary': {'URL': 'https://academic.oup.com/ofid/article/doi/10.1093/ofid/ofaa500/5930834'}}, 'score': 1, 'short-title': [], 'source': 'Crossref', 'subject': [], 'subtitle': [], 'title': 'Safety of Hydroxychloroquine Among Outpatient Clinical Trial Participants for COVID-19', 'type': 'journal-article', 'volume': '7'}
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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