Hydroxychloroquine for COVID-19: A Single Center, Retrospective Cohort Study
Wen Chung Ho, Wei Xin Yong, Khai Shin Tan, Woh Yon Mak, Mandeep Kaur Gill, Agnes Hui, Ching Lok, Shazwani Zulkifli, Salmah Idris, Erwan Khairil, Khalid, Loon Chee, Leong, Kang Nien How, Nien Kang, MRCP How
doi:10.47836/mjmhs19.2.3
Introduction: The outbreak of coronavirus disease in December 2019 called for a rapid solution, leading to repurposing of existing drugs. Due to its immunomodulatory effect and antiviral properties, hydroxychloroquine (HCQ) has been used in early 2020 for treatment of COVID-19 patients. This study was conducted to evaluate the treatment outcome of HCQ monotherapy in Malaysia. Methods: A retrospective cohort study was conducted in COVID-19 ward in Hospital Kuala Lumpur (HKL), from March to April 2020. A total of 446 COVID-19 patients were recruited, only 325 patients were finally included for analysis. Statistical analysis was done using SPSS, with a significant value set at p<0.05. Results: The mean age of the patients were 38.5 ±15.5. They were majority male, (n=210, 64.6%) Malaysian (n=239, 73.5%) and Malay ethnicity (n=204, 62.8%). Ninety-one (28%) patients received HCQ monotherapy. HCQ monotherapy was associated with worse outcome (OR: 10.29, 95% CI 1.17-90.80). There was a significant difference in mean length of stay between those with and without HCQ treatment (t323=5.868, p<0.001, 95% CI, 2.56-5.31). The average length of stay for HCQ treated group was 3.84 days longer than those without treatment. 6.6% of the patient receiving HCQ monotherapy encountered adverse drug effects. Conclusion: Similar to study reported worldwide, our study demonstrated that HCQ did not improve length of stay and the outcome of COVID-19 patients.
References
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'abstract': '<jats:p>Introduction: The outbreak of coronavirus disease (COVID-19) in December 2019 called '
'for a rapid solution, leading to repurposing of existing drugs. Due to its immunomodulatory '
'effect and antiviral properties, hydroxychloroquine (HCQ) has been used in early 2020 for '
'treatment of COVID-19 patients. This study was conducted to evaluate the treatment outcome of '
'HCQ monotherapy in Malaysia. Methods: A retrospective cohort study was conducted in COVID-19 '
'ward in Hospital Kuala Lumpur (HKL), from March to April 2020. A total of 446 COVID-19 '
'patients were recruited, only 325 patients were finally included for analysis. Statistical '
'analysis was done using SPSS, with a significant value set at p<0.05. Results: The mean '
'age of the patients were 38.5 ±15.5. They were majority male, (n=210, 64.6%) Malaysian '
'(n=239, 73.5%) and Malay ethnicity (n=204, 62.8%). Ninety-one (28%) patients received HCQ '
'monotherapy. HCQ monotherapy was associated with worse outcome (OR: 10.29, 95% CI '
'1.17-90.80). There was a significant difference in mean length of stay between those with and '
'without HCQ treatment (t323=5.868, p<0.001, 95% CI, 2.56-5.31). The average length of stay '
'for HCQ treated group was 3.84 days longer than those without treatment. 6.6% of the patient '
'receiving HCQ monotherapy encountered adverse drug effects. Conclusion: Similar to study '
'reported worldwide, our study demonstrated that HCQ did not improve length of stay and the '
'outcome of COVID-19 patients.</jats:p>',
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