Impact of common comorbidities on antimicrobial consumption and mortality amongst critically ill COVID-19 patients: A retrospective two center study in Saudi Arabia

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In Saudi Arabia: ' 'a nationwide retrospective study', 'author': 'Al-Otaiby', 'year': '2022', 'journal-title': 'Front Med.'}, { 'key': '10.1016/j.clinpr.2023.100229_b0030', 'doi-asserted-by': 'crossref', 'first-page': '738', 'DOI': '10.1016/j.sjbs.2020.11.001', 'article-title': 'SARS-CoV-2 associated COVID-19 in geriatric population: a brief ' 'narrative review', 'volume': '28', 'author': 'Al-Zahrani', 'year': '2021', 'journal-title': 'Saudi J. Biol. Sci.'}, { 'key': '10.1016/j.clinpr.2023.100229_b0035', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.micpath.2020.104228', 'article-title': 'In vitro testing of combined hydroxychloroquine and azithromycin on ' 'SARS-CoV-2 shows synergistic effect', 'volume': '145', 'author': 'Andreani', 'year': '2020', 'journal-title': 'Microb. Pathog.'}, { 'key': '10.1016/j.clinpr.2023.100229_b0040', 'doi-asserted-by': 'crossref', 'first-page': '1340', 'DOI': '10.1111/anae.15201', 'article-title': 'Outcomes from intensive care in patients with COVID-19: a systematic ' 'review and meta-analysis of observational studies', 'volume': '75', 'author': 'Armstrong', 'year': '2020', 'journal-title': 'Anaesthesia.'}, { 'key': '10.1016/j.clinpr.2023.100229_b0045', 'doi-asserted-by': 'crossref', 'first-page': '1063', 'DOI': '10.1016/S0140-6736(21)00461-X', 'article-title': 'Azithromycin for community treatment of suspected COVID-19 in people at ' 'increased risk of an adverse clinical course in the UK (PRINCIPLE): a ' 'randomised, controlled, open-label, adaptive platform trial', 'volume': '397', 'author': 'Butler', 'year': '2021', 'journal-title': 'Lancet.'}, { 'key': '10.1016/j.clinpr.2023.100229_b0050', 'unstructured': 'COVID 19 Dashboard: Saudi Arabia [Internet], 2021a. [cited 19 August ' '2022]. <https://covid19.moh.gov.sa/>.'}, { 'key': '10.1016/j.clinpr.2023.100229_b0055', 'unstructured': 'Cucinotta, D., Vanelli, M., 2020. WHO declares COVID-19 a pandemic Acta ' 'Biomed. 91, 157. <https://doi.org/10.23750/abm.v91i1.9397>.'}, { 'key': '10.1016/j.clinpr.2023.100229_b0060', 'doi-asserted-by': 'crossref', 'first-page': '959', 'DOI': '10.1016/S0140-6736(20)31862-6', 'article-title': 'Azithromycin in addition to standard of care versus standard of care ' 'alone in the treatment of patients admitted to the hospital with severe ' 'COVID-19 in Brazil (COALITION II): a randomised clinical trial', 'volume': '396', 'author': 'Furtado', 'year': '2020', 'journal-title': 'Lancet.'}, { 'key': '10.1016/j.clinpr.2023.100229_b0065', 'doi-asserted-by': 'crossref', 'first-page': '446', 'DOI': '10.1016/j.antiviral.2013.09.015', 'article-title': 'Favipiravir (T-705), a novel viral RNA polymerase inhibitor', 'volume': '100', 'author': 'Furuta', 'year': '2013', 'journal-title': 'Antivir. Res.'}, { 'key': '10.1016/j.clinpr.2023.100229_b0070', 'doi-asserted-by': 'crossref', 'first-page': '72', 'DOI': '10.5582/bst.2020.01047', 'article-title': 'Breakthrough: Chloroquine phosphate has shown apparent efficacy in ' 'treatment of COVID-19 associated pneumonia in clinical studies', 'volume': '14', 'author': 'Gao', 'year': '2020', 'journal-title': 'Biosci. Trends.'}, { 'key': '10.1016/j.clinpr.2023.100229_b0075', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.ijantimicag.2020.105949', 'article-title': 'Hydroxychloroquine and azithromycin as a treatment of COVID-19: results ' 'of an open-label non-randomized clinical trial', 'volume': '56', 'author': 'Gautret', 'year': '2020', 'journal-title': 'Int. J. Antimicrob. Agents.'}, { 'key': '10.1016/j.clinpr.2023.100229_b0080', 'doi-asserted-by': 'crossref', 'first-page': '68', 'DOI': '10.1111/aas.13701', 'article-title': 'Characteristics, interventions, and longer term outcomes of COVID-19 ' 'ICU patients in Denmark—a nationwide, observational study', 'volume': '65', 'author': 'Haase', 'year': '2021', 'journal-title': 'Acta Anaesthesiol. Scand.'}, { 'key': '10.1016/j.clinpr.2023.100229_b0085', 'doi-asserted-by': 'crossref', 'first-page': '497', 'DOI': '10.1016/S0140-6736(20)30183-5', 'article-title': 'Clinical features of patients infected with 2019 novel coronavirus in ' 'Wuhan, China', 'volume': '395', 'author': 'Huang', 'year': '2020', 'journal-title': 'Lancet'}, { 'key': '10.1016/j.clinpr.2023.100229_b0090', 'doi-asserted-by': 'crossref', 'article-title': 'The efficacy and adverse effects of favipiravir on COVID-19 patients: a ' 'systematic review and meta-analysis of published clinical trials and ' 'observational studies', 'author': 'Hung', 'year': '2022', 'journal-title': 'Int. J. Infect Dis.', 'DOI': '10.1016/j.ijid.2022.04.035'}, { 'key': '10.1016/j.clinpr.2023.100229_b0095', 'doi-asserted-by': 'crossref', 'first-page': '152', 'DOI': '10.3389/fpubh.2020.00152', 'article-title': 'Gender differences in patients with COVID-19: focus on severity and ' 'mortality', 'author': 'Jin', 'year': '2020', 'journal-title': 'Front Public Health.'}, { 'key': '10.1016/j.clinpr.2023.100229_b0100', 'doi-asserted-by': 'crossref', 'first-page': '59', 'DOI': '10.4103/atm.atm_178_21', 'article-title': 'Characteristics and outcome of tertiary care critically ill COVID-19 ' 'patients with multiple comorbidities admitted to the intensive care ' 'unit', 'volume': '17', 'author': 'Khalid', 'year': '2022', 'journal-title': 'Ann. Thorac. Med.'}, { 'key': '10.1016/j.clinpr.2023.100229_b0105', 'doi-asserted-by': 'crossref', 'unstructured': 'Khan, A., Althunayyan, S., Alsofayan, Y., Alotaibi, R., Mubarak, A., ' 'Arafat, M., et al., 2020. Risk factors associated with worse outcomes in ' 'COVID-19: a retrospective study in Saudi Arabia East Mediterr Health J. ' '2020 1371 –80 10.26719/emhj.20.130.', 'DOI': '10.26719/emhj.20.130'}, { 'key': '10.1016/j.clinpr.2023.100229_b0110', 'doi-asserted-by': 'crossref', 'first-page': '749', 'DOI': '10.1080/14787210.2022.2011719', 'article-title': 'Antimicrobial consumption in patients with COVID-19: a systematic ' 'review and meta-analysis', 'volume': '20', 'author': 'Khan', 'year': '2022', 'journal-title': 'Exp. Rev. Anti Infect Ther.'}, { 'key': '10.1016/j.clinpr.2023.100229_b0115', 'doi-asserted-by': 'crossref', 'first-page': '454', 'DOI': '10.1111/jcpt.13305', 'article-title': 'Observational study of the effects of Favipiravir vs ' 'Lopinavir/Ritonavir on clinical outcomes in critically Ill patients ' 'with COVID-19', 'volume': '46', 'author': 'Kocayiğit', 'year': '2021', 'journal-title': 'J. Clin. Pharm. Ther.'}, { 'key': '10.1016/j.clinpr.2023.100229_b0120', 'unstructured': 'Michelen, M., Jones, N., Stavropoulou, C., 2022. In patients of ' 'COVID-19, what are the symptoms and clinical features of mild and ' 'moderate cases? – The Centre for Evidence-Based Medicine [Internet]. The ' 'Centre for Evidence-Based Medicine. [Online]. ' '<https://www.cebm.net/covid-19/in-patients-of-covid-19-what-are-the-symptoms-and-clinical-features-of-mild-and-moderate-case/>.'}, { 'key': '10.1016/j.clinpr.2023.100229_b0125', 'doi-asserted-by': 'crossref', 'first-page': 'e042008', 'DOI': '10.1136/bmjopen-2020-042008', 'article-title': 'Epidemiology, clinical characteristics and treatment of critically ill ' 'patients with COVID-19: a protocol for a living systematic review', 'volume': '11', 'author': 'Milovanovic', 'year': '2021', 'journal-title': 'BMJ Open.'}, { 'key': '10.1016/j.clinpr.2023.100229_b0130', 'doi-asserted-by': 'crossref', 'first-page': '28', 'DOI': '10.1016/j.hrtlng.2020.10.013', 'article-title': 'Outcomes of patients with COVID-19 in. the intensive care unit in ' 'Mexico: a multicenter observational study', 'volume': '50', 'author': 'Ñamendys-Silva', 'year': '2021', 'journal-title': 'Heart Lung.'}, { 'key': '10.1016/j.clinpr.2023.100229_b0135', 'doi-asserted-by': 'crossref', 'unstructured': 'Pastick, K.A., Okafor, E.C., Wang, F., Lofgren, S.M., Skipper, C.P., ' 'Nicol, M.R., et al., 2020. Hydroxychloroquine and chloroquine for ' 'treatment of SARS-CoV-2 (COVID-19). Open Forum Infect Dis. ' '2020;7:ofaa130. Oxford University Press, US. ' '<https://doi.org/10.1093/ofid/ofaa130>.', 'DOI': '10.1093/ofid/ofaa130'}, { 'key': '10.1016/j.clinpr.2023.100229_b0140', 'doi-asserted-by': 'crossref', 'first-page': '2030', 'DOI': '10.1056/NEJMoa2022926', 'article-title': 'Effect of hydroxychloroquine in hospitalized patients with Covid-19', 'volume': '383', 'author': 'RECOVERY Collaborative Group', 'year': '2020', 'journal-title': 'NEJM.'}, { 'key': '10.1016/j.clinpr.2023.100229_b0145', 'doi-asserted-by': 'crossref', 'first-page': '605', 'DOI': '10.1016/S0140-6736(21)00149-5', 'article-title': 'Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): ' 'a randomised, controlled, open-label, platform trial', 'volume': '397', 'author': 'RECOVERY Collaborative Group', 'year': '2021', 'journal-title': 'Lancet.'}, { 'key': '#cr-split#-10.1016/j.clinpr.2023.100229_b0150.1', 'unstructured': 'Reuters, T., 2020. Russia approves first COVID-19 prescription drug for ' 'sale in pharmacies [Internet]. Thomson Reuters'}, { 'key': '#cr-split#-10.1016/j.clinpr.2023.100229_b0150.2', 'unstructured': '2020 [cited 2023 Apr 9]. ' '<https://www.reuters.com/article/us-health-coronavirus-russia-rpharm-idUSKBN26917Z>.'}, { 'key': '10.1016/j.clinpr.2023.100229_b0155', 'first-page': '5', 'article-title': 'Hydroxychloroquine prophylaxis and treatment is ineffective in macaque ' 'and hamster SARS-CoV-2 disease models', 'author': 'Rosenke', 'year': '2020', 'journal-title': 'Jci Insight.'}, { 'key': '10.1016/j.clinpr.2023.100229_b0160', 'first-page': 'E33', 'article-title': 'Characteristics, management and outcomes of critically ill COVID-19 ' 'patients admitted to ICU in hospitals in Bangladesh: a retrospective ' 'study', 'volume': '62', 'author': 'Saha', 'year': '2021', 'journal-title': 'J. Prev. Med. Hyg.'}, { 'key': '10.1016/j.clinpr.2023.100229_b0165', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1186/s12985-020-01412-z', 'article-title': 'Favipiravir versus other antiviral or standard of care for COVID-19 ' 'treatment: a rapid systematic review and meta-analysis', 'volume': '17', 'author': 'Shrestha', 'year': '2020', 'journal-title': 'Virol. J.'}, { 'key': '10.1016/j.clinpr.2023.100229_b0170', 'article-title': 'The role of organizational characteristics on the outcome of COVID-19 ' 'patients admitted to the ICU in Belgium', 'volume': '2', 'author': 'Taccone', 'year': '2021', 'journal-title': 'Lancet Reg. Health Eur.'}, { 'key': '10.1016/j.clinpr.2023.100229_b0175', 'doi-asserted-by': 'crossref', 'first-page': '545', 'DOI': '10.1002/cpt.2251', 'article-title': 'Japan’s drug regulation during the COVID-19 pandemic: lessons from a ' 'case study of favipiravir', 'volume': '111', 'author': 'Ueda', 'year': '2022', 'journal-title': 'Clin. Pharmacol. Ther.'}, { 'key': '#cr-split#-10.1016/j.clinpr.2023.100229_b0180.1', 'doi-asserted-by': 'crossref', 'unstructured': 'Vaidyanathan, G., 2020. Scientists criticize use of unproven COVID drugs ' 'in India [Internet]. Nature News. Nature Publishing Group', 'DOI': '10.1038/d41586-020-03105-7'}, { 'key': '#cr-split#-10.1016/j.clinpr.2023.100229_b0180.2', 'unstructured': '2020 [cited 2023 Apr 9]. ' '<https://www.nature.com/articles/d41586-020-03105-7>.'}, { 'key': '10.1016/j.clinpr.2023.100229_b0185', 'first-page': '13', 'article-title': 'Characteristics and risk factors associated with mortality in ' 'critically ill patients with COVID-19', 'author': 'Vogels', 'year': '2021', 'journal-title': 'Cureus.'}, { 'key': '10.1016/j.clinpr.2023.100229_b0190', 'unstructured': 'WHO Coronavirus (COVID-19) Dashboard [Internet]. Covid19.who.int. 2021 ' '[cited 19 August 2022]. <https://covid19.who.int/>.'}, { 'key': '10.1016/j.clinpr.2023.100229_b0195', 'unstructured': 'World Health Organization, 2021. 2021 aware classification [Internet]. ' '[cited 7 Dec 2022]. ' '<https://www.who.int/publications/i/item/2021-aware-classification>.'}, { 'key': '10.1016/j.clinpr.2023.100229_b0200', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1186/s12959-021-00284-9', 'article-title': 'Prevalence and risk factors of thrombotic events on patients with ' 'COVID-19: a systematic review and meta-analysis', 'volume': '19', 'author': 'Xiong', 'year': '2021', 'journal-title': 'Thromb. 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