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0 0.5 1 1.5 2+ Mortality 25% Improvement Relative Risk HCQ for COVID-19  Taccone et al.  ICU PATIENTS Is very late treatment with HCQ beneficial for COVID-19? Retrospective 1,747 patients in Belgium Lower mortality with HCQ (p=0.023) Taccone et al., The Lancet Regional He.., Dec 2020 Favors HCQ Favors control

The role of organizational characteristics on the outcome of COVID-19 patients admitted to the ICU in Belgium

Taccone et al., The Lancet Regional Health - Europe, doi:10.1016/j.lanepe.2020.100019
Dec 2020  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
*, now known with p < 0.00000000001 from 421 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments.
Retrospective 1,747 ICU patients in Belgium showing lower mortality with HCQ, multivariate mixed effects analysis HCQ aOR 0.64 [0.45-0.92].
risk of death, 24.7% lower, RR 0.75, p = 0.02, treatment 449 of 1,308 (34.3%), control 183 of 439 (41.7%), NNT 14, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Taccone et al., 23 Dec 2020, retrospective, Belgium, peer-reviewed, 10 authors, average treatment delay 5.0 days.
This PaperHCQAll
The role of organizational characteristics on the outcome of COVID-19 patients admitted to the ICU in Belgium
Fabio Silvio Taccone, Nina Van Goethem, Robby De Pauw, Xavier Wittebole, Koen Blot, Herman Van Oyen, Tinne Lernout, Marion Montourcy, Geert Meyfroidt, Dominique Van Beckhoven
The Lancet Regional Health - Europe, doi:10.1016/j.lanepe.2020.100019
Background: Several studies have investigated the predictors of in-hospital mortality for COVID-19 patients who need to be admitted to the Intensive Care Unit (ICU). However, no data on the role of organizational issues on patients' outcome are available in this setting. The aim of this study was therefore to assess the role of surge capacity organisation on the outcome of critically ill COVID-19 patients admitted to ICUs in Belgium. Methods: We conducted a retrospective analysis of in-hospital mortality in Belgian ICU COVID-19 patients via the national surveillance database. Non-survivors at hospital discharge were compared to survivors using multivariable mixed effects logistic regression analysis. Specific analyses including only patients with invasive ventilation were performed. To assess surge capacity, data were merged with administrative information on the type of hospital, the baseline number of recognized ICU beds, the number of supplementary beds specifically created for COVID-19 ICU care and the "ICU overflow" (i.e. a time-varying ratio between the number of occupied ICU beds by confirmed and suspected COVID-19 patients divided by the number of recognized ICU beds reserved for COVID-19 patients; ICU overflow was present when this ratio is 1.0). Findings: Over a total of 13,612 hospitalised COVID-19 patients with admission and discharge forms registered in the surveillance period (March, 1 to August, 9 2020), 1903 (14.0%) required ICU admission, of whom 1747 had available outcome data. Non-survivors (n = 632, 36.1%) were older and had more frequently various comorbid diseases than survivors. In the multivariable analysis, ICU overflow, together with older age, presence of comorbidities, shorter delay between symptom onset and hospital admission, absence of hydroxychloroquine therapy and use of invasive mechanical ventilation and of ECMO, was independently associated with an increased in-hospital mortality. Similar results were found in in in the subgroup of invasively ventilated patients. In addition, the proportion of supplementary beds specifically created for COVID-19 ICU care to the previously existing total number of ICU beds was associated with increased in-hospital mortality among invasively ventilated patients. The model also indicated a significant between-hospital difference in in-hospital mortality, not explained by the available patients and hospital characteristics. Interpretation: Surge capacity organisation as reflected by ICU overflow or the creation of COVID-19 specific supplementary ICU beds were found to negatively impact ICU patient outcomes.
Authors' contributions FST, NVG and DVB conceived the study; NVG, RDP and KB selected the population; NVG, MM, RDP and KB reviewed all available data; NVG, RDP, KB, HVO, TL and MM conducted the statistical analysis; FST, GM, NVG and DVB and wrote the first draft of the paper; XW, KB, HVO, TL and MM revised the text for intellectual content. All the authors have full access to the data of the present study, approved the final version of this manuscript and accepted responsibility to submit for publication. NVG, GM and DVB has verified the data of the study. Declaration of Competing Interests FST received lecture fees from BD, Zoll, Nihon Khoden and Neuroptics, which are all outside the content of the present study. Other authors declare that they have no competing interests. Ethics approval and consent to participate The hospital data collection performed by Sciensano, the Belgian Institute of Public Health, is legally entitled for surveillance of infectious diseases in Belgium (Royal Decree of 21/03/2018). The COVID-19 clinical surveillance was authorized by an independent administrative authority protecting privacy and personal data, and approved by the ethical committee of Ghent University Hospital (BC-07507). Funding No funding was obtained to this study Supplementary materials Supplementary material associated with this article can be found, in the online version, at doi:10.1016/j.lanepe.2020.100019.
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Late treatment
is less effective
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