Outcomes of patients with COVID-19 in the Intensive Care Unit in Mexico: A multicenter observational study
Ñamendys-Silva et al.,
Outcomes of patients with COVID-19 in the Intensive Care Unit in Mexico: A multicenter observational study,
Heart & Lung, doi:10.1016/j.hrtlng.2020.10.013
Retrospective 164 ICU patients in Mexico showing 32% lower mortality with HCQ+AZ and 37% lower with CQ.
HCQ+AZ vs. neither HCQ or CQ relative risk RR 0.68,
p = 0.03
CQ vs. neither HCQ or CQ relative risk RR 0.63,
p = 0.02
HCQ+AZ or CQ vs. neither relative risk RR 0.65,
p = 0.006
risk of death, 32.3% lower, RR 0.68, p = 0.18, treatment 24 of 54 (44.4%), control 42 of 64 (65.6%), NNT 4.7, HCQ+AZ vs. neither HCQ or CQ.
|
risk of death, 37.1% lower, RR 0.63, p = 0.09, treatment 19 of 46 (41.3%), control 42 of 64 (65.6%), NNT 4.1, CQ vs. neither HCQ or CQ.
|
risk of death, 34.5% lower, RR 0.66, p = 0.006, treatment 43 of 100 (43.0%), control 42 of 64 (65.6%), NNT 4.4, HCQ+AZ or CQ.
|
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
|
Ñamendys-Silva et al., 21 Oct 2020, retrospective, database analysis, Mexico, peer-reviewed, mean age 57.3, 18 authors, average treatment delay 7.0 days.
Abstract: Heart & Lung 50 (2021) 28 32
Contents lists available at ScienceDirect
Heart & Lung
journal homepage: www.heartandlung.com
Outcomes of patients with COVID-19 in the intensive care unit in Mexico:
A multicenter observational study
e
Silvio A. Namendys-Silva,
MD, MSc, FCCP, FCCMa,h,*, Pedro E. Alvarado-Avila,
MDa,
a,b
a
Guillermo Domínguez-Cherit, MD, FCCM , Eduardo Rivero-Sigarroa, MD ,
nchez-Hurtado, MDc, Alan Gutie
rrez-Villasen
~ or, MDd,
Luis A. Sa
lez, MDd, Heber Rodríguez-Bautista, MDa, Alondra García-Briones, MDd,
Juan P. Romero-Gonza
stor G. Cruz-Ruiz, MDf, María O. Gonza
lez-Herrera, MDg,
sar E. Garnica-Camacho, MDe, Ne
Ce
h
h
rrez, MD ,
n, MD , Manuel A. Guerrero-Gutie
Francisco J. García-Guille
i
L. Canto-Castro, MDj,
Jose D. Salmeron-Gonzalez, MD , Laura Romero-Gutierrez, MDc, Jose
Victor H. Cervantes, MDk, on behalf of the Mexico COVID-19 Critical Care Collaborative Group
n, Mexico City 14000, Mexico
n Salvador Zubira
Instituto Nacional de Ciencias Medicas y Nutricio
gico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico
Tecnolo
c
Hospital de Especialidades del Centro Medico Nacional Siglo XXI, IMSS, Mexico City, Mexico
d
Hospital Medica Sur, Mexico City, Mexico
e
Hospital General de Zona No.1 “Dr. Enrique Von Borstel Labastida”, IMSS, La Paz, Baja California Sur, Mexico
f
Hospital General de Zona No. 1, “Dr. Demetrio Mayoral Pardo”, IMSS, Oaxaca, Mexico
g
Hospital General de Zona 1, IMSS, Tlaxcala, Mexico
h
Instituto Nacional de Cancerología (INCan), Mexico City, Mexico
i
n, Mexico
Hospital General “Dr. Miguel Silva”, Morelia, Michoaca
j
n, Mexico
Unidad Medica de Alta Especialidad "Ignacio García Tellez", IMSS, Merida, Yucata
k
n, Guanajuato, Mexico
Hospital General Regional No. 58, IMSS, Leo
a
b
A R T I C L E
I N F O
Article History:
Received 23 July 2020
Revised 16 October 2020
Accepted 20 October 2020
Available online 21 October 2020
Keywords:
COVID-19
SARS-CoV-2 infection
Coronavirus
Intensive care unit
Mexico
Outcomes
A B S T R A C T
Background: As of June 15, 2020, a cumulative total of 7,823,289 confirmed cases of COVID-19 have been
reported across 216 countries and territories worldwide. However, there is little information on the clinical
characteristics and outcomes of critically ill patients with severe COVID-19 who were admitted to intensive
care units (ICUs) in Latin America. The present study evaluated the clinical characteristics and outcomes of
critically ill patients with severe COVID-19 who were admitted to ICUs in Mexico.
Methods: This was a multicenter observational study that included 164 critically ill patients with laboratoryconfirmed COVID-19 who were admitted to 10 ICUs in Mexico, from April 1 to April 30, 2020. Demographic
data, comorbid conditions, clinical presentation, treatment, and outcomes were collected and analyzed. The
date of final follow-up was June 4, 2020.
Results: A total of 164 patients with severe COVID-19 were included in this study. The mean age of patients
was 57.3 years (SD 13.7), 114 (69.5%) were men, and 6.0% were healthcare workers. Comorbid conditions
were common in patients with critical COVID-19: 38.4% of patients had hypertension and 32.3% had diabetes.
Compared to survivors, nonsurvivors were older and more likely to have diabetes, hypertension or other conditions. Patients presented to the hospital a median of 7 days (IQR 4.5 9) after symptom onset. The most
common presenting symptoms were shortness of..
Late treatment
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