HCQ lung pharmacokinetic study confirming that lung concentrations can be much higher than plasma and exceed predicted EC50
values. The median lung epithelial lining fluid concentration was 38 times higher than plasma concentrations. 22 COVID-19 patients, median age 59.5.
Authors note that dosage determinations in studies assuming equilibrium between epithelium and plasma concentrations may lead to overly high dosages. Authors find the median ELF concentration of HCQ above the maximum EC50
value for 400 mg x 1 /day and 200 mg x 3 /day, 7-12 days after treatment initiation.
Ruiz et al., 28 Nov 2020, peer-reviewed, 14 authors.