Detailed disease progression of 213 patients hospitalized with Covid-19 in the Czech Republic: An exploratory analysis
Modrák et al.,
Detailed disease progression of 213 patients hospitalized with Covid-19 in the Czech Republic: An exploratory..,
medRxiv, doi:10.1101/2020.12.03.20239863 (Preprint)
Retrospective 213 hospitalized patients in Czech Republic showing lower mortality with HCQ. Subject to
confounding by indication.
risk of death, 59.0% lower, RR 0.41, p = 0.04, treatment 108, control 105, Cox (single).
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Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
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Modrák et al., 4 Dec 2020, retrospective, Czech Republic, preprint, 26 authors.
Abstract: medRxiv preprint doi: https://doi.org/10.1101/2020.12.03.20239863; this version posted December 22, 2020. The copyright holder for this
preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
It is made available under a CC-BY-NC 4.0 International license .
Detailed disease progression of 213 patients
hospitalized with Covid-19 in the Czech Republic:
An exploratory analysis
Martin Modrák1, Paul-Christian Bürkner2, Tomáš Sieger3, Tomáš Slisz4,
Martina Vašáková4, Grigorij Mesežnikov5, Luis Fernando Casas-Mendez5,
Jaromír Vajter5, Jan Táborský6, Viktor Kubricht7, Daniel Suk8, Jan Horejsek8,
Martin Jedlička9, Adriana Mifková9, Adam Jaroš10, Miroslav Kubiska11,
Jana Váchalová11, Robin Šín11, Markéta Veverková12, Zbyšek Pospíšil13,
Julie Vohryzková14, Rebeka Pokrievková15, Kristián Hrušák14, Kristína Christozova14,
Vianey Leos-Barajas16, Karel Fišer17, Tomáš Hyánek10
Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic
University of Stuttgart, Germany
3 Dept. of Cybernetics, Faculty of Electrical Engineering, Czech Technical University
in Prague, Czech Republic
4 Department of Respiratory Medicine, 1st Faculty of Medicine, Charles University;
Thomayer Hospital, Prague, Czech Republic
5 Motol University Hospital, Prague, Czech Republic
6 AGEL Hospital Nový Jičín, Nový Jičín, Czech Republic
7 Kralovské Vinohrady University Hospital, Prague, Czech Republic
8 General University Hospital in Prague, Czech Republic
9 Military Hospital Olomouc, Olomouc, Czech Republic
10 Na Homolce Hospital, Prague, Czech Republic
11 Department of Infectious Diseases and Travel Medicine, Faculty of Medicine in
Pilsen, Charles University, University Hospital in Pilsen, Pilsen, Czech Republic
12 Hořovice Hospital, Hořovice, Czech Republic
13 Třebíč Hospital, Třebíč, Czech Republic
14 2nd Faculty of Medicine, Charles University in Prague
15 3rd Faculty of Medicine, Charles University in Prague
16 Department of Statistical Sciences, University of Toronto
17 Department of Bioinformatics, 2nd Faculty of Medicine, Charles University in
Prague
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NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice.
medRxiv preprint doi: https://doi.org/10.1101/2020.12.03.20239863; this version posted December 22, 2020. The copyright holder for this
preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
It is made available under a CC-BY-NC 4.0 International license .
Abstract: We collected a multi-centric retrospective dataset of patients (N = 213) who were
admitted to ten hospitals in Czech Republic and tested positive for SARS-CoV-2. The dataset contains
baseline patient characteristics, breathing support required, pharmacological treatment received and
multiple markers on daily resolution. Patients in the dataset were treated with hydroxychloroquine
(N = 108), azithromycin (N = 72), favipiravir (N = 9), convalescent plasma (N = 7), dexamethasone (N
= 4) and remdesivir (N = 3), often in combination. Most patients were admitted during the first wave
of the epidemic. To explore association between treatments and patient outcomes we performed
multiverse analysis, observing how the conclusions change between defensible choices of statistical
model, predictors included in the model and other analytical..
Late treatment
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