The effect of hydroxychloroquine against SARS-CoV-2 infection in rheumatoid arthritis patients

{ 'institution': [{'name': 'Research Square'}], 'indexed': {'date-parts': [[2022, 4, 3]], 'date-time': '2022-04-03T21:16:52Z', 'timestamp': 1649020612300}, 'posted': {'date-parts': [[2020, 7, 20]]}, 'group-title': 'In Review', 'reference-count': 0, 'publisher': 'Research Square Platform LLC', 'license': [ { 'start': { 'date-parts': [[2020, 7, 20]], 'date-time': '2020-07-20T00:00:00Z', 'timestamp': 1595203200000}, 'content-version': 'unspecified', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0/'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'accepted': {'date-parts': [[2020, 7, 15]]}, 'abstract': '<jats:title>Abstract</jats:title>\n' ' <jats:p>INTRODUCTION: The effectiveness of hydroxychloroquine in SARS-CoV-2 ' 'prophylaxis and treatment is still controversial. In this study, our aim is to investigate ' 'the potential effects of hydroxychloroquine therapy on patients with diagnosed with ' 'rheumatoid arthritis and a confirmed SARS-CoV-2 infection.METHOD: We included patients who ' 'were followed up with a diagnosis of rheumatoid arthritis and whose SARS-CoV-2 infection was ' 'confirmed. The patients were divided into two groups as those who previously used ' 'hydroxychloroquine and those who did not, and were compared in terms of clinical and ' 'laboratory data.RESULTS: Our study included 17 patients with adequate data (2 males, 15 ' 'females). The mean age of the patients was 57.2 ± 11.6 years. 7 (41.2%) patients were ' 'receiving hydroxychloroquine regularly for the last 6 months. When the effect of ' 'hydroxychloroquine on clinical and laboratory parameters of patients was examined, there was ' 'no significant difference between the groups of patients using and not using ' 'hydroxychloroquine. The patients using and not using hydroxychloroquine were compared for the ' 'presence of typical SARS-CoV-2 infection findings on computed tomography images, admission to ' 'the hospital and intensive care. No significant differences were observed between these two ' 'groups.CONCLUSIONS: Many studies on the effectiveness of hydroxychloroquine use in SARS-CoV-2 ' 'infection are still ongoing. Due to its importance in rheumatology practice, it is very ' 'important to clarify the position of hydroxychloroquine in SARS-CoV-2 therapy. Our findings ' 'suggest that having previously used hydroxychloroquine does not have any negative or positive ' 'effect on the infection.</jats:p>', 'DOI': '10.21203/rs.3.rs-43812/v1', 'type': 'posted-content', 'created': {'date-parts': [[2020, 7, 20]], 'date-time': '2020-07-20T16:14:01Z', 'timestamp': 1595261641000}, 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'The effect of hydroxychloroquine against SARS-CoV-2 infection in rheumatoid arthritis patients', 'prefix': '10.21203', 'author': [ { 'ORCID': 'http://orcid.org/0000-0001-6971-4229', 'authenticated-orcid': False, 'given': 'Okan', 'family': 'Küçükakkaş', 'sequence': 'first', 'affiliation': [{'name': 'Bezmialem Vakıf University'}]}, { 'ORCID': 'http://orcid.org/0000-0002-0902-6771', 'authenticated-orcid': False, 'given': 'Teoman', 'family': 'Aydın', 'sequence': 'additional', 'affiliation': [{'name': 'Bezmialem Vakıf University'}]}], 'member': '8761', 'container-title': [], 'original-title': [], 'link': [ { 'URL': 'https://www.researchsquare.com/article/rs-43812/v1', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://www.researchsquare.com/article/rs-43812/v1.html', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2021, 3, 17]], 'date-time': '2021-03-17T17:47:07Z', 'timestamp': 1616003227000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.researchsquare.com/article/rs-43812/v1'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2020, 7, 20]]}, 'references-count': 0, 'URL': 'http://dx.doi.org/10.21203/rs.3.rs-43812/v1', 'relation': {}, 'published': {'date-parts': [[2020, 7, 20]]}, 'subtype': 'preprint'}