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0 0.5 1 1.5 2+ ICU admission -43% Improvement Relative Risk HCQ for COVID-19  Küçükakkaş et al.  Prophylaxis Is pre-exposure prophylaxis with HCQ beneficial for COVID-19? Retrospective 17 patients in Turkey Study underpowered to detect differences Küçükakkaş et al., Research Square, Jul 2021 Favors HCQ Favors control

The effect of hydroxychloroquine against SARS-CoV-2 infection in rheumatoid arthritis patients

Küçükakkaş et al., Research Square, doi:10.21203/
Jul 2021  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
*, now known with p < 0.00000000001 from 421 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments.
Retrospective 17 rheumatoid arthritis COVID-19+ patients, 7 on HCQ treatment, showing no significant differences. They study reports only including hospitalized patients, but the results include non-hospitalized patients. Results do not reflect potential difference in the probability that a case is serious enough to have been tested and identified. Few group details are provided (even the age of patients in each group is not specified).
This study is excluded in the after exclusion results of meta analysis: minimal details of groups provided.
risk of ICU admission, 42.9% higher, RR 1.43, p = 1.00, treatment 1 of 7 (14.3%), control 1 of 10 (10.0%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Küçükakkaş et al., 20 Jul 2021, retrospective, Turkey, preprint, 2 authors.
This PaperHCQAll
The effect of hydroxychloroquine against SARS-CoV-2 infection in rheumatoid arthritis patients
Okan Küçükakkaş, Teoman Aydın
INTRODUCTION: The effectiveness of hydroxychloroquine in SARS-CoV-2 prophylaxis and treatment is still controversial. In this study, our aim is to investigate the potential effects of hydroxychloroquine therapy on patients with diagnosed with rheumatoid arthritis and a con rmed SARS-CoV-2 infection. METHOD: We included patients who were followed up with a diagnosis of rheumatoid arthritis and whose SARS-CoV-2 infection was con rmed. The patients were divided into two groups as those who previously used hydroxychloroquine and those who did not, and were compared in terms of clinical and laboratory data. RESULTS: Our study included 17 patients with adequate data (2 males, 15 females). The mean age of the patients was 57.2 ± 11.6 years. 7 (41.2%) patients were receiving hydroxychloroquine regularly for the last 6 months. When the effect of hydroxychloroquine on clinical and laboratory parameters of patients was examined, there was no signi cant difference between the groups of patients using and not using hydroxychloroquine. The patients using and not using hydroxychloroquine were compared for the presence of typical SARS-CoV-2 infection ndings on computed tomography images, admission to the hospital and intensive care. No signi cant differences were observed between these two groups. CONCLUSIONS: Many studies on the effectiveness of hydroxychloroquine use in SARS-CoV-2 infection are still ongoing. Due to its importance in rheumatology practice, it is very important to clarify the position of hydroxychloroquine in SARS-CoV-2 therapy. Our ndings suggest that having previously used hydroxychloroquine does not have any negative or positive effect on the infection.
Declarations Compliance with ethical standards Disclosures: None. Financial support received for the study: None. Ethical approval: Approval has been received by the Institutional Review Board. Competing interests: The declare no competing interests. A statement on participant consent: Ethical was obtained from the institutional ethical committee and no patient consent form was required due to the use of retrospective data.
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