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Inhaled hydroxychloroquine to improve efficacy and reduce harm in the treatment of COVID-19

Kavanagh et al., Med. Hypotheses, doi:10.1016/j.mehy.2020.110110
Jul 2020  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
*, now known with p < 0.00000000001 from 421 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments.
Proposal to use an inhaled formulation of HCQ which has passed safety studies in clinical trials for the treatment of asthma. Authors advocate for early treatment or prophylaxis of COVID-19, using HCQ as an inhaled aerosol, to deliver the drug directly to the lungs at a lower dose than that required for oral systemic delivery.
5 studies investigate novel formulations of HCQ for improved efficacy Alsmadi, Faísca, Kavanagh, Klimke, Zelenko
Kavanagh et al., 15 Jul 2020, peer-reviewed, 9 authors.
This PaperHCQAll
Inhaled hydroxychloroquine to improve efficacy and reduce harm in the treatment of COVID-19
Oisín Kavanagh, Anne Marie Healy, Francis Dayton, Shane Robinson, Niall J O'reilly, Brian Mahoney, Aisling Arthur, Gavin Walker, John P Farragher
Medical Hypotheses, doi:10.1016/j.mehy.2020.110110
Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre -including this research content -immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
PeakProsperity for simulating their first discussions on this topic. Declaration of Competing Interest The authors declare that they have no competing financial interest. The HCQ formulation was developed and IP filed by APT Corporation. The clinical and regulatory work was done by Aradigm under contract to, and paid for by APT. While both corporations no longer exist, the rights to the data have since been licensed to Pulmoquine and development is progressing for COVID-19. Appropriate intellectual property has been filed. Authorship statement JF conceptualised this project. OK and AMH drafted the manuscript and OK preformed the analysis of the data. FD provided the phase I and II clinical data and described the formulation. Discussions with SR, JF, NO'R and BM helped develop the idea. GW and AMH acquired funding to support the project. AA was responsible for logistical arrangements. All authors reviewed and agreed to the final manuscript. Appendix A. Supplementary data Supplementary data to this article can be found online at https://
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