Inhaled hydroxychloroquine to improve efficacy and reduce harm in the treatment of COVID-19

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COVID-19 situation update worldwide, as of 9 May 2020 [Internet]. 2020 [cited 2020 May 9]; Available from: https://www.ecdc.europa.eu/en/geographical-distribution-2019-ncov-cases." }, { "DOI": "10.1001/jama.2020.6019", "article-title": "Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19): a review", "author": "Sanders", "doi-asserted-by": "crossref", "journal-title": "JAMA - J Am Med Assoc", "key": "10.1016/j.mehy.2020.110110_b0010", "year": "2020" }, { "DOI": "10.1038/s41422-020-0282-0", "article-title": "Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro", "author": "Wang", "doi-asserted-by": "crossref", "first-page": "269", "issue": "3", "journal-title": "Cell Res", "key": "10.1016/j.mehy.2020.110110_b0015", "volume": "30", "year": "2020" }, { "DOI": "10.1016/S1473-3099(03)00806-5", "article-title": "Effects of chloroquine on viral infections: an old drug against today’s diseases?", "author": "Savarino", "doi-asserted-by": "crossref", "first-page": "722", "issue": "11", "journal-title": "Lancet Infect Dis", "key": "10.1016/j.mehy.2020.110110_b0020", "volume": "3", "year": "2003" }, { "DOI": "10.1016/S1473-3099(06)70361-9", "article-title": "New insights into the antiviral effects of chloroquine", "author": "Savarino", "doi-asserted-by": "crossref", "first-page": "67", "issue": "2", "journal-title": "Lancet Infect Dis", "key": "10.1016/j.mehy.2020.110110_b0025", "volume": "6", "year": "2006" }, { "DOI": "10.1038/nrrheum.2009.235", "article-title": "Therapy: hydroxychloroquine in SLE: old drug, new perspectives", "author": "Dörner", "doi-asserted-by": "crossref", "first-page": "10", "issue": "1", "journal-title": "Nat Rev Rheumatol", "key": "10.1016/j.mehy.2020.110110_b0030", "volume": "6", "year": "2010" }, { "DOI": "10.1001/jamacardio.2020.1782", "doi-asserted-by": "crossref", "key": "10.1016/j.mehy.2020.110110_b0035", "unstructured": "Bonow RO, Hernandez AF, Turakhia M. Hydroxychloroquine, Coronavirus Disease 2019, and QT Prolongation. JAMA Cardiol [Internet] 2020 [cited 2020 May 7]; Available from: https://jamanetwork.com/journals/jamacardiology/fullarticle/2765632." }, { "DOI": "10.1038/s41586-020-2521-4", "article-title": "OpenSAFELY: factors associated with COVID-19 death in 17 million patients", "author": "Williamson", "doi-asserted-by": "crossref", "journal-title": "Nature", "key": "10.1016/j.mehy.2020.110110_b0040", "year": "2020" }, { "article-title": "Detailed analysis of the impact of age on the QT interval", "author": "Rabkin", "first-page": "740", "issue": "9", "journal-title": "J Geriatr Cardiol", "key": "10.1016/j.mehy.2020.110110_b0045", "volume": "13", "year": "2016" }, { "article-title": "Aging effects on QT interval: implications for cardiac safety of antipsychotic drugs", "author": "Rabkin", "first-page": "20", "issue": "1", "journal-title": "J Geriatr Cardiol", "key": "10.1016/j.mehy.2020.110110_b0050", "volume": "11", "year": "2014" }, { "key": "10.1016/j.mehy.2020.110110_b0055", "unstructured": "European Medicines Agency. COVID-19: reminder of risk of serious side effects with chloroquine and hydroxychloroquine [Internet]. Amsterdam: 2020 [cited 2020 May 9]. Available from: www.ema.europa.eu/contact." }, { "key": "10.1016/j.mehy.2020.110110_b0060", "unstructured": "Food and Drug Administration. FDA Drug Safety Communication: FDA cautions against use of hydroxychloroquine or chloroquine for COVID-19 outside of the hospital setting or a clinical trial due to risk of heart rhythm problems [Internet]. 2020 [cited 2020 May 9]. Available from: www.clinicaltrials.gov." }, { "DOI": "10.1093/cid/ciaa237", "article-title": "In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)", "author": "Yao", "doi-asserted-by": "crossref", "journal-title": "Clin Infect Dis", "key": "10.1016/j.mehy.2020.110110_b0065", "year": "2020" }, { "DOI": "10.1111/cts.12797", "doi-asserted-by": "crossref", "key": "10.1016/j.mehy.2020.110110_b0070", "unstructured": "Arnold SL, Buckner F. Hydroxychloroquine for treatment of SARS-CoV-2 infection? Improving our confidence in a model-based approach to dose selection. Clin Transl Sci [Internet] 2020 [cited 2020 May 9]; DOI:10.1111/cts.12797." }, { "DOI": "10.1002/cpt.1856", "doi-asserted-by": "crossref", "key": "10.1016/j.mehy.2020.110110_b0075", "unstructured": "Garcia-Cremades M, Solans BP, Hughes E, et al. Optimizing hydroxychloroquine dosing for patients with COVID-19: An integrative modeling approach for effective drug repurposing. Clin Pharmacol Ther [Internet] 2020 [cited 2020 May 9]; Available from: DOI:10.1002/cpt.1856." }, { "DOI": "10.1053/j.ackd.2010.05.002", "article-title": "The aging kidney: physiological changes", "author": "Weinstein", "doi-asserted-by": "crossref", "first-page": "302", "issue": "4", "journal-title": "Adv Chronic Kidney Dis", "key": "10.1016/j.mehy.2020.110110_b0080", "volume": "17", "year": "2010" }, { "DOI": "10.1038/s41564-020-0695-z", "article-title": "The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2", "author": "Gorbalenya", "doi-asserted-by": "crossref", "first-page": "536", "issue": "4", "journal-title": "Nat Microbiol", "key": "10.1016/j.mehy.2020.110110_b0085", "volume": "5", "year": "2020" }, { "DOI": "10.1101/2020.01.31.929042", "doi-asserted-by": "crossref", "key": "10.1016/j.mehy.2020.110110_b0090", "unstructured": "Hoffmann M, Kleine-Weber H, Krueger N, Mueller MA, Drosten C, Poehlmann S. The novel coronavirus 2019 (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells [Internet]. bioRxiv. 2020 [cited 2020 May 11];2020.01.31.929042. Available from: http://biorxiv.org/content/early/2020/01/31/2020.01.31.929042.abstract." }, { "DOI": "10.1016/j.mehy.2020.109783", "doi-asserted-by": "crossref", "key": "10.1016/j.mehy.2020.110110_b0095", "unstructured": "Klimke A, Hefner G, Will B, Voss U. Hydroxychloroquine as an aerosol might markedly reduce and even prevent severe clinical symptoms after SARS-CoV-2 infection. Med Hypotheses [Internet] 2020 [cited 2020 May 11];142:109783. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0306987720307076." }, { "key": "10.1016/j.mehy.2020.110110_b0100", "unstructured": "Dayton F. Personal communication (May 11 2020)." }, { "article-title": "Development of an inhaled hydroxychloroquine sulfate product using the AERx ® system to treat asthma", "author": "Dayton", "journal-title": "Respir Drug Deliv", "key": "10.1016/j.mehy.2020.110110_b0105", "year": "2006" }, { "key": "10.1016/j.mehy.2020.110110_b0110", "unstructured": "Dayton F, Personal Communication, Clinical Study Report: A two- part, randomised, double-blind, placebo-controlled, ascending-dose study to evaluate the safety, tolerance and pharmacokinetics of orally inhaled hydroxychloroquine sulfate via the AERx System in healthy adult volunteers. Sponsor Protocol No. PYX-04-01 (2005)." }, { "key": "10.1016/j.mehy.2020.110110_b0115", "unstructured": "Dayton F, Personal Communication, Clinical study Report: A randomised, double-blind, placebo-controlled, multiple-dose study to evaluate the safety, tolerance and efficacy of orally inhaled hydroxychloroquine sulfate (HCQ) via the AERx® System in asthmatic subjects. Sponsor Protocol No. ARD-1300-0501 (2007)." }, { "DOI": "10.1080/87559128509540773", "doi-asserted-by": "crossref", "key": "10.1016/j.mehy.2020.110110_b0120", "unstructured": "Belitz H-D, Wieser H. Food Reviews International Bitter compounds: Occurrence and structure-activity relationships BITTER COMPOUNDS: OCCURRENCE AND STRUCTURE-ACTIVITY RELATIONSHIPS. Food Rev Int [Internet] 1985 [cited 2020 May 12];1(2):271–354. Available from: https://www.tandfonline.com/action/journalInformation?journalCode=lfri20." }, { "DOI": "10.1016/j.xphs.2019.12.014", "article-title": "Evaluation of an immediate-release formulation of hydroxychloroquine sulfate with an interwoven pediatric taste-masking system", "author": "Pauli", "doi-asserted-by": "crossref", "first-page": "1493", "issue": "4", "journal-title": "J Pharm Sci", "key": "10.1016/j.mehy.2020.110110_b0125", "volume": "109", "year": "2020" }, { "DOI": "10.1136/bmjresp-2016-000137", "article-title": "Comprehensive evidence-based review on European antitussives", "author": "Morice", "doi-asserted-by": "crossref", "first-page": "1", "issue": "1", "journal-title": "BMJ Open Respir Res", "key": "10.1016/j.mehy.2020.110110_b0130", "volume": "3", "year": "2016" }, { "DOI": "10.1007/s00408-013-9515-z", "article-title": "Effect of taste sensation on cough reflex sensitivity", "author": "Wise", "doi-asserted-by": "crossref", "first-page": "9", "issue": "1", "journal-title": "Lung", "key": "10.1016/j.mehy.2020.110110_b0135", "volume": "192", "year": "2014" }, { "DOI": "10.1016/j.pupt.2012.03.005", "article-title": "Sweet taste and menthol increase cough reflex thresholds", "author": "Wise", "doi-asserted-by": "crossref", "first-page": "236", "issue": "3", "journal-title": "Pulm Pharmacol Ther", "key": "10.1016/j.mehy.2020.110110_b0140", "volume": "25", "year": "2012" }, { "DOI": "10.3390/ijms20071718", "article-title": "Development and palatability assessment of norvir® (Ritonavir) 100 mg powder for pediatric population", "author": "Morris", "doi-asserted-by": "crossref", "issue": "7", "journal-title": "Int J Mol Sci", "key": "10.1016/j.mehy.2020.110110_b0145", "volume": "20", "year": "2019" } ], "reference-count": 29, "references-count": 29, "relation": {}, "resource": { "primary": { "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0306987720315176" } }, "score": 1, "short-title": [], "source": "Crossref", "subject": [], "subtitle": [], "title": "Inhaled hydroxychloroquine to improve efficacy and reduce harm in the treatment of COVID-19", "type": "journal-article", "update-policy": "http://dx.doi.org/10.1016/elsevier_cm_policy", "volume": "143" }