Development of SARS-CoV-2 infection in patients with rheumatic conditions on hydroxychloroquine monotherapy vs. patients without rheumatic conditions: A retrospective, propensity-matched cohort study
PharmD, BCPS Chris A Gentry, MD Sharanjeet K Thind, PharmD, BCPS Riley J Williams II, PharmD, BCPS Sage C Hendrickson, BCPS George Kurdgelashvili, MD, FACP Mary Beth Humphrey
The American Journal of the Medical Sciences, doi:10.1016/j.amjms.2022.08.006
Development of SARS-CoV-2 infection in patients with rheumatic conditions on hydroxychloroquine monotherapy vs. patients without rheumatic conditions: a retrospective, propensity-matched cohort study,
SARS-CoV
References
Abella, Jolkovsky, Biney, Uspal, Hyman et al., Efficacy and safety of hydroxychloroquine vs placebo for pre-exposure SARS-CoV-2 prophylaxis among health care workers, JAMA Intern Med,
doi:10.1001/jamainternmed.2020.6319
Barnabas, Brown, Bershteyn, Stankiewicz-Karita, Johnston, None
Boulware, Pullen, Bangdiwala, Pastick, Lofgren et al., A randomized trial of hydroxychloroquine as postexposure prophylaxis for Covid
Fiolet, Guihur, Rebeaud, Mulot, Peiffer-Smadja et al., Effect of hydroxychloroquine with or without azithromycin on the mortality of coronavirus disease 2019 (COVID-19) patients: a systematic review and meta-analysis, Clin Microbiol Infect,
doi:.org/10.1016/j.cmi.2020.08.022
Gautret, Lagier, Parola, Hoang, Meddeb et al., Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an openlabel non-randomized clinical trial, Int J Antimicrob Agents. Int J Antimicrob Agents,
doi:10.1016/j.ijantimicag.2020.105949
Geleris, Sun, Platt, Zucker, Baldwin et al., Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19, N Engl J Med,
doi:10.1056/NEJMoa2012410
Gentry, Humphrey, Thind, Hendrickson, Kurdgelashvili et al., Long-term hydroxychloroquine use in patients with rheumatic conditions and development of SARS-CoV-2 infection: a retrospective cohort study, Lancet Rheumatol,
doi:10.1016/S2665-9913(20)30305-2
Goa, Yang, Breakthrough: chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies, Biosci Trends,
doi:10.5582/bst.2020.01047
Kashour, Riaz, Garbati, Aldosary, Tlayjeh et al., Efficacy of chloroquine or hydroxychloroquine in COVID-19 patients: a systematic review and meta-analysis, J Antimicrob Chemother,
doi:10.1093/jac/dkaa403
Lai, Shih, Ko, Tang, Hsueh, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges, Int J Antimicrobe Agents,
doi:10.1016/j.ijantimicag.2020.105924
Mahevas, Tran, Roumier, Chabrol, Paule et al., Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data, BMJ,
doi:10.1136/bmj.m1844
Mitja, Corbacho-Monne, Ubals, Alemany, Suner et al., A cluster-randomized trial of hydroxychloroquine for prevention of Covid-19, N Engl J Med,
doi:10.1056/NEJMoa2021801
Morrisette, Lodise, Scheetz, Goswami, Pogue et al., The pharmacokinetic and pharmacodynamic properties of hydroxychloroquine and dose selection for COVID-19: putting the cart before the horse, Infect Dis Ther,
doi:10.1007/s40121-020-00325-2
Rajasingham, Bangdiwala, Nicol, Skipper, Pastick et al., Hydroxychloroquine as pre-exposure prophylaxis for COVID-19 in healthcare workers: a randomized trial, Clin Infect Dis,
doi:10.1093/cid/ciaa1571
Rosenberg, Dufort, Udo, Wilberschied, Kumar et al., Association of Treatment With Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in New York State, JAMA,
doi:10.1001/jama.2020.8630
Thorpe, Hydroxychloroquine as postexposure prophylaxis to prevent severe acute respiratory syndrome coronavirus 2 infection, Ann Intern Med,
doi:10.7326/M20-6519
Wang, Cao, Zhang, Yang, Liu et al., Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro, Cell Res,
doi:10.1038/s41422-020-0282-0
Yao, Ye, Zhang, Cui, Huang et al., In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2), Clin Infect Dis,
doi:10.1093/cid/ciaa237
Zhao, Zhang, Zheng, Tai, Simpson et al., Serious cardiovascular adverse events associated with hydroxychloroquine/chloroquine alone or with azithromycin in patients with COVID-19: a pharmacovigilance analysis of the FDA adverse event reporting system (FAERS)
{ 'indexed': {'date-parts': [[2022, 9, 11]], 'date-time': '2022-09-11T14:13:58Z', 'timestamp': 1662905638811},
'reference-count': 18,
'publisher': 'Elsevier BV',
'license': [ { 'start': { 'date-parts': [[2022, 9, 1]],
'date-time': '2022-09-01T00:00:00Z',
'timestamp': 1661990400000},
'content-version': 'tdm',
'delay-in-days': 0,
'URL': 'https://www.elsevier.com/tdm/userlicense/1.0/'}],
'content-domain': { 'domain': [ 'clinicalkey.fr', 'clinicalkey.jp', 'clinicalkey.com.au', 'clinicalkey.es',
'amjmedsci.org', 'clinicalkey.com', 'elsevier.com', 'sciencedirect.com'],
'crossmark-restriction': True},
'published-print': {'date-parts': [[2022, 9]]},
'DOI': '10.1016/j.amjms.2022.08.006',
'type': 'journal-article',
'created': {'date-parts': [[2022, 9, 11]], 'date-time': '2022-09-11T13:32:07Z', 'timestamp': 1662903127000},
'update-policy': 'http://dx.doi.org/10.1016/elsevier_cm_policy',
'source': 'Crossref',
'is-referenced-by-count': 0,
'title': 'Development of SARS-CoV-2 infection in patients with rheumatic conditions on hydroxychloroquine '
'monotherapy vs. patients without rheumatic conditions: a retrospective, propensity-matched '
'cohort study',
'prefix': '10.1016',
'author': [ {'given': 'Chris A.', 'family': 'Gentry', 'sequence': 'first', 'affiliation': []},
{'given': 'Sharanjeet K.', 'family': 'Thind', 'sequence': 'additional', 'affiliation': []},
{ 'suffix': 'II',
'given': 'Riley J.',
'family': 'Williams',
'sequence': 'additional',
'affiliation': []},
{'given': 'Sage C.', 'family': 'Hendrickson', 'sequence': 'additional', 'affiliation': []},
{'given': 'George', 'family': 'Kurdgelashvili', 'sequence': 'additional', 'affiliation': []},
{'given': 'Mary Beth', 'family': 'Humphrey', 'sequence': 'additional', 'affiliation': []}],
'member': '78',
'reference': [ { 'key': '10.1016/j.amjms.2022.08.006_bib0001',
'article-title': 'Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and '
'coronavirus disease-2019 (COVID-19): The epidemic and the challenges',
'volume': '55',
'author': 'Lai',
'year': '2020',
'journal-title': 'Int J Antimicrobe Agents'},
{ 'key': '10.1016/j.amjms.2022.08.006_bib0002',
'doi-asserted-by': 'crossref',
'first-page': '269',
'DOI': '10.1038/s41422-020-0282-0',
'article-title': 'Remdesivir and chloroquine effectively inhibit the recently emerged '
'novel coronavirus (2019-nCoV) in vitro',
'volume': '30',
'author': 'Wang',
'year': '2020',
'journal-title': 'Cell Res'},
{ 'key': '10.1016/j.amjms.2022.08.006_bib0003',
'doi-asserted-by': 'crossref',
'first-page': '732',
'DOI': '10.1093/cid/ciaa237',
'article-title': 'In vitro antiviral activity and projection of optimized dosing design '
'of hydroxychloroquine for the treatment of severe acute respiratory '
'syndrome Coronavirus 2 (SARS-CoV-2)',
'volume': '28',
'author': 'Yao',
'year': '2020',
'journal-title': 'Clin Infect Dis'},
{ 'key': '10.1016/j.amjms.2022.08.006_bib0004',
'doi-asserted-by': 'crossref',
'first-page': '30',
'DOI': '10.1093/jac/dkaa403',
'article-title': 'Efficacy of chloroquine or hydroxychloroquine in COVID-19 patients: a '
'systematic review and meta-analysis',
'volume': '76',
'author': 'Kashour',
'year': '2021',
'journal-title': 'J Antimicrob Chemother'},
{ 'key': '10.1016/j.amjms.2022.08.006_bib0005',
'doi-asserted-by': 'crossref',
'first-page': '19',
'DOI': '10.1016/j.cmi.2020.08.022',
'article-title': 'Effect of hydroxychloroquine with or without azithromycin on the '
'mortality of coronavirus disease 2019 (COVID-19) patients: a systematic '
'review and meta-analysis',
'volume': '27',
'author': 'Fiolet',
'year': '2021',
'journal-title': 'Clin Microbiol Infect'},
{ 'key': '10.1016/j.amjms.2022.08.006_bib0006',
'article-title': 'Serious cardiovascular adverse events associated with '
'hydroxychloroquine/chloroquine alone or with azithromycin in patients '
'with COVID-19: a pharmacovigilance analysis of the FDA adverse event '
'reporting system (FAERS)',
'author': 'Zhao',
'year': '2022',
'journal-title': 'Advance online publication'},
{ 'key': '10.1016/j.amjms.2022.08.006_bib0007',
'doi-asserted-by': 'crossref',
'first-page': '517',
'DOI': '10.1056/NEJMoa2016638',
'article-title': 'A randomized trial of hydroxychloroquine as postexposure prophylaxis '
'for Covid-19',
'volume': '383',
'author': 'Boulware',
'year': '2020',
'journal-title': 'N Engl J Med'},
{ 'key': '10.1016/j.amjms.2022.08.006_bib0008',
'doi-asserted-by': 'crossref',
'first-page': '344',
'DOI': '10.7326/M20-6519',
'article-title': 'Hydroxychloroquine as postexposure prophylaxis to prevent severe acute '
'respiratory syndrome coronavirus 2 infection',
'volume': '174',
'author': 'Barnabas',
'year': '2021',
'journal-title': 'Ann Intern Med'},
{ 'key': '10.1016/j.amjms.2022.08.006_bib0009',
'doi-asserted-by': 'crossref',
'first-page': '417',
'DOI': '10.1056/NEJMoa2021801',
'article-title': 'A cluster-randomized trial of hydroxychloroquine for prevention of '
'Covid-19',
'volume': '384',
'author': 'Mitja',
'year': '2021',
'journal-title': 'N Engl J Med'},
{ 'key': '10.1016/j.amjms.2022.08.006_bib0010',
'doi-asserted-by': 'crossref',
'first-page': '195',
'DOI': '10.1001/jamainternmed.2020.6319',
'article-title': 'Efficacy and safety of hydroxychloroquine vs placebo for pre-exposure '
'SARS-CoV-2 prophylaxis among health care workers',
'volume': '181',
'author': 'Abella',
'year': '2021',
'journal-title': 'JAMA Intern Med'},
{ 'key': '10.1016/j.amjms.2022.08.006_bib0011',
'doi-asserted-by': 'crossref',
'first-page': 'e835',
'DOI': '10.1093/cid/ciaa1571',
'article-title': 'Hydroxychloroquine as pre-exposure prophylaxis for COVID-19 in '
'healthcare workers: a randomized trial',
'volume': '72',
'author': 'Rajasingham',
'year': '2021',
'journal-title': 'Clin Infect Dis'},
{ 'key': '10.1016/j.amjms.2022.08.006_bib0012',
'doi-asserted-by': 'crossref',
'first-page': '561',
'DOI': '10.1007/s40121-020-00325-2',
'article-title': 'The pharmacokinetic and pharmacodynamic properties of '
'hydroxychloroquine and dose selection for COVID-19: putting the cart '
'before the horse',
'volume': '9',
'author': 'Morrisette',
'year': '2020',
'journal-title': 'Infect Dis Ther'},
{ 'key': '10.1016/j.amjms.2022.08.006_bib0013',
'doi-asserted-by': 'crossref',
'first-page': 'e689',
'DOI': '10.1016/S2665-9913(20)30305-2',
'article-title': 'Long-term hydroxychloroquine use in patients with rheumatic conditions '
'and development of SARS-CoV-2 infection: a retrospective cohort study',
'volume': '2',
'author': 'Gentry',
'year': '2020',
'journal-title': 'Lancet Rheumatol'},
{ 'key': '10.1016/j.amjms.2022.08.006_bib0014',
'doi-asserted-by': 'crossref',
'first-page': '2411',
'DOI': '10.1056/NEJMoa2012410',
'article-title': 'Observational Study of Hydroxychloroquine in Hospitalized Patients with '
'Covid-19',
'volume': '382',
'author': 'Geleris',
'year': '2020',
'journal-title': 'N Engl J Med'},
{ 'key': '10.1016/j.amjms.2022.08.006_bib0015',
'doi-asserted-by': 'crossref',
'first-page': 'm1844',
'DOI': '10.1136/bmj.m1844',
'article-title': 'Clinical efficacy of hydroxychloroquine in patients with covid-19 '
'pneumonia who require oxygen: observational comparative study using '
'routine care data',
'volume': '369',
'author': 'Mahevas',
'year': '2020',
'journal-title': 'BMJ'},
{ 'key': '10.1016/j.amjms.2022.08.006_bib0016',
'doi-asserted-by': 'crossref',
'first-page': '2493',
'DOI': '10.1001/jama.2020.8630',
'article-title': 'Association of Treatment With Hydroxychloroquine or Azithromycin With '
'In-Hospital Mortality in Patients With COVID-19 in New York State',
'volume': '323',
'author': 'Rosenberg',
'year': '2020',
'journal-title': 'JAMA'},
{ 'key': '10.1016/j.amjms.2022.08.006_bib0017',
'doi-asserted-by': 'crossref',
'first-page': '72',
'DOI': '10.5582/bst.2020.01047',
'article-title': 'Breakthrough: chloroquine phosphate has shown apparent efficacy in '
'treatment of COVID-19 associated pneumonia in clinical studies',
'volume': '14',
'author': 'Goa',
'year': '2020',
'journal-title': 'Biosci Trends'},
{ 'issue': '1',
'key': '10.1016/j.amjms.2022.08.006_bib0018',
'article-title': 'Hydroxychloroquine and azithromycin as a treatment of COVID-19: results '
'of an open-label non-randomized clinical trial',
'volume': '56',
'author': 'Gautret',
'year': '2020',
'journal-title': 'Int J Antimicrob Agents. Int J Antimicrob Agents'}],
'container-title': 'The American Journal of the Medical Sciences',
'original-title': [],
'language': 'en',
'link': [ { 'URL': 'https://api.elsevier.com/content/article/PII:S0002962922003482?httpAccept=text/xml',
'content-type': 'text/xml',
'content-version': 'vor',
'intended-application': 'text-mining'},
{ 'URL': 'https://api.elsevier.com/content/article/PII:S0002962922003482?httpAccept=text/plain',
'content-type': 'text/plain',
'content-version': 'vor',
'intended-application': 'text-mining'}],
'deposited': { 'date-parts': [[2022, 9, 11]],
'date-time': '2022-09-11T13:32:21Z',
'timestamp': 1662903141000},
'score': 1,
'resource': {'primary': {'URL': 'https://linkinghub.elsevier.com/retrieve/pii/S0002962922003482'}},
'subtitle': [],
'short-title': [],
'issued': {'date-parts': [[2022, 9]]},
'references-count': 18,
'alternative-id': ['S0002962922003482'],
'URL': 'http://dx.doi.org/10.1016/j.amjms.2022.08.006',
'relation': {},
'ISSN': ['0002-9629'],
'subject': ['General Medicine'],
'container-title-short': 'The American Journal of the Medical Sciences',
'published': {'date-parts': [[2022, 9]]},
'assertion': [ {'value': 'Elsevier', 'name': 'publisher', 'label': 'This article is maintained by'},
{ 'value': 'Development of SARS-CoV-2 infection in patients with rheumatic conditions on '
'hydroxychloroquine monotherapy vs. patients without rheumatic conditions: a '
'retrospective, propensity-matched cohort study',
'name': 'articletitle',
'label': 'Article Title'},
{ 'value': 'The American Journal of the Medical Sciences',
'name': 'journaltitle',
'label': 'Journal Title'},
{ 'value': 'https://doi.org/10.1016/j.amjms.2022.08.006',
'name': 'articlelink',
'label': 'CrossRef DOI link to publisher maintained version'},
{'value': 'article', 'name': 'content_type', 'label': 'Content Type'},
{ 'value': '© 2022 Published by Elsevier Inc. on behalf of Southern Society for Clinical '
'Investigation.',
'name': 'copyright',
'label': 'Copyright'}]}