Abstract: Article Clinical Course and Risk Factors for In-Hospital Mortality of 205 Patients with SARS-CoV-2 Pneumonia in Como, Lombardy Region, Italy Mauro Turrini 1, * , Angelo Gardellini 1 , Livia Beretta 2 , Lucia Buzzi 3 , Stefano Ferrario 4 , Sabrina Vasile 5 , Raffaella Clerici 6 , Andrea Colzani 4 , Luigi Liparulo 7 , Giovanni Scognamiglio 8 , Gianni Imperiali 9 , Giovanni Corrado 10 , Antonello Strada 11 , Marco Galletti 12 , Nunzio Castiglione 13 and Claudio Zanon 13 1 2 3 4 5 6 7



 8 9 Citation: Turrini, M.; Gardellini, A.; Beretta, L.; Buzzi, L.; Ferrario, S.; 10 Vasile, S.; Clerici, R.; Colzani, A.; 11 Liparulo, L.; Scognamiglio, G.; et al. Clinical Course and Risk Factors for In-Hospital Mortality of 205 Patients with SARS-CoV-2 Pneumonia in Como, Lombardy Region, Italy. Vaccines 2021, 9, 640. https:// doi.org/10.3390/vaccines9060640 Academic Editors: Ralph A. Tripp, Steven B. Bradfute and Scott Anthony Received: 1 May 2021 Accepted: 8 June 2021 Published: 11 June 2021 Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// 12 13 * Department of Medicine, Division of Hematology, Valduce Hospital, 22100 Como, Italy; agardellini@valduce.it Risk Management, Valduce Hospital, 22100 Como, Italy; lberetta@valduce.it Quality Management System, Valduce Hospital, 22100 Como, Italy; lbuzzi@valduce.it Department of Medicine, Division of Pneumology, Valduce Hospital, 22100 Como, Italy; sferrario@valduce.it (S.F.); acolzani@valduce.it (A.C.) Department of Mother and Child, Division of Paediatric and Neonatology, Infectious Diseases Consultant, Valduce Hospital, 22100 Como, Italy; svasile@valduce.it Department of Medicine, Division of Neurology, Valduce Hospital, 22100 Como, Italy; rclerici@valduce.it Department of Medicine, Division of Internal Medicine, Valduce Hospital, 22100 Como, Italy; lliparulo@valduce.it Department of Medicine, Division of Oncology, Valduce Hospital, 22100 Como, Italy; giosco@valduce.it Department of Medicine, Division of Gastroenterology, Valduce Hospital, 22100 Como, Italy; g.imperiali@libero.it Department of Medicine, Division of Cardiology, Valduce Hospital, 22100 Como, Italy; gcorrado@valduce.it Department of Emergency Medicine, Valduce Hospital, 22100 Como, Italy; astrada@valduce.it Department of Intensive Care Medicine, Valduce Hospital, 22100 Como, Italy; mgalletti@valduce.it Hospital Health Management, Valduce Hospital, 22100 Como, Italy; ncastiglione@valduce.it (N.C.); zanonclaudio762@gmail.com (C.Z.) Correspondence: mturrini@valduce.it; Tel.: +39-031324419 Abstract: The aim of this study is to explore risk factors for in-hospital mortality and describe the effectiveness of different treatment strategies of 205 laboratory-confirmed cases infected with SARSCoV-2 during the Lombardy outbreak. All patients received the best supportive care and specific interventions that included the main drugs being tested for repurposing to treat COVID-19, such as hydroxychloroquine, anticoagulation and antiviral drugs, steroids, and interleukin-6 pathway inhibitors. Clinical, laboratory, and treatment characteristics were analyzed with univariate and multivariate logistic regression methods to explore their impact on..