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All Studies   Meta Analysis    Recent:   

Risk factors for hospitalization or mortality for COVID-19 in patients with rheumatic diseases: Results of a nation-wide JCR COVID-19 registry in Japan

Oku et al., Modern Rheumatology, doi:10.1093/mr/roac104
Sep 2022  
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Mortality 92% unadjusted Improvement Relative Risk Hospitalization 12% HCQ for COVID-19  Oku et al.  Prophylaxis Is pre-exposure prophylaxis with HCQ beneficial for COVID-19? Retrospective 220 patients in Japan (June 2020 - June 2021) Lower hospitalization with HCQ (not stat. sig., p=0.34) c19hcq.org Oku et al., Modern Rheumatology, September 2022 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now with p < 0.00000000001 from 411 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments. c19hcq.org
Retrospecttive 220 COVID-19 patients with rheumatic disease in Japan, showing lower mortality and hospitalization with HCQ prophylaxis, without statistical significance.
Study covers remdesivir and HCQ.
risk of death, 92.2% lower, RR 0.08, p = 1.00, treatment 0 of 14 (0.0%), control 11 of 206 (5.3%), NNT 19, unadjusted, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of hospitalization, 11.5% lower, RR 0.88, p = 0.34, treatment 9 of 14 (64.3%), control 177 of 206 (85.9%), NNT 4.6, adjusted per study, odds ratio converted to relative risk, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Oku et al., 6 Sep 2022, retrospective, Japan, peer-reviewed, 8 authors, study period 3 June, 2020 - 30 June, 2021. Contact: horiuchi.takahiko.191@m.kyushu-u.ac.jp.
This PaperHCQAll
MORH-D-22-00049 Received: 20-Jan-2022; Accepted: 4-Aug-2022
Kenji Oku, Yasutaka Kimoto, Takahiko Horiuchi, Mari Yamamoto, Yasushi Kondo, Masashi Okamoto, Tatsuya Atsumi, Tsutomu Takeuchi, Y Makino, Matsubara Mayflower, Hospital Misaki
doi:10.1093/mr/roac104/6692611
Background: The incidence and prognosis of COVID-19 and rheumatic disease vary among ethnicities and regions. COVID-19 outcomes in rheumatic disease patients remain unclear, especially in the Asia-Pacific region. This study aimed to clarify the demographic and clinical factors that may influence COVID-19 prognosis in rheumatic disease patients.
Conflict of interest K. Oku, Y. Kimoto, T. Horiuchi, M. Yamamoto, Y. Kondo, M. Okamoto, and Tatsuya Atsumi have no conflicts of interest to declare. T.Takeuchi has received a speaking fee from Eli Lilly Japan K.K., and a research grant from Chugai Pharmaceutical Co.
References
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This study aimed to clarify the ' 'demographic and clinical factors that may influence COVID-19 prognosis in rheumatic disease ' 'patients.</jats:p>\n' ' <jats:p>Methods: This was a case series of patients registered with the ' 'COVID-19 national registry of Japan College of Rheumatology between June 3, 2020, and June ' '30, 2021. Multivariable logistic regression was used to estimate the risk of hospitalization ' 'or death. Age, sex, smoking status, rheumatic disease diagnosis, comorbidities, and rheumatic ' 'disease medications are taken immediately before infection was analyzed.</jats:p>\n' ' <jats:p>Results: A total of 220 patients from 55 institutions in Japan were ' 'included in the study, among whom 186 (84.5%) were hospitalized and 11 (5.0%) died. COVID-19 ' 'treatments were provided to 126 patients (57.3%), and mainly comprised glucocorticoids, ' 'favipiravir, remdesivir, and tocilizumab.</jats:p>\n' ' <jats:p>In the multiple logistic regression model, older age and a history of ' 'hypertension were associated with hospitalization, while older age was associated with ' 'mortality. No specific treatment was correlated with mortality or hospitalization by the ' 'multi-variate analysis.</jats:p>\n' ' <jats:p>Conclusions: Older age and hypertension were associated with a poor ' 'prognosis in Japanese COVID-19 patients with CTD. Factors not directly related to CTD were ' 'closely associated with the prognosis.</jats:p>', 'DOI': '10.1093/mr/roac104', 'type': 'journal-article', 'created': {'date-parts': [[2022, 9, 6]], 'date-time': '2022-09-06T12:57:08Z', 'timestamp': 1662469028000}, 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Risk factors for hospitalization or mortality for COVID-19 in patients with rheumatic diseases: ' 'Results of a nation-wide JCR COVID-19 registry in Japan', 'prefix': '10.1093', 'author': [ { 'given': 'Kenji', 'family': 'Oku', 'sequence': 'first', 'affiliation': [ { 'name': 'Department of Rheumatology and Infectious Diseases, Kitasato ' 'University , Kanagawa, Japan'}]}, { 'given': 'Yasutaka', 'family': 'Kimoto', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Internal Medicine, Kyushu University Beppu ' 'Hospital , Oita, Japan'}]}, { 'given': 'Takahiko', 'family': 'Horiuchi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Internal Medicine, Kyushu University Beppu ' 'Hospital , Oita, Japan'}]}, { 'given': 'Mari', 'family': 'Yamamoto', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Rheumatology and Nephrology, Chubu Rosai Hospital ' ', Aichi, Japan'}]}, { 'ORCID': 'http://orcid.org/0000-0002-1566-2088', 'authenticated-orcid': False, 'given': 'Yasushi', 'family': 'Kondo', 'sequence': 'additional', 'affiliation': [ { 'name': 'Division of Rheumatology, Department of Internal Medicine, Keio ' 'University School of Medicine , Tokyo, Japan'}]}, { 'given': 'Masashi', 'family': 'Okamoto', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Respiratory Medicine and Clinical Immunology, ' 'Osaka University Graduate School of Medicine , Osaka, Japan'}]}, { 'given': 'Tatsuya', 'family': 'Atsumi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Rheumatology, Endocrinology and Nephrology, ' 'Faculty of Medicine and Graduate School of Medicine , Hokkaido, ' 'Japan'}]}, { 'given': 'Tsutomu', 'family': 'Takeuchi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Division of Rheumatology, Department of Internal Medicine, Keio ' 'University School of Medicine , Tokyo, Japan'}]}], 'member': '286', 'published-online': {'date-parts': [[2022, 9, 6]]}, 'container-title': 'Modern Rheumatology', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://academic.oup.com/mr/advance-article-pdf/doi/10.1093/mr/roac104/45718326/roac104.pdf', 'content-type': 'application/pdf', 'content-version': 'am', 'intended-application': 'syndication'}, { 'URL': 'https://academic.oup.com/mr/advance-article-pdf/doi/10.1093/mr/roac104/45718326/roac104.pdf', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 9, 6]], 'date-time': '2022-09-06T12:57:09Z', 'timestamp': 1662469029000}, 'score': 1, 'resource': { 'primary': { 'URL': 'https://academic.oup.com/mr/advance-article/doi/10.1093/mr/roac104/6692611'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 9, 6]]}, 'references-count': 0, 'URL': 'http://dx.doi.org/10.1093/mr/roac104', 'relation': {}, 'ISSN': ['1439-7595', '1439-7609'], 'subject': ['Rheumatology'], 'published': {'date-parts': [[2022, 9, 6]]}}
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