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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Recovery time 25% Improvement Relative Risk Hospitalization time -13% Viral clearance time 0% HCQ for COVID-19  Hong et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? PSM retrospective 30 patients in South Korea (Feb - Apr 2020) Faster recovery with HCQ (not stat. sig., p=0.45) c19hcq.org Hong et al., PLOS ONE, May 2022 Favors HCQ Favors control

Use of combined treatment of 3rd-generation cephalosporin, azithromycin and antiviral agents on moderate SARs-CoV-2 patients in South Korea: A retrospective cohort study

Hong et al., PLOS ONE, doi:10.1371/journal.pone.0267645
May 2022  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now known with p < 0.00000000001 from 422 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments. c19hcq.org
Retrospective 25 hospitalized patients treated with cephalosporin, azithromycin, and HCQ, and 217 SOC patients in South Korea, reporting no significant differences. 5 patients receiving lopinavir/ritonavir and HCQ >5 days were excluded for unknown reasons. HCQ was typically initiated based on progression or side effects from another treatment. Conflicting results are reported. Table 2 indicates 15 CA/HCQ patients after matching, while Table S2 shows 25, and the Table 3 count is blank. S2 appears to incorrectly show before matching results, and the after matching results are missing in Table 3. 200mg HCQ bid.
Viral load measured by PCR may not accurately reflect infectious virus measured by viral culture. Porter show that viral load early in infection was correlated with infectious virus, but viral load late in infection could be high even with low or undetectable infectious virus. Assessing viral load later in infection may underestimate reductions in infectious virus with treatment.
recovery time, 24.9% lower, HR 0.75, p = 0.45, treatment 15, control 15, inverted to make HR<1 favor treatment, propensity score matching.
hospitalization time, 12.7% higher, HR 1.13, p = 0.75, treatment 15, control 15, inverted to make HR<1 favor treatment, propensity score matching.
viral clearance time, 0.5% lower, HR 1.00, p = 0.99, treatment 15, control 15, inverted to make HR<1 favor treatment, propensity score matching.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Hong et al., 4 May 2022, retrospective, South Korea, peer-reviewed, 11 authors, study period 28 February, 2020 - 28 April, 2020. Contact: kmedicsoon@pusan.ac.kr, thhwang@pusan.ac.kr, wsabf@naver.com.
This PaperHCQAll
Use of combined treatment of 3rd-generation cephalosporin, azithromycin and antiviral agents on moderate SARs-CoV-2 patients in South Korea: A retrospective cohort study
Wooyoung Hong, Yu-Kyung Park, Bong-Ok Kim, Sung Kyu Park, Jiin Shin, Soon-Pyo Jang, Hea-Woon Park, Wonjong Yang, Joonyoung Jang, Soon-Woo Jang, Tae-Ho Hwang
PLOS ONE, doi:10.1371/journal.pone.0267645
Objectives To assess efficacy and safety of the combined treatment of antibiotics (3rd-generation cephalosporin and azithromycin) and antiviral agents (lopinavir/ritonavir or hydroxychloroquine) on moderate COVID-19 patients in South Korea. Methods A retrospective cohort study of the 358 laboratory-confirmed SARS-CoV-2 (COVID-19) patients was conducted. 299 patients met inclusion criteria for analysis. Propensity score matching (PSM) and Cox regression method were used to control and adjust for confounding factors. Mild to moderate COVID-19 patients were managed with either CA/LoP (cephalosporin, azithromycin, and lopinavir/ritonavir) (n = 57), CA/HQ (cephalosporin, azithromycin, and hydroxychloroquine) (n = 25) or standard supportive care (n = 217). We analyzed the association between treatment group and standard supportive group in terms of three endpoints: time to symptom resolution, time to viral clearance, and hospital stay duration. Using propensity-score matching analysis, three rounds of propensity-matching analysis were performed to balance baseline characteristics among three cohorts. Results Kaplan-Meier curves fitted using propensity score-matched data revealed no significant differences on time to symptom resolution, time to viral clearance, hospital stay duration
Supporting information S1 Author Contributions Conceptualization: Wooyoung Hong, Soon-Woo Jang. Data curation: Sung Kyu Park, Soon-Woo Jang. Formal analysis: Wooyoung Hong. Funding acquisition: Tae-Ho Hwang. Investigation: Yu-Kyung Park, Bong-Ok Kim, Sung Kyu Park, Hea-Woon Park, Wonjong Yang, Joonyoung Jang, Soon-Woo Jang. Methodology: Wooyoung Hong. Project administration: Soon-Woo Jang, Tae-Ho Hwang. Resources: Yu-Kyung Park, Bong-Ok Kim, Sung Kyu Park, Hea-Woon Park, Wonjong Yang, Joonyoung Jang. Software: Wooyoung Hong. Supervision: Soon-Woo Jang, Tae-Ho Hwang. Validation: Wooyoung Hong, Soon-Woo Jang. Visualization: Soon-Pyo Jang. Writing -original draft: Wooyoung Hong, Soon-Woo Jang. Writing -review & editing: Wooyoung Hong, Jiin Shin.
References
Adler, Ball, Fisher, Mortimer, Vardhan, Low rate of bacterial co-infection in patients with COVID-19, The Lancet Microbe, doi:10.1016/S2666-5247%2820%2930036-7
Austin, An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies, Multivariate Behav Res, doi:10.1080/00273171.2011.568786
Biot, Daher, Chavain, Fandeur, Khalife et al., Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities, Journal of medicinal chemistry, doi:10.1021/jm0601856
Borba, Val, Sampaio, Alexandre, Melo et al., Effect of high vs low doses of chloroquine diphosphate as adjunctive therapy for patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: a randomized clinical trial, JAMA network open, doi:10.1001/jamanetworkopen.2020.8857
Bosseboeuf, Aubry, Nhan, Pina, Rolain et al., Azithromycin inhibits the replication of Zika virus, J Antivirals Antiretrovirals
Campbell, Marrie, Anstey, Dickinson, Ackroyd-Stolarz et al., The contribution of blood cultures to the clinical management of adult patients admitted to the hospital with communityacquired pneumonia: a prospective observational study, Chest, doi:10.1378/chest.123.4.1142
Cao, Wang, Wen, Liu, Wang et al., A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19, New England Journal of Medicine, doi:10.1056/NEJMoa2001282
Cavalcanti, Zampieri, Rosa, Azevedo, Veiga et al., Hydroxychloroquine with or without azithromycin in mild-to-moderate Covid-19, New England Journal of Medicine
Chen, Chan, Jiang, Kao, Lu et al., In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compounds, Journal of Clinical Virology, doi:10.1016/j.jcv.2004.03.003
Chen, Zhou, Dong, Qu, Gong et al., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study, The lancet, doi:10.1016/S0140-6736%2820%2930211-7
Choi, Kang, Shin, Noh, Cheong et al., Comparison of antiviral effect for mildto-moderate COVID-19 cases between lopinavir/ritonavir versus hydroxychloroquine: A nationwide propensity score-matched cohort study, International Journal of Infectious Diseases, doi:10.1016/j.ijid.2020.10.062
Choi, Kim, Kim, Nam, Sohn, Community treatment centers for isolation of asymptomatic and mildly symptomatic patients with coronavirus disease, South Korea, Emerging infectious diseases, doi:10.3201/eid2610.201539
Choy, Wong, Kaewpreedee, Sia, Hui, Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro, Antiviral research, doi:10.1016/j.antiviral.2020.104786
Colson, Rolain, Lagier, Brouqui, Raoult, Chloroquine and hydroxychloroquine as available weapons to fight COVID-19, Int J Antimicrob Agents, doi:10.1016/j.ijantimicag.2020.105932
Corman, Bleicker, Bru ¨nink S, Drosten, Zambon, Organization, Diagnostic detection of Wuhan coronavirus 2019 by real-time RT-PCR
Fernandes, Silva, Martins, Oliveira, QTc interval prolongation in critically ill patients: Prevalence, risk factors and associated medications, PLoS One, doi:10.1371/journal.pone.0199028
Furst, Lindsley, Baethge, Botstein, Caldwell et al., Dose-loading with hydroxychloroquine improves the rate of response in early, active rheumatoid arthritis: a randomized, doubleblind six-week trial with eighteen-week extension. Arthritis & Rheumatism: Official Journal of the American, College of Rheumatology, doi:10.1002/1529-0131%28199902%2942%3A2%26lt%3B357%3A%3AAID-ANR19%26gt%3B3.0.CO%3B2-J
Gautret, Lagier, Parola, Hoang, Meddeb et al., Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study, Travel Med Infect Dis, doi:10.1016/j.tmaid.2020.101663
Gautret, Lagier, Parola, Hoang, Meddeb et al., Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial, International Journal of Antimicrobial Agents, doi:10.1016/j.ijantimicag.2020.105949
Govind, Freitas, Pritchard, Hayes, Maccabe, Clozapine treatment and risk of COVID-19 infection: retrospective cohort study, The British journal of psychiatry, doi:10.1192/bjp.2020.151
Guaraldi, Meschiari, Cozzi-Lepri, Milic, Tonelli et al., Tocilizumab in patients with severe COVID-19: a retrospective cohort study, The Lancet Rheumatology, doi:10.1016/S2665-9913%2820%2930173-9
Han Yc, Jh, Diagnosis and treatment of bacterial pneumonia in Korea, Respirology, doi:10.1111/j.1440-1843.1996.tb00019.x
Hong, Lee, Kim, Huh, Lee et al., Guidelines for laboratory diagnosis of coronavirus disease 2019 (COVID-19) in Korea, Annals of laboratory medicine, doi:10.3343/alm.2020.40.5.351
Huang, Ran, Lv, Feng, Ran et al., Chronological changes of viral shedding in adult inpatients with COVID-19 in Wuhan, China, Clinical Infectious Diseases, doi:10.1093/cid/ciaa631
Izmirly, Costedoat-Chalumeau, Pisoni, Khamashta, Kim et al., Maternal use of hydroxychloroquine is associated with a reduced risk of recurrent anti-SSA/Ro-antibody-associated cardiac manifestations of neonatal lupus, Circulation, doi:10.1161/CIRCULATIONAHA.111.089268
Jefferson, Dalton, Escobar, Allison, Transportation delay and the microbiological quality of clinical specimens, American journal of clinical pathology, doi:10.1093/ajcp/64.5.689
Ji, Huh, Kang, Hong, Bae et al., Effect of underlying comorbidities on the infection and severity of COVID-19 in Korea: a nationwide case-control study, Journal of Korean medical science, doi:10.3346/jkms.2020.35.e237
Karolyi, Pawelka, Mader, Omid, Kelani et al., Hydroxychloroquine versus lopinavir/ritonavir in severe COVID-19 patients, Wiener Klinische Wochenschrift, doi:10.1007/s00508-020-01720-y
Kcfdca, Management guidelines for coronavirus disease-19
Kim, An, -K, Bitton, Gawande, How South Korea responded to the COVID-19 outbreak in Daegu, NEJM Catalyst Innovations in Care Delivery
Kim, Huh, Heo, Joo, Kim et al., Interim guidelines on antiviral therapy for COVID-19, Infection & chemotherapy, doi:10.3947/ic.2020.52.2.281
Kim, Roslin, Wang, Kane, Hirsch et al., BMI as a risk factor for clinical outcomes in patients hospitalized with COVID-19 in New York, Obesity, doi:10.1002/oby.23076
Kim, Sung, Kim, Kim, Clinical Relevance of Positive NOW™ Legionella Urinary Antigen Test in a Tertiary-Care Hospital in Korea, The Korean journal of laboratory medicine, doi:10.3343/kjlm.2006.26.2.93
Kumar, Kumar, Lee, A computational drug repurposing approach in identifying the cephalosporin antibiotic and anti-hepatitis C drug derivatives for COVID-19 treatment, Computers in biology and medicine, doi:10.1016/j.compbiomed.2020.104186
Li, Xie, Lin, Cai, Wen et al., Efficacy and safety of lopinavir/ritonavir or arbidol in adult patients with mild/moderate COVID-19: an exploratory randomized controlled trial, Med, doi:10.1016/j.medj.2020.04.001
Lin, Zhao, -S, Zhou, -X, Zhou F-C et al., Coronavirus disease 2019 (COVID-19): cytokine storms, hyper-inflammatory phenotypes, and acute respiratory distress syndrome, Genes & Diseases
Lofgren, Nicol, Bangdiwala, Pastick, Okafor et al., Safety of hydroxychloroquine among outpatient clinical trial participants for COVID-19
Mahe ´vas, Tran, Roumier, Chabrol, Paule et al., Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data, Bmj, doi:10.1136/bmj.m1844
Manohar, Loh, Nachimuthu, Hua, Welburn et al., Secondary bacterial infections in patients with viral pneumonia, Frontiers in medicine, doi:10.3389/fmed.2020.00420
Matsunaga, Hayakawa, Terada, Ohtsu, Asai et al., Clinical Epidemiology of Hospitalized Patients With Coronavirus Disease
Min, Jang, Macrolide therapy in respiratory viral infections, Mediators of inflammation, doi:10.1155/2012/649570
Nio, Coronavirus disease 2019 (COVID-19) treatment guidelines
Park, Yu, Kim, Kim, Kim et al., Antiviral Efficacies of FDA-Approved Drugs against SARS-CoV-2 Infection in Ferrets, Mbio, doi:10.1128/mBio.01114-20
Petrilli, Jones, Yang, Rajagopalan, Donnell et al., Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study, Bmj, doi:10.1136/bmj.m1966
Rawson, Moore, Zhu, Ranganathan, Skolimowska et al., Bacterial and fungal coinfection in individuals with coronavirus: a rapid review to support COVID-19 antimicrobial prescribing, Clinical Infectious Diseases, doi:10.1093/cid/ciaa530
Rismanbaf, Potential treatments for COVID-19; a narrative literature review, Archives of Academic Emergency Medicine
Ritchie, Beltekian, Daily confirmed deaths: are we bending the curve
Rosenberg, Dufort, Udo, Wilberschied, Kumar et al., Association of treatment with hydroxychloroquine or azithromycin with in-hospital mortality in patients with COVID-19 in New York State, Jama, doi:10.1001/jama.2020.8630
Roso ´n, ´ndez-Sabe, Carratala, Verdaguer, Dorca et al., Contribution of a urinary antigen assay (Binax NOW) to the early diagnosis of pneumococcal pneumonia, Clinical Infectious Diseases, doi:10.1086/380639
Rubin, Multiple imputation for nonresponse in surveys
Schrezenmeier, Do ¨rner T, Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology, Nature Reviews Rheumatology, doi:10.1038/s41584-020-0372-x
Sharma, Singh, Banerjee, Antibacterial agents used in COVID-19: A systematic review and metaanalysis, Environmental Sustainability, doi:10.4103/ijp.ijp%5F839%5F21
Tang, Cao, Han, Wang, Chen et al., Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial, doi:10.1136/bmj.m1849
Tang, Godfrey, Stawell, Nikpour, Hydroxychloroquine in lupus: emerging evidence supporting multiple beneficial effects, Internal medicine journal, doi:10.1111/j.1445-5994.2012.02886.x
Townsend, Hughes, Kerr, Kelly, Connor et al., Bacterial pneumonia coinfection and antimicrobial therapy duration in SARS-CoV-2 (COVID-19) infection. JAC-Antimicrobial Resistance, doi:10.1093/jacamr/dlaa071
Tran, Sugamata, Hirose, Suzuki, Noguchi et al., Azithromycin, a 15-membered macrolide antibiotic, inhibits influenza A (H1N1) pdm09 virus infection by interfering with virus internalization process, The Journal of antibiotics, doi:10.1038/s41429-019-0204-x
Van Der Eerden, Vlaspolder, Graaff, Groot, Jansen et al., Value of intensive diagnostic microbiological investigation in low-and high-risk patients with community-acquired pneumonia, European Journal of Clinical Microbiology and Infectious Diseases, doi:10.1007/s10096-005-1316-8
Wang, Yang, Li, Wen, Zhang, Clinical features of 69 cases with coronavirus disease 2019 in Wuhan, China, Clinical infectious diseases, doi:10.1093/cid/ciaa272
Who, World Health Organization
Wu, Mcgoogan, Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention, Jama, doi:10.1001/jama.2020.2648
Yang, Yu, Xu, Shu, Liu et al., Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study, The Lancet Respiratory Medicine, doi:10.1016/S2213-2600%2820%2930079-5
Yao, Ye, Zhang, Cui, Huang et al., In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Clinical Infectious Diseases
Ye, Luo, Xia, Sun, Ding et al., Clinical efficacy of lopinavir/ritonavir in the treatment of Coronavirus disease 2019, Eur Rev Med Pharmacol Sci, doi:10.26355/eurrev%5F202003%5F20706
Yeon Lee, Hong, Hyun, Park, Lee et al., Epidemiological and clinical characteristics of coronavirus disease 2019 in Daegu, South Korea, International Journal of Infectious Diseases, doi:10.1016/j.ijid.2020.07.017
You, Wu, -H, Fu, -N et al., The use of methylprednisolone in COVID-19 patients: A propensity score matched retrospective cohort study, PloS one, doi:10.1371/journal.pone.0244128
Yu, Sun, Shi, Wang, Zhao et al., SARS-CoV-2 viral load in sputum correlates with risk of COVID-19 progression, Critical care, doi:10.1186/s13054-019-2683-3
Zhao, He, Tang, Xie, Tang et al., The relationship between chest imaging findings and the viral load of COVID-19, Frontiers in Medicine, doi:10.3389/fmed.2020.558539
Zheng, Yu, Feng, Lou, Zou, Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, doi:10.1136/bmj.m1443
Late treatment
is less effective
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