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0 0.5 1 1.5 2+ Case 47% Improvement Relative Risk c19hcq.org Ferreira et al. HCQ for COVID-19 PrEP Favors HCQ Favors control
Chronic treatment with hydroxychloroquine and SARS-CoV-2 infection
Ferreira et al., J. Medical Virology, July 9, 2020, doi:10.1002/jmv.26286 (date from earlier preprint)
29 Jun 2020    Source   PDF   Share   Tweet
Chronic treatment with HCQ provides protection against COVID, odds ratio 0.51 (0.37-0.70).
The actual benefit is likely to be larger becasue research shows that the risk of COVID-19 for systemic autoimmune disease patients is much higher overall. Ferri et al. show OR 4.42, p<0.001 [Ferri], which is the observed real-world risk, taking into account factors such as these patients potentially being more careful to avoid exposure.
risk of case, 47.1% lower, RR 0.53, p < 0.001, adjusted per study, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ferreira et al., 29 Jun 2020, retrospective, population-based cohort, database analysis, Portugal, peer-reviewed, 3 authors.
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