Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All HCQ studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19hcq.org COVID-19 treatment researchHCQHCQ (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 3% Improvement Relative Risk HCQ for COVID-19  Çiyiltepe et al.  ICU PATIENTS Is very late treatment with HCQ beneficial for COVID-19? Retrospective 147 patients in Turkey No significant difference in mortality c19hcq.org Çiyiltepe et al., South. Clin. Ist. Eu.., Apr 2021 Favors HCQ Favors control

The Effect of Pre-admission Hydroxychloroquine Treatment on COVID-19-Related Intensive Care Follow-up in Geriatric Patients

Çiyiltepe et al., South. Clin. Ist. Euras., doi:10.14744/scie.2021.89847
Apr 2021  
  Post
  Facebook
Share
  Source   PDF   All   Meta
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now known with p < 0.00000000001 from 422 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments. c19hcq.org
Retrospective 147 ICU patients in Turkey, showing no significant difference in outcomes based on HCQ treatment before ICU admission. This is not very informative, for example we do not know if HCQ treated patients were much less likely to be admitted to the ICU.
This study is excluded in the after exclusion results of meta analysis: treatment group only includes patients where treatment failed resulting in ICU admission.
risk of death, 3.2% lower, RR 0.97, p = 0.85, treatment 69 of 95 (72.6%), control 39 of 52 (75.0%), NNT 42.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Çiyiltepe et al., 30 Apr 2021, retrospective, Turkey, peer-reviewed, 5 authors.
This PaperHCQAll
Effect of Pre-admission Hydroxychloroquine Treatment on COVID-19-related Intensive Care Follow-up in Geriatric Patients
SBÜ Fulya Çiyiltepe, Ayten Saracoglu, Yeliz Bilir, Elif Bombacı, Kemal Saracoglu, Dr İstanbul Kartal, Lütfi Kırdar, Şehir Hastanesi, Anesteziyoloji Ve
Southern Clinics of Istanbul Eurasia, doi:10.14744/scie.2021.89847
Objective: The admission rates to intensive care units and mortalities in geriatric patients are higher than the rest of the population with COVID-19 infection. Although the efficacy of hydroxychloroquine sulfate has been recognized, especially when started early during infection, its effectiveness at these early time points in geriatric patients has not been investigated. In this study, our primary aim was to investigate the effects of early treatment of hydroxychloroquine sulfate on COVID-19 positive geriatric patients, according to their clinical symptoms, situation before the intensive care, and patient survival. Methods: A total of 147 geriatric patients diagnosed with COVID-19 in the intensive care unit were divided into three groups: Patients who were admitted to the intensive care unit from the emergency department but did not receive treatment (Group 1); from the service for whose a 5-day treatment was initiated but not completed (Group 2); and those who completed 5-days of drug therapy (Group 3). Results: Although demographic data were similar between the three groups, the age parameters were significantly differed between them. Furthermore, there was no difference between the groups regarding mortality rate, discharge time, or extubation. The time to mortality and the duration of mechanical ventilation were found to be significantly shorter in Group 1 (p=0.001). Conclusion: No significant effect was observed on patient survival and outcome due to early administration of hydroxychloroquine sulfate.According to our main findings, this study cannot recommend pre-admission hydroxychloroquine treatment for critically ill geriatric patients with COVID-19.
Conflict of Interest None declared.
References
Amaç, Gereç ve Yöntem: Yoğun bakım ünitesinde COVID-19 tanısı alan toplam 147 geriatrik hasta üç gruba ayrıldı: Acil servisten yoğun bakım ünitesine kabul edilen ancak tedavi almayan hastalar (Grup 1); beş günlük tedavi başlatılan ancak tamamlanmayan klinikten kabul edilen hastalar (Grup 2); ve beş günlük ilaç tedavisini tamamlamış olanlar
Andreani, Bideau, Duflot, Jardot, Rolland et al., In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect, Microb Pathog, doi:10.1016/j.micpath.2020.104228
Astuti, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response, Diabetes Metab Syndr, doi:10.1016/j.dsx.2020.04.020
Boccardi, Ruggiero, Mecocci, COVID-19: A geriatric emergency, Geriatrics, doi:10.3390/geriatrics5020024
Bulgular, Üç grup arasında demografik veriler benzer olmasına rağmen, yaş parametreleri aralarında önemli ölçüde farklıydı. Ayrıca ölüm oranı, taburculuk veya ekstübasyon zamanı açısından gruplar arasında fark yoktu
Celotto, Veronese, Barbagallo, Ometto, Smith et al., An umbrella review of systematic reviews with meta-analyses evaluating positive and negative outcomes of Hydroxychloroquine and chloroquine therapy, Int J Infect Dis, doi:10.1016/j.ijid.2020.12.018
El Mershati, Thouvenin, Secretan, Lonlay, Tuchmann-Durand et al., Formulation and stability study of hydroxychloroquine sulfate oral suspensions, Pharm Dev Technol, doi:10.1080/10837450.2021.1871918
Fda, against use of hydroxychloroquine or chloroquine for COVID-19 outside of the hospital setting or a clinical trial due to risk of heart rhythm problems
Grasselli, Zangrillo, Zanella, Antonelli, Cabrini et al., Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy Region, Italy, JAMA, doi:10.1001/jama.2020.5394
Guan, Ni, Hu, Zhou, Wang et al., China medical treatment expert group for covid-19. Clinical characteristics of coronavirus disease 2019 in China, N Engl J Med
Koenig, Beÿ, Mcdonald, 2019-nCoV: The identify-isolate-inform (3I) tool applied to a novel emerging coronavirus, West J Emerg Med, doi:10.5811/westjem.2020.1.46760
Lara, Nguyen, Macias-Verde, Burgos-Burgos, Arenas et al., Whole-lung low dose irradiation for SARS-Cov2 induced pneumonia in the geriatric population: An old effective treatment for a new disease? Recommendation of the International Geriatric Radiotherapy Group, Aging Dis, doi:10.14336/AD.2020.0506
Liu, Cao, Xu, Wang, Zhang et al., Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro, Cell Discov, doi:10.1038/s41421-020-0156-0
Liu, Chen, Lin, Han, Clinical features of COVID-19 in elderly patients: A comparison with young and middle-aged patients, J Infect, doi:10.1016/j.jinf.2020.03.005
Liu, Chen, Liu, Nie, Lu, Comorbid chronic diseases are strongly correlated with disease severity among COVID-19 patients: A systematic review and meta-analysis, Aging Dis, doi:10.14336/AD.2020.0502
Magrone, Magrone, Russo, Jirillo, Peripheral immunosenescence and central neuroinflammation: a dangerous liaison. A dietary approach, Endocr Metab Immune Disord Drug Targets, doi:10.2174/1871530320666200406123734
Mertz, Kim, Johnstone, Lam, Science et al., Populations at risk for severe or complicated influenza illness: systematic review and meta-analysis, BMJ, doi:10.1136/bmj.f5061
Million, Lagier, Gautret, Colson, Fournier et al., Early treatment of COVID-19 patients with hydroxychloroquine and azithromycin: A retrospective analysis of 1061 cases in Marseille, France, Travel Med Infect Dis, doi:10.1016/j.tmaid.2020.101738
Porcheddu, Serra, Kelvin, Rubino, Similarity in case fatality rates (CFR) of COVID-19/SARS-COV-2 in Italy and China, J Infect Dev Ctries, doi:10.3855/jidc.12600
Schrezenmeier, Dörner, Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology, Nat Rev Rheumatol, doi:10.1038/s41584-020-0372-x
Singh, Bajorek, Defining ' elderly' in clinical practice guidelines for pharmaco therapy, Pharm Pract, doi:10.4321/S1886-36552014000400007
Sinha, Harwood, Semple, Hawcutt, Thursfield et al., COVID-19 infection in children, Lancet Respir Med, doi:10.1016/S2213-2600(20)30152-1
Sonuç, Ana bulgularımıza göre, bu çalışma COVID-19'u olan geriatrik kritik hastalarda başvuru öncesi hidroksiklorokin tedavisi önermemektedir
Van Den Brand, Smits, Haagmans, Pathogenesis of Middle East respiratory syndrome coronavirus, J Pathol, doi:10.1002/path.4458
Who, Definition of an older or elderly person
Wong, Lai, Wong, Comparison of initial high resolution computed tomography features in viral pneumonia between metapneumovirus infection and severe acute respiratory syndrome, Eur J Radiol2012, doi:10.1016/j.ejrad.2011.02.050
Yao, Ye, Zhang, Cui, Huang et al., In Vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Clin Infect Dis, doi:10.1093/cid/ciaa237
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit