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0 0.5 1 1.5 2+ Case 37% Improvement Relative Risk Case, close contact 52% HCQ for COVID-19  Becetti et al.  Prophylaxis Is pre-exposure prophylaxis with HCQ beneficial for COVID-19? Retrospective 700 patients in Qatar (April - July 2020) Fewer cases with HCQ (not stat. sig., p=0.17) Becetti et al., Qatar Medical J., August 2022 Favors HCQ Favors control

Prevalence of coronavirus disease 2019 in a multiethnic cohort of patients with autoimmune rheumatic diseases in Qatar

Becetti et al., Qatar Medical Journal, doi:10.5339/qmj.2022.37
Aug 2022  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
*, now known with p < 0.00000000001 from 422 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments.
Retrospective 700 patients with autoimmune rheumatic disease in Qatar, showing lower risk of COVID-19 with HCQ use, without statistical significance. For patients having close contact with COVID-19 cases, there was a statistically significant association with HCQ use and lower risk of COVID-19 in unadjusted results.
risk of case, 36.8% lower, RR 0.63, p = 0.17, treatment 26 of 314 (8.3%), control 49 of 386 (12.7%), NNT 23, adjusted per study, odds ratio converted to relative risk, multivariable.
risk of case, 52.0% lower, RR 0.48, p < 0.001, treatment 16 of 46 (34.8%), control 29 of 40 (72.5%), NNT 2.7, patients with close contact to cases, close contact.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Becetti et al., 5 Aug 2022, retrospective, Qatar, peer-reviewed, mean age 43.2, 12 authors, study period 1 April, 2020 - 31 July, 2020. Contact:
This PaperHCQAll
Prevalence of coronavirus disease 2019 in a multiethnic cohort of patients with autoimmune rheumatic diseases in Qatar
Karima Becetti, Eman Satti, Betsy Varughese, Yousef Al Rimawi, Rawan Sheikh Saleh, Nawal Hadwan, Miral H Gharib, Mohamed Awni Al Kahlout, Essa Abuhelaiqa, Hadil Afif Ashour, Rajvir Singh, Samar Al Emadi
Qatar Medical Journal, doi:10.5339/qmj.2022.37
Background: Autoimmune rheumatic diseases (ARDs) are characterized by immune dysfunction and associated with an increased risk of infections, which were of significant concern during the coronavirus disease 2019 (COVID-19) pandemic. Variable rates of COVID-19 incidence have been reported in patients with ARDs; however, the true effect of this infection on this patient population is still unclear. We, therefore, aimed to evaluate the COVID-19 prevalence among a multiethnic cohort of patients with ARDs in Qatar. Material and Methods: We used telephonic surveys to collect demographic and clinical information of patients with ARD in Qatar between April 1 and July 31, 2020, including any close contact with a COVID-19 case at home or work and polymerase chain reaction (PCR)-confirmed COVID-19 diagnosis. An electronic medical records review was conducted to verify pertinent data collected through the surveys. Prevalence with 95% confidence interval (CI), Student's t-tests, and chi-square/Fisher's exact tests were used for univariate analyses, whereas multivariate logistic regression was used to identify factors associated with COVID-19. Results: The study included 700 patients with ARD (mean age, 43.2 ^12.3 years), and 73% were female. Until July 2020, 75 (11%, 95% CI 9% -13%) patients had COVID-19. Factors associated with COVID-19 included being a man (adjusted odds ratio [aOR] 2.56, 95% CI 1.35-4.88, p ¼ 0.01) and having close contact with a COVID-19 case (aOR 27.89, 95% CI 14.85-52.38, p ¼ 0.01). Disease severity and rheumatic medications had no significant
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