Prevalence of coronavirus disease 2019 in a multiethnic cohort of patients with autoimmune rheumatic diseases in Qatar
Karima Becetti, Eman Satti, Betsy Varughese, Yousef Al Rimawi, Rawan Sheikh Saleh, Nawal Hadwan, Miral H Gharib, Mohamed Awni Al Kahlout, Essa Abuhelaiqa, Hadil Afif Ashour, Rajvir Singh, Samar Al Emadi
Qatar Medical Journal, doi:10.5339/qmj.2022.37
Background: Autoimmune rheumatic diseases (ARDs) are characterized by immune dysfunction and associated with an increased risk of infections, which were of significant concern during the coronavirus disease 2019 (COVID-19) pandemic. Variable rates of COVID-19 incidence have been reported in patients with ARDs; however, the true effect of this infection on this patient population is still unclear. We, therefore, aimed to evaluate the COVID-19 prevalence among a multiethnic cohort of patients with ARDs in Qatar. Material and Methods: We used telephonic surveys to collect demographic and clinical information of patients with ARD in Qatar between April 1 and July 31, 2020, including any close contact with a COVID-19 case at home or work and polymerase chain reaction (PCR)-confirmed COVID-19 diagnosis. An electronic medical records review was conducted to verify pertinent data collected through the surveys. Prevalence with 95% confidence interval (CI), Student's t-tests, and chi-square/Fisher's exact tests were used for univariate analyses, whereas multivariate logistic regression was used to identify factors associated with COVID-19. Results: The study included 700 patients with ARD (mean age, 43.2 ^12.3 years), and 73% were female. Until July 2020, 75 (11%, 95% CI 9% -13%) patients had COVID-19. Factors associated with COVID-19 included being a man (adjusted odds ratio [aOR] 2.56, 95% CI 1.35-4.88, p ¼ 0.01) and having close contact with a COVID-19 case (aOR 27.89, 95% CI 14.85-52.38, p ¼ 0.01). Disease severity and rheumatic medications had no significant
References
Akiyama, Hamdeh, Micic, Sakuraba, Prevalence and clinical outcomes of COVID-19 in patients with autoimmune diseases: A systematic review and metaanalysis, Ann Rheum Dis. Published online,
doi:10.1136/annrheumdis-2020-218946Alattar, Shaar, Othman, Coronavirus disease 2019 in solid organ transplant recipients in a setting of proactive screening and contact tracing, Qatar Med J,
doi:10.5339/jemtac.2021.qhc.3Aries, Iking-Konert, No increased rate of SARS-CoV-2 infection for patients with inflammatory rheumatic diseases compared with the general population in the city of Hamburg (Germany), Ann Rheum Dis,
doi:10.1136/annrheumdis-2020-218400Bosch, Guilabert, Pallarés, Cerveral, Ramos-Casals et al., Infections in systemic lupus erythematosus: A prospective and controlled study of 110 patients, Lupus,
doi:10.1177/0961203306071919Bozzalla Cassione, Zanframundo, Biglia, Codullo, Montecucco et al., COVID-19 infection in a northern-Italian cohort of systemic lupus erythematosus assessed by telemedicine, Ann Rheum Dis,
doi:10.1136/annrheumdis-2020-217717Conticini, Bargagli, Bardelli, Rana, Baldi et al., COVID-19 pneumonia in a large cohort of patients treated with biological and targeted synthetic antirheumatic drugs, Ann Rheum Dis,
doi:10.1136/annrheumdis-2020-217681Cross, Smith, Hoy, Carmona, Wolfe et al., The global burden of rheumatoid arthritis: Estimates from the Global Burden of Disease 2010 study, Ann Rheum Dis,
doi:10.1136/annrheumdis-2013-204627Doran, Crowson, Pond, 'fallon, Gabriel, Frequency of infection in patients with rheumatoid arthritis compared with controls: A population-based study, Arthritis Rheum,
doi:10.1002/art.10524Emmi, Bettiol, Mattioli, Silvestri, Scala et al., SARS-CoV-2 infection among patients with systemic autoimmune diseases, Autoimmun Rev,
doi:10.1016/j.autrev.2020.102575England, Roul, Yang, Kalil, Michaud et al., Risk of COVID-19 in rheumatoid arthritis: a National Veterans affairs matched cohort study in at-risk individuals, Arthritis Rheumatol,
doi:10.1002/art.41800Ferri, Giuggioli, Raimondo, 'andolina, Tavoni et al., COVID-19 and rheumatic autoimmune systemic diseases: report of a large Italian patients series, Clin Rheumatol,
doi:10.1007/s10067-020-05334-7Fitzgerald, Mecoli, Douglas, Harris, Aravidis et al., Risk factors for infection and health impacts of the Covid-19 pandemic in people with autoimmune diseases, medRxiv
Landewé, Machado, Kroon, Bijlsma, Burmester et al., EULAR provisional recommendations for the management of rheumatic and musculoskeletal diseases in the context of SARS-CoV-2, Ann Rheum Dis,
doi:10.1136/annrheumdis-2020-217877Macías, González-Moreno, Sánchez-García, Morillo-Verdugo, Venegas et al., Prevalence of coronavirus disease 2019 in a multiethnic cohort of patients with autoimmune rheumatic diseases Becetti et al, QATAR MEDICAL JOURNAL
Mehta, Pedro, Ozen, Kalil, Wolfe et al., Serious infection risk in rheumatoid arthritis compared with non-inflammatory rheumatic and musculoskeletal diseases: A US national cohort study, RMD Open,
doi:10.1136/rmdopen-2019-000935Michelena, Borrell, López-Corbeto, López-Lasanta, Moreno et al., Incidence of COVID-19 in a cohort of adult and paediatric patients with rheumatic diseases treated with targeted biologic and synthetic disease-modifying anti-rheumatic drugs, Semin Arthritis Rheum,
doi:10.1016/j.semarthrit.2020.05.001Mikuls, Johnson, Fraenkel, Arasaratnam, Baden et al., American College of Rheumatology Guidance for the Management of Rheumatic Disease in Adult Patients During the COVID-19 Pandemic: Version 2, Arthritis Rheumatol,
doi:10.1002/art.41437Monti, Balduzzi, Delvino, Bellis, Quadrelli et al., Clinical course of COVID-19 in a series of patients with chronic arthritis treated with immunosuppressive targeted therapies, Ann Rheum Dis
Murtas, Andreano, Gervasi, Guido, Consolazio et al., Association between autoimmune diseases and COVID-19 as assessed in both a testnegative case-control and population case-control design, Autoimmun Highlights,
doi:10.1186/s13317-020-00141-1Omrani, Almaslamani, Daghfal, The first consecutive 5000 patients with COVID-19 disease 2019 in Qatar; a nation-wide cohort study, medRxiv,
doi:10.1101/2020.07.15.20154690Ouédraogo, Tiendrébéogo, Kaboré, Ntsiba, COVID-19, chronic inflammatory rheumatic disease and anti-rheumatic treatments, Clin Rheumatol,
doi:10.1007/s10067-020-05189-yPablos, Abasolo, Alvaro-Gracia, Blanco, Blanco et al., Prevalence of hospital PCRconfirmed COVID-19 cases in patients with chronic inflammatory and autoimmune rheumatic diseases, Ann Rheum Dis,
doi:10.1136/annrheumdis-2020-217763Quartuccio, Valent, Pasut, Tascini, Vita, Prevalence of COVID-19 among patients with chronic inflammatory rheumatic diseases treated with biologic agents or small molecules: A population-based study in the first two months of COVID-19 outbreak in Italy, Jt Bone Spine,
doi:10.1016/j.jbspin.2020.05.003Ramirez, Gerosa, Beretta, Bellocchi, Argolini et al., COVID-19 in systemic lupus erythematosus: data from a survey on 417 patients, Semin Arthritis Rheum,
doi:10.1016/j.semarthrit.2020.06.012Salvarani, Mancuso, Gradellini, Viani, Pandolfi et al., Susceptibility to COVID-19 in patients treated with antimalarials: a population-based study in Emilia-Romagna, Northern Italy, Arthritis Rheumatol,
doi:10.1002/art.41475Sattui, Liew, Graef, Coler-Reilly, Berenbaum et al., Swinging the pendulum: lessons learned from public discourse concerning hydroxychloroquine and COVID-19, Expert Rev Clin Immunol,
doi:10.1080/1744666x.2020.1792778Silman, Pearson, Epidemiology and genetics of rheumatoid arthritis, Arthritis Res,
doi:10.1186/ar578Smitten, Choi, Hochberg, Suissa, Simon et al., The risk of hospitalized infection in patients with rheumatoid arthritis, J Rheumatol
Stokes, Zambrano, Anderson, Marder, Raz et al., Coronavirus disease 2019 case surveillance-United States, MMWR,
doi:10.15585/mmwr.mm6924e2Tektonidou, Wang, Dasgupta, Ward, Burden of serious infections in adults with systemic lupus erythematosus: A national population-based study, 1996-2011, Arthritis Care Res,
doi:10.1002/acr.22575Wu, Mcgoogan, Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72314 cases from the Chinese Center for Disease Control and Prevention, JAMA,
doi:10.1001/jama.2020.2648Xu, Chen, Wang, Feng, Zhou et al., Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission, Sci China Life Sci
Zhong, Shen, Yang, Huang, Chen et al., COVID-19 in patients with rheumatic disease in Hubei Province, China: a multicentre retrospective observational study, Lancet Rheumatol,
doi:10.1016/s2665-9913(20)30227-7DOI record:
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