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0 0.5 1 1.5 2+ Case 6% Improvement Relative Risk c19hcq.org Salvarani et al. HCQ for COVID-19 PrEP Is pre-exposure prophylaxis with HCQ beneficial for COVID-19? Retrospective study in Italy No significant difference in cases Salvarani et al., Arthritis & Rheumatology, doi:10.1002/art.41475 Favors HCQ Favors control
Susceptibility to COVID-19 in Patients Treated With Antimalarials: A Population-Based Study in Emilia-Romagna, Northern Italy
Salvarani et al., Arthritis & Rheumatology, doi:10.1002/art.41475
Salvarani et al., Susceptibility to COVID-19 in Patients Treated With Antimalarials: A Population-Based Study in Emilia-Romagna,.., Arthritis & Rheumatology, doi:10.1002/art.41475
Aug 2020   Source   PDF  
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Comparison of CQ/HCQ users with the general population in a region of Italy, showing no significant difference in the probability of COVID-19.
CQ/HCQ users were mostly systemic autoimmune disease patients and authors do not adjust for the very different baseline risk for these patients. Other research shows that the risk of COVID-19 for systemic autoimmune disease patients is much higher overall, Ferri et al. show OR 4.42, p<0.001 [Ferri]. This study is excluded in the after exclusion results of meta analysis: not fully adjusting for the different baseline risk of systemic autoimmune patients.
risk of case, 6.0% lower, OR 0.94, p = 0.75, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Salvarani et al., 6 Aug 2020, retrospective, population-based cohort, Italy, peer-reviewed, 18 authors.
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