Sero-survey for health-care workers provides corroborative evidence for the effectiveness of Hydroxychloroquine prophylaxis against COVID-19 infection
Yadav et al.,
Sero-survey for health-care workers provides corroborative evidence for the effectiveness of..,
ResearchGate, doi:10.13140/RG.2.2.34411.77603 (Preprint)
ICMR seroprevalence survey of 500 healthcare workers in India, 279 taking HCQ prophylaxis, showing a significantly lower risk with treatment, and lower severity.
risk of hospitalization, 82.4% lower, RR 0.18, p = 0.01, treatment 2 of 279 (0.7%), control 9 of 221 (4.1%), NNT 30, PCR+.
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risk of IgG+, 41.8% lower, RR 0.58, p = 0.049, treatment 17 of 178 (9.6%), control 27 of 221 (12.2%), odds ratio converted to relative risk, multivariate logistic regression.
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risk of IgG+, 79.0% lower, RR 0.21, p = 0.09, treatment 1 of 39 (2.6%), control 27 of 221 (12.2%), NNT 10, HCQ >10 weeks.
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risk of IgG+, 52.4% lower, RR 0.48, p = 0.14, treatment 5 of 86 (5.8%), control 27 of 221 (12.2%), NNT 16, HCQ 6-10 weeks.
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risk of IgG+, 69.9% higher, RR 1.70, p = 0.12, treatment 11 of 53 (20.8%), control 27 of 221 (12.2%), HCQ <6 weeks.
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Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
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Yadav et al., 30 Sep 2020, retrospective, India, preprint, 11 authors.
Abstract: See discussions, stats, and author profiles for this publication at: https://www.researchgate.net/publication/344221734
Sero-survey for health-care workers provides corroborative evidence for the
effectiveness of Hydroxychloroquine prophylaxis against COVID-19 infection
Preprint · September 2020
DOI: 10.13140/RG.2.2.34411.77603
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National Institute of Immunohaematology
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Umair Bargir
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National Institute of Immunohaematology
Indian Council of Medical Research
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Sero-survey for health-care workers provides corroborative evidence for the effectiveness
of Hydroxychloroquine prophylaxis against COVID-19 infection.
Reetika M. Yadav1, Archana Pate2, Aruna Shankarkumar1, Shreyasi Athalye1, Shweta Shinde1, Umair Ahmed
Bargir1, Mangesh Pate2, Makarand Ganapule2, Meena Pruthi2, Hemant Patil2, Manisha Madkaikar1
1 ICMR-National Institute of Immunohematology, Mumbai, India
2 Indian Medical Association Dombivli, India
Complete Address:
1ICMR-National Institute of Immunohematology, 13th floor, New multi-storeyed building, KEM hospital
complex, Parel, Mumbai -400012, India
2 Indian Medical Association Dombivli, IMA hall, 2nd floor, Deepshikha CHS, Dombivli- 421201, India
Corresponding author: Dr. Manisha Madkaikar, Director, ICMR- National Institute of
Immunohematology, Mumbai, India. Email: madkaikarmanisha@gmail.com
Phone: 91-022-24132928
Word Count: 1729
Abstract
Background
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has resulted in occupational exposure
among health care workers (HCWs) and a high risk of nosocomial transmission. Asymptomatic infection and
transmission of infection before the development of symptoms are well-recognised factors contributing to the
spread of infection. The importance of understanding the dynamics of transmission in HCWs lies in planning
strategies for the reduction of nosocomial spread.
Methods
A cross-sectional sero-surveillance study was conducted among 500 HCWs in Dombivli and surrounding Mumbai
Metropolitan area (MMR, Maharashtra, India). The vulnerability of the study participants to SARS-CoV-2
infection was ascertained through a history of (i) involvement in direct care of Novel Coronavirus Disease
(COVID-19) patients, (ii) exposure to aerosol-generating procedures, (iii) presence of co-morbidities, (iv) use of
Personal protective equipment(PPE), and (v) HCQ prophylaxis collected through a structured questionnaire. A
systematic analysis of the correlation between the development of antibodies and factors affecting vulnerability
to infection was performed.
Findings
The overall SARS-CoV-2 seroprevalence in the study population was 11%. Only about two-fifths of the HCWs
who had detectable anti-SARS-CoV-2 antibodies reported symptoms consistent with a prior viral illness. Direct
care to COVID -19 patients for longer..
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